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Items: 47

1.

In Vitro Culture of Cryptosporidium parvum Using Stem Cell-Derived Intestinal Epithelial Monolayers.

Wilke G, Wang Y, Ravindran S, Stappenbeck T, Witola WH, Sibley LD.

Methods Mol Biol. 2020;2052:351-372. doi: 10.1007/978-1-4939-9748-0_20.

PMID:
31452172
2.

Novel lactate dehydrogenase inhibitors with in vivo efficacy against Cryptosporidium parvum.

Li K, Nader SM, Zhang X, Ray BC, Kim CY, Das A, Witola WH.

PLoS Pathog. 2019 Jul 29;15(7):e1007953. doi: 10.1371/journal.ppat.1007953. eCollection 2019 Jul.

3.

A Stem-Cell-Derived Platform Enables Complete Cryptosporidium Development In Vitro and Genetic Tractability.

Wilke G, Funkhouser-Jones LJ, Wang Y, Ravindran S, Wang Q, Beatty WL, Baldridge MT, VanDussen KL, Shen B, Kuhlenschmidt MS, Kuhlenschmidt TB, Witola WH, Stappenbeck TS, Sibley LD.

Cell Host Microbe. 2019 Jul 10;26(1):123-134.e8. doi: 10.1016/j.chom.2019.05.007. Epub 2019 Jun 20.

4.

Morpholino-mediated in vivo silencing of Cryptosporidium parvum lactate dehydrogenase decreases oocyst shedding and infectivity.

Zhang X, Kim CY, Worthen T, Witola WH.

Int J Parasitol. 2018 Jul;48(8):649-656. doi: 10.1016/j.ijpara.2018.01.005. Epub 2018 Mar 9.

5.

Small GTPase Immunity-Associated Proteins Mediate Resistance to Toxoplasma gondii Infection in Lewis Rat.

Kim CY, Zhang X, Witola WH.

Infect Immun. 2018 Mar 22;86(4). pii: e00582-17. doi: 10.1128/IAI.00582-17. Print 2018 Apr.

6.

In vitro antagonistic and indifferent activity of combination of 3-deoxyanthocyanidins against Toxoplasma gondii.

Abugri DA, Witola WH, Jaynes JM.

Parasitol Res. 2017 Dec;116(12):3387-3400. doi: 10.1007/s00436-017-5661-1. Epub 2017 Oct 30.

PMID:
29086004
7.

Inherent Oxidative Stress in the Lewis Rat Is Associated with Resistance to Toxoplasmosis.

Witola WH, Kim CY, Zhang X.

Infect Immun. 2017 Sep 20;85(10). pii: e00289-17. doi: 10.1128/IAI.00289-17. Print 2017 Oct.

8.

In vitro activity of the interaction between taxifolin (dihydroquercetin) and pyrimethamine against Toxoplasma gondii.

Abugri DA, Witola WH, Russell AE, Troy RM.

Chem Biol Drug Des. 2018 Jan;91(1):194-201. doi: 10.1111/cbdd.13070. Epub 2017 Aug 11.

PMID:
28696589
9.

Targeted gene knockdown validates the essential role of lactate dehydrogenase in Cryptosporidium parvum.

Witola WH, Zhang X, Kim CY.

Int J Parasitol. 2017 Nov;47(13):867-874. doi: 10.1016/j.ijpara.2017.05.002. Epub 2017 Jun 9.

10.

Knockdown of phosphoethanolamine transmethylation enzymes decreases viability of Haemonchus contortus.

Witola WH, Cooks-Fagbodun S, Ordonez AR, Matthews K, Abugri DA, McHugh M.

Vet Parasitol. 2016 Jun 15;223:1-6. doi: 10.1016/j.vetpar.2016.04.008. Epub 2016 Apr 8.

PMID:
27198768
11.

In vitro anthelmintic efficacy of inhibitors of phosphoethanolamine Methyltransferases in Haemonchus contortus.

Witola WH, Matthews K, McHugh M.

Int J Parasitol Drugs Drug Resist. 2016 Jan 18;6(1):44-53. doi: 10.1016/j.ijpddr.2016.01.002. eCollection 2016 Apr.

12.

In vitro activity of Sorghum bicolor extracts, 3-deoxyanthocyanidins, against Toxoplasma gondii.

Abugri DA, Witola WH, Jaynes JM, Toufic N.

