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Items: 30

1.

Safety, pharmacokinetics, and immunogenicity of the combination of the broadly neutralizing anti-HIV-1 antibodies 3BNC117 and 10-1074 in healthy adults: A randomized, phase 1 study.

Cohen YZ, Butler AL, Millard K, Witmer-Pack M, Levin R, Unson-O'Brien C, Patel R, Shimeliovich I, Lorenzi JCC, Horowitz J, Walsh SR, Lin S, Weiner JA, Tse A, Sato A, Bennett C, Mayer B, Seaton KE, Yates NL, Baden LR, deCamp AC, Ackerman ME, Seaman MS, Tomaras GD, Nussenzweig MC, Caskey M.

PLoS One. 2019 Aug 8;14(8):e0219142. doi: 10.1371/journal.pone.0219142. eCollection 2019.

2.

Safety and antiviral activity of combination HIV-1 broadly neutralizing antibodies in viremic individuals.

Bar-On Y, Gruell H, Schoofs T, Pai JA, Nogueira L, Butler AL, Millard K, Lehmann C, Suárez I, Oliveira TY, Karagounis T, Cohen YZ, Wyen C, Scholten S, Handl L, Belblidia S, Dizon JP, Vehreschild JJ, Witmer-Pack M, Shimeliovich I, Jain K, Fiddike K, Seaton KE, Yates NL, Horowitz J, Gulick RM, Pfeifer N, Tomaras GD, Seaman MS, Fätkenheuer G, Caskey M, Klein F, Nussenzweig MC.

Nat Med. 2018 Nov;24(11):1701-1707. doi: 10.1038/s41591-018-0186-4. Epub 2018 Sep 26.

3.

Combination therapy with anti-HIV-1 antibodies maintains viral suppression.

Mendoza P, Gruell H, Nogueira L, Pai JA, Butler AL, Millard K, Lehmann C, Suárez I, Oliveira TY, Lorenzi JCC, Cohen YZ, Wyen C, Kümmerle T, Karagounis T, Lu CL, Handl L, Unson-O'Brien C, Patel R, Ruping C, Schlotz M, Witmer-Pack M, Shimeliovich I, Kremer G, Thomas E, Seaton KE, Horowitz J, West AP Jr, Bjorkman PJ, Tomaras GD, Gulick RM, Pfeifer N, Fätkenheuer G, Seaman MS, Klein F, Caskey M, Nussenzweig MC.

Nature. 2018 Sep;561(7724):479-484. doi: 10.1038/s41586-018-0531-2. Epub 2018 Sep 26.

4.

Relationship between latent and rebound viruses in a clinical trial of anti-HIV-1 antibody 3BNC117.

Cohen YZ, Lorenzi JCC, Krassnig L, Barton JP, Burke L, Pai J, Lu CL, Mendoza P, Oliveira TY, Sleckman C, Millard K, Butler AL, Dizon JP, Belblidia SA, Witmer-Pack M, Shimeliovich I, Gulick RM, Seaman MS, Jankovic M, Caskey M, Nussenzweig MC.

J Exp Med. 2018 Sep 3;215(9):2311-2324. doi: 10.1084/jem.20180936. Epub 2018 Aug 2.

5.

Antibody 10-1074 suppresses viremia in HIV-1-infected individuals.

Caskey M, Schoofs T, Gruell H, Settler A, Karagounis T, Kreider EF, Murrell B, Pfeifer N, Nogueira L, Oliveira TY, Learn GH, Cohen YZ, Lehmann C, Gillor D, Shimeliovich I, Unson-O'Brien C, Weiland D, Robles A, Kümmerle T, Wyen C, Levin R, Witmer-Pack M, Eren K, Ignacio C, Kiss S, West AP Jr, Mouquet H, Zingman BS, Gulick RM, Keler T, Bjorkman PJ, Seaman MS, Hahn BH, Fätkenheuer G, Schlesinger SJ, Nussenzweig MC, Klein F.

