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Items: 1 to 50 of 135

1.

Global Proteome of LonP1+/- Mouse Embryonal Fibroblasts Reveals Impact on Respiratory Chain, but No Interdependence between Eral1 and Mitoribosomes.

Key J, Kohli A, Bárcena C, López-Otín C, Heidler J, Wittig I, Auburger G.

Int J Mol Sci. 2019 Sep 12;20(18). pii: E4523. doi: 10.3390/ijms20184523.

2.

Activation of Caspase-6 Is Promoted by a Mutant Huntingtin Fragment and Blocked by an Allosteric Inhibitor Compound.

Ehrnhoefer DE, Skotte NH, Reinshagen J, Qiu X, Windshügel B, Jaishankar P, Ladha S, Petina O, Khankischpur M, Nguyen YTN, Caron NS, Razeto A, Meyer Zu Rheda M, Deng Y, Huynh KT, Wittig I, Gribbon P, Renslo AR, Geffken D, Gul S, Hayden MR.

Cell Chem Biol. 2019 Sep 19;26(9):1295-1305.e6. doi: 10.1016/j.chembiol.2019.07.001. Epub 2019 Jul 25.

PMID:
31353319
3.

Nitric oxide maintains endothelial redox homeostasis through PKM2 inhibition.

Siragusa M, Thöle J, Bibli SI, Luck B, Loot AE, de Silva K, Wittig I, Heidler J, Stingl H, Randriamboavonjy V, Kohlstedt K, Brüne B, Weigert A, Fisslthaler B, Fleming I.

EMBO J. 2019 Sep 2;38(17):e100938. doi: 10.15252/embj.2018100938. Epub 2019 Jul 22.

PMID:
31328803
4.

Myeloid-Specific Deletion of the AMPKα2 Subunit Alters Monocyte Protein Expression and Atherogenesis.

Fisslthaler B, Zippel N, Abdel Malik R, Delgado Lagos F, Zukunft S, Thoele J, Siuda D, Soehnlein O, Wittig I, Heidler J, Weigert A, Fleming I.

Int J Mol Sci. 2019 Jun 19;20(12). pii: E3005. doi: 10.3390/ijms20123005.

5.

Mutations in a conserved loop in the PSST subunit of respiratory complex I affect ubiquinone binding and dynamics.

Galemou Yoga E, Haapanen O, Wittig I, Siegmund K, Sharma V, Zickermann V.

Biochim Biophys Acta Bioenerg. 2019 Jul 1;1860(7):573-581. doi: 10.1016/j.bbabio.2019.06.006. Epub 2019 Jun 19.

6.

AKAP12 deficiency impairs VEGF-induced endothelial cell migration and sprouting.

Benz PM, Ding Y, Stingl H, Loot AE, Zink J, Wittig I, Popp R, Fleming I.

Acta Physiol (Oxf). 2019 Jun 4:e13325. doi: 10.1111/apha.13325. [Epub ahead of print]

PMID:
31162891
7.

Redox-Dependent Loss of Flavin by Mitochondrial Complex I in Brain Ischemia/Reperfusion Injury.

Stepanova A, Sosunov S, Niatsetskaya Z, Konrad C, Starkov AA, Manfredi G, Wittig I, Ten V, Galkin A.

Antioxid Redox Signal. 2019 Sep 20;31(9):608-622. doi: 10.1089/ars.2018.7693. Epub 2019 Jul 1.

PMID:
31037949
8.

TLR2-Dependent Reversible Oxidation of Connexin 43 at Cys260 Modifies Electrical Coupling After Experimental Myocardial Ischemia/Reperfusion.

Raimann FJ, Dröse S, Bonke E, Schneider L, Tybl E, Wittig I, Heidler J, Heide H, Josipovic I, Leisegang M, Brandes RP, Roeper J, Zacharowski K, Mersmann J.

J Cardiovasc Transl Res. 2019 Oct;12(5):478-487. doi: 10.1007/s12265-019-09887-0. Epub 2019 Apr 8.

