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Items: 1 to 50 of 131

1.

A microtubule-dynein tethering complex regulates the axonemal inner dynein f (I1).

Kubo T, Hou Y, Cochran DA, Witman GB, Oda T.

Mol Biol Cell. 2018 May 1;29(9):1060-1074. doi: 10.1091/mbc.E17-11-0689. Epub 2018 Apr 9.

2.

The N-terminus of IFT46 mediates intraflagellar transport of outer arm dynein and its cargo-adaptor ODA16.

Hou Y, Witman GB.

Mol Biol Cell. 2017 Sep 1;28(18):2420-2433. doi: 10.1091/mbc.E17-03-0172. Epub 2017 Jul 12.

3.

IFT trains in different stages of assembly queue at the ciliary base for consecutive release into the cilium.

Wingfield JL, Mengoni I, Bomberger H, Jiang YY, Walsh JD, Brown JM, Picariello T, Cochran DA, Zhu B, Pan J, Eggenschwiler J, Gaertig J, Witman GB, Kner P, Lechtreck K.

Elife. 2017 May 31;6. pii: e26609. doi: 10.7554/eLife.26609.

4.

Characterization of a new oda3 allele, oda3-6, defective in assembly of the outer dynein arm-docking complex in Chlamydomonas reinhardtii.

Brown JM, Mosley M, Montes-Berrueta D, Hou Y, Yang F, Scarbrough C, Witman GB, Wirschell M.

PLoS One. 2017 Mar 14;12(3):e0173842. doi: 10.1371/journal.pone.0173842. eCollection 2017.

5.

Together, the IFT81 and IFT74 N-termini form the main module for intraflagellar transport of tubulin.

Kubo T, Brown JM, