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Items: 1 to 50 of 114

1.

Computer-Aided Selective Optimization of Side Activities of Talinolol.

Hiesinger K, Kramer JS, Achenbach J, Moser D, Weber J, Wittmann SK, Morisseau C, Angioni C, Geisslinger G, Kahnt AS, Kaiser A, Proschak A, Steinhilber D, Pogoryelov D, Wagner K, Hammock BD, Proschak E.

ACS Med Chem Lett. 2019 May 29;10(6):899-903. doi: 10.1021/acsmedchemlett.9b00075. eCollection 2019 Jun 13.

PMID:
31223445
2.

IFI16 Targets the Transcription Factor Sp1 to Suppress HIV-1 Transcription and Latency Reactivation.

Hotter D, Bosso M, Jønsson KL, Krapp C, Stürzel CM, Das A, Littwitz-Salomon E, Berkhout B, Russ A, Wittmann S, Gramberg T, Zheng Y, Martins LJ, Planelles V, Jakobsen MR, Hahn BH, Dittmer U, Sauter D, Kirchhoff F.

Cell Host Microbe. 2019 Jun 12;25(6):858-872.e13. doi: 10.1016/j.chom.2019.05.002. Epub 2019 Jun 4.

PMID:
31175045
3.

Predictors of delirium after cardiac surgery in patients with sleep disordered breathing.

Tafelmeier M, Knapp M, Lebek S, Floerchinger B, Camboni D, Creutzenberg M, Wittmann S, Zeman F, Schmid C, Maier LS, Wagner S, Arzt M.

Eur Respir J. 2019 Aug 8;54(2). pii: 1900354. doi: 10.1183/13993003.00354-2019. Print 2019 Aug.

PMID:
31109986
4.

Anaesthesia-related complications and side-effects in TAVI: a retrospective study in Germany.

Goldfuss S, Wittmann S, Würschinger F, Bitzinger D, Seyfried T, Holzamer A, Fischer M, Camboni D, Sinner B, Zausig YA.

BMJ Open. 2019 May 1;9(4):e025825. doi: 10.1136/bmjopen-2018-025825.

5.

Zafirlukast Is a Dual Modulator of Human Soluble Epoxide Hydrolase and Peroxisome Proliferator-Activated Receptor γ.

Göbel T, Diehl O, Heering J, Merk D, Angioni C, Wittmann SK, Buscato E, Kottke R, Weizel L, Schader T, Maier TJ, Geisslinger G, Schubert-Zsilavecz M, Steinhilber D, Proschak E, Kahnt AS.

Front Pharmacol. 2019 Mar 20;10:263. doi: 10.3389/fphar.2019.00263. eCollection 2019.

6.

ERα condensates: chronic stimulation is hard to ignore.

Wittmann S, Alberti S.

Nat Struct Mol Biol. 2019 Mar;26(3):153-154. doi: 10.1038/s41594-019-0198-x. No abstract available.

PMID:
30833783
7.

Neoepitopes-based vaccines: challenges and perspectives.

Alcazer V, Bonaventura P, Tonon L, Wittmann S, Caux C, Depil S.

Eur J Cancer. 2019 Feb;108:55-60. doi: 10.1016/j.ejca.2018.12.011. Epub 2019 Jan 12.

PMID:
30648630
8.

Novel Synthesis of Trisubstituted Olefins for the Preparation of the C16-C30 Fragment of Dolabelide C.

Tiniakos AF, Wittmann S, Audic A, Prunet J.

Org Lett. 2019 Feb 1;21(3):589-592. doi: 10.1021/acs.orglett.8b03552. Epub 2018 Dec 27.

9.

Postoperative complications after elective coronary artery bypass grafting surgery in patients with sleep-disordered breathing.

Tafelmeier M, Weizenegger T, Ripfel S, Fauser M, Floerchinger B, Camboni D, Zausig Y, Wittmann S, Drzymalski MA, Zeman F, Schmid C, Maier LS, Wagner S, Arzt M.

Clin Res Cardiol. 2018 Dec;107(12):1148-1159. doi: 10.1007/s00392-018-1289-0. Epub 2018 Jun 12.

PMID:
29943269
10.

Synthesis of fused tricyclic systems by thermal Cope rearrangement of furan-substituted vinyl cyclopropanes.

