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Items: 1 to 50 of 58


Dentin Priming with Amphipathic Antimicrobial Peptides.

Moussa DG, Kirihara JA, Ye Z, Fischer NG, Khot J, Witthuhn BA, Aparicio C.

J Dent Res. 2019 Sep;98(10):1112-1121. doi: 10.1177/0022034519863772. Epub 2019 Jul 17.


Dystrophinopathy-associated dysfunction of Krebs cycle metabolism.

Lindsay A, Chamberlain CM, Witthuhn BA, Lowe DA, Ervasti JM.

Hum Mol Genet. 2019 Mar 15;28(6):942-951. doi: 10.1093/hmg/ddy404.


Proteomic analysis of a mosquito host cell response to persistent Wolbachia infection.

Baldridge G, Higgins L, Witthuhn B, Markowski T, Baldridge A, Armien A, Fallon A.

Res Microbiol. 2017 Sep;168(7):609-625. doi: 10.1016/j.resmic.2017.04.005. Epub 2017 Apr 21.


Plasma sphingolipids in HIV-associated chronic obstructive pulmonary disease.

Hodgson S, Griffin TJ, Reilly C, Harvey S, Witthuhn BA, Sandri BJ, Kunisaki KM, Wendt CH.

BMJ Open Respir Res. 2017 Apr 3;4(1):e000180. doi: 10.1136/bmjresp-2017-000180. eCollection 2017.


Tryptophan catabolism in acute exacerbations of chronic obstructive pulmonary disease.

Gulcev M, Reilly C, Griffin TJ, Broeckling CD, Sandri BJ, Witthuhn BA, Hodgson SW, Woodruff PG, Wendt CH.

Int J Chron Obstruct Pulmon Dis. 2016 Sep 29;11:2435-2446. eCollection 2016.


The Wolbachia WO bacteriophage proteome in the Aedes albopictus C/wStr1 cell line: evidence for lytic activity?

Baldridge GD, Markowski TW, Witthuhn BA, Higgins L, Baldridge AS, Fallon AM.

In Vitro Cell Dev Biol Anim. 2016 Jan;52(1):77-88. doi: 10.1007/s11626-015-9949-0. Epub 2015 Oct 1.


Mosaic composition of ribA and wspB genes flanking the virB8-D4 operon in the Wolbachia supergroup B-strain, wStr.

Baldridge GD, Li YG, Witthuhn BA, Higgins L, Markowski TW, Baldridge AS, Fallon AM.

Arch Microbiol. 2016 Jan;198(1):53-69. doi: 10.1007/s00203-015-1154-8. Epub 2015 Sep 23.


Proteomic profiling of a robust Wolbachia infection in an Aedes albopictus mosquito cell line.

Baldridge GD, Baldridge AS, Witthuhn BA, Higgins L, Markowski TW, Fallon AM.

Mol Microbiol. 2014 Nov;94(3):537-56. doi: 10.1111/mmi.12768. Epub 2014 Sep 22.


Detection of the Wolbachia-encoded DNA binding protein, HU beta, in mosquito gonads.

Beckmann JF, Markowski TW, Witthuhn BA, Fallon AM.

Insect Biochem Mol Biol. 2013 Mar;43(3):272-9. doi: 10.1016/j.ibmb.2012.12.007. Epub 2012 Dec 31.


Wolbachia from the planthopper Laodelphax striatellus establishes a robust, persistent, streptomycin-resistant infection in clonal mosquito cells.

Fallon AM, Baldridge GD, Higgins LA, Witthuhn BA.

In Vitro Cell Dev Biol Anim. 2013 Jan;49(1):66-73. doi: 10.1007/s11626-012-9571-3. Epub 2012 Dec 28.


Identification and origin of N-linked β-D-N-acetylglucosamine monosaccharide modifications on Arabidopsis proteins.

Kim YC, Jahren N, Stone MD, Udeshi ND, Markowski TW, Witthuhn BA, Shabanowitz J, Hunt DF, Olszewski NE.

Plant Physiol. 2013 Jan;161(1):455-64. doi: 10.1104/pp.112.208900. Epub 2012 Nov 8.


The essentiality of staphylococcal Gcp is independent of its repression of branched-chain amino acids biosynthesis.

Lei T, Yang J, Zheng L, Markowski T, Witthuhn BA, Ji Y.

PLoS One. 2012;7(10):e46836. doi: 10.1371/journal.pone.0046836. Epub 2012 Oct 4.


Mouse prostate proteomes are differentially altered by supranutritional intake of four selenium compounds.

Zhang J, Wang L, Li G, Anderson LB, Xu Y, Witthuhn B, Lü J.