Exp Parasitol. 2016 May;164:12-9. doi: 10.1016/j.exppara.2016.02.001. Epub 2016 Feb 16.

PMID:
26855040
13.

Silencing of GRA10 protein expression inhibits Toxoplasma gondii intracellular growth and development.

Witola WH, Bauman B, McHugh M, Matthews K.

Parasitol Int. 2014 Oct;63(5):651-8. doi: 10.1016/j.parint.2014.05.001. Epub 2014 May 13.

PMID:
24832208
14.

ALOX12 in human toxoplasmosis.

Witola WH, Liu SR, Montpetit A, Welti R, Hypolite M, Roth M, Zhou Y, Mui E, Cesbron-Delauw MF, Fournie GJ, Cavailles P, Bisanz C, Boyer K, Withers S, Noble AG, Swisher CN, Heydemann PT, Rabiah P, Muench SP, McLeod R.

Infect Immun. 2014 Jul;82(7):2670-9. doi: 10.1128/IAI.01505-13. Epub 2014 Mar 31.

15.

Plasmodium falciparum phosphoethanolamine methyltransferase is essential for malaria transmission.

Bobenchik AM, Witola WH, Augagneur Y, Nic Lochlainn L, Garg A, Pachikara N, Choi JY, Zhao YO, Usmani-Brown S, Lee A, Adjalley SH, Samanta S, Fidock DA, Voelker DR, Fikrig E, Ben Mamoun C.

Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18262-7. doi: 10.1073/pnas.1313965110. Epub 2013 Oct 21.

16.

Isolation, cloning, and pathologic analysis of Trypanosoma evansi field isolates.

Mekata H, Konnai S, Mingala CN, Abes NS, Gutierrez CA, Dargantes AP, Witola WH, Inoue N, Onuma M, Murata S, Ohashi K.

Parasitol Res. 2013 Apr;112(4):1513-21. doi: 10.1007/s00436-013-3297-3. Epub 2013 Jan 25.

17.

Molecular target validation, antimicrobial delivery, and potential treatment of Toxoplasma gondii infections.

Lai BS, Witola WH, El Bissati K, Zhou Y, Mui E, Fomovska A, McLeod R.

Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14182-7. doi: 10.1073/pnas.1208775109. Epub 2012 Aug 13.

18.

Kinetics of regulatory dendritic cells in inflammatory responses during Trypanosoma evansi infection.

Mekata H, Konnai S, Mingala CN, Abes NS, Gutierrez CA, Dargantes AP, Witola WH, Inoue N, Onuma M, Murata S, Ohashi K.

Parasite Immunol. 2012 Jun;34(6):318-29. doi: 10.1111/j.1365-3024.2012.01362.x.

19.

Novel N-benzoyl-2-hydroxybenzamide disrupts unique parasite secretory pathway.

Fomovska A, Huang Q, El Bissati K, Mui EJ, Witola WH, Cheng G, Zhou Y, Sommerville C, Roberts CW, Bettis S, Prigge ST, Afanador GA, Hickman MR, Lee PJ, Leed SE, Auschwitz JM, Pieroni M, Stec J, Muench SP, Rice DW, Kozikowski AP, McLeod R.

Antimicrob Agents Chemother. 2012 May;56(5):2666-82. doi: 10.1128/AAC.06450-11. Epub 2012 Feb 21.

20.

Synthesis, biological evaluation, and structure-activity relationships of N-benzoyl-2-hydroxybenzamides as agents active against P. falciparum (K1 strain), Trypanosomes, and Leishmania.

Stec J, Huang Q, Pieroni M, Kaiser M, Fomovska A, Mui E, Witola WH, Bettis S, McLeod R, Brun R, Kozikowski AP.

J Med Chem. 2012 Apr 12;55(7):3088-100. doi: 10.1021/jm2015183. Epub 2012 Mar 20.

21.

Toxoplasma gondii HLA-B*0702-restricted GRA7(20-28) peptide with adjuvants and a universal helper T cell epitope elicits CD8(+) T cells producing interferon-γ and reduces parasite burden in HLA-B*0702 mice.

Cong H, Mui EJ, Witola WH, Sidney J, Alexander J, Sette A, Maewal A, El Bissati K, Zhou Y, Suzuki Y, Lee D, Woods S, Sommerville C, Henriquez FL, Roberts CW, McLeod R.

