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Items: 1 to 50 of 448

2.

Exploring pelvic floor muscle activity in men with lower urinary tract symptoms.

Vrolijks RO, Notenboom-Nas FJM, de Boer D, Schouten T, Timmerman A, Zijlstra A, Witte LPW, Knol-de Vries GE, Blanker MH.

Neurourol Urodyn. 2020 Feb;39(2):732-737. doi: 10.1002/nau.24267. Epub 2020 Jan 3.

3.

Challenges of combining work and unpaid care, and solutions: A scoping review.

Spann A, Vicente J, Allard C, Hawley M, Spreeuwenberg M, de Witte L.

Health Soc Care Community. 2020 May;28(3):699-715. doi: 10.1111/hsc.12912. Epub 2019 Dec 17. Review.

PMID:
31845451
4.

No association between anti-thyroidperoxidase antibodies and bipolar disorder: a study in the Dutch Bipolar Cohort and a meta-analysis.

Snijders GJLJ, de Witte LD, van den Berk D, van der Laan C, Regeer E, Begemann MJH, Berdenis van Berlekom A, Litjens M, Boks MP, Ophoff RA, Kahn RS, Hillegers MHJ.

Psychoneuroendocrinology. 2020 Feb;112:104518. doi: 10.1016/j.psyneuen.2019.104518. Epub 2019 Nov 16.

5.

The association between antibodies to neurotropic pathogens and bipolar disorder : A study in the Dutch Bipolar (DB) Cohort and meta-analysis.

Snijders GJLJ, van Mierlo HC, Boks MP, Begemann MJH, Sutterland AL, Litjens M, Ophoff RA, Kahn RS, de Witte LD.

Transl Psychiatry. 2019 Nov 20;9(1):311. doi: 10.1038/s41398-019-0636-x.

6.

Microglial activation in schizophrenia: Is translocator 18 kDa protein (TSPO) the right marker?

Sneeboer MAM, van der Doef T, Litjens M, Psy NBB, Melief J, Hol EM, Kahn RS, de Witte LD.

Schizophr Res. 2020 Jan;215:167-172. doi: 10.1016/j.schres.2019.10.045. Epub 2019 Nov 4.

PMID:
31699629
7.

Increased number of T-lymphocytes in post-mortem brain tissue of patients with schizophrenia.

Sneeboer MAM, van Mierlo HC, Stotijn E, MacIntyre DJ, Smith C, Kahn RS, Hol EM, de Witte LD.

Schizophr Res. 2019 Oct 29. pii: S0920-9964(19)30467-0. doi: 10.1016/j.schres.2019.10.032. [Epub ahead of print] No abstract available.

PMID:
31676171
8.

Influences on selection of assistive technology for young children in South Africa: perspectives from rehabilitation professionals (Van Niekerk, Dada and Tönsing).

de Witte LP.

Disabil Rehabil Assist Technol. 2019 Nov;14(8):755. doi: 10.1080/17483107.2019.1657509. Epub 2019 Aug 29. No abstract available.

PMID:
31462101
9.

CSF-1 controls cerebellar microglia and is required for motor function and social interaction.

Kana V, Desland FA, Casanova-Acebes M, Ayata P, Badimon A, Nabel E, Yamamuro K, Sneeboer M, Tan IL, Flanigan ME, Rose SA, Chang C, Leader A, Le Bourhis H, Sweet ES, Tung N, Wroblewska A, Lavin Y, See P, Baccarini A, Ginhoux F, Chitu V, Stanley ER, Russo SJ, Yue Z, Brown BD, Joyner AL, De Witte LD, Morishita H, Schaefer A, Merad M.

J Exp Med. 2019 Oct 7;216(10):2265-2281. doi: 10.1084/jem.20182037. Epub 2019 Jul 26.

10.
11.

Vitamin D concentration and psychotic disorder: associations with disease status, clinical variables and urbanicity.

van der Leeuw C, de Witte LD, Stellinga A, van der Ley C, Bruggeman R, Kahn RS, van Os J, Marcelis M; for G.R.O.U.P.

Psychol Med. 2019 Jul 22:1-7. doi: 10.1017/S0033291719001739. [Epub ahead of print]

PMID:
31327333
12.

