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Items: 1 to 50 of 152

1.

A novel pathogenic variant in OFD1 results in X-linked Joubert syndrome with orofaciodigital features and pituitary aplasia.

Aljeaid D, Lombardo RC, Witte DP, Hopkin RJ.

Am J Med Genet A. 2019 Jun;179(6):1010-1014. doi: 10.1002/ajmg.a.61018. Epub 2019 Mar 20.

PMID:
30895720
2.

Limited detection of human polyomaviruses in Fanconi anemia related squamous cell carcinoma.

Toptan T, Brusadelli MG, Turpin B, Witte DP, Surrallés J, Velleuer E, Schramm M, Dietrich R, Brakenhoff RH, Moore PS, Chang Y, Wells SI.

PLoS One. 2018 Dec 27;13(12):e0209235. doi: 10.1371/journal.pone.0209235. eCollection 2018.

3.

Protease-activated receptor-1 impedes prostate and intestinal tumor progression in mice.

Adams GN, Sharma BK, Rosenfeldt L, Frederick M, Flick MJ, Witte DP, Mosnier LO, Harmel-Laws E, Steinbrecher KA, Palumbo JS.

J Thromb Haemost. 2018 Nov;16(11):2258-2269. doi: 10.1111/jth.14277. Epub 2018 Sep 27.

PMID:
30152921
4.

Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes.

Hayashi Y, Zhang Y, Yokota A, Yan X, Liu J, Choi K, Li B, Sashida G, Peng Y, Xu Z, Huang R, Zhang L, Freudiger GM, Wang J, Dong Y, Zhou Y, Wang J, Wu L, Bu J, Chen A, Zhao X, Sun X, Chetal K, Olsson A, Watanabe M, Romick-Rosendale LE, Harada H, Shih LY, Tse W, Bridges JP, Caligiuri MA, Huang T, Zheng Y, Witte DP, Wang QF, Qu CK, Salomonis N, Grimes HL, Nimer SD, Xiao Z, Huang G.

Cancer Discov. 2018 Nov;8(11):1438-1457. doi: 10.1158/2159-8290.CD-17-1203. Epub 2018 Aug 23.

PMID:
30139811
5.

Hamartin regulates cessation of mouse nephrogenesis independently of Mtor.

Volovelsky O, Nguyen T, Jarmas AE, Combes AN, Wilson SB, Little MH, Witte DP, Brunskill EW, Kopan R.

Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):5998-6003. doi: 10.1073/pnas.1712955115. Epub 2018 May 21.

6.

Case Report: Hemolytic Anemia Following Deceased Donor Renal Transplantation Associated With Tranexamic Acid Administration for Disseminated Intravascular Coagulation.

Revollo JY, Cuffy MC, Witte DP, Paterno F, Alloway RR, Woodle ES.

Transplant Proc. 2015 Sep;47(7):2239-42. doi: 10.1016/j.transproceed.2015.05.027.

PMID:
26361688
7.

Early-lethal Costello syndrome due to rare HRAS Tandem Base substitution (c.35_36GC>AA; p.G12E)-associated pulmonary vascular disease.

Weaver KN, Wang D, Cnota J, Gardner N, Stabley D, Sol-Church K, Gripp KW, Witte DP, Bove KE, Hopkin RJ.

Pediatr Dev Pathol. 2014 Nov-Dec;17(6):421-30. doi: 10.2350/14-05-1488-OA.1. Epub 2014 Aug 18.

8.

Thrombin drives tumorigenesis in colitis-associated colon cancer.

Turpin B, Miller W, Rosenfeldt L, Kombrinck K, Flick MJ, Steinbrecher KA, Harmel-Laws E, Mullins ES, Shaw M, Witte DP, Revenko A, Monia B, Palumbo JS.

Cancer Res. 2014 Jun 1;74(11):3020-3030. doi: 10.1158/0008-5472.CAN-13-3276. Epub 2014 Apr 7.

9.

DEK promotes HPV-positive and -negative head and neck cancer cell proliferation.

