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Items: 1 to 50 of 222

1.

Glycolytic shunts replenish the Calvin-Benson-Bassham cycle as anaplerotic reactions in Cyanobacteria.

Makowka A, Nichelmann L, Schulze D, Spengler K, Wittmann C, Forchhammer K, Gutekunst K.

Mol Plant. 2020 Feb 7. pii: S1674-2052(20)30032-0. doi: 10.1016/j.molp.2020.02.002. [Epub ahead of print]

PMID:
32044444
2.

Limited life cycle and cost assessment for the bioconversion of lignin-derived aromatics into adipic acid.

van Duuren JBJH, de Wild PJ, Starck S, Bradtmöller C, Selzer M, Mehlmann K, Schneider R, Kohlstedt M, Poblete-Castro I, Stolzenberger J, Barton N, Fritz M, Scholl S, Venus J, Wittmann C.

Biotechnol Bioeng. 2020 Feb 5. doi: 10.1002/bit.27299. [Epub ahead of print]

PMID:
32022244
3.

[Erratum to: Palliative sedation : Development and consensus of a German language documentation template].

Klein C, Wittmann C, Wendt KN, Ostgathe C, Stiel S.

Anaesthesist. 2020 Feb;69(2):121. doi: 10.1007/s00101-020-00729-2. German. No abstract available.

PMID:
31980838
4.

Fermentation of plant-based milk alternatives for improved flavour and nutritional value.

Tangyu M, Muller J, Bolten CJ, Wittmann C.

Appl Microbiol Biotechnol. 2019 Dec;103(23-24):9263-9275. doi: 10.1007/s00253-019-10175-9. Epub 2019 Nov 4. Review.

5.

Polyunsaturated fatty acid production by Yarrowia lipolytica employing designed myxobacterial PUFA synthases.

Gemperlein K, Dietrich D, Kohlstedt M, Zipf G, Bernauer HS, Wittmann C, Wenzel SC, Müller R.

Nat Commun. 2019 Sep 6;10(1):4055. doi: 10.1038/s41467-019-12025-8.

6.

Systems Metabolic Engineering Approaches for Rewiring Cells.

Alper HS, Wittmann C.

Biotechnol J. 2019 Sep;14(9):e1900312. doi: 10.1002/biot.201900312. No abstract available.

PMID:
31476113
7.

Novel latonduine derived proligands and their copper(ii) complexes show cytotoxicity in the nanomolar range in human colon adenocarcinoma cells and in vitro cancer selectivity.

Bacher F, Wittmann C, Nové M, Spengler G, Marć MA, Enyedy EA, Darvasiová D, Rapta P, Reiner T, Arion VB.

Dalton Trans. 2019 Jul 16;48(28):10464-10478. doi: 10.1039/c9dt01238a.

PMID:
31125040
8.

Metabolic Engineering of Corynebacterium glutamicum for High-Level Ectoine Production: Design, Combinatorial Assembly, and Implementation of a Transcriptionally Balanced Heterologous Ectoine Pathway.

Gießelmann G, Dietrich D, Jungmann L, Kohlstedt M, Jeon EJ, Yim SS, Sommer F, Zimmer D, Mühlhaus T, Schroda M, Jeong KJ, Becker J, Wittmann C.

Biotechnol J. 2019 Sep;14(9):e1800417. doi: 10.1002/biot.201800417. Epub 2019 Jul 3.

PMID:
31106985
9.

Balanced sex distribution in patients with Menière's disease.

Becker-Bense S, Wittmann C, Dieterich M.

J Neurol. 2019 Sep;266(Suppl 1):42-46. doi: 10.1007/s00415-019-09301-4. Epub 2019 Apr 10. No abstract available.

PMID:
30972498
10.

A field of dreams: Lignin valorization into chemicals, materials, fuels, and health-care products.

Becker J, Wittmann C.

Biotechnol Adv. 2019 Nov 1;37(6):107360. doi: 10.1016/j.biotechadv.2019.02.016. Epub 2019 Apr 6. Review.

11.

Biochemistry, genetics and biotechnology of glycerol utilization in Pseudomonas species.

Poblete-Castro I, Wittmann C, Nikel PI.

Microb Biotechnol. 2020 Jan;13(1):32-53. doi: 10.1111/1751-7915.13400. Epub 2019 Mar 18. Review.

12.
13.

Optoregulated Drug Release from an Engineered Living Material: Self-Replenishing Drug Depots for Long-Term, Light-Regulated Delivery.

Sankaran S, Becker J, Wittmann C, Del Campo A.

Small. 2019 Feb;15(5):e1804717. doi: 10.1002/smll.201804717. Epub 2018 Dec 27.

PMID:
30589209
14.

Metabolic flux analysis in Ashbya gossypii using 13C-labeled yeast extract: industrial riboflavin production under complex nutrient conditions.

