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Items: 37

1.

Serial genomic inversions induce tissue-specific architectural stripes, gene misexpression and congenital malformations.

Kraft K, Magg A, Heinrich V, Riemenschneider C, Schöpflin R, Markowski J, Ibrahim DM, Acuna-Hidalgo R, Despang A, Andrey G, Wittler L, Timmermann B, Vingron M, Mundlos S.

Nat Cell Biol. 2019 Mar;21(3):305-310. doi: 10.1038/s41556-019-0273-x. Epub 2019 Feb 11.

PMID:
30742094
2.

Dynamic 3D chromatin architecture contributes to enhancer specificity and limb morphogenesis.

Kragesteen BK, Spielmann M, Paliou C, Heinrich V, Schöpflin R, Esposito A, Annunziatella C, Bianco S, Chiariello AM, Jerković I, Harabula I, Guckelberger P, Pechstein M, Wittler L, Chan WL, Franke M, Lupiáñez DG, Kraft K, Timmermann B, Vingron M, Visel A, Nicodemi M, Mundlos S, Andrey G.

Nat Genet. 2018 Oct;50(10):1463-1473. doi: 10.1038/s41588-018-0221-x. Epub 2018 Sep 27.

PMID:
30262816
3.

Polymer physics predicts the effects of structural variants on chromatin architecture.

Bianco S, Lupiáñez DG, Chiariello AM, Annunziatella C, Kraft K, Schöpflin R, Wittler L, Andrey G, Vingron M, Pombo A, Mundlos S, Nicodemi M.

Nat Genet. 2018 May;50(5):662-667. doi: 10.1038/s41588-018-0098-8. Epub 2018 Apr 16.

PMID:
29662163
4.

Noncoding copy-number variations are associated with congenital limb malformation.

Flöttmann R, Kragesteen BK, Geuer S, Socha M, Allou L, Sowińska-Seidler A, Bosquillon de Jarcy L, Wagner J, Jamsheer A, Oehl-Jaschkowitz B, Wittler L, de Silva D, Kurth I, Maya I, Santos-Simarro F, Hülsemann W, Klopocki E, Mountford R, Fryer A, Borck G, Horn D, Lapunzina P, Wilson M, Mascrez B, Duboule D, Mundlos S, Spielmann M.

Genet Med. 2018 Jun;20(6):599-607. doi: 10.1038/gim.2017.154. Epub 2017 Oct 12.

PMID:
29236091
5.

BRACHYURY directs histone acetylation to target loci during mesoderm development.

Beisaw A, Tsaytler P, Koch F, Schmitz SU, Melissari MT, Senft AD, Wittler L, Pennimpede T, Macura K, Herrmann BG, Grote P.

EMBO Rep. 2018 Jan;19(1):118-134. doi: 10.15252/embr.201744201. Epub 2017 Nov 15.

6.

Composition and dosage of a multipartite enhancer cluster control developmental expression of Ihh (Indian hedgehog).

Will AJ, Cova G, Osterwalder M, Chan WL, Wittler L, Brieske N, Heinrich V, de Villartay JP, Vingron M, Klopocki E, Visel A, Lupiáñez DG, Mundlos S.

Nat Genet. 2017 Oct;49(10):1539-1545. doi: 10.1038/ng.3939. Epub 2017 Aug 28.

7.

Antagonistic Activities of Sox2 and Brachyury Control the Fate Choice of Neuro-Mesodermal Progenitors.

Koch F, Scholze M, Wittler L, Schifferl D, Sudheer S, Grote P, Timmermann B, Macura K, Herrmann BG.

Dev Cell. 2017 Sep 11;42(5):514-526.e7. doi: 10.1016/j.devcel.2017.07.021. Epub 2017 Aug 17.

8.

Patterning and gastrulation defects caused by the tw18 lethal are due to loss of Ppp2r1a.

Lange L, Marks M, Liu J, Wittler L, Bauer H, Piehl S, Bläß G, Timmermann B, Herrmann BG.

Biol Open. 2017 Jun 15;6(6):752-764. doi: 10.1242/bio.023200.

9.

Formation of new chromatin domains determines pathogenicity of genomic duplications.