Adams AK, Hallenbeck GE, Casper KA, Patil YJ, Wilson KM, Kimple RJ, Lambert PF, Witte DP, Xiao W, Gillison ML, Wikenheiser-Brokamp KA, Wise-Draper TM, Wells SI.

Oncogene. 2015 Feb 12;34(7):868-77. doi: 10.1038/onc.2014.15. Epub 2014 Mar 10.

10.

Tissue-specific effects of saposin A and saposin B on glycosphingolipid degradation in mutant mice.

Sun Y, Zamzow M, Ran H, Zhang W, Quinn B, Barnes S, Witte DP, Setchell KD, Williams MT, Vorhees CV, Grabowski GA.

Hum Mol Genet. 2013 Jun 15;22(12):2435-50. doi: 10.1093/hmg/ddt096. Epub 2013 Feb 27.

11.

Small noncoding differentially methylated copy-number variants, including lncRNA genes, cause a lethal lung developmental disorder.

Szafranski P, Dharmadhikari AV, Brosens E, Gurha P, Kolodziejska KE, Zhishuo O, Dittwald P, Majewski T, Mohan KN, Chen B, Person RE, Tibboel D, de Klein A, Pinner J, Chopra M, Malcolm G, Peters G, Arbuckle S, Guiang SF 3rd, Hustead VA, Jessurun J, Hirsch R, Witte DP, Maystadt I, Sebire N, Fisher R, Langston C, Sen P, Stankiewicz P.

Genome Res. 2013 Jan;23(1):23-33. doi: 10.1101/gr.141887.112. Epub 2012 Oct 3.

12.

Tetrasomy 15q25.2→qter identified with SNP microarray in a patient with multiple anomalies including complex cardiovascular malformation.

George-Abraham JK, Zimmerman SL, Hinton RB, Marino BS, Witte DP, Hopkin RJ.

Am J Med Genet A. 2012 Aug;158A(8):1971-6. doi: 10.1002/ajmg.a.35428. Epub 2012 Jun 18.

PMID:
22711292
13.

The fanconi anemia pathway limits human papillomavirus replication.

Hoskins EE, Morreale RJ, Werner SP, Higginbotham JM, Laimins LA, Lambert PF, Brown DR, Gillison ML, Nuovo GJ, Witte DP, Kim MO, Davies SM, Mehta PA, Butsch Kovacic M, Wikenheiser-Brokamp KA, Wells SI.

J Virol. 2012 Aug;86(15):8131-8. doi: 10.1128/JVI.00408-12. Epub 2012 May 23.

14.

Impact of perinatal exposure to equol enantiomers on reproductive development in rodents.

Brown NM, Lindley SL, Witte DP, Setchell KD.

Reprod Toxicol. 2011 Jul;32(1):33-42. doi: 10.1016/j.reprotox.2011.05.008. Epub 2011 May 20.

15.

Mammary gland differentiation by early life exposure to enantiomers of the soy isoflavone metabolite equol.

Brown NM, Belles CA, Lindley SL, Zimmer-Nechemias L, Witte DP, Kim MO, Setchell KD.

Food Chem Toxicol. 2010 Nov;48(11):3042-50. doi: 10.1016/j.fct.2010.07.042. Epub 2010 Aug 4.

PMID:
20691242
16.

Fetal surgical management of congenital heart block in a hydropic fetus: lessons learned from a clinical experience.

Eghtesady P, Michelfelder EC, Knilans TK, Witte DP, Manning PB, Crombleholme TM.

J Thorac Cardiovasc Surg. 2011 Mar;141(3):835-7. doi: 10.1016/j.jtcvs.2010.06.048. Epub 2010 Aug 1. No abstract available.

17.

Colitis-associated cancer is dependent on the interplay between the hemostatic and inflammatory systems and supported by integrin alpha(M)beta(2) engagement of fibrinogen.

Steinbrecher KA, Horowitz NA, Blevins EA, Barney KA, Shaw MA, Harmel-Laws E, Finkelman FD, Flick MJ, Pinkerton MD, Talmage KE, Kombrinck KW, Witte DP, Palumbo JS.

