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Items: 1 to 50 of 58

1.

Deciphering the Allosteric Binding Mechanism of the Human Tropomyosin Receptor Kinase A ( hTrkA) Inhibitors.

Subramanian G, Johnson PD, Zachary T, Roush N, Zhu Y, Bowen SJ, Janssen A, Duclos BA, Williams T, Javens C, Shalaly ND, Molina DM, Wittwer AJ, Hirsch JL.

ACS Chem Biol. 2019 May 14. doi: 10.1021/acschembio.9b00126. [Epub ahead of print]

PMID:
31059222
2.

Aminopyrazole Carboxamide Bruton's Tyrosine Kinase Inhibitors. Irreversible to Reversible Covalent Reactive Group Tuning.

Schnute ME, Benoit SE, Buchler IP, Caspers N, Grapperhaus ML, Han S, Hotchandani R, Huang N, Hughes RO, Juba BM, Kim KH, Liu E, McCarthy E, Messing D, Miyashiro JS, Mohan S, O'Connell TN, Ohren JF, Parikh MD, Schmidt M, Selness SR, Springer JR, Thanabal V, Trujillo JI, Walker DP, Wan ZK, Withka JM, Wittwer AJ, Wood NL, Xing L, Zapf CW, Douhan J 3rd.

ACS Med Chem Lett. 2018 Dec 3;10(1):80-85. doi: 10.1021/acsmedchemlett.8b00461. eCollection 2019 Jan 10.

PMID:
30655951
3.

Quantum Decision Theory in Simple Risky Choices.

Favre M, Wittwer A, Heinimann HR, Yukalov VI, Sornette D.

PLoS One. 2016 Dec 9;11(12):e0168045. doi: 10.1371/journal.pone.0168045. eCollection 2016.

4.

Risky Decisions in a Lottery Task Are Associated with an Increase of Cocaine Use.

Wittwer A, Hulka LM, Heinimann HR, Vonmoos M, Quednow BB.

Front Psychol. 2016 May 9;7:640. doi: 10.3389/fpsyg.2016.00640. eCollection 2016.

5.

Salivary Alpha-Amylase Correlates with Subjective Heat Pain Perception.

Wittwer A, Krummenacher P, La Marca R, Ehlert U, Folkers G.

Pain Med. 2016 Jun;17(6):1131-6. doi: 10.1093/pm/pnv085. Epub 2016 Jan 13.

PMID:
26764337
6.

Juicy lemons for measuring basic empathic resonance.

Hagenmuller F, Rössler W, Wittwer A, Haker H.

Psychiatry Res. 2014 Oct 30;219(2):391-6. doi: 10.1016/j.psychres.2014.05.053. Epub 2014 Jun 6.

PMID:
24953424
7.

Help-seeking in people with exceptional experiences: results from a general population sample.

Landolt K, Wittwer A, Wyss T, Unterassner L, Fach W, Krummenacher P, Brugger P, Haker H, Kawohl W, Schubiger PA, Folkers G, Rössler W.

Front Public Health. 2014 May 21;2:51. doi: 10.3389/fpubh.2014.00051. eCollection 2014.

8.

Preventing T7 RNA polymerase read-through transcription-A synthetic termination signal capable of improving bioprocess stability.

Mairhofer J, Wittwer A, Cserjan-Puschmann M, Striedner G.

ACS Synth Biol. 2015 Mar 20;4(3):265-73. doi: 10.1021/sb5000115. Epub 2014 May 30.

PMID:
24847676
9.

Intra-rater and inter-rater reliability of the five image-based criteria of the foot posture index-6.

Terada M, Wittwer AM, Gribble PA.

Int J Sports Phys Ther. 2014 Apr;9(2):187-94.

10.

Differential kinetics and inhibition of purified recombinant tyrosine kinase 2 (TYK-2) and its catalytic domain JH-1.

Emmons TL, Wrightstone AD, Baima ET, Brown S, Sommers CD, Hirsch JL, Pegg LE, Weinberg RA, Fischer HD, Wittwer AJ, Tomasselli AG.

Protein Pept Lett. 2012 May;19(5):485-91.

PMID:
22486643
11.

Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1.