PMID:
30963423
9.

The polarity protein Scrib limits atherosclerosis development in mice.

Schürmann C, Dienst FL, Pálfi K, Vasconez AE, Oo JA, Wang S, Buchmann GK, Offermanns S, van de Sluis B, Leisegang MS, Günther S, Humbert PO, Lee E, Zhu J, Weigert A, Mathoor P, Wittig I, Kruse C, Brandes RP.

Cardiovasc Res. 2019 Apr 5. pii: cvz093. doi: 10.1093/cvr/cvz093. [Epub ahead of print]

PMID:
30949676
10.

Ubiquitylome profiling of Parkin-null brain reveals dysregulation of calcium homeostasis factors ATP1A2, Hippocalcin and GNA11, reflected by altered firing of noradrenergic neurons.

Key J, Mueller AK, Gispert S, Matschke L, Wittig I, Corti O, Münch C, Decher N, Auburger G.

Neurobiol Dis. 2019 Jul;127:114-130. doi: 10.1016/j.nbd.2019.02.008. Epub 2019 Feb 11.

PMID:
30763678
11.

BIAM switch assay coupled to mass spectrometry identifies novel redox targets of NADPH oxidase 4.

Löwe O, Rezende F, Heidler J, Wittig I, Helfinger V, Brandes RP, Schröder K.

Redox Biol. 2019 Feb;21:101125. doi: 10.1016/j.redox.2019.101125. Epub 2019 Jan 29.

12.

Redox Activation of Nox1 (NADPH Oxidase 1) Involves an Intermolecular Disulfide Bond Between Protein Disulfide Isomerase and p47phox in Vascular Smooth Muscle Cells.

Gimenez M, Veríssimo-Filho S, Wittig I, Schickling BM, Hahner F, Schürmann C, Netto LES, Rosa JC, Brandes RP, Sartoretto S, De Lucca Camargo L, Abdulkader F, Miller FJ Jr, Lopes LR.

Arterioscler Thromb Vasc Biol. 2019 Feb;39(2):224-236. doi: 10.1161/ATVBAHA.118.311038.

PMID:
30580571
13.

Deep proteome of human nNOS/NOS1-positive versus MOCK SH-SY5Y neuroblastoma cells under full nutrition, serum free starvation and rapamycin treatment.

Heidler J, Valek L, Wittig I, Tegeder I.

Data Brief. 2018 Oct 26;21:1309-1314. doi: 10.1016/j.dib.2018.10.079. eCollection 2018 Dec.

14.

Redox-proteomes of human NOS1-transduced versus MOCK SH-SY5Y neuroblastoma cells under full nutrition, serum-free starvation, and rapamycin treatment.

Heidler J, Valek L, Wittig I, Tegeder I.

Data Brief. 2018 Oct 26;21:1302-1308. doi: 10.1016/j.dib.2018.10.078. eCollection 2018 Dec.

15.

Nitric oxide contributes to protein homeostasis by S-nitrosylations of the chaperone HSPA8 and the ubiquitin ligase UBE2D.

Valek L, Heidler J, Scheving R, Wittig I, Tegeder I.

Redox Biol. 2019 Jan;20:217-235. doi: 10.1016/j.redox.2018.10.002. Epub 2018 Oct 16.

16.

TMEM126B deficiency reduces mitochondrial SDH oxidation by LPS, attenuating HIF-1α stabilization and IL-1β expression.

Fuhrmann DC, Wittig I, Brüne B.

Redox Biol. 2019 Jan;20:204-216. doi: 10.1016/j.redox.2018.10.007. Epub 2018 Oct 19.

17.

Bi-allelic Mutations in NDUFA6 Establish Its Role in Early-Onset Isolated Mitochondrial Complex I Deficiency.

