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Items: 1 to 50 of 361

1.

RICOPILI: Rapid Imputation for COnsortias PIpeLIne.

Lam M, Awasthi S, Watson HJ, Goldstein J, Panagiotaropoulou G, Trubetskoy V, Karlsson R, Frei O, Fan CC, De Witte W, Mota NR, Mullins N, Brügger K, Lee H, Wray N, Skarabis N, Huang H, Neale B, Daly M, Mattheissen M, Walters R, Ripke S.

Bioinformatics. 2019 Aug 8. pii: btz633. doi: 10.1093/bioinformatics/btz633. [Epub ahead of print]

PMID:
31393554
2.

Nasal Colonization of Humans with Occupational Exposure to Raw Meat and to Raw Meat Products with Methicillin-Susceptible and Methicillin-Resistant Staphylococcus aureus.

Cuny C, Layer F, Hansen S, Werner G, Witte W.

Toxins (Basel). 2019 Mar 30;11(4). pii: E190. doi: 10.3390/toxins11040190.

3.

The implications of target saturation for the use of drug-target residence time.

de Witte WEA, Danhof M, van der Graaf PH, de Lange ECM.

Nat Rev Drug Discov. 2018 Dec 28;18(1):82-84. doi: 10.1038/nrd.2018.234. No abstract available.

PMID:
30591716
4.

Comparative Secretome Analyses of Human and Zoonotic Staphylococcus aureus Isolates CC8, CC22, and CC398.

Busche T, Hillion M, Van Loi V, Berg D, Walther B, Semmler T, Strommenger B, Witte W, Cuny C, Mellmann A, Holmes MA, Kalinowski J, Adrian L, Bernhardt J, Antelmann H.

Mol Cell Proteomics. 2018 Dec;17(12):2412-2433. doi: 10.1074/mcp.RA118.001036. Epub 2018 Sep 10.

5.

Correction to: Modelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment models.

de Witte WEA, Rottschäfer V, Danhof M, van der Graaf PH, Peletier LA, de Lange ECM.

J Pharmacokinet Pharmacodyn. 2018 Oct;45(5):763. doi: 10.1007/s10928-018-9604-y.

6.

In vitro and in silico analysis of the effects of D2 receptor antagonist target binding kinetics on the cellular response to fluctuating dopamine concentrations.

de Witte WEA, Versfelt JW, Kuzikov M, Rolland S, Georgi V, Gribbon P, Gul S, Huntjens D, van der Graaf PH, Danhof M, Fernández-Montalván A, Witt G, de Lange ECM.

Br J Pharmacol. 2018 Nov;175(21):4121-4136. doi: 10.1111/bph.14456. Epub 2018 Sep 21.

7.

Modelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment models.

de Witte WEA, Rottschäfer V, Danhof M, van der Graaf PH, Peletier LA, de Lange ECM.

J Pharmacokinet Pharmacodyn. 2018 Aug;45(4):621-635. doi: 10.1007/s10928-018-9593-x. Epub 2018 May 18. Erratum in: J Pharmacokinet Pharmacodyn. 2018 Aug 31;:.

8.

Target and Tissue Selectivity Prediction by Integrated Mechanistic Pharmacokinetic-Target Binding and Quantitative Structure Activity Modeling.

Vlot AHC, de Witte WEA, Danhof M, van der Graaf PH, van Westen GJP, de Lange ECM.

AAPS J. 2017 Dec 4;20(1):11. doi: 10.1208/s12248-017-0172-7.

PMID:
29204742
9.

Evidence for Chemical and Electronic Nonuniformities in the Formation of the Interface of RbF-Treated Cu(In,Ga)Se2 with CdS.

Nicoara N, Kunze T, Jackson P, Hariskos D, Duarte RF, Wilks RG, Witte W, Bär M, Sadewasser S.

ACS Appl Mater Interfaces. 2017 Dec 20;9(50):44173-44180. doi: 10.1021/acsami.7b12448. Epub 2017 Dec 11.

10.

From receptor binding kinetics to signal transduction; a missing link in predicting in vivo drug-action.

Nederpelt I, Kuzikov M, de Witte WEA, Schnider P, Tuijt B, Gul S, IJzerman AP, de Lange ECM, Heitman LH.

Sci Rep. 2017 Oct 26;7(1):14169. doi: 10.1038/s41598-017-14257-4.

11.