Franke M, Ibrahim DM, Andrey G, Schwarzer W, Heinrich V, Schöpflin R, Kraft K, Kempfer R, Jerković I, Chan WL, Spielmann M, Timmermann B, Wittler L, Kurth I, Cambiaso P, Zuffardi O, Houge G, Lambie L, Brancati F, Pombo A, Vingron M, Spitz F, Mundlos S.

Nature. 2016 Oct 13;538(7624):265-269. doi: 10.1038/nature19800. Epub 2016 Oct 5.

PMID:
27706140
10.

Different Concentrations of FGF Ligands, FGF2 or FGF8 Determine Distinct States of WNT-Induced Presomitic Mesoderm.

Sudheer S, Liu J, Marks M, Koch F, Anurin A, Scholze M, Senft AD, Wittler L, Macura K, Grote P, Herrmann BG.

Stem Cells. 2016 Jul;34(7):1790-800. doi: 10.1002/stem.2371. Epub 2016 Apr 18.

11.

Exome sequencing and CRISPR/Cas genome editing identify mutations of ZAK as a cause of limb defects in humans and mice.

Spielmann M, Kakar N, Tayebi N, Leettola C, Nürnberg G, Sowada N, Lupiáñez DG, Harabula I, Flöttmann R, Horn D, Chan WL, Wittler L, Yilmaz R, Altmüller J, Thiele H, van Bokhoven H, Schwartz CE, Nürnberg P, Bowie JU, Ahmad J, Kubisch C, Mundlos S, Borck G.

Genome Res. 2016 Feb;26(2):183-91. doi: 10.1101/gr.199430.115. Epub 2016 Jan 11.

12.

Analysis of the Fam181 gene family during mouse development reveals distinct strain-specific expression patterns, suggesting a role in nervous system development and function.

Marks M, Pennimpede T, Lange L, Grote P, Herrmann BG, Wittler L.

Gene. 2016 Jan 10;575(2 Pt 2):438-451. doi: 10.1016/j.gene.2015.09.035. Epub 2015 Sep 25.

PMID:
26407640
13.

Disruptions of topological chromatin domains cause pathogenic rewiring of gene-enhancer interactions.

Lupiáñez DG, Kraft K, Heinrich V, Krawitz P, Brancati F, Klopocki E, Horn D, Kayserili H, Opitz JM, Laxova R, Santos-Simarro F, Gilbert-Dussardier B, Wittler L, Borschiwer M, Haas SA, Osterwalder M, Franke M, Timmermann B, Hecht J, Spielmann M, Visel A, Mundlos S.

Cell. 2015 May 21;161(5):1012-1025. doi: 10.1016/j.cell.2015.04.004. Epub 2015 May 7.

14.

Deletions, Inversions, Duplications: Engineering of Structural Variants using CRISPR/Cas in Mice.

Kraft K, Geuer S, Will AJ, Chan WL, Paliou C, Borschiwer M, Harabula I, Wittler L, Franke M, Ibrahim DM, Kragesteen BK, Spielmann M, Mundlos S, Lupiáñez DG, Andrey G.

Cell Rep. 2015 Feb 10;10(5):833-839. doi: 10.1016/j.celrep.2015.01.016. Epub 2015 Feb 7.

15.

SRF is essential for mesodermal cell migration during elongation of the embryonic body axis.

Schwartz B, Marks M, Wittler L, Werber M, Währisch S, Nordheim A, Herrmann BG, Grote P.

Mech Dev. 2014 Aug;133:23-35. doi: 10.1016/j.mod.2014.07.001. Epub 2014 Jul 11.

16.

Genome-wide association study and mouse expression data identify a highly conserved 32 kb intergenic region between WNT3 and WNT9b as possible susceptibility locus for isolated classic exstrophy of the bladder.

Reutter H, Draaken M, Pennimpede T, Wittler L, Brockschmidt FF, Ebert AK, Bartels E, Rösch W, Boemers TM, Hirsch K, Schmiedeke E, Meesters C, Becker T, Stein R, Utsch B, Mangold E, Nordenskjöld A, Barker G, Kockum CC, Zwink N, Holmdahl G, Läckgren G, Jenetzky E, Feitz WF, Marcelis C, Wijers CH, Van Rooij IA, Gearhart JP, Herrmann BG, Ludwig M, Boyadjiev SA, Nöthen MM, Mattheisen M.

