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Discovery of a 3,4,5-trisubstituted-1,2,4-triazole agonist with high affinity and selectivity at the somatostatin subtype-4 (sst4) receptor.

Daryaei I, Sandoval K, Witt K, Kontoyianni M, Michael Crider A.

Medchemcomm. 2018 Nov 7;9(12):2083-2090. doi: 10.1039/c8md00388b. eCollection 2018 Dec 1.


A comparison of transgenic rodent mutation and in vivo comet assay responses for 91 chemicals.

Kirkland D, Levy DD, LeBaron MJ, Aardema MJ, Beevers C, Bhalli J, Douglas GR, Escobar PA, Farabaugh CS, Guerard M, Johnson GE, Kulkarni R, Le Curieux F, Long AS, Lott J, Lovell DP, Luijten M, Marchetti F, Nicolette JJ, Pfuhler S, Roberts DJ, Stankowski LF Jr, Thybaud V, Weiner SK, Williams A, Witt KL, Young R.

Mutat Res. 2019 Mar;839:21-35. doi: 10.1016/j.mrgentox.2019.01.007. Epub 2019 Jan 18.


Sentinel Surveillance for Self-Harm.

Witt K, Robinson J.

Crisis. 2019 Jan;40(1):1-6. doi: 10.1027/0227-5910/a000583. No abstract available.


Evaluation of Breast Cancer and Melanoma Metastasis in Syngeneic Mouse Models.

Witt K, Lundqvist A.

Methods Mol Biol. 2019;1913:197-206. doi: 10.1007/978-1-4939-8979-9_14.


White Matter Changes Along the Electrode Lead in Patients Treated With Deep Brain Stimulation.

Erasmi R, Granert O, Zorenkov D, Falk D, Wodarg F, Deuschl G, Witt K.

Front Neurol. 2018 Nov 21;9:983. doi: 10.3389/fneur.2018.00983. eCollection 2018.


Recognition of, and attitudes towards, people with depression and psychosis with/without alcohol and other drug problems: results from a national survey of Australian paramedics.

McCann TV, Savic M, Ferguson N, Cheetham A, Witt K, Emond K, Bosley E, Smith K, Roberts L, Lubman DI.

BMJ Open. 2018 Dec 4;8(12):e023860. doi: 10.1136/bmjopen-2018-023860.


Neural Correlates of Hypokinetic Dysarthria and Mechanisms of Effective Voice Treatment in Parkinson Disease.

Baumann A, Nebel A, Granert O, Giehl K, Wolff S, Schmidt W, Baasch C, Schmidt G, Witt K, Deuschl G, Hartwigsen G, Zeuner KE, van Eimeren T.

Neurorehabil Neural Repair. 2018 Dec;32(12):1055-1066. doi: 10.1177/1545968318812726. Epub 2018 Nov 16.


Patterns of self-harm methods over time and the association with methods used at repeat episodes of non-fatal self-harm and suicide: A systematic review.

Witt K, Daly C, Arensman E, Pirkis J, Lubman D.

J Affect Disord. 2019 Feb 15;245:250-264. doi: 10.1016/j.jad.2018.11.001. Epub 2018 Nov 2. Review.


Mfsd2a and Glut1 Brain Nutrient Transporters Expression Increase with 32-Week Low and High Lard Compared with Fish-Oil Dietary Treatment in C57Bl/6 Mice.

Sandoval KE, Wooten JS, Harris MP, Schaller ML, Umbaugh DS, Witt KA.

Curr Dev Nutr. 2018 Jul 27;2(10):nzy065. doi: 10.1093/cdn/nzy065. eCollection 2018 Oct.


Bilateral stemless shoulder hemiarthroplasty in a female patient suffering from pseudoachondroplasia: A case report.

Holschen M, Witt KA, Steinbeck J.

J Orthop Sci. 2018 Oct 11. pii: S0949-2658(18)30263-X. doi: 10.1016/j.jos.2018.09.014. [Epub ahead of print] No abstract available.


Cognitive decline in Parkinson's disease: the impact of the motor phenotype on cognition.

Wojtala J, Heber IA, Neuser P, Heller J, Kalbe E, Rehberg SP, Storch A, Linse K, Schneider C, Gräber S, Berg D, Dams J, Balzer-Geldsetzer M, Hilker-Roggendorf R, Oberschmidt C, Baudrexel S, Witt K, Schmidt N, Deuschl G, Mollenhauer B, Trenkwalder C, Liepelt-Scarfone I, Spottke A, Roeske S, Wüllner U, Wittchen HU, Riedel O, Dodel R, Schulz JB, Reetz K.