Alston CL, Heidler J, Dibley MG, Kremer LS, Taylor LS, Fratter C, French CE, Glasgow RIC, Feichtinger RG, Delon I, Pagnamenta AT, Dolling H, Lemonde H, Aiton N, Bjørnstad A, Henneke L, Gärtner J, Thiele H, Tauchmannova K, Quaghebeur G, Houstek J, Sperl W, Raymond FL, Prokisch H, Mayr JA, McFarland R, Poulton J, Ryan MT, Wittig I, Henneke M, Taylor RW.

Am J Hum Genet. 2018 Oct 4;103(4):592-601. doi: 10.1016/j.ajhg.2018.08.013. Epub 2018 Sep 20.

18.

Imbalances in protein homeostasis caused by mutant desmin.

Winter L, Unger A, Berwanger C, Spörrer M, Türk M, Chevessier F, Strucksberg KH, Schlötzer-Schrehardt U, Wittig I, Goldmann WH, Marcus K, Linke WA, Clemen CS, Schröder R.

Neuropathol Appl Neurobiol. 2019 Aug;45(5):476-494. doi: 10.1111/nan.12516. Epub 2018 Sep 26.

PMID:
30179276
19.

Oxidation of cardiac myofilament proteins: Priming for dysfunction?

Cuello F, Wittig I, Lorenz K, Eaton P.

Mol Aspects Med. 2018 Oct;63:47-58. doi: 10.1016/j.mam.2018.08.003. Epub 2018 Aug 23. Review.

PMID:
30130564
20.

Clinical, biochemical and genetic spectrum of 70 patients with ACAD9 deficiency: is riboflavin supplementation effective?

Repp BM, Mastantuono E, Alston CL, Schiff M, Haack TB, Rötig A, Ardissone A, Lombès A, Catarino CB, Diodato D, Schottmann G, Poulton J, Burlina A, Jonckheere A, Munnich A, Rolinski B, Ghezzi D, Rokicki D, Wellesley D, Martinelli D, Wenhong D, Lamantea E, Ostergaard E, Pronicka E, Pierre G, Smeets HJM, Wittig I, Scurr I, de Coo IFM, Moroni I, Smet J, Mayr JA, Dai L, de Meirleir L, Schuelke M, Zeviani M, Morscher RJ, McFarland R, Seneca S, Klopstock T, Meitinger T, Wieland T, Strom TM, Herberg U, Ahting U, Sperl W, Nassogne MC, Ling H, Fang F, Freisinger P, Van Coster R, Strecker V, Taylor RW, Häberle J, Vockley J, Prokisch H, Wortmann S.

Orphanet J Rare Dis. 2018 Jul 19;13(1):120. doi: 10.1186/s13023-018-0784-8.

21.

Cystathionine γ Lyase Sulfhydrates the RNA Binding Protein Human Antigen R to Preserve Endothelial Cell Function and Delay Atherogenesis.

Bibli SI, Hu J, Sigala F, Wittig I, Heidler J, Zukunft S, Tsilimigras DI, Randriamboavonjy V, Wittig J, Kojonazarov B, Schürmann C, Siragusa M, Siuda D, Luck B, Abdel Malik R, Filis KA, Zografos G, Chen C, Wang DW, Pfeilschifter J, Brandes RP, Szabo C, Papapetropoulos A, Fleming I.

Circulation. 2019 Jan 2;139(1):101-114. doi: 10.1161/CIRCULATIONAHA.118.034757.

PMID:
29970364
22.

Metabolic Maturation during Muscle Stem Cell Differentiation Is Achieved by miR-1/133a-Mediated Inhibition of the Dlk1-Dio3 Mega Gene Cluster.

Wüst S, Dröse S, Heidler J, Wittig I, Klockner I, Franko A, Bonke E, Günther S, Gärtner U, Boettger T, Braun T.

Cell Metab. 2018 May 1;27(5):1026-1039.e6. doi: 10.1016/j.cmet.2018.02.022. Epub 2018 Apr 5.

23.

Degradation of the mitochondrial complex I assembly factor TMEM126B under chronic hypoxia.

Fuhrmann DC, Wittig I, Dröse S, Schmid T, Dehne N, Brüne B.

