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Items: 39


Diagnostic yield of hypertrophic cardiomyopathy in first-degree relatives of decedents with idiopathic left ventricular hypertrophy.

Finocchiaro G, Dhutia H, Gray B, Ensam B, Papatheodorou S, Miles C, Malhotra A, Fanton Z, Bulleros P, Homfray T, Witney AA, Bunce N, Anderson LJ, Ware JS, Sharma R, Tome M, Behr ER, Sheppard MN, Papadakis M, Sharma S.

Europace. 2020 Feb 3. pii: euaa012. doi: 10.1093/europace/euaa012. [Epub ahead of print]


Protein kinase B controls Mycobacterium tuberculosis growth via phosphorylation of the transcriptional regulator Lsr2 at threonine 112.

Alqaseer K, Turapov O, Barthe P, Jagatia H, De Visch A, Roumestand C, Wegrzyn M, Bartek IL, Voskuil MI, O'Hare HM, Ajuh P, Bottrill AR, Witney AA, Cohen-Gonsaud M, Waddell SJ, Mukamolova GV.

Mol Microbiol. 2019 Dec;112(6):1847-1862. doi: 10.1111/mmi.14398. Epub 2019 Oct 10.


Use of whole-genome sequencing to distinguish relapse from reinfection in a completed tuberculosis clinical trial.

Witney AA, Bateson AL, Jindani A, Phillips PP, Coleman D, Stoker NG, Butcher PD, McHugh TD; RIFAQUIN Study Team.

BMC Med. 2017 Mar 29;15(1):71. doi: 10.1186/s12916-017-0834-4.


Genetic variation in Mycobacterium tuberculosis isolates from a London outbreak associated with isoniazid resistance.

Satta G, Witney AA, Shorten RJ, Karlikowska M, Lipman M, McHugh TD.

BMC Med. 2016 Aug 16;14(1):117. doi: 10.1186/s12916-016-0659-6.


A computational strategy for the search of regulatory small RNAs in Actinobacillus pleuropneumoniae.

Rossi CC, Bossé JT, Li Y, Witney AA, Gould KA, Langford PR, Bazzolli DM.

RNA. 2016 Sep;22(9):1373-85. doi: 10.1261/rna.055129.115. Epub 2016 Jul 11.


Identification of Streptococcus suis Meningitis through Population-Based Surveillance, Togo, 2010-2014.

Tall H, Njanpop-Lafourcade BM, Mounkoro D, Tidjani L, Agbenoko K, Alassani I, Amidou M, Tamekloe S, Laing KG, Witney AA, Hinds J, van der Linden MP, Gessner BD, Moïsi JC.

Emerg Infect Dis. 2016 Jul;22(7):1262-4. doi: 10.3201/eid2207.151511.


XDR-TB transmission in London: Case management and contact tracing investigation assisted by early whole genome sequencing.

Arnold A, Witney AA, Vergnano S, Roche A, Cosgrove CA, Houston A, Gould KA, Hinds J, Riley P, Macallan D, Butcher PD, Harrison TS.

J Infect. 2016 Sep;73(3):210-8. doi: 10.1016/j.jinf.2016.04.037. Epub 2016 Jun 14.


Clinical use of whole genome sequencing for Mycobacterium tuberculosis.

Witney AA, Cosgrove CA, Arnold A, Hinds J, Stoker NG, Butcher PD.

BMC Med. 2016 Mar 23;14:46. doi: 10.1186/s12916-016-0598-2. Review.


Mycobacterium tuberculosis Is Resistant to Isoniazid at a Slow Growth Rate by Single Nucleotide Polymorphisms in katG Codon Ser315.

Jeeves RE, Marriott AA, Pullan ST, Hatch KA, Allnutt JC, Freire-Martin I, Hendon-Dunn CL, Watson R, Witney AA, Tyler RH, Arnold C, Marsh PD, McHugh TD, Bacon J.

PLoS One. 2015 Sep 18;10(9):e0138253. doi: 10.1371/journal.pone.0138253. eCollection 2015.


High-Resolution Analysis by Whole-Genome Sequencing of an International Lineage (Sequence Type 111) of Pseudomonas aeruginosa Associated with Metallo-Carbapenemases in the United Kingdom.

Turton JF, Wright L, Underwood A, Witney AA, Chan YT, Al-Shahib A, Arnold C, Doumith M, Patel B, Planche TD, Green J, Holliman R, Woodford N.

J Clin Microbiol. 2015 Aug;53(8):2622-31. doi: 10.1128/JCM.00505-15. Epub 2015 Jun 3.


Within-host diversity of MRSA antimicrobial resistances.

Stanczak-Mrozek KI, Manne A, Knight GM, Gould K, Witney AA, Lindsay JA.