Hum Mol Genet. 2014 Oct 15;23(20):5536-44. doi: 10.1093/hmg/ddu259. Epub 2014 May 22.

17.

The tissue-specific transcriptomic landscape of the mid-gestational mouse embryo.

Werber M, Wittler L, Timmermann B, Grote P, Herrmann BG.

Development. 2014 Jun;141(11):2325-30. doi: 10.1242/dev.105858. Epub 2014 May 6.

18.

Classic bladder exstrophy: Frequent 22q11.21 duplications and definition of a 414 kb phenocritical region.

Draaken M, Baudisch F, Timmermann B, Kuhl H, Kerick M, Proske J, Wittler L, Pennimpede T, Ebert AK, Rösch W, Stein R, Bartels E, von Lowtzow C, Boemers TM, Herms S, Gearhart JP, Lakshmanan Y, Kockum CC, Holmdahl G, Läckgren G, Nordenskjöld A, Boyadjiev SA, Herrmann BG, Nöthen MM, Ludwig M, Reutter H.

Birth Defects Res A Clin Mol Teratol. 2014 Jun;100(6):512-7. doi: 10.1002/bdra.23249. Epub 2014 Apr 25.

PMID:
24764164
19.

Dlk1 promotes a fast motor neuron biophysical signature required for peak force execution.

Müller D, Cherukuri P, Henningfeld K, Poh CH, Wittler L, Grote P, Schlüter O, Schmidt J, Laborda J, Bauer SR, Brownstone RM, Marquardt T.

Science. 2014 Mar 14;343(6176):1264-6. doi: 10.1126/science.1246448.

20.

De novo microduplications at 1q41, 2q37.3, and 8q24.3 in patients with VATER/VACTERL association.

Hilger A, Schramm C, Pennimpede T, Wittler L, Dworschak GC, Bartels E, Engels H, Zink AM, Degenhardt F, Müller AM, Schmiedeke E, Grasshoff-Derr S, Märzheuser S, Hosie S, Holland-Cunz S, Wijers CH, Marcelis CL, van Rooij IA, Hildebrandt F, Herrmann BG, Nöthen MM, Ludwig M, Reutter H, Draaken M.

Eur J Hum Genet. 2013 Dec;21(12):1377-82. doi: 10.1038/ejhg.2013.58. Epub 2013 Apr 3.

21.

The tissue-specific lncRNA Fendrr is an essential regulator of heart and body wall development in the mouse.

Grote P, Wittler L, Hendrix D, Koch F, Währisch S, Beisaw A, Macura K, Bläss G, Kellis M, Werber M, Herrmann BG.

Dev Cell. 2013 Jan 28;24(2):206-14. doi: 10.1016/j.devcel.2012.12.012.

22.

Isolated bladder exstrophy associated with a de novo 0.9 Mb microduplication on chromosome 19p13.12.

Draaken M, Mughal SS, Pennimpede T, Wolter S, Wittler L, Ebert AK, Rösch W, Stein R, Bartels E, Schmidt D, Boemers TM, Schmiedeke E, Hoffmann P, Moebus S, Herrmann BG, Nöthen MM, Reutter H, Ludwig M.

Birth Defects Res A Clin Mol Teratol. 2013 Mar;97(3):133-9. doi: 10.1002/bdra.23112. Epub 2013 Jan 29.

PMID:
23359465
23.

Homeotic arm-to-leg transformation associated with genomic rearrangements at the PITX1 locus.

Spielmann M, Brancati F, Krawitz PM, Robinson PN, Ibrahim DM, Franke M, Hecht J, Lohan S, Dathe K, Nardone AM, Ferrari P, Landi A, Wittler L, Timmermann B, Chan D, Mennen U, Klopocki E, Mundlos S.

Am J Hum Genet. 2012 Oct 5;91(4):629-35. doi: 10.1016/j.ajhg.2012.08.014. Epub 2012 Sep 27.

24.

In vivo knockdown of Brachyury results in skeletal defects and urorectal malformations resembling caudal regression syndrome.

Pennimpede T, Proske J, König A, Vidigal JA, Morkel M, Bramsen JB, Herrmann BG, Wittler L.

Dev Biol. 2012 Dec 1;372(1):55-67. doi: 10.1016/j.ydbio.2012.09.003. Epub 2012 Sep 18.