Cancer Res. 2010 Apr 1;70(7):2634-43. doi: 10.1158/0008-5472.CAN-09-3465. Epub 2010 Mar 16.

18.

The chemopreventive action of equol enantiomers in a chemically induced animal model of breast cancer.

Brown NM, Belles CA, Lindley SL, Zimmer-Nechemias LD, Zhao X, Witte DP, Kim MO, Setchell KD.

Carcinogenesis. 2010 May;31(5):886-93. doi: 10.1093/carcin/bgq025. Epub 2010 Jan 28.

19.

Neuronopathic Gaucher disease in the mouse: viable combined selective saposin C deficiency and mutant glucocerebrosidase (V394L) mice with glucosylsphingosine and glucosylceramide accumulation and progressive neurological deficits.

Sun Y, Liou B, Ran H, Skelton MR, Williams MT, Vorhees CV, Kitatani K, Hannun YA, Witte DP, Xu YH, Grabowski GA.

Hum Mol Genet. 2010 Mar 15;19(6):1088-97. doi: 10.1093/hmg/ddp580. Epub 2010 Jan 4.

20.

Specific saposin C deficiency: CNS impairment and acid beta-glucosidase effects in the mouse.

Sun Y, Ran H, Zamzow M, Kitatani K, Skelton MR, Williams MT, Vorhees CV, Witte DP, Hannun YA, Grabowski GA.

Hum Mol Genet. 2010 Feb 15;19(4):634-47. doi: 10.1093/hmg/ddp531. Epub 2009 Dec 16.

21.

Cancer-selective targeting and cytotoxicity by liposomal-coupled lysosomal saposin C protein.

Qi X, Chu Z, Mahller YY, Stringer KF, Witte DP, Cripe TP.

Clin Cancer Res. 2009 Sep 15;15(18):5840-51. doi: 10.1158/1078-0432.CCR-08-3285. Epub 2009 Sep 8.

22.

The APC tumor suppressor is required for epithelial integrity in the mouse mammary gland.

Prosperi JR, Becher KR, Willson TA, Collins MH, Witte DP, Goss KH.

J Cell Physiol. 2009 Aug;220(2):319-31. doi: 10.1002/jcp.21766.

PMID:
19326388
23.

Spermidine/spermine-N1-acetyltransferase ablation protects against liver and kidney ischemia-reperfusion injury in mice.

Zahedi K, Lentsch AB, Okaya T, Barone S, Sakai N, Witte DP, Arend LJ, Alhonen L, Jell J, Jänne J, Porter CW, Soleimani M.

Am J Physiol Gastrointest Liver Physiol. 2009 Apr;296(4):G899-909. doi: 10.1152/ajpgi.90507.2008. Epub 2009 Jan 22.

24.

DEK proto-oncogene expression interferes with the normal epithelial differentiation program.

Wise-Draper TM, Morreale RJ, Morris TA, Mintz-Cole RA, Hoskins EE, Balsitis SJ, Husseinzadeh N, Witte DP, Wikenheiser-Brokamp KA, Lambert PF, Wells SI.

Am J Pathol. 2009 Jan;174(1):71-81. doi: 10.2353/ajpath.2009.080330. Epub 2008 Nov 26.

25.

Genetic elimination of prothrombin in adult mice is not compatible with survival and results in spontaneous hemorrhagic events in both heart and brain.

Mullins ES, Kombrinck KW, Talmage KE, Shaw MA, Witte DP, Ullman JM, Degen SJ, Sun W, Flick MJ, Degen JL.

Blood. 2009 Jan 15;113(3):696-704. doi: 10.1182/blood-2008-07-169003. Epub 2008 Oct 16.

26.

Temporal gene expression profiling reveals CEBPD as a candidate regulator of brain disease in prosaposin deficient mice.

Sun Y, Jia L, Williams MT, Zamzow M, Ran H, Quinn B, Aronow BJ, Vorhees CV, Witte DP, Grabowski GA.