Nat Med. 2017 Feb;23(2):185-191. doi: 10.1038/nm.4268. Epub 2017 Jan 16.

6.

HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption.

Scheid JF, Horwitz JA, Bar-On Y, Kreider EF, Lu CL, Lorenzi JC, Feldmann A, Braunschweig M, Nogueira L, Oliveira T, Shimeliovich I, Patel R, Burke L, Cohen YZ, Hadrigan S, Settler A, Witmer-Pack M, West AP Jr, Juelg B, Keler T, Hawthorne T, Zingman B, Gulick RM, Pfeifer N, Learn GH, Seaman MS, Bjorkman PJ, Klein F, Schlesinger SJ, Walker BD, Hahn BH, Nussenzweig MC, Caskey M.

Nature. 2016 Jul 28;535(7613):556-60. Epub 2016 Jun 22.

7.

Corrigendum: Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117.

Caskey M, Klein F, Lorenzi JC, Seaman MS, West AP, Buckley N, Kremer G, Nogueira L, Braunschweig M, Scheid JF, Horwitz JA, Shimeliovich I, Ben-Avraham S, Witmer-Pack M, Platten M, Lehmann C, Burke LA, Hawthorne T, Gorelick RJ, Walker BD, Keler T, Gulick RM, Fätkenheuer G, Schlesinger SJ, Nussenzweig MC.

Nature. 2016 Jul 28;535(7613):580. doi: 10.1038/nature17642. Epub 2016 Mar 23. No abstract available.

PMID:
27007847
8.

Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117.

Caskey M, Klein F, Lorenzi JC, Seaman MS, West AP Jr, Buckley N, Kremer G, Nogueira L, Braunschweig M, Scheid JF, Horwitz JA, Shimeliovich I, Ben-Avraham S, Witmer-Pack M, Platten M, Lehmann C, Burke LA, Hawthorne T, Gorelick RJ, Walker BD, Keler T, Gulick RM, Fätkenheuer G, Schlesinger SJ, Nussenzweig MC.

Nature. 2015 Jun 25;522(7557):487-91. doi: 10.1038/nature14411. Epub 2015 Apr 8. Erratum in: Nature. 2016 Jul 28;535(7613):580.

9.
10.
11.

Expression of B7 costimulator molecules on mouse dendritic cells.

Inaba K, Inaba M, Witmer-Pack M, Hatchcock K, Hodes R, Steinman RM.

Adv Exp Med Biol. 1995;378:65-70.

PMID:
8526146
12.

TCR selection and allelic exclusion in RAG transgenic mice that exhibit abnormal T cell localization in lymph nodes and lymphatics.

Wayne J, Suh H, Sokol KA, Petrie HT, Witmer-Pack M, Edelhoff S, Disteche CM, Nussenzweig MC.

J Immunol. 1994 Dec 15;153(12):5491-502.

PMID:
7989751
13.

The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro.

Inaba K, Witmer-Pack M, Inaba M, Hathcock KS, Sakuta H, Azuma M, Yagita H, Okumura K, Linsley PS, Ikehara S, Muramatsu S, Hodes RJ, Steinman RM.

J Exp Med. 1994 Nov 1;180(5):1849-60.

14.

Macrophages, but not dendritic cells, accumulate colloidal carbon following administration in situ.

Witmer-Pack MD, Crowley MT, Inaba K, Steinman RM.

J Cell Sci. 1993 Aug;105 ( Pt 4):965-73.

15.

Identification of macrophages and dendritic cells in the osteopetrotic (op/op) mouse.

Witmer-Pack MD, Hughes DA, Schuler G, Lawson L, McWilliam A, Inaba K, Steinman RM, Gordon S.

J Cell Sci. 1993 Apr;104 ( Pt 4):1021-9.

16.

Dendritic cells: antigen presentation, accessory function and clinical relevance.

Steinman RM, Witmer-Pack M, Inaba K.

Adv Exp Med Biol. 1993;329:1-9. Review.