25.

Murine expression and mutation analyses of the prostate androgen-regulated mucin-like protein 1 (Parm1) gene, a candidate for human epispadias.

Wittler L, Hilger A, Proske J, Pennimpede T, Draaken M, Ebert AK, Rösch W, Stein R, Nöthen MM, Reutter H, Ludwig M.

Gene. 2012 Sep 15;506(2):392-5. doi: 10.1016/j.gene.2012.06.082. Epub 2012 Jul 2.

PMID:
22766399
26.

Genome-wide expression profiling of urinary bladder implicates desmosomal and cytoskeletal dysregulation in the bladder exstrophy-epispadias complex.

Qi L, Chen K, Hur DJ, Yagnik G, Lakshmanan Y, Kotch LE, Ashrafi GH, Martinez-Murillo F, Kowalski J, Naydenov C, Wittler L, Gearhart JP, Draaken M, Reutter H, Ludwig M, Boyadjiev SA.

Int J Mol Med. 2011 Jun;27(6):755-65. doi: 10.3892/ijmm.2011.654. Epub 2011 Mar 22.

PMID:
21431277
27.

p63 (TP73L) a key player in embryonic urogenital development with significant dysregulation in human bladder exstrophy tissue.

Ching BJ, Wittler L, Proske J, Yagnik G, Qi L, Draaken M, Reutter H, Gearhart JP, Ludwig M, Boyadjiev SA.

Int J Mol Med. 2010 Dec;26(6):861-7.

PMID:
21042780
28.

Embryonic expression of the cysteine rich protein 61 (CYR61) gene: A candidate for the development of human epispadias.

Draaken M, Proske J, Schramm C, Wittler L, Bartels E, Nöthen MM, Reutter H, Ludwig M.

Birth Defects Res A Clin Mol Teratol. 2010 Jul;88(7):546-50. doi: 10.1002/bdra.20668.

PMID:
20641097
29.

An inducible RNA interference system for the functional dissection of mouse embryogenesis.

Vidigal JA, Morkel M, Wittler L, Brouwer-Lehmitz A, Grote P, Macura K, Herrmann BG.

Nucleic Acids Res. 2010 Jun;38(11):e122. doi: 10.1093/nar/gkq199. Epub 2010 Mar 28.

30.

Expression of the chick Sizzled gene in progenitors of the cardiac outflow tract.

Wittler L, Saborowski M, Kessel M.

Gene Expr Patterns. 2008 Jul;8(6):471-6. doi: 10.1016/j.gep.2008.02.004. Epub 2008 Feb 29.

PMID:
18411073
31.

Expression of Msgn1 in the presomitic mesoderm is controlled by synergism of WNT signalling and Tbx6.

Wittler L, Shin EH, Grote P, Kispert A, Beckers A, Gossler A, Werber M, Herrmann BG.

EMBO Rep. 2007 Aug;8(8):784-9. Epub 2007 Jul 13.

32.

The acquisition of neural fate in the chick.

Wittler L, Kessel M.

Mech Dev. 2004 Sep;121(9):1031-42. Review.

33.

Restricted expression domains of Ezrin in developing epithelia of the chick.

Richter U, Wittler L, Kessel M.

Gene Expr Patterns. 2004 Mar;4(2):199-204.

PMID:
15161100
34.

Involvement of Pax6 and Otx2 in the forebrain-specific regulation of the vertebrate homeobox gene ANF/Hesx1.

Spieler D, Bäumer N, Stebler J, Köprunner M, Reichman-Fried M, Teichmann U, Raz E, Kessel M, Wittler L.

Dev Biol. 2004 May 15;269(2):567-79.

35.

The avian organizer.

Boettger T, Knoetgen H, Wittler L, Kessel M.

Int J Dev Biol. 2001;45(1):281-7. Review.

36.

Anterior neural induction by nodes from rabbits and mice.

Knoetgen H, Teichmann U, Wittler L, Viebahn C, Kessel M.

Dev Biol. 2000 Sep 15;225(2):370-80.

37.

FGF8 functions in the specification of the right body side of the chick.

Boettger T, Wittler L, Kessel M.

Curr Biol. 1999 Mar 11;9(5):277-80.

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