J Neurol Neurosurg Psychiatry. 2019 Feb;90(2):171-179. doi: 10.1136/jnnp-2018-319008. Epub 2018 Oct 8.


Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1.

Li Y, Fu TM, Lu A, Witt K, Ruan J, Shen C, Wu H.

Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):10845-10852. doi: 10.1073/pnas.1810524115. Epub 2018 Oct 2.


Employment and occupational outcomes following adolescent-onset mental illness: analysis of a nationally representative French cohort.

Witt K, Milner A, Chastang JF, LaMontagne AD, Niedhammer I.

J Public Health (Oxf). 2018 Sep 25. doi: 10.1093/pubmed/fdy160. [Epub ahead of print]


Cripto-1 Plasmid DNA Vaccination Targets Metastasis and Cancer Stem Cells in Murine Mammary Carcinoma.

Witt K, Ligtenberg MA, Conti L, Lanzardo S, Ruiu R, Wallmann T, Tufvesson-Stiller H, Chambers BJ, Rolny C, Lladser A, Lundqvist A, Cavallo F, Kiessling R.

Cancer Immunol Res. 2018 Nov;6(11):1417-1425. doi: 10.1158/2326-6066.CIR-17-0572. Epub 2018 Aug 24.


Psychometric Properties of an Abbreviated Version of the Apathy Evaluation Scale for Parkinson Disease (AES-12PD).

Stankevich Y, Lueken U, Balzer-Geldsetzer M, Dodel R, Gräber-Sultan S, Berg D, Liepelt-Scarfone I, Hilker-Roggendorf R, Kalbe E, Kaut O, Mollenhauer B, Reetz K, Schäffer E, Schmidt N, Schulz JB, Spottke A, Witt K, Linse K, Storch A, Riedel O.

Am J Geriatr Psychiatry. 2018 Oct;26(10):1079-1090. doi: 10.1016/j.jagp.2018.06.012. Epub 2018 Jun 30.


Comprehensive Analyses and Prioritization of Tox21 10K Chemicals Affecting Mitochondrial Function by in-Depth Mechanistic Studies.

Xia M, Huang R, Shi Q, Boyd WA, Zhao J, Sun N, Rice JR, Dunlap PE, Hackstadt AJ, Bridge MF, Smith MV, Dai S, Zheng W, Chu PH, Gerhold D, Witt KL, DeVito M, Freedman JH, Austin CP, Houck KA, Thomas RS, Paules RS, Tice RR, Simeonov A.

Environ Health Perspect. 2018 Jul 26;126(7):077010. doi: 10.1289/EHP2589. eCollection 2018 Jul.


Impact of superior ophthalmic vein thrombosis: a case series and literature review.

van der Poel NA, de Witt KD, van den Berg R, de Win MM, Mourits MP.

Orbit. 2018 Jul 24:1-7. doi: 10.1080/01676830.2018.1497068. [Epub ahead of print]


Life-threatening DBS withdrawal syndrome in Parkinson's disease can be treated with early reimplantation.

Reuter S, Deuschl G, Berg D, Helmers A, Falk D, Witt K.

Parkinsonism Relat Disord. 2018 Nov;56:88-92. doi: 10.1016/j.parkreldis.2018.06.035. Epub 2018 Jul 2.


Acute harms associated with inhalant misuse: Co-morbidities and trends relative to age and gender among ambulance attendees.

Crossin R, Scott D, Witt KG, Duncan JR, Smith K, Lubman DI.

Drug Alcohol Depend. 2018 Sep 1;190:46-53. doi: 10.1016/j.drugalcdep.2018.05.026. Epub 2018 Jun 28.


The evolutionary history of dogs in the Americas.

Ní Leathlobhair M, Perri AR, Irving-Pease EK, Witt KE, Linderholm A, Haile J, Lebrasseur O, Ameen C, Blick J, Boyko AR, Brace S, Cortes YN, Crockford SJ, Devault A, Dimopoulos EA, Eldridge M, Enk J, Gopalakrishnan S, Gori K, Grimes V, Guiry E, Hansen AJ, Hulme-Beaman A, Johnson J, Kitchen A, Kasparov AK, Kwon YM, Nikolskiy PA, Lope CP, Manin A, Martin T, Meyer M, Myers KN, Omura M, Rouillard JM, Pavlova EY, Sciulli P, Sinding MS, Strakova A, Ivanova VV, Widga C, Willerslev E, Pitulko VV, Barnes I, Gilbert MTP, Dobney KM, Malhi RS, Murchison EP, Larson G, Frantz LAF.

