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Items: 1 to 50 of 314

1.

Small-Molecule Inhibition of the UNC-Src Interaction Impairs Dynamic Src Localization in Cells.

Garivet G, Hofer W, Konitsiotis A, Klein C, Kaiser N, Mejuch T, Fansa E, Alsaabi R, Wittinghofer A, Bastiaens PIH, Waldmann H.

Cell Chem Biol. 2019 Mar 13. pii: S2451-9456(19)30074-1. doi: 10.1016/j.chembiol.2019.02.019. [Epub ahead of print]

PMID:
30956149
2.

Biochemical and kinetic properties of the complex Roco G-protein cycle.

Wauters L, Terheyden S, Gilsbach BK, Leemans M, Athanasopoulos PS, Guaitoli G, Wittinghofer A, Gloeckner CJ, Versées W, Kortholt A.

Biol Chem. 2018 Nov 27;399(12):1447-1456. doi: 10.1515/hsz-2018-0227.

PMID:
30067506
3.

Characterization of a novel RP2-OSTF1 interaction and its implication for actin remodelling.

Lyraki R, Lokaj M, Soares DC, Little A, Vermeren M, Marsh JA, Wittinghofer A, Hurd T.

J Cell Sci. 2018 Feb 20;131(4). pii: jcs211748. doi: 10.1242/jcs.211748.

4.

A recombinant BBSome core complex and how it interacts with ciliary cargo.

Klink BU, Zent E, Juneja P, Kuhlee A, Raunser S, Wittinghofer A.

Elife. 2017 Nov 15;6. pii: e27434. doi: 10.7554/eLife.27434.

5.

Mechanism and dynamics of INPP5E transport into and inside the ciliary compartment.

Kösling SK, Fansa EK, Maffini S, Wittinghofer A.

Biol Chem. 2018 Feb 23;399(3):277-292. doi: 10.1515/hsz-2017-0226.

PMID:
29140789
6.

Domain topology of human Rasal.

Cuellar J, Valpuesta JM, Wittinghofer A, Sot B.

Biol Chem. 2017 Dec 20;399(1):63-72. doi: 10.1515/hsz-2017-0159.

PMID:
28885980
7.

Small-Molecule Inhibition of the UNC119-Cargo Interaction.

Mejuch T, Garivet G, Hofer W, Kaiser N, Fansa EK, Ehrt C, Koch O, Baumann M, Ziegler S, Wittinghofer A, Waldmann H.

Angew Chem Int Ed Engl. 2017 May 22;56(22):6181-6186. doi: 10.1002/anie.201701905. Epub 2017 May 4.

PMID:
28471079
8.

Covalent Protein Labeling at Glutamic Acids.

Martín-Gago P, Fansa EK, Winzker M, Murarka S, Janning P, Schultz-Fademrecht C, Baumann M, Wittinghofer A, Waldmann H.

Cell Chem Biol. 2017 May 18;24(5):589-597.e5. doi: 10.1016/j.chembiol.2017.03.015. Epub 2017 Apr 20.

9.

A PDE6δ-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2.

Martín-Gago P, Fansa EK, Klein CH, Murarka S, Janning P, Schürmann M, Metz M, Ismail S, Schultz-Fademrecht C, Baumann M, Bastiaens PI, Wittinghofer A, Waldmann H.

Angew Chem Int Ed Engl. 2017 Feb 20;56(9):2423-2428. doi: 10.1002/anie.201610957. Epub 2017 Jan 20.

PMID:
28106325
10.

Structure-based development of PDEδ inhibitors.

Martín-Gago P, Fansa EK, Wittinghofer A, Waldmann H.

Biol Chem. 2017 May 1;398(5-6):535-545. doi: 10.1515/hsz-2016-0272. Review.

PMID:
27935847
11.

Development of Pyridazinone Chemotypes Targeting the PDEδ Prenyl Binding Site.

Murarka S, Martín-Gago P, Schultz-Fademrecht C, Al Saabi A, Baumann M, Fansa EK, Ismail S, Nussbaumer P, Wittinghofer A, Waldmann H.

Chemistry. 2017 May 2;23(25):6083-6093. doi: 10.1002/chem.201603222. Epub 2016 Nov 3.

PMID:
27809361
12.