PMID:
8379358
17.

Two populations of splenic dendritic cells detected with M342, a new monoclonal to an intracellular antigen of interdigitating dendritic cells and some B lymphocytes.

Agger R, Witmer-Pack M, Romani N, Stossel H, Swiggard WJ, Metlay JP, Storozynsky E, Freimuth P, Steinman RM.

J Leukoc Biol. 1992 Jul;52(1):34-42.

PMID:
1379295
18.

Migration and maturation of Langerhans cells in skin transplants and explants.

Larsen CP, Steinman RM, Witmer-Pack M, Hankins DF, Morris PJ, Austyn JM.

J Exp Med. 1990 Nov 1;172(5):1483-93.

19.

Antigen processing by epidermal Langerhans cells correlates with the level of biosynthesis of major histocompatibility complex class II molecules and expression of invariant chain.

Puré E, Inaba K, Crowley MT, Tardelli L, Witmer-Pack MD, Ruberti G, Fathman G, Steinman RM.

J Exp Med. 1990 Nov 1;172(5):1459-69.

20.

Use of the fluorescence activated cell sorter to enrich dendritic cells from mouse spleen.

Crowley MT, Inaba K, Witmer-Pack MD, Gezelter S, Steinman RM.

J Immunol Methods. 1990 Oct 4;133(1):55-66.

PMID:
2145370
21.

The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies.

Metlay JP, Witmer-Pack MD, Agger R, Crowley MT, Lawless D, Steinman RM.

J Exp Med. 1990 May 1;171(5):1753-71.

22.

The surface of dendritic cells in the mouse as studied with monoclonal antibodies.

Agger R, Crowley MT, Witmer-Pack MD.

Int Rev Immunol. 1990;6(2-3):89-101. Review.

PMID:
2152504
23.

Dendritic cells as antigen presenting cells in vivo.

Inaba K, Metlay JP, Crowley MT, Witmer-Pack M, Steinman RM.

Int Rev Immunol. 1990;6(2-3):197-206. Review.

PMID:
2152503
24.

Presentation of exogenous protein antigens by dendritic cells to T cell clones. Intact protein is presented best by immature, epidermal Langerhans cells.

Romani N, Koide S, Crowley M, Witmer-Pack M, Livingstone AM, Fathman CG, Inaba K, Steinman RM.

J Exp Med. 1989 Mar 1;169(3):1169-78.

25.

A small number of anti-CD3 molecules on dendritic cells stimulate DNA synthesis in mouse T lymphocytes.

Romani N, Inaba K, Puré E, Crowley M, Witmer-Pack M, Steinman RM.

J Exp Med. 1989 Mar 1;169(3):1153-68.

26.

The cell surface of mouse dendritic cells: FACS analyses of dendritic cells from different tissues including thymus.

Crowley M, Inaba K, Witmer-Pack M, Steinman RM.

Cell Immunol. 1989 Jan;118(1):108-25.

PMID:
2910499
27.

Macrophages phagocytose thymic lymphocytes with productively rearranged T cell receptor alpha and beta genes.

Inaba K, Inaba M, Kinashi T, Tashiro K, Witmer-Pack M, Crowley M, Kaplan G, Valinsky J, Romani N, Ikehara S, et al.

J Exp Med. 1988 Dec 1;168(6):2279-94.

28.

Quantitation of surface antigens on cultured murine epidermal Langerhans cells: rapid and selective increase in the level of surface MHC products.

Witmer-Pack MD, Valinsky J, Olivier W, Steinman RM.

J Invest Dermatol. 1988 Mar;90(3):387-94. Erratum in: J Invest Dermatol 1988 Sep;91(3):286.

29.
30.

Granulocyte/macrophage colony-stimulating factor is essential for the viability and function of cultured murine epidermal Langerhans cells.

Witmer-Pack MD, Olivier W, Valinsky J, Schuler G, Steinman RM.

J Exp Med. 1987 Nov 1;166(5):1484-98.

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