J Antimicrob Chemother. 2015 Aug;70(8):2191-8. doi: 10.1093/jac/dkv119. Epub 2015 May 8.


Clinical application of whole-genome sequencing to inform treatment for multidrug-resistant tuberculosis cases.

Witney AA, Gould KA, Arnold A, Coleman D, Delgado R, Dhillon J, Pond MJ, Pope CF, Planche TD, Stoker NG, Cosgrove CA, Butcher PD, Harrison TS, Hinds J.

J Clin Microbiol. 2015 May;53(5):1473-83. doi: 10.1128/JCM.02993-14. Epub 2015 Feb 11.


Extensive horizontal gene transfer during Staphylococcus aureus co-colonization in vivo.

McCarthy AJ, Loeffler A, Witney AA, Gould KA, Lloyd DH, Lindsay JA.

Genome Biol Evol. 2014 Sep 25;6(10):2697-708. doi: 10.1093/gbe/evu214.


Genome sequencing and characterization of an extensively drug-resistant sequence type 111 serotype O12 hospital outbreak strain of Pseudomonas aeruginosa.

Witney AA, Gould KA, Pope CF, Bolt F, Stoker NG, Cubbon MD, Bradley CR, Fraise A, Breathnach AS, Butcher PD, Planche TD, Hinds J.

Clin Microbiol Infect. 2014 Oct;20(10):O609-18. doi: 10.1111/1469-0691.12528. Epub 2014 Feb 8.


High prevalence of antibiotic-resistant Mycoplasma genitalium in nongonococcal urethritis: the need for routine testing and the inadequacy of current treatment options.

Pond MJ, Nori AV, Witney AA, Lopeman RC, Butcher PD, Sadiq ST.

Clin Infect Dis. 2014 Mar;58(5):631-7. doi: 10.1093/cid/cit752. Epub 2013 Nov 26.


Deciphering the response of Mycobacterium smegmatis to nitrogen stress using bipartite active modules.

Williams KJ, Bryant WA, Jenkins VA, Barton GR, Witney AA, Pinney JW, Robertson BD.

BMC Genomics. 2013 Jul 2;14:436. doi: 10.1186/1471-2164-14-436.


Transcriptional analysis of temporal gene expression in germinating Clostridium difficile 630 endospores.

Dembek M, Stabler RA, Witney AA, Wren BW, Fairweather NF.

PLoS One. 2013 May 15;8(5):e64011. doi: 10.1371/journal.pone.0064011. Print 2013.


Staphylococcus aureus temperate bacteriophage: carriage and horizontal gene transfer is lineage associated.

McCarthy AJ, Witney AA, Lindsay JA.

Front Cell Infect Microbiol. 2012 Feb 8;2:6. doi: 10.3389/fcimb.2012.00006. eCollection 2012.


BμG@Sbase--a microbial gene expression and comparative genomic database.

Witney AA, Waldron DE, Brooks LA, Tyler RH, Withers M, Stoker NG, Wren BW, Butcher PD, Hinds J.

Nucleic Acids Res. 2012 Jan;40(Database issue):D605-9. doi: 10.1093/nar/gkr796. Epub 2011 Sep 24.


The distribution of mobile genetic elements (MGEs) in MRSA CC398 is associated with both host and country.

McCarthy AJ, Witney AA, Gould KA, Moodley A, Guardabassi L, Voss A, Denis O, Broens EM, Hinds J, Lindsay JA.

Genome Biol Evol. 2011;3:1164-74. doi: 10.1093/gbe/evr092. Epub 2011 Sep 13.


Genomic variations define divergence of water/wildlife-associated Campylobacter jejuni niche specialists from common clonal complexes.

Hepworth PJ, Ashelford KE, Hinds J, Gould KA, Witney AA, Williams NJ, Leatherbarrow H, French NP, Birtles RJ, Mendonca C, Dorrell N, Wren BW, Wigley P, Hall N, Winstanley C.

Environ Microbiol. 2011 Jun;13(6):1549-60. doi: 10.1111/j.1462-2920.2011.02461.x. Epub 2011 Mar 21.


Genetic variation in spatio-temporal confined USA300 community-associated MRSA isolates: a shift from clonal dispersion to genetic evolution?

Carpaij N, Willems RJ, Rice TW, Weinstein RA, Hinds J, Witney AA, Lindsay JA, Bonten MJ, Fluit AC.

PLoS One. 2011 Feb 4;6(2):e16419. doi: 10.1371/journal.pone.0016419.


Posttranscriptional regulation of flagellin synthesis in Helicobacter pylori by the RpoN chaperone HP0958.

Douillard FP, Ryan KA, Caly DL, Hinds J, Witney AA, Husain SE, O'Toole PW.

J Bacteriol. 2008 Dec;190(24):7975-84. doi: 10.1128/JB.00879-08. Epub 2008 Oct 17.