Science. 2018 Jul 6;361(6397):81-85. doi: 10.1126/science.aao4776.


Impact of lifetime compared to adolescent-onset mental illness on psychosocial employment quality in adulthood: analysis of a nationally representative French cohort.

Witt K, Milner A, Chastang JF, LaMontagne AD, Niedhammer I.

Int Arch Occup Environ Health. 2018 Oct;91(7):887-900. doi: 10.1007/s00420-018-1331-6. Epub 2018 Jun 30.


Erratum: "Diversity Outbred Mice Identify Population-Based Exposure Thresholds and Genetic Factors that Influence Benzene-Induced Genotoxicity".

French JE, Gatti DM, Morgan DL, Kissling GE, Shockley KR, Knudsen GA, Shepard KG, Price HC, King D, Witt KL, Pedersen LC, Munger SC, Svenson KL, Churchill GA.

Environ Health Perspect. 2018 Jun 27;126(6):069003. doi: 10.1289/EHP3950. eCollection 2018 Jun.


Dynamic causal modeling revealed dysfunctional effective connectivity in both, the cortico-basal-ganglia and the cerebello-cortical motor network in writers' cramp.

Rothkirch I, Granert O, Knutzen A, Wolff S, Gövert F, Pedersen A, Zeuner KE, Witt K.

Neuroimage Clin. 2018 Jan 28;18:149-159. doi: 10.1016/j.nicl.2018.01.015. eCollection 2018.


Five-year outcome after conversion of a hemiarthroplasty when used for the treatment of a proximal humeral fracture to a reverse total shoulder arthroplasty.

Holschen M, Siemes MK, Witt KA, Steinbeck J.

Bone Joint J. 2018 Jun 1;100-B(6):761-766. doi: 10.1302/0301-620X.100B6.BJJ-2017-1280.R1.


Does Post-task Declarative Learning Have an Influence on Early Motor Memory Consolidation Over Day? An fMRI Study.

Rothkirch I, Wolff S, Margraf NG, Pedersen A, Witt K.

Front Neurosci. 2018 Apr 26;12:280. doi: 10.3389/fnins.2018.00280. eCollection 2018.


How similar is similar enough? A sufficient similarity case study with Ginkgo biloba extract.

Catlin NR, Collins BJ, Auerbach SS, Ferguson SS, Harnly JM, Gennings C, Waidyanatha S, Rice GE, Smith-Roe SL, Witt KL, Rider CV.

Food Chem Toxicol. 2018 Aug;118:328-339. doi: 10.1016/j.fct.2018.05.013. Epub 2018 May 9.


Effective suicide prevention: Where is the discussion on alcohol?

Witt K, Lubman DI.

Aust N Z J Psychiatry. 2018 Jun;52(6):507-508. doi: 10.1177/0004867418774415. Epub 2018 May 3. No abstract available.


Genetic Structure and Diversity Among Historic and Modern Populations of the Sumatran Rhinoceros (Dicerorhinus sumatrensis).

Brandt JR, van Coeverden de Groot PJ, Witt KE, Engelbrektsson PK, Helgen KM, Malhi RS, Ryder OA, Roca AL.

J Hered. 2018 Jun 27;109(5):553-565. doi: 10.1093/jhered/esy019.


Treatment as usual (TAU) as a control condition in trials of cognitive behavioural-based psychotherapy for self-harm: Impact of content and quality on outcomes in a systematic review.

Witt K, de Moraes DP, Salisbury TT, Arensman E, Gunnell D, Hazell P, Townsend E, van Heeringen K, Hawton K.

J Affect Disord. 2018 Aug 1;235:434-447. doi: 10.1016/j.jad.2018.04.025. Epub 2018 Apr 4.


In silico toxicology protocols.