Novel CNS drug discovery and development approach: model-based integration to predict neuro-pharmacokinetics and pharmacodynamics.

de Lange ECM, van den Brink W, Yamamoto Y, de Witte WEA, Wong YC.

Expert Opin Drug Discov. 2017 Dec;12(12):1207-1218. doi: 10.1080/17460441.2017.1380623. Epub 2017 Sep 21. Review.

PMID:
28933618
12.

The influence of drug distribution and drug-target binding on target occupancy: The rate-limiting step approximation.

de Witte WEA, Vauquelin G, van der Graaf PH, de Lange ECM.

Eur J Pharm Sci. 2017 Nov 15;109S:S83-S89. doi: 10.1016/j.ejps.2017.05.024. Epub 2017 May 12.

13.

Kinetics for Drug Discovery: an industry-driven effort to target drug residence time.

Schuetz DA, de Witte WEA, Wong YC, Knasmueller B, Richter L, Kokh DB, Sadiq SK, Bosma R, Nederpelt I, Heitman LH, Segala E, Amaral M, Guo D, Andres D, Georgi V, Stoddart LA, Hill S, Cooke RM, De Graaf C, Leurs R, Frech M, Wade RC, de Lange ECM, IJzerman AP, Müller-Fahrnow A, Ecker GF.

Drug Discov Today. 2017 Jun;22(6):896-911. doi: 10.1016/j.drudis.2017.02.002. Epub 2017 Apr 13. Review.

PMID:
28412474
14.

A novel CCR2 antagonist inhibits atherogenesis in apoE deficient mice by achieving high receptor occupancy.

Bot I, Ortiz Zacarías NV, de Witte WE, de Vries H, van Santbrink PJ, van der Velden D, Kröner MJ, van der Berg DJ, Stamos D, de Lange EC, Kuiper J, IJzerman AP, Heitman LH.

Sci Rep. 2017 Mar 3;7(1):52. doi: 10.1038/s41598-017-00104-z.

15.

Evidence for Human Adaptation and Foodborne Transmission of Livestock-Associated Methicillin-Resistant Staphylococcus aureus.

Larsen J, Stegger M, Andersen PS, Petersen A, Larsen AR, Westh H, Agersø Y, Fetsch A, Kraushaar B, Käsbohrer A, Feβler AT, Schwarz S, Cuny C, Witte W, Butaye P, Denis O, Haenni M, Madec JY, Jouy E, Laurent F, Battisti A, Franco A, Alba P, Mammina C, Pantosti A, Monaco M, Wagenaar JA, de Boer E, van Duijkeren E, Heck M, Domínguez L, Torres C, Zarazaga M, Price LB, Skov RL.

Clin Infect Dis. 2016 Nov 15;63(10):1349-1352. Epub 2016 Sep 20.

16.

Molecular Epidemiology of Staphylococcus aureus in the General Population in Northeast Germany: Results of the Study of Health in Pomerania (SHIP-TREND-0).

Holtfreter S, Grumann D, Balau V, Barwich A, Kolata J, Goehler A, Weiss S, Holtfreter B, Bauerfeind SS, Döring P, Friebe E, Haasler N, Henselin K, Kühn K, Nowotny S, Radke D, Schulz K, Schulz SR, Trübe P, Vu CH, Walther B, Westphal S, Cuny C, Witte W, Völzke H, Grabe HJ, Kocher T, Steinmetz I, Bröker BM.

J Clin Microbiol. 2016 Nov;54(11):2774-2785. Epub 2016 Sep 7.

17.

In vivo Target Residence Time and Kinetic Selectivity: The Association Rate Constant as Determinant.

de Witte WEA, Danhof M, van der Graaf PH, de Lange ECM.

Trends Pharmacol Sci. 2016 Oct;37(10):831-842. doi: 10.1016/j.tips.2016.06.008. Epub 2016 Jul 6. Review.

PMID:
27394919
18.

Epidemiology of Staphylococcus aureus Nasal Carriage Patterns in the Community.

Mehraj J, Witte W, Akmatov MK, Layer F, Werner G, Krause G.

Curr Top Microbiol Immunol. 2016;398:55-87. doi: 10.1007/82_2016_497. Review.

PMID:
27370344
19.

Occurrence of cfr-mediated multiresistance in staphylococci from veal calves and pigs, from humans at the corresponding farms, and from veterinarians and their family members.