Nutr Cancer. 2011;63(5):778-89. doi: 10.1080/01635581.2011.563029. Epub 2011 Jun 1.


Iron-sparing response of Mycobacterium avium subsp. paratuberculosis is strain dependent.

Janagama HK, Senthilkumar, Bannantine JP, Kugadas A, Jagtap P, Higgins L, Witthuhn B, Sreevatsan S.

BMC Microbiol. 2010 Oct 22;10:268. doi: 10.1186/1471-2180-10-268.


The insect repellent DEET (N,N-diethyl-3-methylbenzamide) increases the synthesis of glutathione S-transferase in cultured mosquito cells.

Hellestad VJ, Witthuhn BA, Fallon AM.

Cell Biol Toxicol. 2011 Apr;27(2):149-57. doi: 10.1007/s10565-010-9177-z. Epub 2010 Oct 21.


Leucine-rich alpha-2-glycoprotein-1 is upregulated in sera and tumors of ovarian cancer patients.

Andersen JD, Boylan KL, Jemmerson R, Geller MA, Misemer B, Harrington KM, Weivoda S, Witthuhn BA, Argenta P, Vogel RI, Skubitz AP.

J Ovarian Res. 2010 Sep 10;3:21. doi: 10.1186/1757-2215-3-21.


Proteomic profiling of potential molecular targets of methyl-selenium compounds in the transgenic adenocarcinoma of mouse prostate model.

Zhang J, Wang L, Anderson LB, Witthuhn B, Xu Y, Lü J.

Cancer Prev Res (Phila). 2010 Aug;3(8):994-1006. doi: 10.1158/1940-6207.CAPR-09-0261. Epub 2010 Jul 20.


In vivo assessment and potential diagnosis of xenobiotics that perturb the thyroid pathway: Proteomic analysis of Xenopus laevis brain tissue following exposure to model T4 inhibitors.

Serrano J, Higgins Ln, Witthuhn BA, Anderson LB, Markowski T, Holcombe GW, Kosian PA, Korte JJ, Tietge JE, Degitz SJ.

Comp Biochem Physiol Part D Genomics Proteomics. 2010 Jun;5(2):138-50. doi: 10.1016/j.cbd.2010.03.007. Epub 2010 Apr 2.


Identification of candidate biomarkers in ovarian cancer serum by depletion of highly abundant proteins and differential in-gel electrophoresis.

Andersen JD, Boylan KL, Xue FS, Anderson LB, Witthuhn BA, Markowski TW, Higgins L, Skubitz AP.

Electrophoresis. 2010 Jan;31(4):599-610. doi: 10.1002/elps.200900441.


Proteasome activity in a naïve mosquito cell line infected with Wolbachia pipientis wAlbB.

Fallon AM, Witthuhn BA.

In Vitro Cell Dev Biol Anim. 2009 Sep;45(8):460-6. doi: 10.1007/s11626-009-9193-6. Epub 2009 Mar 19.


Proteomic comparison of needles from blister rust-resistant and susceptible Pinus strobus seedlings reveals upregulation of putative disease resistance proteins.

Smith JA, Blanchette RA, Burnes TA, Jacobs JJ, Higgins L, Witthuhn BA, David AJ, Gillman JH.

Mol Plant Microbe Interact. 2006 Feb;19(2):150-60.


Determination of the transphosphorylation sites of Jak2 kinase.

Matsuda T, Feng J, Witthuhn BA, Sekine Y, Ihle JN.

Biochem Biophys Res Commun. 2004 Dec 10;325(2):586-94.


Requirement for Jak3 in mature T cells: its role in regulation of T cell homeostasis.

Sohn SJ, Forbush KA, Nguyen N, Witthuhn B, Nosaka T, Ihle JN, Perlmutter RM.

J Immunol. 1998 Mar 1;160(5):2130-8.


Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop.

Feng J, Witthuhn BA, Matsuda T, Kohlhuber F, Kerr IM, Ihle JN.

Mol Cell Biol. 1997 May;17(5):2497-501.


A JAK1/JAK2 chimera can sustain alpha and gamma interferon responses.

Kohlhuber F, Rogers NC, Watling D, Feng J, Guschin D, Briscoe J, Witthuhn BA, Kotenko SV, Pestka S, Stark GR, Ihle JN, Kerr IM.

Mol Cell Biol. 1997 Feb;17(2):695-706.


Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state.

Briscoe J, Rogers NC, Witthuhn BA, Watling D, Harpur AG, Wilks AF, Stark GR, Ihle JN, Kerr IM.

EMBO J. 1996 Feb 15;15(4):799-809.


Defective lymphoid development in mice lacking Jak3.

Nosaka T, van Deursen JM, Tripp RA, Thierfelder WE, Witthuhn BA, McMickle AP, Doherty PC, Grosveld GC, Ihle JN.