Schwechheimer SK, Becker J, Peyriga L, Portais JC, Wittmann C.

Microb Cell Fact. 2018 Oct 16;17(1):162. doi: 10.1186/s12934-018-1003-y.

15.

From systems biology to metabolically engineered cells-an omics perspective on the development of industrial microbes.

Becker J, Wittmann C.

Curr Opin Microbiol. 2018 Oct;45:180-188. doi: 10.1016/j.mib.2018.06.001. Epub 2018 Aug 29. Review.

PMID:
30172106
16.

Towards better understanding of industrial cell factories: novel approaches for 13C metabolic flux analysis in complex nutrient environments.

Schwechheimer SK, Becker J, Wittmann C.

Curr Opin Biotechnol. 2018 Dec;54:128-137. doi: 10.1016/j.copbio.2018.07.001. Epub 2018 Aug 2. Review.

PMID:
30077860
17.

Metabolically engineered Corynebacterium glutamicum for bio-based production of chemicals, fuels, materials, and healthcare products.

Becker J, Rohles CM, Wittmann C.

Metab Eng. 2018 Nov;50:122-141. doi: 10.1016/j.ymben.2018.07.008. Epub 2018 Jul 20. Review.

PMID:
30031852
18.

Metabolic engineering of Corynebacterium glutamicum for the production of cis, cis-muconic acid from lignin.

Becker J, Kuhl M, Kohlstedt M, Starck S, Wittmann C.

Microb Cell Fact. 2018 Jul 20;17(1):115. doi: 10.1186/s12934-018-0963-2.

19.

More than just CO2 -recycling: corticular photosynthesis as a mechanism to reduce the risk of an energy crisis induced by low oxygen.

Wittmann C, Pfanz H.

New Phytol. 2018 Jul;219(2):551-564. doi: 10.1111/nph.15198. Epub 2018 May 16.

20.

[Palliative sedation : Development and consensus of a German language documentation template].

Klein C, Wittmann C, Wendt KN, Ostgathe C, Stiel S.

Anaesthesist. 2018 Jul;67(7):504-511. doi: 10.1007/s00101-018-0451-4. German. Erratum in: Anaesthesist. 2020 Feb;69(2):121.

PMID:
29767825
21.

Lysine production from the sugar alcohol mannitol: Design of the cell factory Corynebacterium glutamicum SEA-3 through integrated analysis and engineering of metabolic pathway fluxes.

Hoffmann SL, Jungmann L, Schiefelbein S, Peyriga L, Cahoreau E, Portais JC, Becker J, Wittmann C.

Metab Eng. 2018 May;47:475-487. doi: 10.1016/j.ymben.2018.04.019. Epub 2018 Apr 27.

PMID:
29709649
22.

Improved riboflavin production with Ashbya gossypii from vegetable oil based on 13C metabolic network analysis with combined labeling analysis by GC/MS, LC/MS, 1D, and 2D NMR.

Schwechheimer SK, Becker J, Peyriga L, Portais JC, Sauer D, Müller R, Hoff B, Haefner S, Schröder H, Zelder O, Wittmann C.

Metab Eng. 2018 May;47:357-373. doi: 10.1016/j.ymben.2018.04.005. Epub 2018 Apr 12.

PMID:
29654833
23.

From lignin to nylon: Cascaded chemical and biochemical conversion using metabolically engineered Pseudomonas putida.

Kohlstedt M, Starck S, Barton N, Stolzenberger J, Selzer M, Mehlmann K, Schneider R, Pleissner D, Rinkel J, Dickschat JS, Venus J, B J H van Duuren J, Wittmann C.

Metab Eng. 2018 May;47:279-293. doi: 10.1016/j.ymben.2018.03.003. Epub 2018 Mar 14.

PMID:
29548984
24.

Anodic electro-fermentation: Anaerobic production of L-Lysine by recombinant Corynebacterium glutamicum.

Vassilev I, Gießelmann G, Schwechheimer SK, Wittmann C, Virdis B, Krömer JO.

Biotechnol Bioeng. 2018 Jun;115(6):1499-1508. doi: 10.1002/bit.26562. Epub 2018 Mar 24.

PMID:
29427435
25.

Enabling the valorization of guaiacol-based lignin: Integrated chemical and biochemical production of cis,cis-muconic acid using metabolically engineered Amycolatopsis sp ATCC 39116.

Barton N, Horbal L, Starck S, Kohlstedt M, Luzhetskyy A, Wittmann C.

Metab Eng. 2018 Jan;45:200-210. doi: 10.1016/j.ymben.2017.12.001. Epub 2017 Dec 12.

26.

Bio-based succinate from sucrose: High-resolution 13C metabolic flux analysis and metabolic engineering of the rumen bacterium Basfia succiniciproducens.