Cuny C, Arnold P, Hermes J, Eckmanns T, Mehraj J, Schoenfelder S, Ziebuhr W, Zhao Q, Wang Y, Feßler AT, Krause G, Schwarz S, Witte W.

Vet Microbiol. 2017 Feb;200:88-94. doi: 10.1016/j.vetmic.2016.04.002. Epub 2016 Apr 6.

PMID:
27102205
20.

Persistence of nasal colonisation with methicillin resistant Staphylococcus aureus CC398 among participants of veterinary conferences and occurrence among their household members: A prospective cohort study, Germany 2008-2014.

Walter J, Espelage W, Adlhoch C, Cuny C, Schink S, Jansen A, Witte W, Eckmanns T, Hermes J.

Vet Microbiol. 2017 Feb;200:13-18. doi: 10.1016/j.vetmic.2016.03.015. Epub 2016 Mar 26.

PMID:
27039883
21.

Impact of bacteriophage Saint3 carriage on the immune evasion capacity and hemolytic potential of Staphylococcus aureus CC398.

Jung P, Abdelbary MM, Kraushaar B, Fetsch A, Geisel J, Herrmann M, Witte W, Cuny C, Bischoff M.

Vet Microbiol. 2017 Feb;200:46-51. doi: 10.1016/j.vetmic.2016.02.015. Epub 2016 Feb 23.

PMID:
26923248
22.

MRSA in equine hospitals and its significance for infections in humans.

Cuny C, Witte W.

Vet Microbiol. 2017 Feb;200:59-64. doi: 10.1016/j.vetmic.2016.01.013. Epub 2016 Jan 21. Review.

PMID:
26869097
23.

Methicillin-resistant Staphylococcus aureus from infections in horses in Germany are frequent colonizers of veterinarians but rare among MRSA from infections in humans.

Cuny C, Abdelbary MMH, Köck R, Layer F, Scheidemann W, Werner G, Witte W.

One Health. 2015 Dec 12;2:11-17. doi: 10.1016/j.onehlt.2015.11.004. eCollection 2016 Dec.

24.

Assessment of Interspecies Differences in Drug-Induced QTc Interval Prolongation in Cynomolgus Monkeys, Dogs and Humans.

Dubois VF, de Witte WE, Visser SA, Danhof M, Della Pasqua O; Cardiovascular Safety Project Team; TI Pharma PKPD Platform.

Pharm Res. 2016 Jan;33(1):40-51. doi: 10.1007/s11095-015-1760-9. Epub 2015 Nov 9.

25.

Mechanistic models enable the rational use of in vitro drug-target binding kinetics for better drug effects in patients.

de Witte WE, Wong YC, Nederpelt I, Heitman LH, Danhof M, van der Graaf PH, Gilissen RA, de Lange EC.

Expert Opin Drug Discov. 2016;11(1):45-63. doi: 10.1517/17460441.2016.1100163. Epub 2015 Oct 20. Review.

PMID:
26484747
26.

Veterinarians Visiting Swine Farms Are at High Risk for Colonization With Livestock-Associated Methicillin-Resistant Staphylococcus aureus.

Walter J, Espelage W, Cuny C, Jansen A, Witte W, Eckmanns T, Hermes J.

Clin Infect Dis. 2016 Jan 1;62(1):126-8. doi: 10.1093/cid/civ752. Epub 2015 Sep 3. No abstract available.

PMID:
26338785
27.

Comprehensive molecular, genomic and phenotypic analysis of a major clone of Enterococcus faecalis MLST ST40.

Zischka M, Künne CT, Blom J, Wobser D, Sakιnç T, Schmidt-Hohagen K, Dabrowski PW, Nitsche A, Hübner J, Hain T, Chakraborty T, Linke B, Goesmann A, Voget S, Daniel R, Schomburg D, Hauck R, Hafez HM, Tielen P, Jahn D, Solheim M, Sadowy E, Larsen J, Jensen LB, Ruiz-Garbajosa P, Quiñones Pérez D, Mikalsen T, Bender J, Steglich M, Nübel U, Witte W, Werner G.

BMC Genomics. 2015 Mar 12;16:175. doi: 10.1186/s12864-015-1367-x.

28.

The impact of zoonotic MRSA colonization and infection in Germany.

Köck R, Ballhausen B, Bischoff M, Cuny C, Eckmanns T, Fetsch A, Harmsen D, Goerge T, Oberheitmann B, Schwarz S, Selhorst T, Tenhagen BA, Walther B, Witte W, Ziebuhr W, Becker K.