Science. 1995 Nov 3;270(5237):800-2. Erratum in: Science 1996 Jan 5;271(5245):17.


A kinase-deficient splice variant of the human JAK3 is expressed in hematopoietic and epithelial cancer cells.

Lai KS, Jin Y, Graham DK, Witthuhn BA, Ihle JN, Liu ET.

J Biol Chem. 1995 Oct 20;270(42):25028-36.


Interleukin-9 induces tyrosine phosphorylation of insulin receptor substrate-1 via JAK tyrosine kinases.

Yin T, Keller SR, Quelle FW, Witthuhn BA, Tsang ML, Lienhard GE, Ihle JN, Yang YC.

J Biol Chem. 1995 Sep 1;270(35):20497-502.


Interleukin 4 signals through two related pathways.

Pernis A, Witthuhn B, Keegan AD, Nelms K, Garfein E, Ihle JN, Paul WE, Pierce JH, Rothman P.

Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7971-5.


The action of interleukin-2 receptor subunits defines a new type of signaling mechanism for hematopoietin receptors in hepatic cells and fibroblasts.

Morella KK, Lai CF, Kumaki S, Kumaki N, Wang Y, Bluman EM, Witthuhn BA, Ihle JN, Giri J, Gearing DP, et al.

J Biol Chem. 1995 Apr 7;270(14):8298-310.


A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6.

Guschin D, Rogers N, Briscoe J, Witthuhn B, Watling D, Horn F, Pellegrini S, Yasukawa K, Heinrich P, Stark GR, et al.

EMBO J. 1995 Apr 3;14(7):1421-9.


Signaling through the hematopoietic cytokine receptors.

Ihle JN, Witthuhn BA, Quelle FW, Yamamoto K, Silvennoinen O.

Annu Rev Immunol. 1995;13:369-98. Review.


Induction of tyrosine phosphorylation of Vav and expression of Pim-1 correlates with Jak2-mediated growth signaling from the erythropoietin receptor.

Miura O, Miura Y, Nakamura N, Quelle FW, Witthuhn BA, Ihle JN, Aoki N.

Blood. 1994 Dec 15;84(12):4135-41.


Activation of JAK kinases and STAT proteins by interleukin-2 and interferon alpha, but not the T cell antigen receptor, in human T lymphocytes.

Beadling C, Guschin D, Witthuhn BA, Ziemiecki A, Ihle JN, Kerr IM, Cantrell DA.

EMBO J. 1994 Dec 1;13(23):5605-15.


Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits.

Miyazaki T, Kawahara A, Fujii H, Nakagawa Y, Minami Y, Liu ZJ, Oishi I, Silvennoinen O, Witthuhn BA, Ihle JN, et al.

Science. 1994 Nov 11;266(5187):1045-7.


Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID.

Russell SM, Johnston JA, Noguchi M, Kawamura M, Bacon CM, Friedmann M, Berg M, McVicar DW, Witthuhn BA, Silvennoinen O, et al.

Science. 1994 Nov 11;266(5187):1042-5.


Erythropoietin induces association of the JAK2 protein tyrosine kinase with the erythropoietin receptor in vivo.

Miura O, Nakamura N, Quelle FW, Witthuhn BA, Ihle JN, Aoki N.

Blood. 1994 Sep 1;84(5):1501-7.


Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells.

Witthuhn BA, Silvennoinen O, Miura O, Lai KS, Cwik C, Liu ET, Ihle JN.

Nature. 1994 Jul 14;370(6485):153-7.


JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region.

Quelle FW, Sato N, Witthuhn BA, Inhorn RC, Eder M, Miyajima A, Griffin JD, Ihle JN.

Mol Cell Biol. 1994 Jul;14(7):4335-41.


The identification of JAK2 tyrosine kinase as a signaling molecule for growth hormone.

Carter-Su C, Argetsinger LS, Campbell GS, Wang X, Ihle J, Witthuhn B.

Proc Soc Exp Biol Med. 1994 Jul;206(3):210-5. Review.


Signaling by the cytokine receptor superfamily: JAKs and STATs.

Ihle JN, Witthuhn BA, Quelle FW, Yamamoto K, Thierfelder WE, Kreider B, Silvennoinen O.

Trends Biochem Sci. 1994 May;19(5):222-7. Review.


Activation of JAK2 kinase mediated by the interleukin 6 signal transducer gp130.

Narazaki M, Witthuhn BA, Yoshida K, Silvennoinen O, Yasukawa K, Ihle JN, Kishimoto T, Taga T.

Proc Natl Acad Sci U S A. 1994 Mar 15;91(6):2285-9.

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