Schnute ME, McReynolds MD, Kasten T, Yates M, Jerome G, Rains JW, Hall T, Chrencik J, Kraus M, Cronin CN, Saabye M, Highkin MK, Broadus R, Ogawa S, Cukyne K, Zawadzke LE, Peterkin V, Iyanar K, Scholten JA, Wendling J, Fujiwara H, Nemirovskiy O, Wittwer AJ, Nagiec MM.

Biochem J. 2012 May 15;444(1):79-88. doi: 10.1042/BJ20111929.

PMID:
22397330
12.

High-performance liquid chromatography-tandem mass spectrometry assay of fatty acid amide hydrolase (FAAH) in blood: FAAH inhibition as clinical biomarker.

Yapa U, Prusakiewicz JJ, Wrightstone AD, Christine LJ, Palandra J, Groeber E, Wittwer AJ.

Anal Biochem. 2012 Feb 15;421(2):556-65. doi: 10.1016/j.ab.2011.10.042. Epub 2011 Oct 29.

PMID:
22107886
13.

Imidazo[1,5-a]quinoxalines as irreversible BTK inhibitors for the treatment of rheumatoid arthritis.

Kim KH, Maderna A, Schnute ME, Hegen M, Mohan S, Miyashiro J, Lin L, Li E, Keegan S, Lussier J, Wrocklage C, Nickerson-Nutter CL, Wittwer AJ, Soutter H, Caspers N, Han S, Kurumbail R, Dunussi-Joannopoulos K, Douhan J 3rd, Wissner A.

Bioorg Med Chem Lett. 2011 Nov 1;21(21):6258-63. doi: 10.1016/j.bmcl.2011.09.008. Epub 2011 Sep 10.

PMID:
21958547
14.

Structure analysis reveals the flexibility of the ADAMTS-5 active site.

Shieh HS, Tomasselli AG, Mathis KJ, Schnute ME, Woodard SS, Caspers N, Williams JM, Kiefer JR, Munie G, Wittwer A, Malfait AM, Tortorella MD.

Protein Sci. 2011 Apr;20(4):735-44. doi: 10.1002/pro.606.

15.

Kinetic and structural characterization of caspase-3 and caspase-8 inhibition by a novel class of irreversible inhibitors.

Wang Z, Watt W, Brooks NA, Harris MS, Urban J, Boatman D, McMillan M, Kahn M, Heinrikson RL, Finzel BC, Wittwer AJ, Blinn J, Kamtekar S, Tomasselli AG.

Biochim Biophys Acta. 2010 Sep;1804(9):1817-31. doi: 10.1016/j.bbapap.2010.05.007. Epub 2010 May 24.

PMID:
20580860
16.

Expression, purification, and characterization of TYK-2 kinase domain, a member of the Janus kinase family.

Korniski B, Wittwer AJ, Emmons TL, Hall T, Brown S, Wrightstone AD, Hirsch JL, Gormley JA, Weinberg RA, Leone JW, Day JE, Chrencik JE, Sommers CD, Fischer HD, Tomasselli AG.

Biochem Biophys Res Commun. 2010 May 28;396(2):543-8. doi: 10.1016/j.bbrc.2010.04.141. Epub 2010 May 8.

PMID:
20435017
17.

A novel autotaxin inhibitor reduces lysophosphatidic acid levels in plasma and the site of inflammation.

Gierse J, Thorarensen A, Beltey K, Bradshaw-Pierce E, Cortes-Burgos L, Hall T, Johnston A, Murphy M, Nemirovskiy O, Ogawa S, Pegg L, Pelc M, Prinsen M, Schnute M, Wendling J, Wene S, Weinberg R, Wittwer A, Zweifel B, Masferrer J.

J Pharmacol Exp Ther. 2010 Jul;334(1):310-7. doi: 10.1124/jpet.110.165845. Epub 2010 Apr 14.

PMID:
20392816
18.

Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis.

Schnute ME, O'Brien PM, Nahra J, Morris M, Howard Roark W, Hanau CE, Ruminski PG, Scholten JA, Fletcher TR, Hamper BC, Carroll JN, Patt WC, Shieh HS, Collins B, Pavlovsky AG, Palmquist KE, Aston KW, Hitchcock J, Rogers MD, McDonald J, Johnson AR, Munie GE, Wittwer AJ, Man CF, Settle SL, Nemirovskiy O, Vickery LE, Agawal A, Dyer RD, Sunyer T.

Bioorg Med Chem Lett. 2010 Jan 15;20(2):576-80. doi: 10.1016/j.bmcl.2009.11.081. Epub 2009 Nov 22.