Sorting of lipidated cargo by the Arl2/Arl3 system.

Fansa EK, Wittinghofer A.

Small GTPases. 2016 Oct;7(4):222-230. Epub 2016 Nov 2. Review.

13.

Novel Biochemical and Structural Insights into the Interaction of Myristoylated Cargo with Unc119 Protein and Their Release by Arl2/3.

Jaiswal M, Fansa EK, Kösling SK, Mejuch T, Waldmann H, Wittinghofer A.

J Biol Chem. 2016 Sep 23;291(39):20766-78. doi: 10.1074/jbc.M116.741827. Epub 2016 Aug 1.

14.

Biosynthesis-driven structure-activity relationship study of premonensin-derivatives.

Ismail-Ali A, Fansa EK, Pryk N, Yahiaoui S, Kushnir S, Pflieger M, Wittinghofer A, Schulz F.

Org Biomol Chem. 2016 Aug 10;14(32):7671-5. doi: 10.1039/c6ob01201a.

PMID:
27452503
15.

GTP and ATP hydrolysis in biology.

Wittinghofer A.

Biopolymers. 2016 Aug;105(8):419-21. doi: 10.1002/bip.22867. No abstract available.

PMID:
27135900
16.

Identification of pyrazolopyridazinones as PDEδ inhibitors.

Papke B, Murarka S, Vogel HA, Martín-Gago P, Kovacevic M, Truxius DC, Fansa EK, Ismail S, Zimmermann G, Heinelt K, Schultz-Fademrecht C, Al Saabi A, Baumann M, Nussbaumer P, Wittinghofer A, Waldmann H, Bastiaens PI.

Nat Commun. 2016 Apr 20;7:11360. doi: 10.1038/ncomms11360.

17.

Galectin-1 dimers can scaffold Raf-effectors to increase H-ras nanoclustering.

Blaževitš O, Mideksa YG, Šolman M, Ligabue A, Ariotti N, Nakhaeizadeh H, Fansa EK, Papageorgiou AC, Wittinghofer A, Ahmadian MR, Abankwa D.

Sci Rep. 2016 Apr 18;6:24165. doi: 10.1038/srep24165.

18.

PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity.

Fansa EK, Kösling SK, Zent E, Wittinghofer A, Ismail S.

Nat Commun. 2016 Apr 11;7:11366. doi: 10.1038/ncomms11366.

19.

Selective Targeting of the KRAS G12C Mutant: Kicking KRAS When It's Down.

Hobbs GA, Wittinghofer A, Der CJ.

Cancer Cell. 2016 Mar 14;29(3):251-253. doi: 10.1016/j.ccell.2016.02.015. Review.

20.

The N- and C-terminal ends of RPGR can bind to PDE6δ.

Fansa EK, O'Reilly NJ, Ismail S, Wittinghofer A.

EMBO Rep. 2015 Dec;16(12):1583-5. doi: 10.15252/embr.201541404. Epub 2015 Nov 9. No abstract available.

21.

A G-protein activation cascade from Arl13B to Arl3 and implications for ciliary targeting of lipidated proteins.

Gotthardt K, Lokaj M, Koerner C, Falk N, Gießl A, Wittinghofer A.

Elife. 2015 Nov 9;4. pii: e11859. doi: 10.7554/eLife.11859.

22.

Effect of the N-Terminal Helix and Nucleotide Loading on the Membrane and Effector Binding of Arl2/3.

Kapoor S, Fansa EK, Möbitz S, Ismail SA, Winter R, Wittinghofer A, Weise K.

Biophys J. 2015 Oct 20;109(8):1619-29. doi: 10.1016/j.bpj.2015.08.033.

23.

The Interaction of CCDC104/BARTL1 with Arl3 and Implications for Ciliary Function.

Lokaj M, Kösling SK, Koerner C, Lange SM, van Beersum SE, van Reeuwijk J, Roepman R, Horn N, Ueffing M, Boldt K, Wittinghofer A.

Structure. 2015 Nov 3;23(11):2122-32. doi: 10.1016/j.str.2015.08.016. Epub 2015 Oct 9.

24.

Conformational heterogeneity of the Roc domains in C. tepidum Roc-COR and implications for human LRRK2 Parkinson mutations.