Lange A, Becker J, Schulze D, Cahoreau E, Portais JC, Haefner S, Schröder H, Krawczyk J, Zelder O, Wittmann C.

Metab Eng. 2017 Nov;44:198-212. doi: 10.1016/j.ymben.2017.10.003. Epub 2017 Oct 14.

27.

The SPOT GRADE: A New Method for Reproducibly Quantifying Surgical Wound Bleeding.

Spotnitz WD, Zielske D, Centis V, Hoffman R, Gillen DL, Wittmann C, Guyot V, Campos DM, Forest P, Pearson A, McAfee PC.

Spine (Phila Pa 1976). 2018 Jun 1;43(11):E664-E671. doi: 10.1097/BRS.0000000000002447.

PMID:
29019803
28.

ED utilization of medical clearance testing for psychiatric admission: National Hospital Ambulatory Medical Care Survey analysis.

Yun BJ, Chou SC, Nagurney JM, White BA, Wittmann CW, Raja AS.

Am J Emerg Med. 2018 May;36(5):745-748. doi: 10.1016/j.ajem.2017.10.002. Epub 2017 Oct 4.

29.

Use of Single-Frequency Impedance Spectroscopy to Characterize the Growth Dynamics of Biofilm Formation in Pseudomonas aeruginosa.

van Duuren JBJH, Müsken M, Karge B, Tomasch J, Wittmann C, Häussler S, Brönstrup M.

Sci Rep. 2017 Jul 12;7(1):5223. doi: 10.1038/s41598-017-05273-5.

30.

Prevalence of Parkinson symptoms in patients with different peripheral vestibular disorders.

Becker-Bense S, Wittmann C, van Wensen E, van Leeuwen RB, Bloem B, Dieterich M.

J Neurol. 2017 Jun;264(6):1287-1289. doi: 10.1007/s00415-017-8470-7. Epub 2017 Mar 31. No abstract available.

PMID:
28364298
31.

Biotechnological Production of Organic Acids from Renewable Resources.

Pleissner D, Dietz D, van Duuren JBJH, Wittmann C, Yang X, Lin CSK, Venus J.

Adv Biochem Eng Biotechnol. 2019;166:373-410. doi: 10.1007/10_2016_73. Review.

PMID:
28265703
32.

Respiratory adaptations to a combination of oxygen deprivation and extreme carbon dioxide concentration in nematodes.

Pilz M, Hohberg K, Pfanz H, Wittmann C, Xylander WER.

Respir Physiol Neurobiol. 2017 May;239:34-40. doi: 10.1016/j.resp.2017.01.015. Epub 2017 Jan 31.

PMID:
28159631
33.

A Precise Temperature-Responsive Bistable Switch Controlling Yersinia Virulence.

Nuss AM, Schuster F, Roselius L, Klein J, Bücker R, Herbst K, Heroven AK, Pisano F, Wittmann C, Münch R, Müller J, Jahn D, Dersch P.

PLoS Pathog. 2016 Dec 22;12(12):e1006091. doi: 10.1371/journal.ppat.1006091. eCollection 2016 Dec.

34.

Corynebacterium glutamicum for Sustainable Bioproduction: From Metabolic Physiology to Systems Metabolic Engineering.

Becker J, Gießelmann G, Hoffmann SL, Wittmann C.

Adv Biochem Eng Biotechnol. 2018;162:217-263. doi: 10.1007/10_2016_21. Review.

PMID:
27872959
35.

Editorial overview: Chemical biotechnology.

Wittmann C, Gonzalez R.

Curr Opin Biotechnol. 2016 Dec;42:iv-v. doi: 10.1016/j.copbio.2016.11.003. Epub 2016 Nov 14. No abstract available.

PMID:
27856095
36.

In silico metabolic network analysis of Arabidopsis leaves.

Beckers V, Dersch LM, Lotz K, Melzer G, Bläsing OE, Fuchs R, Ehrhardt T, Wittmann C.

BMC Syst Biol. 2016 Oct 29;10(1):102.

37.

Systems metabolic engineering of Corynebacterium glutamicum for the production of the carbon-5 platform chemicals 5-aminovalerate and glutarate.

Rohles CM, Gießelmann G, Kohlstedt M, Wittmann C, Becker J.

Microb Cell Fact. 2016 Sep 13;15(1):154. doi: 10.1186/s12934-016-0553-0.

38.

Systems metabolic engineering of Escherichia coli for the heterologous production of high value molecules-a veteran at new shores.

Becker J, Wittmann C.

Curr Opin Biotechnol. 2016 Dec;42:178-188. doi: 10.1016/j.copbio.2016.05.004. Epub 2016 Aug 8. Review.

PMID:
27513555
39.