PMID:
20005097
19.

Structural and inhibition analysis reveals the mechanism of selectivity of a series of aggrecanase inhibitors.

Tortorella MD, Tomasselli AG, Mathis KJ, Schnute ME, Woodard SS, Munie G, Williams JM, Caspers N, Wittwer AJ, Malfait AM, Shieh HS.

J Biol Chem. 2009 Sep 4;284(36):24185-91. doi: 10.1074/jbc.M109.029116. Epub 2009 Jul 8.

20.

Heat pain threshold and tolerance show no left-right perceptual differences at complementary sites of the human forearm.

Schaffner N, Wittwer A, Kut E, Folkers G, Benninger DH, Candia V.

Neurosci Lett. 2008 Aug 8;440(3):309-13. doi: 10.1016/j.neulet.2008.05.084. Epub 2008 May 28.

PMID:
18571850
21.

Changes in self-perceived role identity modulate pain perception.

Kut E, Schaffner N, Wittwer A, Candia V, Brockmann M, Storck C, Folkers G.

Pain. 2007 Sep;131(1-2):191-201. Epub 2007 May 22.

22.

Substrate-dependent inhibition kinetics of an active site-directed inhibitor of ADAMTS-4 (Aggrecanase 1).

Wittwer AJ, Hills RL, Keith RH, Munie GE, Arner EC, Anglin CP, Malfait AM, Tortorella MD.

Biochemistry. 2007 May 29;46(21):6393-401. Epub 2007 May 8.

PMID:
17487981
23.

Ex vivo/in vitro absorption of STW 5 (Iberogast) and its extract components.

Kelber O, Wittwer A, Lapke C, Kroll U, Weiser D, Okpanyi SN, Heilmann J.

Phytomedicine. 2006;13 Suppl 5:107-13. Epub 2006 Aug 22.

PMID:
16920344
24.

Alpha2-macroglobulin is a novel substrate for ADAMTS-4 and ADAMTS-5 and represents an endogenous inhibitor of these enzymes.

Tortorella MD, Arner EC, Hills R, Easton A, Korte-Sarfaty J, Fok K, Wittwer AJ, Liu RQ, Malfait AM.

J Biol Chem. 2004 Apr 23;279(17):17554-61. Epub 2004 Jan 7.

25.

Examination of the kinetic mechanism of mitogen-activated protein kinase activated protein kinase-2.

Schindler JF, Godbey A, Hood WF, Bolten SL, Broadus RM, Kasten TP, Cassely AJ, Hirsch JL, Merwood MA, Nagy MA, Fok KF, Saabye MJ, Morgan HM, Compton RP, Mourey RJ, Wittwer AJ, Monahan JB.

Biochim Biophys Acta. 2002 Jul 29;1598(1-2):88-97.

PMID:
12147348
26.
27.

Computer assisted retraining of attentional impairments in patients with multiple sclerosis.

Plohmann AM, Kappos L, Ammann W, Thordai A, Wittwer A, Huber S, Bellaiche Y, Lechner-Scott J.

J Neurol Neurosurg Psychiatry. 1998 Apr;64(4):455-62.

28.

The herpesvirus protease: mechanistic studies and discovery of inhibitors of the human cytomegalovirus protease.

Flynn DL, Becker DP, Dilworth VM, Highkin MK, Hippenmeyer PJ, Houseman KA, Levine LM, Li M, Moormann AE, Rankin A, Toth MV, Villamil CI, Wittwer AJ, Holwerda BC.

Drug Des Discov. 1997 May;15(1):3-15. Review.

PMID:
9332827
29.

Three-dimensional structure of human cytomegalovirus protease.

Shieh HS, Kurumbail RG, Stevens AM, Stegeman RA, Sturman EJ, Pak JY, Wittwer AJ, Palmier MO, Wiegand RC, Holwerda BC, Stallings WC.

Nature. 1996 Sep 19;383(6597):279-82. Erratum in: Nature 1996 Nov 21;384(6606):288.

PMID:
8805708
30.
31.

Intratracheal injection of endotoxin and cytokines. IX. Contribution of CD11a/ICAM-1 to neutrophil emigration.

Tang WW, Yi ES, Remick DG, Wittwer A, Yin S, Qi M, Ulich TR.

Am J Physiol. 1995 Nov;269(5 Pt 1):L653-9.