Rudi K, Ho FY, Gilsbach BK, Pots H, Wittinghofer A, Kortholt A, Klare JP.

Biosci Rep. 2015 Aug 26;35(5). pii: e00254. doi: 10.1042/BSR20150128.

25.

Structural Characterization of LRRK2 Inhibitors.

Gilsbach BK, Messias AC, Ito G, Sattler M, Alessi DR, Wittinghofer A, Kortholt A.

J Med Chem. 2015 May 14;58(9):3751-6. doi: 10.1021/jm5018779. Epub 2015 May 1.

PMID:
25897865
26.

Revisiting the Roco G-protein cycle.

Terheyden S, Ho FY, Gilsbach BK, Wittinghofer A, Kortholt A.

Biochem J. 2015 Jan 1;465(1):139-47. doi: 10.1042/BJ20141095.

PMID:
25317655
27.

Predicted incorporation of non-native substrates by a polyketide synthase yields bioactive natural product derivatives.

Bravo-Rodriguez K, Ismail-Ali AF, Klopries S, Kushnir S, Ismail S, Fansa EK, Wittinghofer A, Schulz F, Sanchez-Garcia E.

Chembiochem. 2014 Sep 5;15(13):1991-7. doi: 10.1002/cbic.201402206. Epub 2014 Jul 15.

PMID:
25044264
28.

C2 domains as protein-protein interaction modules in the ciliary transition zone.

Remans K, Bürger M, Vetter IR, Wittinghofer A.

Cell Rep. 2014 Jul 10;8(1):1-9. doi: 10.1016/j.celrep.2014.05.049. Epub 2014 Jun 26.

29.

Structure guided design and kinetic analysis of highly potent benzimidazole inhibitors targeting the PDEδ prenyl binding site.

Zimmermann G, Schultz-Fademrecht C, Küchler P, Murarka S, Ismail S, Triola G, Nussbaumer P, Wittinghofer A, Waldmann H.

J Med Chem. 2014 Jun 26;57(12):5435-48. doi: 10.1021/jm500632s. Epub 2014 Jun 11.

PMID:
24884780
30.

Human septin isoforms and the GDP-GTP cycle.

Zent E, Wittinghofer A.

Biol Chem. 2014 Feb;395(2):169-80. doi: 10.1515/hsz-2013-0268.

PMID:
24246286
31.

Structural insights into the small G-protein Arl13B and implications for Joubert syndrome.

Miertzschke M, Koerner C, Spoerner M, Wittinghofer A.

Biochem J. 2014 Jan 15;457(2):301-11. doi: 10.1042/BJ20131097.

PMID:
24168557
32.

How to switch a master switch.

Hein C, Wittinghofer A, Dötsch V.

Elife. 2013 Jul 30;2:e01159. doi: 10.7554/eLife.01159.

33.

Proteins special issue of biopolymers.

Wittinghofer A, Martin JB, Blacklow S.

Biopolymers. 2013 Nov;99(11):807-8. doi: 10.1002/bip.22353. No abstract available.

PMID:
23893350
34.

Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling.

Zimmermann G, Papke B, Ismail S, Vartak N, Chandra A, Hoffmann M, Hahn SA, Triola G, Wittinghofer A, Bastiaens PI, Waldmann H.

Nature. 2013 May 30;497(7451):638-42. doi: 10.1038/nature12205. Epub 2013 May 22.

PMID:
23698361
35.

The interplay between RPGR, PDEδ and Arl2/3 regulate the ciliary targeting of farnesylated cargo.

Wätzlich D, Vetter I, Gotthardt K, Miertzschke M, Chen YX, Wittinghofer A, Ismail S.

EMBO Rep. 2013 May;14(5):465-72. doi: 10.1038/embor.2013.37. Epub 2013 Apr 5.

36.

Ras GTPase activating (RasGAP) activity of the dual specificity GAP protein Rasal requires colocalization and C2 domain binding to lipid membranes.

Sot B, Behrmann E, Raunser S, Wittinghofer A.

Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):111-6. doi: 10.1073/pnas.1201658110. Epub 2012 Dec 18.

37.

Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119.

Ismail SA, Chen YX, Miertzschke M, Vetter IR, Koerner C, Wittinghofer A.

EMBO J. 2012 Oct 17;31(20):4085-94. doi: 10.1038/emboj.2012.257. Epub 2012 Sep 7.