Development and application of the active surveillance of pathogens microarray to monitor bacterial gene flux.

Stabler RA, Dawson LF, Oyston PC, Titball RW, Wade J, Hinds J, Witney AA, Wren BW.

BMC Microbiol. 2008 Oct 9;8:177. doi: 10.1186/1471-2180-8-177.


BmuG@Sbase--a microarray database and analysis tool.

Witney AA, Hinds J.

Comp Funct Genomics. 2002;3(4):369-71. doi: 10.1002/cfg.197.


Comparative phylogenomics of Clostridium difficile reveals clade specificity and microevolution of hypervirulent strains.

Stabler RA, Gerding DN, Songer JG, Drudy D, Brazier JS, Trinh HT, Witney AA, Hinds J, Wren BW.

J Bacteriol. 2006 Oct;188(20):7297-305.


Microarrays reveal that each of the ten dominant lineages of Staphylococcus aureus has a unique combination of surface-associated and regulatory genes.

Lindsay JA, Moore CE, Day NP, Peacock SJ, Witney AA, Stabler RA, Husain SE, Butcher PD, Hinds J.

J Bacteriol. 2006 Jan;188(2):669-76.


Design, validation, and application of a seven-strain Staphylococcus aureus PCR product microarray for comparative genomics.

Witney AA, Marsden GL, Holden MT, Stabler RA, Husain SE, Vass JK, Butcher PD, Hinds J, Lindsay JA.

Appl Environ Microbiol. 2005 Nov;71(11):7504-14.


Comparative phylogenomics of the food-borne pathogen Campylobacter jejuni reveals genetic markers predictive of infection source.

Champion OL, Gaunt MW, Gundogdu O, Elmi A, Witney AA, Hinds J, Dorrell N, Wren BW.

Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):16043-8. Epub 2005 Oct 17.


Identification of pathogen-specific genes through microarray analysis of pathogenic and commensal Neisseria species.

Stabler RA, Marsden GL, Witney AA, Li Y, Bentley SD, Tang CM, Hinds J.

Microbiology. 2005 Sep;151(Pt 9):2907-2922. doi: 10.1099/mic.0.28099-0.


Novel antigen identification method for discovery of protective malaria antigens by rapid testing of DNA vaccines encoding exons from the parasite genome.

Haddad D, Bilcikova E, Witney AA, Carlton JM, White CE, Blair PL, Chattopadhyay R, Russell J, Abot E, Charoenvit Y, Aguiar JC, Carucci DJ, Weiss WR.

Infect Immun. 2004 Mar;72(3):1594-602.


Identification of Plasmodium falciparum antigens by antigenic analysis of genomic and proteomic data.

Doolan DL, Southwood S, Freilich DA, Sidney J, Graber NL, Shatney L, Bebris L, Florens L, Dobano C, Witney AA, Appella E, Hoffman SL, Yates JR 3rd, Carucci DJ, Sette A.

Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9952-7. Epub 2003 Jul 28.


Construction of a Yersinia pestis microarray.

Stabler RA, Hinds J, Witney AA, Isherwood K, Oyston P, Titball R, Wren B, Hinchliffe S, Prentice M, Mangan JA, Butcher PD.

Adv Exp Med Biol. 2003;529:47-9. No abstract available.


A proteomic view of the Plasmodium falciparum life cycle.

Florens L, Washburn MP, Raine JD, Anthony RM, Grainger M, Haynes JD, Moch JK, Muster N, Sacci JB, Tabb DL, Witney AA, Wolters D, Wu Y, Gardner MJ, Holder AA, Sinden RE, Yates JR, Carucci DJ.

Nature. 2002 Oct 3;419(6906):520-6.


Quantitation of liver-stage parasites by automated TaqMan real-time PCR.

Witney AA, Anthony RM, Carucci DJ.

Methods Mol Med. 2002;72:137-9. No abstract available.


Determining liver stage parasite burden by real time quantitative PCR as a method for evaluating pre-erythrocytic malaria vaccine efficacy.

Witney AA, Doolan DL, Anthony RM, Weiss WR, Hoffman SL, Carucci DJ.

Mol Biochem Parasitol. 2001 Dec;118(2):233-45.


Guanylyl cyclase activity associated with putative bifunctional integral membrane proteins in Plasmodium falciparum.

Carucci DJ, Witney AA, Muhia DK, Warhurst DC, Schaap P, Meima M, Li JL, Taylor MC, Kelly JM, Baker DA.

J Biol Chem. 2000 Jul 21;275(29):22147-56.


gammadelta T cells are a component of early immunity against preerythrocytic malaria parasites.

McKenna KC, Tsuji M, Sarzotti M, Sacci JB Jr, Witney AA, Azad AF.

Infect Immun. 2000 Apr;68(4):2224-30.

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