Myatt GJ, Ahlberg E, Akahori Y, Allen D, Amberg A, Anger LT, Aptula A, Auerbach S, Beilke L, Bellion P, Benigni R, Bercu J, Booth ED, Bower D, Brigo A, Burden N, Cammerer Z, Cronin MTD, Cross KP, Custer L, Dettwiler M, Dobo K, Ford KA, Fortin MC, Gad-McDonald SE, Gellatly N, Gervais V, Glover KP, Glowienke S, Van Gompel J, Gutsell S, Hardy B, Harvey JS, Hillegass J, Honma M, Hsieh JH, Hsu CW, Hughes K, Johnson C, Jolly R, Jones D, Kemper R, Kenyon MO, Kim MT, Kruhlak NL, Kulkarni SA, Kümmerer K, Leavitt P, Majer B, Masten S, Miller S, Moser J, Mumtaz M, Muster W, Neilson L, Oprea TI, Patlewicz G, Paulino A, Lo Piparo E, Powley M, Quigley DP, Reddy MV, Richarz AN, Ruiz P, Schilter B, Serafimova R, Simpson W, Stavitskaya L, Stidl R, Suarez-Rodriguez D, Szabo DT, Teasdale A, Trejo-Martin A, Valentin JP, Vuorinen A, Wall BA, Watts P, White AT, Wichard J, Witt KL, Woolley A, Woolley D, Zwickl C, Hasselgren C.

Regul Toxicol Pharmacol. 2018 Jul;96:1-17. doi: 10.1016/j.yrtph.2018.04.014. Epub 2018 Apr 17.


Black cohosh extracts and powders induce micronuclei, a biomarker of genetic damage, in human cells.

Smith-Roe SL, Swartz CD, Shepard KG, Bryce SM, Dertinger SD, Waidyanatha S, Kissling GE, Auerbach SS, Witt KL.

Environ Mol Mutagen. 2018 Jun;59(5):416-426. doi: 10.1002/em.22182. Epub 2018 Apr 18.


Comparison of Uncleaved and Mature Human Immunodeficiency Virus Membrane Envelope Glycoprotein Trimers.

Castillo-Menendez LR, Witt K, Espy N, Princiotto A, Madani N, Pacheco B, Finzi A, Sodroski J.

J Virol. 2018 May 29;92(12). pii: e00277-18. doi: 10.1128/JVI.00277-18. Print 2018 Jun 15.


Rhythmical massage improves autonomic nervous system function: a single-blind randomised controlled trial.

Seifert G, Kanitz JL, Rihs C, Krause I, Witt K, Voss A.

J Integr Med. 2018 May;16(3):172-177. doi: 10.1016/j.joim.2018.03.002. Epub 2018 Mar 6.


All-Extra-articular Repair of Anterosuperior Rotator Cuff Tears.

Holschen M, Witt KA, Steinbeck J.

Arthrosc Tech. 2018 Jan 1;7(2):e83-e88. doi: 10.1016/j.eats.2017.08.056. eCollection 2018 Feb.


Complications of Impulse Generator Exchange Surgery for Deep Brain Stimulation: A Single-Center, Retrospective Study.

Helmers AK, Lübbing I, Birkenfeld F, Witt K, Synowitz M, Mehdorn HM, Falk D.

World Neurosurg. 2018 May;113:e108-e112. doi: 10.1016/j.wneu.2018.01.183. Epub 2018 Feb 14.


Behavioural outcomes of subthalamic stimulation and medical therapy versus medical therapy alone for Parkinson's disease with early motor complications (EARLYSTIM trial): secondary analysis of an open-label randomised trial.

Lhommée E, Wojtecki L, Czernecki V, Witt K, Maier F, Tonder L, Timmermann L, Hälbig TD, Pineau F, Durif F, Witjas T, Pinsker M, Mehdorn M, Sixel-Döring F, Kupsch A, Krüger R, Elben S, Chabardès S, Thobois S, Brefel-Courbon C, Ory-Magne F, Regis JM, Maltête D, Sauvaget A, Rau J, Schnitzler A, Schüpbach M, Schade-Brittinger C, Deuschl G, Houeto JL, Krack P; EARLYSTIM study group.

Lancet Neurol. 2018 Mar;17(3):223-231. doi: 10.1016/S1474-4422(18)30035-8.


Next generation high throughput DNA damage detection platform for genotoxic compound screening.

Sykora P, Witt KL, Revanna P, Smith-Roe SL, Dismukes J, Lloyd DG, Engelward BP, Sobol RW.

Sci Rep. 2018 Feb 9;8(1):2771. doi: 10.1038/s41598-018-20995-w.


Depression literacy and help-seeking in Australian police.

Reavley NJ, Milner AJ, Martin A, Too LS, Papas A, Witt K, Keegel T, LaMontagne AD.

Aust N Z J Psychiatry. 2018 Nov;52(11):1063-1074. doi: 10.1177/0004867417753550. Epub 2018 Feb 5.


Population attributable risk of factors associated with the repetition of self-harm behaviour in young people presenting to clinical services: a systematic review and meta-analysis.

Witt K, Milner A, Spittal MJ, Hetrick S, Robinson J, Pirkis J, Carter G.