BMC Neurosci. 2008 Aug 1;9:76. doi: 10.1186/1471-2202-9-76.

27.

Neurological deficits and glycosphingolipid accumulation in saposin B deficient mice.

Sun Y, Witte DP, Ran H, Zamzow M, Barnes S, Cheng H, Han X, Williams MT, Skelton MR, Vorhees CV, Grabowski GA.

Hum Mol Genet. 2008 Aug 1;17(15):2345-56. doi: 10.1093/hmg/ddn135. Epub 2008 May 14.

28.

Fibrin(ogen) exacerbates inflammatory joint disease through a mechanism linked to the integrin alphaMbeta2 binding motif.

Flick MJ, LaJeunesse CM, Talmage KE, Witte DP, Palumbo JS, Pinkerton MD, Thornton S, Degen JL.

J Clin Invest. 2007 Nov;117(11):3224-35.

29.

Laser capture microdissection-microarray analysis of focal segmental glomerulosclerosis glomeruli.

Bennett MR, Czech KA, Arend LJ, Witte DP, Devarajan P, Potter SS.

Nephron Exp Nephrol. 2007;107(1):e30-40. Epub 2007 Aug 6.

PMID:
17684420
30.

Combined saposin C and D deficiencies in mice lead to a neuronopathic phenotype, glucosylceramide and alpha-hydroxy ceramide accumulation, and altered prosaposin trafficking.

Sun Y, Witte DP, Zamzow M, Ran H, Quinn B, Matsuda J, Grabowski GA.

Hum Mol Genet. 2007 Apr 15;16(8):957-71. Epub 2007 Mar 12.

PMID:
17353235
31.

Cytomegalovirus and recurrent idiopathic membranoproliferative glomerulonephritis type 1: cause or consequence?

Wenderfer SE, Swinford RD, Mauiyyedi S, Witte DP, Braun MC.

Transplantation. 2007 Feb 27;83(4):523-4. No abstract available.

PMID:
17318089
32.

Conditional expression of human acid beta-glucosidase improves the visceral phenotype in a Gaucher disease mouse model.

Sun Y, Quinn B, Xu YH, Leonova T, Witte DP, Grabowski GA.

J Lipid Res. 2006 Oct;47(10):2161-70. Epub 2006 Jul 21.

33.

The role of mannosylated enzyme and the mannose receptor in enzyme replacement therapy.

Du H, Levine M, Ganesa C, Witte DP, Cole ES, Grabowski GA.

Am J Hum Genet. 2005 Dec;77(6):1061-74. Epub 2005 Oct 27.

34.
35.

Prevalence and outcome of allergic colitis in healthy infants with rectal bleeding: a prospective cohort study.

Xanthakos SA, Schwimmer JB, Melin-Aldana H, Rothenberg ME, Witte DP, Cohen MB.

J Pediatr Gastroenterol Nutr. 2005 Jul;41(1):16-22.

PMID:
15990624
36.

Angiopoietin-like-4 is a potential angiogenic mediator in arthritis.

Hermann LM, Pinkerton M, Jennings K, Yang L, Grom A, Sowders D, Kersten S, Witte DP, Hirsch R, Thornton S.

Clin Immunol. 2005 Apr;115(1):93-101.

PMID:
15870027
38.

Expression and regulation of small proline-rich protein 2 in allergic inflammation.

Zimmermann N, Doepker MP, Witte DP, Stringer KF, Fulkerson PC, Pope SM, Brandt EB, Mishra A, King NE, Nikolaidis NM, Wills-Karp M, Finkelman FD, Rothenberg ME.

Am J Respir Cell Mol Biol. 2005 May;32(5):428-35. Epub 2005 Feb 24.

PMID:
15731505
39.

Saposin C-LBPA interaction in late-endosomes/lysosomes.

Chu Z, Witte DP, Qi X.

Exp Cell Res. 2005 Feb 15;303(2):300-7.

PMID:
15652344
40.