Hum Immunol. 2012 Jan;73(1):1-10. doi: 10.1016/j.humimm.2011.10.006. Epub 2011 Oct 12.

23.

T. gondii RP promoters & knockdown reveal molecular pathways associated with proliferation and cell-cycle arrest.

Hutson SL, Mui E, Kinsley K, Witola WH, Behnke MS, El Bissati K, Muench SP, Rohrman B, Liu SR, Wollmann R, Ogata Y, Sarkeshik A, Yates JR 3rd, McLeod R.

PLoS One. 2010 Nov 22;5(11):e14057. doi: 10.1371/journal.pone.0014057.

24.

NALP1 influences susceptibility to human congenital toxoplasmosis, proinflammatory cytokine response, and fate of Toxoplasma gondii-infected monocytic cells.

Witola WH, Mui E, Hargrave A, Liu S, Hypolite M, Montpetit A, Cavailles P, Bisanz C, Cesbron-Delauw MF, Fournié GJ, McLeod R.

Infect Immun. 2011 Feb;79(2):756-66. doi: 10.1128/IAI.00898-10. Epub 2010 Nov 22.

25.

Towards an immunosense vaccine to prevent toxoplasmosis: protective Toxoplasma gondii epitopes restricted by HLA-A*0201.

Cong H, Mui EJ, Witola WH, Sidney J, Alexander J, Sette A, Maewal A, McLeod R.

Vaccine. 2011 Jan 17;29(4):754-62. doi: 10.1016/j.vaccine.2010.11.015. Epub 2010 Nov 21.

26.

P2X7 receptor-mediated killing of an intracellular parasite, Toxoplasma gondii, by human and murine macrophages.

Lees MP, Fuller SJ, McLeod R, Boulter NR, Miller CM, Zakrzewski AM, Mui EJ, Witola WH, Coyne JJ, Hargrave AC, Jamieson SE, Blackwell JM, Wiley JS, Smith NC.

J Immunol. 2010 Jun 15;184(12):7040-6. doi: 10.4049/jimmunol.1000012. Epub 2010 May 19.

27.

Identification of T. gondii epitopes, adjuvants, and host genetic factors that influence protection of mice and humans.

Tan TG, Mui E, Cong H, Witola WH, Montpetit A, Muench SP, Sidney J, Alexander J, Sette A, Grigg ME, Maewal A, McLeod R.

Vaccine. 2010 May 21;28(23):3977-89. doi: 10.1016/j.vaccine.2010.03.028. Epub 2010 Mar 26.

28.

The malarial CDK Pfmrk and its effector PfMAT1 phosphorylate DNA replication proteins and co-localize in the nucleus.

Jirage D, Chen Y, Caridha D, O'Neil MT, Eyase F, Witola WH, Mamoun CB, Waters NC.

Mol Biochem Parasitol. 2010 Jul;172(1):9-18. doi: 10.1016/j.molbiopara.2010.03.009. Epub 2010 Mar 21.

PMID:
20332005
29.

Molecular detection of trypanosomes in cattle in South America and genetic diversity of Trypanosoma evansi based on expression-site-associated gene 6.

Mekata H, Konnai S, Witola WH, Inoue N, Onuma M, Ohashi K.

Infect Genet Evol. 2009 Dec;9(6):1301-5. doi: 10.1016/j.meegid.2009.07.009. Epub 2009 Aug 5.

PMID:
19664722
30.

Development and application of a quantitative real-time PCR for the diagnosis of Surra in water buffaloes.

Konnai S, Mekata H, Mingala CN, Abes NS, Gutierrez CA, Herrera JR, Dargantes AP, Witola WH, Cruz LC, Inoue N, Onuma M, Ohashi K.

Infect Genet Evol. 2009 Jul;9(4):449-52. doi: 10.1016/j.meegid.2009.01.006. Epub 2009 Jan 24.

PMID:
19460309
31.

Expression and activity of glycogen synthase kinase during vitellogenesis and embryogenesis of Rhipicephalus (Boophilus) microplus.

Logullo C, Witola WH, Andrade C, Abreu L, Gomes J, da Silva Vaz I Jr, Imamura S, Konnai S, Ohashi K, Onuma M.

Vet Parasitol. 2009 May 12;161(3-4):261-9. doi: 10.1016/j.vetpar.2009.01.029. Epub 2009 Feb 6.