Cell Mol Life Sci. 2018 Aug;75(16):3051-3067. doi: 10.1007/s00018-018-2779-y. Epub 2018 Feb 20.

PMID:
29464284
24.

Identification of the TXNIP IRES and characterization of the impact of regulatory IRES trans-acting factors.

Lampe S, Kunze M, Scholz A, Brauß TF, Winslow S, Simm S, Keller M, Heidler J, Wittig I, Brüne B, Schmid T.

Biochim Biophys Acta Gene Regul Mech. 2018 Feb;1861(2):147-157. doi: 10.1016/j.bbagrm.2018.01.010. Epub 2018 Jan 31. No abstract available.

PMID:
29378331
25.

An artificial transport metabolon facilitates improved substrate utilization in yeast.

Thomik T, Wittig I, Choe JY, Boles E, Oreb M.

Nat Chem Biol. 2017 Nov;13(11):1158-1163. doi: 10.1038/nchembio.2457. Epub 2017 Sep 4.

PMID:
28869594
26.

Cristae architecture is determined by an interplay of the MICOS complex and the F1FO ATP synthase via Mic27 and Mic10.

Eydt K, Davies KM, Behrendt C, Wittig I, Reichert AS.

Microb Cell. 2017 Jul 20;4(8):259-272. doi: 10.15698/mic2017.08.585.

27.

Acyl modification and binding of mitochondrial ACP to multiprotein complexes.

Angerer H, Schönborn S, Gorka J, Bahr U, Karas M, Wittig I, Heidler J, Hoffmann J, Morgner N, Zickermann V.

Biochim Biophys Acta Mol Cell Res. 2017 Oct;1864(10):1913-1920. doi: 10.1016/j.bbamcr.2017.08.006. Epub 2017 Aug 9.

28.

Coi1 is a novel assembly factor of the yeast complex III-complex IV supercomplex.

Singhal RK, Kruse C, Heidler J, Strecker V, Zwicker K, Düsterwald L, Westermann B, Herrmann JM, Wittig I, Rapaport D.

Mol Biol Cell. 2017 Aug 9. pii: mbc.E17-02-0093. doi: 10.1091/mbc.E17-02-0093. [Epub ahead of print]

29.

Loss of synaptic zinc transport in progranulin deficient mice may contribute to progranulin-associated psychopathology and chronic pain.

Hardt S, Heidler J, Albuquerque B, Valek L, Altmann C, Wilken-Schmitz A, Schäfer MKE, Wittig I, Tegeder I.

Biochim Biophys Acta Mol Basis Dis. 2017 Nov;1863(11):2727-2745. doi: 10.1016/j.bbadis.2017.07.014. Epub 2017 Jul 15.

30.

Drug-Mediated Intracellular Donation of Nitric Oxide Potently Inhibits 5-Lipoxygenase: A Possible Key to Future Antileukotriene Therapy.

Roos J, Peters M, Maucher IV, Kühn B, Fettel J, Hellmuth N, Brat C, Sommer B, Urbschat A, Piesche M, Vogel A, Proschak E, Blöcher R, Buscató E, Häfner AK, Matrone C, Werz O, Heidler J, Wittig I, Angioni C, Geisslinger G, Parnham MJ, Zacharowski K, Steinhilber D, Maier TJ.

Antioxid Redox Signal. 2018 May 10;28(14):1265-1285. doi: 10.1089/ars.2017.7155. Epub 2017 Sep 8.

PMID:
28699354
31.

Conserved and species-specific molecular denominators in mammalian skeletal muscle aging.

Mercken EM, Capri M, Carboneau BA, Conte M, Heidler J, Santoro A, Martin-Montalvo A, Gonzalez-Freire M, Khraiwesh H, González-Reyes JA, Moaddel R, Zhang Y, Becker KG, Villalba JM, Mattison JA, Wittig I, Franceschi C, de Cabo R.