38.

Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations.

Gilsbach BK, Ho FY, Vetter IR, van Haastert PJ, Wittinghofer A, Kortholt A.

Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10322-7. doi: 10.1073/pnas.1203223109. Epub 2012 Jun 11.

39.

The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins.

Chandra A, Grecco HE, Pisupati V, Perera D, Cassidy L, Skoulidis F, Ismail SA, Hedberg C, Hanzal-Bayer M, Venkitaraman AR, Wittinghofer A, Bastiaens PI.

Nat Cell Biol. 2011 Dec 18;14(2):148-58. doi: 10.1038/ncb2394. Erratum in: Nat Cell Biol. 2012 Mar;14(3):329.

PMID:
22179043
40.

Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo.

Ismail SA, Chen YX, Rusinova A, Chandra A, Bierbaum M, Gremer L, Triola G, Waldmann H, Bastiaens PI, Wittinghofer A.

Nat Chem Biol. 2011 Oct 16;7(12):942-9. doi: 10.1038/nchembio.686.

PMID:
22002721
41.

Structural analysis of the Ras-like G protein MglA and its cognate GAP MglB and implications for bacterial polarity.

Miertzschke M, Koerner C, Vetter IR, Keilberg D, Hot E, Leonardy S, Søgaard-Andersen L, Wittinghofer A.

EMBO J. 2011 Aug 16;30(20):4185-97. doi: 10.1038/emboj.2011.291.

42.

Structural and biochemical properties of Sept7, a unique septin required for filament formation.

Zent E, Vetter I, Wittinghofer A.

Biol Chem. 2011 Aug;392(8-9):791-7. doi: 10.1515/BC.2011.082.

PMID:
21824007
43.

Highlight on septins.

Wittinghofer A.

Biol Chem. 2011 Aug;392(8-9):679-80. doi: 10.1515/BC.2011.094. No abstract available.

PMID:
21824001
44.

Dimeric plant RhoGAPs are regulated by its CRIB effector motif to stimulate a sequential GTP hydrolysis.

Schaefer A, Miertzschke M, Berken A, Wittinghofer A.

J Mol Biol. 2011 Aug 26;411(4):808-22. doi: 10.1016/j.jmb.2011.06.033. Epub 2011 Jun 23.

PMID:
21723292
45.

GTPase activity of Di-Ras proteins is stimulated by Rap1GAP proteins.

Gasper R, Sot B, Wittinghofer A.

Small GTPases. 2010 Nov;1(3):133-141.

46.

Structure-function relationships of the G domain, a canonical switch motif.

Wittinghofer A, Vetter IR.

Annu Rev Biochem. 2011;80:943-71. doi: 10.1146/annurev-biochem-062708-134043. Review.

PMID:
21675921
47.

The unique plant RhoGAPs are dimeric and contain a CRIB motif required for affinity and specificity towards cognate small G proteins.

Schaefer A, Höhner K, Berken A, Wittinghofer A.

Biopolymers. 2011 Jun;95(6):420-33. doi: 10.1002/bip.21601.

PMID:
21294109
48.

Rho proteins of plants--functional cycle and regulation of cytoskeletal dynamics.

Mucha E, Fricke I, Schaefer A, Wittinghofer A, Berken A.

Eur J Cell Biol. 2011 Nov;90(11):934-43. doi: 10.1016/j.ejcb.2010.11.009. Epub 2011 Jan 28. Review.

PMID:
21277045
49.

Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders.

Gremer L, Merbitz-Zahradnik T, Dvorsky R, Cirstea IC, Kratz CP, Zenker M, Wittinghofer A, Ahmadian MR.

Hum Mutat. 2011 Jan;32(1):33-43. doi: 10.1002/humu.21377. Epub 2010 Dec 9.

50.

Actin filament bundling and different nucleating effects of mouse Diaphanous-related formin FH2 domains on actin/ADF and actin/cofilin complexes.

Machaidze G, Sokoll A, Shimada A, Lustig A, Mazur A, Wittinghofer A, Aebi U, Mannherz HG.

J Mol Biol. 2010 Nov 5;403(4):529-45. doi: 10.1016/j.jmb.2010.09.017. Epub 2010 Oct 1.

PMID:
20869367

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