B-cells and schizophrenia: A promising link or a finding lost in translation?

van Mierlo HC, Broen JCA, Kahn RS, de Witte LD.

Brain Behav Immun. 2019 Oct;81:52-62. doi: 10.1016/j.bbi.2019.06.043. Epub 2019 Jul 2. Review.

PMID:
31271869
13.

Synapse Pathology in Schizophrenia: A Meta-analysis of Postsynaptic Elements in Postmortem Brain Studies.

Berdenis van Berlekom A, Muflihah CH, Snijders GJLJ, MacGillavry HD, Middeldorp J, Hol EM, Kahn RS, de Witte LD.

Schizophr Bull. 2020 Feb 26;46(2):374-386. doi: 10.1093/schbul/sbz060.

PMID:
31192350
14.

Neurons and glial cells in bipolar disorder: A systematic review of postmortem brain studies of cell number and size.

Gigase FAJ, Snijders GJLJ, Boks MP, de Witte LD.

Neurosci Biobehav Rev. 2019 Aug;103:150-162. doi: 10.1016/j.neubiorev.2019.05.027. Epub 2019 Jun 1. Review.

PMID:
31163205
15.

A Virtual Agent to Support Individuals Living With Physical and Mental Comorbidities: Co-Design and Acceptability Testing.

Easton K, Potter S, Bec R, Bennion M, Christensen H, Grindell C, Mirheidari B, Weich S, de Witte L, Wolstenholme D, Hawley MS.

J Med Internet Res. 2019 May 30;21(5):e12996. doi: 10.2196/12996.

16.

Smartphone Apps to Support Self-Management of Hypertension: Review and Content Analysis.

Alessa T, Hawley MS, Hock ES, de Witte L.

JMIR Mhealth Uhealth. 2019 May 28;7(5):e13645. doi: 10.2196/13645. Review.

17.

The association between schizophrenia and the immune system: Review of the evidence from unbiased 'omic-studies'.

van Mierlo HC, Schot A, Boks MPM, de Witte LD.

Schizophr Res. 2019 May 23. pii: S0920-9964(19)30204-X. doi: 10.1016/j.schres.2019.05.028. [Epub ahead of print]

PMID:
31130400
18.

Microglia in post-mortem brain tissue of patients with bipolar disorder are not immune activated.

Sneeboer MAM, Snijders GJLJ, Berdowski WM, Fernández-Andreu A; Psychiatric Donor Program of the Netherlands Brain Bank (NBB-Psy), van Mierlo HC, Berdenis van Berlekom A, Litjens M, Kahn RS, Hol EM, de Witte LD.

Transl Psychiatry. 2019 May 24;9(1):153. doi: 10.1038/s41398-019-0490-x.

19.

DNA methylation changes related to nutritional deprivation: a genome-wide analysis of population and in vitro data.

He Y, de Witte LD, Houtepen LC, Nispeling DM, Xu Z, Yu Q, Yu Y, Hol EM, Kahn RS, Boks MP.

Clin Epigenetics. 2019 May 16;11(1):80. doi: 10.1186/s13148-019-0680-7.

20.

Health issues in a Bangalore slum: findings from a household survey using a mobile screening toolkit in Devarajeevanahalli.

George CE, Norman G, Wadugodapitya A, Rao SV, Nalige S, Radhakrishnan V, Behar S, de Witte L.

BMC Public Health. 2019 Apr 29;19(1):456. doi: 10.1186/s12889-019-6756-7.

21.

Exploring Differences in the Lives and Well-Being of Sexual and Gender Minority Adults Experiencing Homelessness Relative to Their Cisgender Heterosexual Counterparts.

Schick V, Witte L, Misedah L, Benedict W, Falk K, Brown C, Isbell F.

Health Equity. 2019 Mar 14;3(1):68-72. doi: 10.1089/heq.2018.0068. eCollection 2019.

22.

Liprin alfa 2 gene expression is increased by cannabis use and associated with neuropsychological function.

He Y, de Witte LD, Schubart CD, Van Gastel WA, Koeleman BPC, de Jong S, Ophoff RA, Hol EM, Boks MP.

Eur Neuropsychopharmacol. 2019 May;29(5):643-652. doi: 10.1016/j.euroneuro.2019.03.004. Epub 2019 Mar 15.

PMID:
30879928
23.