Klaus V, Wittmann S, Senn HM, Clark JS.

Org Biomol Chem. 2018 May 30;16(21):3970-3982. doi: 10.1039/c8ob00924d.

PMID:
29761822
11.

Correction to: The SAMHD1-mediated block of LINE-1 retroelements is regulated by phosphorylation.

Herrmann A, Wittmann S, Thomas D, Shepard CN, Kim B, Ferreirós N, Gramberg T.

Mob DNA. 2018 May 1;9:16. doi: 10.1186/s13100-018-0121-8. eCollection 2018.

12.

Complications after transcatheter aortic valve implantation using transfemoral and transapical approach in general anaesthesia.

Würschinger F, Wittmann S, Goldfuß S, Zech N, Debl K, Hilker M, Graf BM, Zausig YA.

PLoS One. 2018 Apr 13;13(4):e0193558. doi: 10.1371/journal.pone.0193558. eCollection 2018.

13.

Histone deacetylation promotes transcriptional silencing at facultative heterochromatin.

Watts BR, Wittmann S, Wery M, Gautier C, Kus K, Birot A, Heo DH, Kilchert C, Morillon A, Vasiljeva L.

Nucleic Acids Res. 2018 Jun 20;46(11):5426-5440. doi: 10.1093/nar/gky232.

14.

The SAMHD1-mediated block of LINE-1 retroelements is regulated by phosphorylation.

Herrmann A, Wittmann S, Thomas D, Shepard CN, Kim B, Ferreirós N, Gramberg T.

Mob DNA. 2018 Mar 28;9:11. doi: 10.1186/s13100-018-0116-5. eCollection 2018. Erratum in: Mob DNA. 2018 May 1;9:16.

15.

Sleep-disordered breathing is associated with disturbed cardiac repolarization in patients with a coronary artery bypass graft surgery.

Schmidleitner C, Arzt M, Tafelmeier M, Ripfel S, Fauser M, Weizenegger T, Flörchinger B, Camboni D, Wittmann S, Zeman F, Schmid C, Maier LS, Wagner S, Fisser C.

Sleep Med. 2018 Feb;42:13-20. doi: 10.1016/j.sleep.2017.12.007. Epub 2018 Jan 8.

PMID:
29458741
16.

A coupled fluorescence-based assay for the detection of protein arginine N-methyltransferase 6 (PRMT6) enzymatic activity.

Kramer J, Désor V, Brunst S, Wittmann SK, Lausen J, Heering J, Proschak A, Proschak E.

Anal Biochem. 2018 Apr 15;547:7-13. doi: 10.1016/j.ab.2018.01.023. Epub 2018 Feb 2.

PMID:
29410016
17.

Perforation of myocardial wall and great vessels after cardiovascular interventions-a 5-year analysis.

Provaznik Z, Holzamer A, Camboni D, Rupprecht L, Resch M, Wittmann S, Schmid C, Floerchinger B.

J Thorac Dis. 2017 Dec;9(12):5288-5294. doi: 10.21037/jtd.2017.10.113.

18.

Challenges in the Development of a Thiol-Based Broad-Spectrum Inhibitor for Metallo-β-Lactamases.

Büttner D, Kramer JS, Klingler FM, Wittmann SK, Hartmann MR, Kurz CG, Kohnhäuser D, Weizel L, Brüggerhoff A, Frank D, Steinhilber D, Wichelhaus TA, Pogoryelov D, Proschak E.

ACS Infect Dis. 2018 Mar 9;4(3):360-372. doi: 10.1021/acsinfecdis.7b00129. Epub 2017 Dec 12.

PMID:
29172434
19.

Influence of spine surgery on the ability to perform an emergency stop while driving a car.

Hofmann UK, Wittmann S, Fischer AN, Jordan M, Feierabend MM, Rondak IC, Ipach I, Mittag F.

J Back Musculoskelet Rehabil. 2018 Feb 6;31(1):29-36. doi: 10.3233/BMR-169570.

PMID:
28854497
20.

A Dual Modulator of Farnesoid X Receptor and Soluble Epoxide Hydrolase To Counter Nonalcoholic Steatohepatitis.

Schmidt J, Rotter M, Weiser T, Wittmann S, Weizel L, Kaiser A, Heering J, Goebel T, Angioni C, Wurglics M, Paulke A, Geisslinger G, Kahnt A, Steinhilber D, Proschak E, Merk D.