Berl Munch Tierarztl Wochenschr. 2014 Sep-Oct;127(9-10):384-98.

PMID:
25868166
29.

Prevalence of the immune evasion gene cluster in Staphylococcus aureus CC398.

Cuny C, Abdelbary M, Layer F, Werner G, Witte W.

Vet Microbiol. 2015 May 15;177(1-2):219-23. doi: 10.1016/j.vetmic.2015.02.031. Epub 2015 Mar 6.

PMID:
25778546
30.

State-wide surveillance of antibiotic resistance patterns and spa types of methicillin-resistant Staphylococcus aureus from blood cultures in North Rhine-Westphalia, 2011-2013.

Cuny C, Layer F, Werner G, Harmsen D, Daniels-Haardt I, Jurke A, Mellmann A, Witte W, Köck R.

Clin Microbiol Infect. 2015 Aug;21(8):750-7. doi: 10.1016/j.cmi.2015.02.013. Epub 2015 Feb 20.

31.

Livestock-Associated MRSA: The Impact on Humans.

Cuny C, Wieler LH, Witte W.

Antibiotics (Basel). 2015 Nov 6;4(4):521-43. doi: 10.3390/antibiotics4040521. Review.

32.

Methicillin-sensitive and methicillin-resistant Staphylococcus aureus nasal carriage in a random sample of non-hospitalized adult population in northern Germany.

Mehraj J, Akmatov MK, Strömpl J, Gatzemeier A, Layer F, Werner G, Pieper DH, Medina E, Witte W, Pessler F, Krause G.

PLoS One. 2014 Sep 24;9(9):e107937. doi: 10.1371/journal.pone.0107937. eCollection 2014.

33.

Systematic literature analysis and review of targeted preventive measures to limit healthcare-associated infections by meticillin-resistant Staphylococcus aureus.

Kock R, Becker K, Cookson B, van Gemert-Pijnen JE, Harbarth S, Kluytmans J, Mielke M, Peters G, Skov RL, Struelens MJ, Tacconelli E, Witte W, Friedrich AW.

Euro Surveill. 2014 Jul 24;19(29). pii: 20860. Review.

34.

Serial home-based self-collection of anterior nasal swabs to detect Staphylococcus aureus carriage in a randomized population-based study in Germany.

Akmatov MK, Mehraj J, Gatzemeier A, Strömpl J, Witte W, Krause G, Pessler F.

Int J Infect Dis. 2014 Aug;25:4-10. doi: 10.1016/j.ijid.2014.01.021. Epub 2014 May 9. Erratum in: Int J Infect Dis. 2015 Jan;30:166.

35.

Insufficient discriminatory power of MALDI-TOF mass spectrometry for typing of Enterococcus faecium and Staphylococcus aureus isolates.

Lasch P, Fleige C, Stämmler M, Layer F, Nübel U, Witte W, Werner G.

J Microbiol Methods. 2014 May;100:58-69. doi: 10.1016/j.mimet.2014.02.015. Epub 2014 Mar 12.

PMID:
24614010
37.

[Infectivity-resistotype-genotype clustering of methicillin-resistant Staphylococcus aureus strains in the Central Blacksea Region of Turkey].

Kırca Yılmaz S, Acuner IC, Strommenger B, Bek Y, Witte W.

Mikrobiyol Bul. 2014 Jan;48(1):14-27. Turkish.

38.

Phylogenetic analysis of Staphylococcus aureus CC398 reveals a sub-lineage epidemiologically associated with infections in horses.

Abdelbary MM, Wittenberg A, Cuny C, Layer F, Kurt K, Wieler LH, Walther B, Skov R, Larsen J, Hasman H, Fitzgerald JR, Smith TC, Wagenaar JA, Pantosti A, Hallin M, Struelens MJ, Edwards G, Böse R, Nübel U, Witte W.

PLoS One. 2014 Feb 4;9(2):e88083. doi: 10.1371/journal.pone.0088083. eCollection 2014.

39.

Methicillin susceptible Staphylococcus aureus (MSSA) of clonal complex CC398, t571 from infections in humans are still rare in Germany.

Cuny C, Layer F, Köck R, Werner G, Witte W.

PLoS One. 2013 Dec 18;8(12):e83165. doi: 10.1371/journal.pone.0083165. eCollection 2013.

40.

Evolution of methicillin-resistant Staphylococcus aureus towards increasing resistance.