Childhood Adversity Is Associated With Increased KITLG Methylation in Healthy Individuals but Not in Bipolar Disorder Patients.

He Y, Vinkers CH, Houtepen LC, de Witte LD, Boks MP.

Front Psychiatry. 2019 Jan 22;9:743. doi: 10.3389/fpsyt.2018.00743. eCollection 2018.

24.

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.

Théry C, Witwer KW, Aikawa E, Alcaraz MJ, Anderson JD, Andriantsitohaina R, Antoniou A, Arab T, Archer F, Atkin-Smith GK, Ayre DC, Bach JM, Bachurski D, Baharvand H, Balaj L, Baldacchino S, Bauer NN, Baxter AA, Bebawy M, Beckham C, Bedina Zavec A, Benmoussa A, Berardi AC, Bergese P, Bielska E, Blenkiron C, Bobis-Wozowicz S, Boilard E, Boireau W, Bongiovanni A, Borràs FE, Bosch S, Boulanger CM, Breakefield X, Breglio AM, Brennan MÁ, Brigstock DR, Brisson A, Broekman ML, Bromberg JF, Bryl-Górecka P, Buch S, Buck AH, Burger D, Busatto S, Buschmann D, Bussolati B, Buzás EI, Byrd JB, Camussi G, Carter DR, Caruso S, Chamley LW, Chang YT, Chen C, Chen S, Cheng L, Chin AR, Clayton A, Clerici SP, Cocks A, Cocucci E, Coffey RJ, Cordeiro-da-Silva A, Couch Y, Coumans FA, Coyle B, Crescitelli R, Criado MF, D'Souza-Schorey C, Das S, Datta Chaudhuri A, de Candia P, De Santana EF, De Wever O, Del Portillo HA, Demaret T, Deville S, Devitt A, Dhondt B, Di Vizio D, Dieterich LC, Dolo V, Dominguez Rubio AP, Dominici M, Dourado MR, Driedonks TA, Duarte FV, Duncan HM, Eichenberger RM, Ekström K, El Andaloussi S, Elie-Caille C, Erdbrügger U, Falcón-Pérez JM, Fatima F, Fish JE, Flores-Bellver M, Försönits A, Frelet-Barrand A, Fricke F, Fuhrmann G, Gabrielsson S, Gámez-Valero A, Gardiner C, Gärtner K, Gaudin R, Gho YS, Giebel B, Gilbert C, Gimona M, Giusti I, Goberdhan DC, Görgens A, Gorski SM, Greening DW, Gross JC, Gualerzi A, Gupta GN, Gustafson D, Handberg A, Haraszti RA, Harrison P, Hegyesi H, Hendrix A, Hill AF, Hochberg FH, Hoffmann KF, Holder B, Holthofer H, Hosseinkhani B, Hu G, Huang Y, Huber V, Hunt S, Ibrahim AG, Ikezu T, Inal JM, Isin M, Ivanova A, Jackson HK, Jacobsen S, Jay SM, Jayachandran M, Jenster G, Jiang L, Johnson SM, Jones JC, Jong A, Jovanovic-Talisman T, Jung S, Kalluri R, Kano SI, Kaur S, Kawamura Y, Keller ET, Khamari D, Khomyakova E, Khvorova A, Kierulf P, Kim KP, Kislinger T, Klingeborn M, Klinke DJ 2nd, Kornek M, Kosanović MM, Kovács ÁF, Krämer-Albers EM, Krasemann S, Krause M, Kurochkin IV, Kusuma GD, Kuypers S, Laitinen S, Langevin SM, Languino LR, Lannigan J, Lässer C, Laurent LC, Lavieu G, Lázaro-Ibáñez E, Le Lay S, Lee MS, Lee YXF, Lemos DS, Lenassi M, Leszczynska A, Li IT, Liao K, Libregts SF, Ligeti E, Lim R, Lim SK, Linē A, Linnemannstöns K, Llorente A, Lombard CA, Lorenowicz MJ, Lörincz ÁM, Lötvall J, Lovett J, Lowry MC, Loyer X, Lu Q, Lukomska B, Lunavat TR, Maas SL, Malhi H, Marcilla A, Mariani J, Mariscal J, Martens-Uzunova ES, Martin-Jaular L, Martinez MC, Martins VR, Mathieu M, Mathivanan S, Maugeri M, McGinnis LK, McVey MJ, Meckes DG Jr, Meehan KL, Mertens I, Minciacchi VR, Möller A, Møller Jørgensen M, Morales-Kastresana A, Morhayim J, Mullier F, Muraca M, Musante L, Mussack V, Muth DC, Myburgh KH, Najrana T, Nawaz M, Nazarenko I, Nejsum P, Neri C, Neri T, Nieuwland R, Nimrichter L, Nolan JP, Nolte-'t Hoen EN, Noren Hooten N, O'Driscoll L, O'Grady T, O'Loghlen A, Ochiya T, Olivier M, Ortiz A, Ortiz LA, Osteikoetxea X, Østergaard O, Ostrowski M, Park J, Pegtel DM, Peinado H, Perut F, Pfaffl MW, Phinney DG, Pieters BC, Pink RC, Pisetsky DS, Pogge von Strandmann E, Polakovicova I, Poon IK, Powell BH, Prada I, Pulliam L, Quesenberry P, Radeghieri A, Raffai RL, Raimondo S, Rak J, Ramirez MI, Raposo G, Rayyan MS, Regev-Rudzki N, Ricklefs FL, Robbins PD, Roberts DD, Rodrigues SC, Rohde E, Rome S, Rouschop KM, Rughetti A, Russell AE, Saá P, Sahoo S, Salas-Huenuleo E, Sánchez C, Saugstad JA, Saul MJ, Schiffelers RM, Schneider R, Schøyen TH, Scott A, Shahaj E, Sharma S, Shatnyeva O, Shekari F, Shelke GV, Shetty AK, Shiba K, Siljander PR, Silva AM, Skowronek A, Snyder OL 2nd, Soares RP, Sódar BW, Soekmadji C, Sotillo J, Stahl PD, Stoorvogel W, Stott SL, Strasser EF, Swift S, Tahara H, Tewari M, Timms K, Tiwari S, Tixeira R, Tkach M, Toh WS, Tomasini R, Torrecilhas AC, Tosar JP, Toxavidis V, Urbanelli L, Vader P, van Balkom BW, van der Grein SG, Van Deun J, van Herwijnen MJ, Van Keuren-Jensen K, van Niel G, van Royen ME, van Wijnen AJ, Vasconcelos MH, Vechetti IJ Jr, Veit TD, Vella LJ, Velot É, Verweij FJ, Vestad B, Viñas JL, Visnovitz T, Vukman KV, Wahlgren J, Watson DC, Wauben MH, Weaver A, Webber JP, Weber V, Wehman AM, Weiss DJ, Welsh JA, Wendt S, Wheelock AM, Wiener Z, Witte L, Wolfram J, Xagorari A, Xander P, Xu J, Yan X, Yáñez-Mó M, Yin H, Yuana Y, Zappulli V, Zarubova J, Žėkas V, Zhang JY, Zhao Z, Zheng L, Zheutlin AR, Zickler AM, Zimmermann P, Zivkovic AM, Zocco D, Zuba-Surma EK.

J Extracell Vesicles. 2018 Nov 23;7(1):1535750. doi: 10.1080/20013078.2018.1535750. eCollection 2018.

25.

Human microglia regional heterogeneity and phenotypes determined by multiplexed single-cell mass cytometry.

Böttcher C, Schlickeiser S, Sneeboer MAM, Kunkel D, Knop A, Paza E, Fidzinski P, Kraus L, Snijders GJL, Kahn RS, Schulz AR, Mei HE; NBB-Psy, Hol EM, Siegmund B, Glauben R, Spruth EJ, de Witte LD, Priller J.

Nat Neurosci. 2019 Jan;22(1):78-90. doi: 10.1038/s41593-018-0290-2. Epub 2018 Dec 17.

PMID:
30559476
26.

Microglia innately develop within cerebral organoids.

Ormel PR, Vieira de Sá R, van Bodegraven EJ, Karst H, Harschnitz O, Sneeboer MAM, Johansen LE, van Dijk RE, Scheefhals N, Berdenis van Berlekom A, Ribes Martínez E, Kling S, MacGillavry HD, van den Berg LH, Kahn RS, Hol EM, de Witte LD, Pasterkamp RJ.

Nat Commun. 2018 Oct 9;9(1):4167. doi: 10.1038/s41467-018-06684-2.

27.

Genetic vulnerability to DUSP22 promoter hypermethylation is involved in the relation between in utero famine exposure and schizophrenia.

Boks MP, Houtepen LC, Xu Z, He Y, Ursini G, Maihofer AX, Rajarajan P, Yu Q, Xu H, Wu Y, Wang S, Shi JP, Hulshoff Pol HE, Strengman E, Rutten BPF, Jaffe AE, Kleinman JE, Baker DG, Hol EM, Akbarian S, Nievergelt CM, De Witte LD, Vinkers CH, Weinberger DR, Yu J, Kahn RS.

NPJ Schizophr. 2018 Aug 21;4(1):16. doi: 10.1038/s41537-018-0058-4.

28.

Mobile Apps to Support the Self-Management of Hypertension: Systematic Review of Effectiveness, Usability, and User Satisfaction.

Alessa T, Abdi S, Hawley MS, de Witte L.

JMIR Mhealth Uhealth. 2018 Jul 23;6(7):e10723. doi: 10.2196/10723. Review.

29.

Roles, Strengths and Challenges of Using Robots in Interventions for Children with Autism Spectrum Disorder (ASD).

Huijnen CAGJ, Lexis MAS, Jansens R, de Witte LP.

J Autism Dev Disord. 2019 Jan;49(1):11-21. doi: 10.1007/s10803-018-3683-x.

30.

Absence of cerebrospinal fluid antineuronal antibodies in schizophrenia spectrum disorders - CORRIGENDUM.

Oviedo-Salcedo T, de Witte L, Kümpfel T, Kahn RS, Falkai P, Eichhorn P, Luykx J, Hasan A.

Br J Psychiatry. 2018 Sep;213(3):561. doi: 10.1192/bjp.2018.77. Epub 2018 Jul 10.

PMID:
29986772
31.

[Is psychiatry ready to let patients review their own files? Inventory of initial experiences].

van Veen SMP, Mostert M, de Witte L, Somers M.

Tijdschr Psychiatr. 2018;60(5):333-337. Dutch.

32.

Assistive technology provision: towards an international framework for assuring availability and accessibility of affordable high-quality assistive technology.

de Witte L, Steel E, Gupta S, Ramos VD, Roentgen U.

Disabil Rehabil Assist Technol. 2018 Jul;13(5):467-472. doi: 10.1080/17483107.2018.1470264. Epub 2018 May 9. Erratum in: Disabil Rehabil Assist Technol. 2018 Jul;13(5):i.

33.

Development and testing of an online community care platform for frail older adults in the Netherlands: a user-centred design.

Willard S, Cremers G, Man YP, van Rossum E, Spreeuwenberg M, de Witte L.

BMC Geriatr. 2018 Apr 7;18(1):87. doi: 10.1186/s12877-018-0774-7.

34.

Lessons Learned From a Living Lab on the Broad Adoption of eHealth in Primary Health Care.

Swinkels ICS, Huygens MWJ, Schoenmakers TM, Oude Nijeweme-D'Hollosy W, van Velsen L, Vermeulen J, Schoone-Harmsen M, Jansen YJ, van Schayck OC, Friele R, de Witte L.

J Med Internet Res. 2018 Mar 29;20(3):e83. doi: 10.2196/jmir.9110.

35.

Absence of cerebrospinal fluid antineuronal antibodies in schizophrenia spectrum disorders.

Oviedo-Salcedo T, de Witte L, Kümpfel T, Kahn RS, Falkai P, Eichhorn P, Luykx J, Hasan A.

Br J Psychiatry. 2018 May;212(5):318-320. doi: 10.1192/bjp.2018.24. Epub 2018 Mar 28. Erratum in: Br J Psychiatry. 2018 Sep;213(3):561.

PMID:
29587895
36.

Identification of priority health conditions for field-based screening in urban slums in Bangalore, India.

Abdi S, Wadugodapitiya A, Bedaf S, George CE, Norman G, Hawley M, de Witte L.

BMC Public Health. 2018 Mar 2;18(1):309. doi: 10.1186/s12889-018-5194-2.

37.

Virus discovery analyses on post-mortem brain tissue and cerebrospinal fluid of schizophrenia patients.