Integrated analysis of gene expression and metabolic fluxes in PHA-producing Pseudomonas putida grown on glycerol.

Beckers V, Poblete-Castro I, Tomasch J, Wittmann C.

Microb Cell Fact. 2016 May 3;15:73. doi: 10.1186/s12934-016-0470-2.

40.

Novel Approach for High-Throughput Metabolic Screening of Whole Plants by Stable Isotopes.

Dersch LM, Beckers V, Rasch D, Melzer G, Bolten C, Kiep K, Becker H, Bläsing OE, Fuchs R, Ehrhardt T, Wittmann C.

Plant Physiol. 2016 May;171(1):25-41. doi: 10.1104/pp.15.01217. Epub 2016 Mar 10.

41.

Proteome and carbon flux analysis of Pseudomonas aeruginosa clinical isolates from different infection sites.

Lassek C, Berger A, Zühlke D, Wittmann C, Riedel K.

Proteomics. 2016 May;16(9):1381-5. doi: 10.1002/pmic.201500228. Epub 2016 Apr 13.

PMID:
26959854
42.

Biotechnology of riboflavin.

Schwechheimer SK, Park EY, Revuelta JL, Becker J, Wittmann C.

Appl Microbiol Biotechnol. 2016 Mar;100(5):2107-19. doi: 10.1007/s00253-015-7256-z. Epub 2016 Jan 13. Review.

PMID:
26758294
43.

Green pathways: Metabolic network analysis of plant systems.

Dersch LM, Beckers V, Wittmann C.

Metab Eng. 2016 Mar;34:1-24. doi: 10.1016/j.ymben.2015.12.001. Epub 2015 Dec 17. Review.

PMID:
26704307
44.

A Zebrafish Drug-Repurposing Screen Reveals sGC-Dependent and sGC-Independent Pro-Inflammatory Activities of Nitric Oxide.

Wittmann C, Reischl M, Shah AH, Kronfuss E, Mikut R, Liebel U, Grabher C.

PLoS One. 2015 Oct 7;10(10):e0137286. doi: 10.1371/journal.pone.0137286. eCollection 2015.

45.

Top value platform chemicals: bio-based production of organic acids.

Becker J, Lange A, Fabarius J, Wittmann C.

Curr Opin Biotechnol. 2015 Dec;36:168-75. doi: 10.1016/j.copbio.2015.08.022. Epub 2015 Sep 8. Review.

PMID:
26360870
46.

Acetate Dissimilation and Assimilation in Mycobacterium tuberculosis Depend on Carbon Availability.

Rücker N, Billig S, Bücker R, Jahn D, Wittmann C, Bange FC.

J Bacteriol. 2015 Oct;197(19):3182-90. doi: 10.1128/JB.00259-15. Epub 2015 Jul 27.

47.

A roadmap for interpreting (13)C metabolite labeling patterns from cells.

Buescher JM, Antoniewicz MR, Boros LG, Burgess SC, Brunengraber H, Clish CB, DeBerardinis RJ, Feron O, Frezza C, Ghesquiere B, Gottlieb E, Hiller K, Jones RG, Kamphorst JJ, Kibbey RG, Kimmelman AC, Locasale JW, Lunt SY, Maddocks OD, Malloy C, Metallo CM, Meuillet EJ, Munger J, Nöh K, Rabinowitz JD, Ralser M, Sauer U, Stephanopoulos G, St-Pierre J, Tennant DA, Wittmann C, Vander Heiden MG, Vazquez A, Vousden K, Young JD, Zamboni N, Fendt SM.

Curr Opin Biotechnol. 2015 Aug;34:189-201. doi: 10.1016/j.copbio.2015.02.003. Epub 2015 Feb 28. Review.

48.

Redox imaging using genetically encoded redox indicators in zebrafish and mice.

Breckwoldt MO, Wittmann C, Misgeld T, Kerschensteiner M, Grabher C.

Biol Chem. 2015 May;396(5):511-22. doi: 10.1515/hsz-2014-0294. Review.

PMID:
25720068
49.

Advanced biotechnology: metabolically engineered cells for the bio-based production of chemicals and fuels, materials, and health-care products.

Becker J, Wittmann C.

Angew Chem Int Ed Engl. 2015 Mar 9;54(11):3328-50. doi: 10.1002/anie.201409033. Epub 2015 Feb 11. Review.

PMID:
25684732
50.

Large-Scale 13C flux profiling reveals conservation of the Entner-Doudoroff pathway as a glycolytic strategy among marine bacteria that use glucose.

Klingner A, Bartsch A, Dogs M, Wagner-Döbler I, Jahn D, Simon M, Brinkhoff T, Becker J, Wittmann C.

Appl Environ Microbiol. 2015 Apr;81(7):2408-22. doi: 10.1128/AEM.03157-14. Epub 2015 Jan 23.

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