NPJ Aging Mech Dis. 2017 May 5;3:8. doi: 10.1038/s41514-017-0009-8. eCollection 2017.

32.

Cellular differentiation state modulates the mRNA export activity of SR proteins.

Botti V, McNicoll F, Steiner MC, Richter FM, Solovyeva A, Wegener M, Schwich OD, Poser I, Zarnack K, Wittig I, Neugebauer KM, Müller-McNicoll M.

J Cell Biol. 2017 Jul 3;216(7):1993-2009. doi: 10.1083/jcb.201610051. Epub 2017 Jun 7.

33.

Rab7-a novel redox target that modulates inflammatory pain processing.

Kallenborn-Gerhardt W, Möser CV, Lorenz JE, Steger M, Heidler J, Scheving R, Petersen J, Kennel L, Flauaus C, Lu R, Edinger AL, Tegeder I, Geisslinger G, Heide H, Wittig I, Schmidtko A.

Pain. 2017 Jul;158(7):1354-1365. doi: 10.1097/j.pain.0000000000000920.

PMID:
28394828
34.

Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function.

Leisegang MS, Fork C, Josipovic I, Richter FM, Preussner J, Hu J, Miller MJ, Epah J, Hofmann P, Günther S, Moll F, Valasarajan C, Heidler J, Ponomareva Y, Freiman TM, Maegdefessel L, Plate KH, Mittelbronn M, Uchida S, Künne C, Stellos K, Schermuly RT, Weissmann N, Devraj K, Wittig I, Boon RA, Dimmeler S, Pullamsetti SS, Looso M, Miller FJ Jr, Brandes RP.

Circulation. 2017 Jul 4;136(1):65-79. doi: 10.1161/CIRCULATIONAHA.116.026991. Epub 2017 Mar 28.

35.

Mutational Analysis of the QRRQ Motif in the Yeast Hig1 Type 2 Protein Rcf1 Reveals a Regulatory Role for the Cytochrome c Oxidase Complex.

Garlich J, Strecker V, Wittig I, Stuart RA.

J Biol Chem. 2017 Mar 31;292(13):5216-5226. doi: 10.1074/jbc.M116.758045. Epub 2017 Feb 6.

36.

Cytochrome c Oxidase Biogenesis and Metallochaperone Interactions: Steps in the Assembly Pathway of a Bacterial Complex.

Schimo S, Wittig I, Pos KM, Ludwig B.

PLoS One. 2017 Jan 20;12(1):e0170037. doi: 10.1371/journal.pone.0170037. eCollection 2017.

37.

Broad AOX expression in a genetically tractable mouse model does not disturb normal physiology.

Szibor M, Dhandapani PK, Dufour E, Holmström KM, Zhuang Y, Salwig I, Wittig I, Heidler J, Gizatullina Z, Gainutdinov T; German Mouse Clinic Consortium, Fuchs H, Gailus-Durner V, de Angelis MH, Nandania J, Velagapudi V, Wietelmann A, Rustin P, Gellerich FN, Jacobs HT, Braun T.

Dis Model Mech. 2017 Feb 1;10(2):163-171. doi: 10.1242/dmm.027839. Epub 2016 Dec 14.

38.

ArgC-Like Digestion: Complementary or Alternative to Tryptic Digestion?

Golghalyani V, Neupärtl M, Wittig I, Bahr U, Karas M.

J Proteome Res. 2017 Feb 3;16(2):978-987. doi: 10.1021/acs.jproteome.6b00921. Epub 2017 Jan 11.

PMID:
28051317
39.

Calpain 1 cleaves and inactivates prostacyclin synthase in mesenteric arteries from diabetic mice.

Randriamboavonjy V, Kyselova A, Elgheznawy A, Zukunft S, Wittig I, Fleming I.

Basic Res Cardiol. 2017 Jan;112(1):10. doi: 10.1007/s00395-016-0596-8. Epub 2016 Dec 24.

PMID:
28013348
40.

The mitochondrial complexome of Arabidopsis thaliana.