Tomasik J, Smits SL, Leweke FM, Eljasz P, Pas S, Kahn RS, Osterhaus ADME, Bahn S, de Witte LD.

Schizophr Res. 2018 Jul;197:605-606. doi: 10.1016/j.schres.2018.02.012. Epub 2018 Feb 23. No abstract available.

PMID:
29478863
38.

[In- and out-of-hospital emergency psychiatry: what is the best approach?]

Luykx JJ, Tijdink JK, Tempelaar W, Vinkers CH, de Witte L.

Ned Tijdschr Geneeskd. 2018;162:D2387. Dutch.

PMID:
29451111
39.

Understanding the use of email consultation in primary care using a retrospective observational study with data of Dutch electronic health records.

Huygens MWJ, Swinkels ICS, Verheij RA, Friele RD, van Schayck OCP, de Witte LP.

BMJ Open. 2018 Jan 21;8(1):e019233. doi: 10.1136/bmjopen-2017-019233.

40.

Dark clouds in co-creation, and their silver linings practical challenges we faced in a participatory project in a resource-constrained community in India, and how we overcame (some of) them.

Sushama P, Ghergu C, Meershoek A, de Witte LP, van Schayck OCP, Krumeich A.

Glob Health Action. 2018;11(1):1421342. doi: 10.1080/16549716.2017.1421342.

41.

Are infectious agents involved in the pathogenesis of postpartum psychosis?

de Witte LD, Snijders G, Litjens M, Kamperman AM, Kushner SA, Kahn RS, Bergink V.

J Affect Disord. 2018 Mar 15;229:141-144. doi: 10.1016/j.jad.2017.12.069. Epub 2018 Jan 3.

PMID:
29310062
42.

Characterization of macrophages from schizophrenia patients.

Ormel PR, van Mierlo HC, Litjens M, Strien MEV, Hol EM, Kahn RS, de Witte LD.

NPJ Schizophr. 2017 Nov 14;3(1):41. doi: 10.1038/s41537-017-0042-4.

43.

No neuronal autoantibodies detected in plasma of patients with a bipolar I disorder.

Snijders G, Titulaer MJ, Bergink V, Bastiaansen AE, Schreurs MWJ, Ophoff RA, Boks MP, Kahn RS, de Witte LD.

Psychiatry Res. 2018 Jan;259:460-462. doi: 10.1016/j.psychres.2017.10.043. Epub 2017 Nov 2.

PMID:
29136601
44.

What are the preferred characteristics of a service robot for the elderly? A multi-country focus group study with older adults and caregivers.

Bedaf S, Marti P, De Witte L.

Assist Technol. 2019;31(3):147-157. doi: 10.1080/10400435.2017.1402390. Epub 2017 Dec 11.

PMID:
29125807
45.

Telomere quantification in frontal and temporal brain tissue of patients with schizophrenia.

van Mierlo HC, Wichers CGK, He Y, Sneeboer MAM, Radstake TRDJ, Kahn RS, Broen JCA, de Witte LD.

J Psychiatr Res. 2017 Dec;95:231-234. doi: 10.1016/j.jpsychires.2017.09.006. Epub 2017 Sep 7.

PMID:
28910708
46.

Evaluation of Dynamic Arm Supports in Real Life Environments.

van der Heide LA, Roentgen U, de Witte L.

Stud Health Technol Inform. 2017;242:517-522.

PMID:
28873847
47.

Introducing ZORA to Children with Severe Physical Disabilities.

van den Heuvel R, Lexis M, de Witte L.

Stud Health Technol Inform. 2017;242:510-516.

PMID:
28873846
48.

Robots for Elderly Care: Their Level of Social Interactions and the Targeted End User.

Bedaf S, de Witte L.

Stud Health Technol Inform. 2017;242:472-478.

PMID:
28873841
49.

Reconnecting People with Dementia by Using the Interactive Instrument CRDL.

Teunissen L, Luyten T, de Witte L.

Stud Health Technol Inform. 2017;242:9-15.

PMID:
28873769
50.

Robot ZORA in rehabilitation and special education for children with severe physical disabilities: a pilot study.

van den Heuvel RJF, Lexis MAS, de Witte LP.

Int J Rehabil Res. 2017 Dec;40(4):353-359. doi: 10.1097/MRR.0000000000000248.

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