J Med Chem. 2017 Sep 28;60(18):7703-7724. doi: 10.1021/acs.jmedchem.7b00398. Epub 2017 Sep 8.

PMID:
28845983
21.

Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase.

Garscha U, Romp E, Pace S, Rossi A, Temml V, Schuster D, König S, Gerstmeier J, Liening S, Werner M, Atze H, Wittmann S, Weinigel C, Rummler S, Scriba GK, Sautebin L, Werz O.

Sci Rep. 2017 Aug 24;7(1):9398. doi: 10.1038/s41598-017-09795-w.

22.

The integration of graphene into microelectronic devices.

Ruhl G, Wittmann S, Koenig M, Neumaier D.

Beilstein J Nanotechnol. 2017 May 15;8:1056-1064. doi: 10.3762/bjnano.8.107. eCollection 2017. Review.

23.

Trialkylphosphine-Mediated Synthesis of 2-Acyl Furans from Ynenones.

Xu C, Wittmann S, Gemander M, Ruohonen V, Clark JS.

Org Lett. 2017 Jul 7;19(13):3556-3559. doi: 10.1021/acs.orglett.7b01533. Epub 2017 Jun 27.

PMID:
28654294
24.

The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA.

Wittmann S, Renner M, Watts BR, Adams O, Huseyin M, Baejen C, El Omari K, Kilchert C, Heo DH, Kecman T, Cramer P, Grimes JM, Vasiljeva L.

Nat Commun. 2017 Apr 3;8:14861. doi: 10.1038/ncomms14861.

25.

Characterization and cellular localization of human 5-lipoxygenase and its protein isoforms 5-LOΔ13, 5-LOΔ4 and 5-LOp12.

Ball AK, Beilstein K, Wittmann S, Sürün D, Saul MJ, Schnütgen F, Flamand N, Capelo R, Kahnt AS, Frey H, Schaefer L, Marschalek R, Häfner AK, Steinhilber D.

Biochim Biophys Acta Mol Cell Biol Lipids. 2017 May;1862(5):561-571. doi: 10.1016/j.bbalip.2017.02.015. Epub 2017 Feb 28.

PMID:
28257804
26.

Design, Synthesis and Cellular Characterization of a Dual Inhibitor of 5-Lipoxygenase and Soluble Epoxide Hydrolase.

Meirer K, Glatzel D, Kretschmer S, Wittmann SK, Hartmann M, Blöcher R, Angioni C, Geisslinger G, Steinhilber D, Hofmann B, Fürst R, Proschak E.

Molecules. 2016 Dec 29;22(1). pii: E45. doi: 10.3390/molecules22010045.

27.

Thermodynamic properties of leukotriene A4 hydrolase inhibitors.

Wittmann SK, Kalinowsky L, Kramer JS, Bloecher R, Knapp S, Steinhilber D, Pogoryelov D, Proschak E, Heering J.

Bioorg Med Chem. 2016 Nov 1;24(21):5243-5248. doi: 10.1016/j.bmc.2016.08.047. Epub 2016 Aug 26.

PMID:
27651294
28.

Bacterial Expression and HTS Assessment of Soluble Epoxide Hydrolase Phosphatase.

Klingler FM, Wolf M, Wittmann S, Gribbon P, Proschak E.

J Biomol Screen. 2016 Aug;21(7):689-94. doi: 10.1177/1087057116637609. Epub 2016 Mar 23.

PMID:
27009944
29.

Low Radiation Dose and Low Cell Dose Increase the Risk of Graft Rejection in a Canine Hematopoietic Stem Cell Transplantation Model.

Lange S, Steder A, Glass Ä, Killian D, Wittmann S, Machka C, Werner J, Schäfer S, Roolf C, Junghanss C.

Biol Blood Marrow Transplant. 2016 Apr;22(4):637-643. doi: 10.1016/j.bbmt.2016.01.021. Epub 2016 Jan 21.

30.

The regulation and functions of the nuclear RNA exosome complex.

Kilchert C, Wittmann S, Vasiljeva L.

Nat Rev Mol Cell Biol. 2016 Apr;17(4):227-39. doi: 10.1038/nrm.2015.15. Epub 2016 Jan 4. Review.

PMID:
26726035
31.