Senkler J, Senkler M, Eubel H, Hildebrandt T, Lengwenus C, Schertl P, Schwarzländer M, Wagner S, Wittig I, Braun HP.

Plant J. 2017 Mar;89(6):1079-1092. doi: 10.1111/tpj.13448. Epub 2017 Feb 20.

41.
42.

Accessory subunit NUYM (NDUFS4) is required for stability of the electron input module and activity of mitochondrial complex I.

Kahlhöfer F, Kmita K, Wittig I, Zwicker K, Zickermann V.

Biochim Biophys Acta Bioenerg. 2017 Feb;1858(2):175-181. doi: 10.1016/j.bbabio.2016.11.010. Epub 2016 Nov 19.

43.

Cytochrome P450 enzymes but not NADPH oxidases are the source of the NADPH-dependent lucigenin chemiluminescence in membrane assays.

Rezende F, Prior KK, Löwe O, Wittig I, Strecker V, Moll F, Helfinger V, Schnütgen F, Kurrle N, Wempe F, Walter M, Zukunft S, Luck B, Fleming I, Weissmann N, Brandes RP, Schröder K.

Free Radic Biol Med. 2017 Jan;102:57-66. doi: 10.1016/j.freeradbiomed.2016.11.019. Epub 2016 Nov 15.

44.

A Bak-dependent mitochondrial amplification step contributes to Smac mimetic/glucocorticoid-induced necroptosis.

Rohde K, Kleinesudeik L, Roesler S, Löwe O, Heidler J, Schröder K, Wittig I, Dröse S, Fulda S.

Cell Death Differ. 2017 Jan;24(1):83-97. doi: 10.1038/cdd.2016.102. Epub 2016 Nov 11.

45.

Recognition of enzymes lacking bound cofactor by protein quality control.

Martínez-Limón A, Alriquet M, Lang WH, Calloni G, Wittig I, Vabulas RM.

Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12156-12161. Epub 2016 Oct 12.

46.

AMP-Activated Protein Kinase α2 in Neutrophils Regulates Vascular Repair via Hypoxia-Inducible Factor-1α and a Network of Proteins Affecting Metabolism and Apoptosis.

Abdel Malik R, Zippel N, Frömel T, Heidler J, Zukunft S, Walzog B, Ansari N, Pampaloni F, Wingert S, Rieger MA, Wittig I, Fisslthaler B, Fleming I.

Circ Res. 2017 Jan 6;120(1):99-109. doi: 10.1161/CIRCRESAHA.116.309937. Epub 2016 Oct 24.

47.

Progranulin promotes peripheral nerve regeneration and reinnervation: role of notch signaling.

Altmann C, Vasic V, Hardt S, Heidler J, Häussler A, Wittig I, Schmidt MHH, Tegeder I.

Mol Neurodegener. 2016 Oct 22;11(1):69.

48.

Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice: Role of autophagy.

Altmann C, Hardt S, Fischer C, Heidler J, Lim HY, Häussler A, Albuquerque B, Zimmer B, Möser C, Behrends C, Koentgen F, Wittig I, Schmidt MHH, Clement AM, Deller T, Tegeder I.

Neurobiol Dis. 2016 Dec;96:294-311. doi: 10.1016/j.nbd.2016.09.010. Epub 2016 Sep 11.

PMID:
27629805
49.

Mic13 Is Essential for Formation of Crista Junctions in Mammalian Cells.

Anand R, Strecker V, Urbach J, Wittig I, Reichert AS.

PLoS One. 2016 Aug 1;11(8):e0160258. doi: 10.1371/journal.pone.0160258. eCollection 2016.

50.

Quantitative Persulfide Site Identification (qPerS-SID) Reveals Protein Targets of H2S Releasing Donors in Mammalian Cells.

Longen S, Richter F, Köhler Y, Wittig I, Beck KF, Pfeilschifter J.

Sci Rep. 2016 Jul 14;6:29808. doi: 10.1038/srep29808.

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