Eur Child Adolesc Psychiatry. 2019 Jan;28(1):5-18. doi: 10.1007/s00787-018-1111-6. Epub 2018 Feb 3. Review.


Authors' reply: 'Response to: 'Psychosocial job stressors and suicidality: a meta-analysis and systematic review' by Milneret al'.

Milner A, Witt K, LaMontagne AD, Niedhammer I.

Occup Environ Med. 2018 Apr;75(4):318. doi: 10.1136/oemed-2018-104997. Epub 2018 Jan 27. No abstract available.


A smart-phone intervention to address mental health stigma in the construction industry: A two-arm randomised controlled trial.

Milner A, Law PCF, Mann C, Cooper T, Witt K, LaMontagne AD.

SSM Popul Health. 2017 Dec 31;4:164-168. doi: 10.1016/j.ssmph.2017.12.007. eCollection 2018 Apr.


Response to letter to the editor from Dr Rahman Shiri: The challenging topic of suicide across occupational groups.

Niedhammer I, Milner A, Witt K, Klingelschmidt J, Khireddine-Medouni I, Alexopoulos EC, Toivanen S, Chastang JF, LaMontagne AD.

Scand J Work Environ Health. 2018 Jan 1;44(1):108-110. doi: 10.5271/sjweh.3698. Epub 2017 Dec 8.


Identification of Estrogen-Related Receptor α Agonists in the Tox21 Compound Library.

Lynch C, Zhao J, Huang R, Kanaya N, Bernal L, Hsieh JH, Auerbach SS, Witt KL, Merrick BA, Chen S, Teng CT, Xia M.

Endocrinology. 2018 Feb 1;159(2):744-753. doi: 10.1210/en.2017-00658.


Spatial orientation and postural control in patients with Parkinson's disease.

Pawlitzki E, Schlenstedt C, Schmidt N, Rotkirch I, Gövert F, Hartwigsen G, Witt K.

Gait Posture. 2018 Feb;60:50-54. doi: 10.1016/j.gaitpost.2017.11.011. Epub 2017 Nov 13.


MicroRNA expression patterns in canine mammary cancer show significant differences between metastatic and non-metastatic tumours.

Bulkowska M, Rybicka A, Senses KM, Ulewicz K, Witt K, Szymanska J, Taciak B, Klopfleisch R, Hellmén E, Dolka I, Gure AO, Mucha J, Mikow M, Gizinski S, Krol M.

BMC Cancer. 2017 Nov 7;17(1):728. doi: 10.1186/s12885-017-3751-1.


Investigating the Generalizability of the MultiFlow ® DNA Damage Assay and Several Companion Machine Learning Models With a Set of 103 Diverse Test Chemicals.

Bryce SM, Bernacki DT, Smith-Roe SL, Witt KL, Bemis JC, Dertinger SD.

Toxicol Sci. 2018 Mar 1;162(1):146-166. doi: 10.1093/toxsci/kfx235.


Comparison of the Battery Life of Nonrechargeable Generators for Deep Brain Stimulation.

Helmers AK, Lübbing I, Deuschl G, Witt K, Synowitz M, Mehdorn HM, Falk D.

Neuromodulation. 2018 Aug;21(6):593-596. doi: 10.1111/ner.12720. Epub 2017 Nov 3.


Suicide among agricultural, forestry, and fishery workers: a systematic literature review and meta-analysis.

Klingelschmidt J, Milner A, Khireddine-Medouni I, Witt K, Alexopoulos EC, Toivanen S, LaMontagne AD, Chastang JF, Niedhammer I.

Scand J Work Environ Health. 2018 Jan 1;44(1):3-15. doi: 10.5271/sjweh.3682. Epub 2017 Oct 31. Review.


Zoledronic acid inhibits NFAT and IL-2 signaling pathways in regulatory T cells and diminishes their suppressive function in patients with metastatic cancer.

Sarhan D, Leijonhufvud C, Murray S, Witt K, Seitz C, Wallerius M, Xie H, Ullén A, Harmenberg U, Lidbrink E, Rolny C, Andersson J, Lundqvist A.

Oncoimmunology. 2017 Jun 14;6(8):e1338238. doi: 10.1080/2162402X.2017.1338238. eCollection 2017.


Psychosocial job stressors and suicidality: a meta-analysis and systematic review.

Milner A, Witt K, LaMontagne AD, Niedhammer I.

Occup Environ Med. 2018 Apr;75(4):245-253. doi: 10.1136/oemed-2017-104531. Epub 2017 Aug 29. Review.


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