TRIM19/PML Restricts HIV Infection in a Cell Type-Dependent Manner.

Kahle T, Volkmann B, Eissmann K, Herrmann A, Schmitt S, Wittmann S, Merkel L, Reuter N, Stamminger T, Gramberg T.

Viruses. 2015 Dec 23;8(1). pii: E2. doi: 10.3390/v8010002.

32.

Regulation of mRNA Levels by Decay-Promoting Introns that Recruit the Exosome Specificity Factor Mmi1.

Kilchert C, Wittmann S, Passoni M, Shah S, Granneman S, Vasiljeva L.

Cell Rep. 2015 Dec 22;13(11):2504-2515. doi: 10.1016/j.celrep.2015.11.026. Epub 2015 Dec 6.

33.

Phosphorylation of murine SAMHD1 regulates its antiretroviral activity.

Wittmann S, Behrendt R, Eissmann K, Volkmann B, Thomas D, Ebert T, Cribier A, Benkirane M, Hornung V, Bouzas NF, Gramberg T.

Retrovirology. 2015 Dec 15;12:103. doi: 10.1186/s12977-015-0229-6.

34.

N-Benzylbenzamides: A Novel Merged Scaffold for Orally Available Dual Soluble Epoxide Hydrolase/Peroxisome Proliferator-Activated Receptor γ Modulators.

Blöcher R, Lamers C, Wittmann SK, Merk D, Hartmann M, Weizel L, Diehl O, Brüggerhoff A, Boß M, Kaiser A, Schader T, Göbel T, Grundmann M, Angioni C, Heering J, Geisslinger G, Wurglics M, Kostenis E, Brüne B, Steinhilber D, Schubert-Zsilavecz M, Kahnt AS, Proschak E.

J Med Chem. 2016 Jan 14;59(1):61-81. doi: 10.1021/acs.jmedchem.5b01239. Epub 2015 Dec 25.

PMID:
26595749
35.

Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA.

Herzner AM, Hagmann CA, Goldeck M, Wolter S, Kübler K, Wittmann S, Gramberg T, Andreeva L, Hopfner KP, Mertens C, Zillinger T, Jin T, Xiao TS, Bartok E, Coch C, Ackermann D, Hornung V, Ludwig J, Barchet W, Hartmann G, Schlee M.

Nat Immunol. 2015 Oct;16(10):1025-33. doi: 10.1038/ni.3267. Epub 2015 Sep 7.

36.

[Anesthesia management in implantation of baroreceptor stimulators].

Werner T, Lebar L, Wittmann S, Keyser A, Fischer M, Schmidli J, Graf BM, Zausig YA.

Anaesthesist. 2015 Sep;64(9):683-8. doi: 10.1007/s00101-015-0061-3. Review. German.

PMID:
26275386
37.

PENG: a neural gas-based approach for pharmacophore elucidation. method design, validation, and virtual screening for novel ligands of LTA4H.

Moser D, Wittmann SK, Kramer J, Blöcher R, Achenbach J, Pogoryelov D, Proschak E.

J Chem Inf Model. 2015 Feb 23;55(2):284-93. doi: 10.1021/ci500618u. Epub 2015 Feb 9.

PMID:
25625859
38.

Cytoplasmic HIV-RNA in monocytes determines microglial activation and neuronal cell death in HIV-associated neurodegeneration.

Faissner S, Ambrosius B, Schanzmann K, Grewe B, Potthoff A, Münch J, Sure U, Gramberg T, Wittmann S, Brockmeyer N, Uberla K, Gold R, Grunwald T, Chan A.

Exp Neurol. 2014 Nov;261:685-97. doi: 10.1016/j.expneurol.2014.08.011. Epub 2014 Aug 19.

PMID:
25150097
39.

PADI4 acts as a coactivator of Tal1 by counteracting repressive histone arginine methylation.

Kolodziej S, Kuvardina ON, Oellerich T, Herglotz J, Backert I, Kohrs N, Buscató El, Wittmann SK, Salinas-Riester G, Bonig H, Karas M, Serve H, Proschak E, Lausen J.

Nat Commun. 2014 May 29;5:3995. doi: 10.1038/ncomms4995.

40.

lncRNA recruits RNAi and the exosome to dynamically regulate pho1 expression in response to phosphate levels in fission yeast.

Shah S, Wittmann S, Kilchert C, Vasiljeva L.