PMID:
7491985
32.

Chemokine gene expression in anti-glomerular basement membrane antibody glomerulonephritis.

Tang WW, Yin S, Wittwer AJ, Qi M.

Am J Physiol. 1995 Sep;269(3 Pt 2):F323-30.

PMID:
7573480
33.

Intratracheal administration of endotoxin and cytokines. VI. Antiserum to CINC inhibits acute inflammation.

Ulich TR, Howard SC, Remick DG, Wittwer A, Yi ES, Yin S, Guo K, Welply JK, Williams JH.

Am J Physiol. 1995 Feb;268(2 Pt 1):L245-50.

PMID:
7532369
34.

Activity of two-chain recombinant human cytomegalovirus protease.

Holwerda BC, Wittwer AJ, Duffin KL, Smith C, Toth MV, Carr LS, Wiegand RC, Bryant ML.

J Biol Chem. 1994 Oct 14;269(41):25911-5.

35.

Cytokine-induced neutrophil chemoattractant mediates neutrophil influx in immune complex glomerulonephritis in rat.

Wu X, Wittwer AJ, Carr LS, Crippes BA, DeLarco JE, Lefkowith JB.

J Clin Invest. 1994 Jul;94(1):337-44.

36.

High-level expression of cytokine-induced neutrophil chemoattractant (CINC) by a metastatic rat cell line: purification and production of blocking antibodies.

Wittwer AJ, Carr LS, Zagorski J, Dolecki GJ, Crippes BA, De Larco JE.

J Cell Physiol. 1993 Aug;156(2):421-7.

PMID:
8344996
37.

Investigation of possible autocrine functions for rat GRO/CINC (cytokine-induced neutrophil chemoattractant).

Crippes BA, Zagorski J, Carr LS, Wittwer AJ, Dolecki GJ, De Larco JE.

J Cell Physiol. 1993 Aug;156(2):412-20.

PMID:
8344995
41.

Secretion of active kringle-2-serine protease in Escherichia coli.

Obukowicz MG, Gustafson ME, Junger KD, Leimgruber RM, Wittwer AJ, Wun TC, Warren TG, Bishop BF, Mathis KJ, McPherson DT, et al.

Biochemistry. 1990 Oct 16;29(41):9737-45.

PMID:
2125481
42.

Binding of tissue plasminogen activator to human aortic endothelial cells.

Sanzo MA, Howard SC, Wittwer AJ, Cochrane HM.

Biochem J. 1990 Jul 15;269(2):475-82.

43.
44.

Effects of N-glycosylation on in vitro activity of Bowes melanoma and human colon fibroblast derived tissue plasminogen activator.

Wittwer AJ, Howard SC, Carr LS, Harakas NK, Feder J, Parekh RB, Rudd PM, Dwek RA, Rademacher TW.

Biochemistry. 1989 Sep 19;28(19):7662-9.

PMID:
2514792
45.

Cell-type-specific and site-specific N-glycosylation of type I and type II human tissue plasminogen activator.

Parekh RB, Dwek RA, Thomas JR, Opdenakker G, Rademacher TW, Wittwer AJ, Howard SC, Nelson R, Siegel NR, Jennings MG, et al.

Biochemistry. 1989 Sep 19;28(19):7644-62.

PMID:
2514791
47.

Purification and characterization of a tissue plasminogen activator-inhibitor complex from human umbilical vein endothelial cell conditioned medium.

Sanzo MA, Marasa JC, Wittwer AJ, Siegel NR, Harakas NK, Feder J.

Biochemistry. 1987 Nov 17;26(23):7443-9.

PMID:
3122830
48.

Biosynthesis of 5-methylaminomethyl-2-selenouridine, a naturally occurring nucleoside in Escherichia coli tRNA.

Wittwer AJ, Stadtman TC.

Arch Biochem Biophys. 1986 Aug 1;248(2):540-50.

PMID:
2874771
49.

Determination of the number of endothelial cells in culture using an acid phosphatase assay.

Connolly DT, Knight MB, Harakas NK, Wittwer AJ, Feder J.

Anal Biochem. 1986 Jan;152(1):136-40.

PMID:
3954035
50.

Selenium-containing transfer RNAs.

Ching WM, Tsai L, Wittwer AJ.

Curr Top Cell Regul. 1985;27:497-507. No abstract available.

PMID:
4092497

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