Emergence and compartmentalization of fatal multi-drug-resistant cytomegalovirus infection in a patient with autosomal-recessive severe combined immune deficiency.

Blackman SC, Lurain NS, Witte DP, Filipovich AH, Groen P, Schleiss MR.

J Pediatr Hematol Oncol. 2004 Sep;26(9):601-5.

PMID:
15342989
41.

Influence of dietary lysine level, pre-slaughter fasting, and rendement napole genotype on fresh pork quality.

Bidner BS, Ellis M, Witte DP, Carr SN, McKeith FK.

Meat Sci. 2004 Sep;68(1):53-60. doi: 10.1016/j.meatsci.2003.10.018.

PMID:
22062007
42.

Microarray analysis of focal segmental glomerulosclerosis.

Schwab K, Witte DP, Aronow BJ, Devarajan P, Potter SS, Patterson LT.

Am J Nephrol. 2004 Jul-Aug;24(4):438-47. Epub 2004 Aug 11.

PMID:
15308877
43.

Leukocyte engagement of fibrin(ogen) via the integrin receptor alphaMbeta2/Mac-1 is critical for host inflammatory response in vivo.

Flick MJ, Du X, Witte DP, Jirousková M, Soloviev DA, Busuttil SJ, Plow EF, Degen JL.

J Clin Invest. 2004 Jun;113(11):1596-606.

44.

Neural system-enriched gene expression: relationship to biological pathways and neurological diseases.

Zhang J, Moseley A, Jegga AG, Gupta A, Witte DP, Sartor M, Medvedovic M, Williams SS, Ley-Ebert C, Coolen LM, Egnaczyk G, Genter MB, Lehman M, Lingrel J, Maggio J, Parysek L, Walsh R, Xu M, Aronow BJ.

Physiol Genomics. 2004 Jul 8;18(2):167-83.

PMID:
15126645
45.

Expression and regulation of a disintegrin and metalloproteinase (ADAM) 8 in experimental asthma.

King NE, Zimmermann N, Pope SM, Fulkerson PC, Nikolaidis NM, Mishra A, Witte DP, Rothenberg ME.

Am J Respir Cell Mol Biol. 2004 Sep;31(3):257-65. Epub 2004 Apr 15.

PMID:
15087305
46.

An ACE inhibitor reduces Th2 cytokines and TGF-beta1 and TGF-beta2 isoforms in murine lupus nephritis.

De Albuquerque DA, Saxena V, Adams DE, Boivin GP, Brunner HI, Witte DP, Singh RR.

Kidney Int. 2004 Mar;65(3):846-59.

47.

Negative regulation of eosinophil recruitment to the lung by the chemokine monokine induced by IFN-gamma (Mig, CXCL9).

Fulkerson PC, Zimmermann N, Brandt EB, Muntel EE, Doepker MP, Kavanaugh JL, Mishra A, Witte DP, Zhang H, Farber JM, Yang M, Foster PS, Rothenberg ME.

Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):1987-92. Epub 2004 Feb 9.

48.

Reduction of atherosclerotic plaques by lysosomal acid lipase supplementation.

Du H, Schiavi S, Wan N, Levine M, Witte DP, Grabowski GA.

Arterioscler Thromb Vasc Biol. 2004 Jan;24(1):147-54. Epub 2003 Nov 13.

PMID:
14615393
49.

Microarray-based discovery of highly expressed olfactory mucosal genes: potential roles in the various functions of the olfactory system.

Genter MB, Van Veldhoven PP, Jegga AG, Sakthivel B, Kong S, Stanley K, Witte DP, Ebert CL, Aronow BJ.

Physiol Genomics. 2003 Dec 16;16(1):67-81.

PMID:
14570983
50.

Epstein-Barr virus-related bilateral acute retinal necrosis in a patient with X-linked lymphoproliferative disorder.

Hershberger VS, Hutchins RK, Witte DP, Schneider S, Harris RE, McGonegle SJ.

Arch Ophthalmol. 2003 Jul;121(7):1047-9. No abstract available.

PMID:
12860814

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