Genes Dev. 2014 Feb 1;28(3):231-44. doi: 10.1101/gad.230177.113.

41.

Mouse SAMHD1 has antiretroviral activity and suppresses a spontaneous cell-intrinsic antiviral response.

Behrendt R, Schumann T, Gerbaulet A, Nguyen LA, Schubert N, Alexopoulou D, Berka U, Lienenklaus S, Peschke K, Gibbert K, Wittmann S, Lindemann D, Weiss S, Dahl A, Naumann R, Dittmer U, Kim B, Mueller W, Gramberg T, Roers A.

Cell Rep. 2013 Aug 29;4(4):689-96. doi: 10.1016/j.celrep.2013.07.037. Epub 2013 Aug 22.

42.

Significance of intraoperative testing in right-sided implantable cardioverter-defibrillators.

Keyser A, Hilker MK, Ucer E, Wittmann S, Schmid C, Diez C.

J Cardiothorac Surg. 2013 Apr 11;8:77. doi: 10.1186/1749-8090-8-77.

43.

Restriction of diverse retroviruses by SAMHD1.

Gramberg T, Kahle T, Bloch N, Wittmann S, Müllers E, Daddacha W, Hofmann H, Kim B, Lindemann D, Landau NR.

Retrovirology. 2013 Mar 5;10:26. doi: 10.1186/1742-4690-10-26.

44.

Synthesis and structure-activity relationship studies of novel dual inhibitors of soluble epoxide hydrolase and 5-lipoxygenase.

Meirer K, Rödl CB, Wisniewska JM, George S, Häfner AK, Buscató EL, Klingler FM, Hahn S, Berressem D, Wittmann SK, Steinhilber D, Hofmann B, Proschak E.

J Med Chem. 2013 Feb 28;56(4):1777-81. doi: 10.1021/jm301617j. Epub 2013 Feb 7.

PMID:
23356879
45.

Lactate flux in astrocytes is enhanced by a non-catalytic action of carbonic anhydrase II.

Stridh MH, Alt MD, Wittmann S, Heidtmann H, Aggarwal M, Riederer B, Seidler U, Wennemuth G, McKenna R, Deitmer JW, Becker HM.

J Physiol. 2012 May 15;590(10):2333-51. doi: 10.1113/jphysiol.2011.220152. Epub 2012 Mar 25.

46.

Nursing U a new concept for nursing orientation.

Culley T, Babbie A, Clancey J, Clouse K, Hines R, Kraynek M, Tutro J, Wittmann S.

Nurs Manage. 2012 Mar;43(3):45-7. doi: 10.1097/01.NUMA.0000412950.80510.95. No abstract available.

PMID:
22377606
47.

Nursing U: a new concept for nursing orientation.

Culley T, Babbie A, Clancey J, Clouse K, Hines R, Kraynek M, Tutro J, Wittmann S.

Nursing. 2011 Nov;41(11):59-61. doi: 10.1097/01.NURSE.0000406194.73311.8f. No abstract available.

PMID:
22005816
48.

L-Proline/CoCl2-catalyzed highly diastereo- and enantioselective direct aldol reactions.

Karmakar A, Maji T, Wittmann S, Reiser O.

Chemistry. 2011 Sep 19;17(39):11024-9. doi: 10.1002/chem.201101299.

PMID:
21932236
49.

Herpesvirus saimiri infection of rhesus macaques: a model for acute rhadinovirus-induced t-cell transformation and oncogenesis.

Rosenwirth B, Kondova I, Niphuis H, Greenwood EJ, Schmidt F, Verschoor EJ, Wittmann S, Heeney JL, Bogers WM, Fickenscher H, Koopman G.

J Med Virol. 2011 Nov;83(11):1938-50. doi: 10.1002/jmv.22197.

PMID:
21915869
50.

Expansion of human trophoblastic spheroids is promoted by decidualized endometrial stromal cells and enhanced by heparin-binding epidermal growth factor-like growth factor and interleukin-1 β.

Gonzalez M, Neufeld J, Reimann K, Wittmann S, Samalecos A, Wolf A, Bamberger AM, Gellersen B.

Mol Hum Reprod. 2011 Jul;17(7):421-33. doi: 10.1093/molehr/gar015. Epub 2011 Feb 27.

PMID:
21357210

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