Strommenger B, Bartels MD, Kurt K, Layer F, Rohde SM, Boye K, Westh H, Witte W, De Lencastre H, Nübel U.

J Antimicrob Chemother. 2014 Mar;69(3):616-22. doi: 10.1093/jac/dkt413. Epub 2013 Oct 22.

PMID:
24150844
41.

Antibiotic resistance.

Witte W.

Int J Med Microbiol. 2013 Aug;303(6-7):285-6. doi: 10.1016/j.ijmm.2013.06.003. Epub 2013 Jun 14. No abstract available.

PMID:
23871292
42.

Livestock associated MRSA (LA-MRSA) and its relevance for humans in Germany.

Cuny C, Köck R, Witte W.

Int J Med Microbiol. 2013 Aug;303(6-7):331-7. doi: 10.1016/j.ijmm.2013.02.010. Epub 2013 Apr 20. Review.

PMID:
23607972
43.

Subpopulations of Staphylococcus aureus clonal complex 121 are associated with distinct clinical entities.

Kurt K, Rasigade JP, Laurent F, Goering RV, Žemličková H, Machova I, Struelens MJ, Zautner AE, Holtfreter S, Bröker B, Ritchie S, Reaksmey S, Limmathurotsakul D, Peacock SJ, Cuny C, Layer F, Witte W, Nübel U.

PLoS One. 2013;8(3):e58155. doi: 10.1371/journal.pone.0058155. Epub 2013 Mar 7.

44.

MRSA transmission on a neonatal intensive care unit: epidemiological and genome-based phylogenetic analyses.

Nübel U, Nachtnebel M, Falkenhorst G, Benzler J, Hecht J, Kube M, Bröcker F, Moelling K, Bührer C, Gastmeier P, Piening B, Behnke M, Dehnert M, Layer F, Witte W, Eckmanns T.

PLoS One. 2013;8(1):e54898. doi: 10.1371/journal.pone.0054898. Epub 2013 Jan 31.

45.

A genomic portrait of the emergence, evolution, and global spread of a methicillin-resistant Staphylococcus aureus pandemic.

Holden MT, Hsu LY, Kurt K, Weinert LA, Mather AE, Harris SR, Strommenger B, Layer F, Witte W, de Lencastre H, Skov R, Westh H, Zemlicková H, Coombs G, Kearns AM, Hill RL, Edgeworth J, Gould I, Gant V, Cooke J, Edwards GF, McAdam PR, Templeton KE, McCann A, Zhou Z, Castillo-Ramírez S, Feil EJ, Hudson LO, Enright MC, Balloux F, Aanensen DM, Spratt BG, Fitzgerald JR, Parkhill J, Achtman M, Bentley SD, Nübel U.

Genome Res. 2013 Apr;23(4):653-64. doi: 10.1101/gr.147710.112. Epub 2013 Jan 8.

46.

[Pandemic without drama. Influenza vaccination and Asian flu in Germany].

Witte W.

Medizinhist J. 2013;48(1):34-66. German.

PMID:
24844113
47.

[Vancomycin-resistant enterococci (VRE). Recent results and trends in development of antibiotic resistance].

Klare I, Witte W, Wendt C, Werner G.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2012 Nov;55(11-12):1387-400. doi: 10.1007/s00103-012-1564-6. German.

PMID:
23114437
48.

[Current data and trends on methicillin-resistant Staphylococcus aureus (MRSA)].

Layer F, Cuny C, Strommenger B, Werner G, Witte W.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2012 Nov;55(11-12):1377-86. doi: 10.1007/s00103-012-1560-x. German.

PMID:
23114436
49.

Genetic characterization of Panton-Valentine leukocidin-producing methicillin-resistant Staphylococcus aureus in Western Austria.

Berktold M, Grif K, Mäser M, Witte W, Würzner R, Orth-Höller D.

Wien Klin Wochenschr. 2012 Oct;124(19-20):709-15. doi: 10.1007/s00508-012-0244-8. Epub 2012 Sep 28.

PMID:
23053569
50.

Direct detection and genotyping of Klebsiella pneumoniae carbapenemases from urine by use of a new DNA microarray test.

Peter H, Berggrav K, Thomas P, Pfeifer Y, Witte W, Templeton K, Bachmann TT.

J Clin Microbiol. 2012 Dec;50(12):3990-8. doi: 10.1128/JCM.00990-12. Epub 2012 Oct 3.

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