PMID:
19285806
32.

Prevalence and source of trypanosome infections in field-captured vector flies (Glossina pallidipes) in southeastern Zambia.

Mekata H, Konnai S, Simuunza M, Chembensofu M, Kano R, Witola WH, Tembo ME, Chitambo H, Inoue N, Onuma M, Ohashi K.

J Vet Med Sci. 2008 Sep;70(9):923-8.

33.
34.

Detection of Trypanosoma brucei in field-captured tsetse flies and identification of host species fed on by the infected flies.

Konnai S, Mekata H, Odbileg R, Simuunza M, Chembensof M, Witola WH, Tembo ME, Chitambo H, Inoue N, Onuma M, Ohashi K.

Vector Borne Zoonotic Dis. 2008 Aug;8(4):565-73. doi: 10.1089/vbz.2007.0223.

PMID:
18399780
35.

Biochemical and genetic analysis of the phosphoethanolamine methyltransferase of the human malaria parasite Plasmodium falciparum.

Reynolds JM, Takebe S, Choi JY, El Bissati K, Witola WH, Bobenchik AM, Hoch JC, Voelker DR, Mamoun CB.

J Biol Chem. 2008 Mar 21;283(12):7894-900. doi: 10.1074/jbc.M709869200. Epub 2008 Jan 4.

36.
37.

Purification of components of the translation elongation factor complex of Plasmodium falciparum by tandem affinity purification.

Takebe S, Witola WH, Schimanski B, Günzl A, Ben Mamoun C.

Eukaryot Cell. 2007 Apr;6(4):584-91. Epub 2007 Feb 16.

38.

Acquisition and transmission of Theileria parva by vector tick, Rhipicephalus appendiculatus.

Konnai S, Imamura S, Nakajima C, Witola WH, Yamada S, Simuunza M, Nambota A, Yasuda J, Ohashi K, Onuma M.

Acta Trop. 2006 Aug;99(1):34-41. Epub 2006 Aug 8.

39.

The plasma membrane permease PfNT1 is essential for purine salvage in the human malaria parasite Plasmodium falciparum.

El Bissati K, Zufferey R, Witola WH, Carter NS, Ullman B, Ben Mamoun C.

Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9286-91. Epub 2006 Jun 2.

40.

Localization of the phosphoethanolamine methyltransferase of the human malaria parasite Plasmodium falciparum to the Golgi apparatus.

Witola WH, Pessi G, El Bissati K, Reynolds JM, Mamoun CB.

J Biol Chem. 2006 Jul 28;281(30):21305-11. Epub 2006 May 16.

41.

The effect of TAO expression on PCD-like phenomenon development and drug resistance in Trypanosoma brucei.

Tsuda A, Witola WH, Konnai S, Ohashi K, Onuma M.

Parasitol Int. 2006 Jun;55(2):135-42. Epub 2006 Mar 3.

PMID:
16516538
42.

Acquired resistance to berenil in a cloned isolate of Trypanosoma evansi is associated with upregulation of a novel gene, TeDR40.

Witola WH, Tsuda A, Inoue N, Ohashi K, Onuma M.

Parasitology. 2005 Nov;131(Pt 5):635-46.

PMID:
16255822
43.
44.

Expression of a gene encoding Trypanosoma congolense putative Abc1 family protein is developmentally regulated.

Baticados WN, Witola WH, Inoue N, Kim JY, Kuboki N, Xuan X, Yokoyama N, Sugimoto C.

J Vet Med Sci. 2005 Feb;67(2):157-64.

45.

Genetic variability in ESAG6 genes among Trypanosoma evansi isolates and in comparison to other Trypanozoon members.

Witola WH, Sarataphan N, Inoue N, Ohashi K, Onuma M.

Acta Trop. 2005 Jan;93(1):63-73.

PMID:
15589799
46.

RNA-interference silencing of the adenosine transporter-1 gene in Trypanosoma evansi confers resistance to diminazene aceturate.

Witola WH, Inoue N, Ohashi K, Onuma M.

Exp Parasitol. 2004 May-Jun;107(1-2):47-57.

PMID:
15208037
47.

Demonstration of erythrophagocytosis in Trypanosoma congolense-infected goats.

Witola WH, Lovelace CE.

Vet Parasitol. 2001 Mar 20;96(2):115-26.

PMID:
11230918

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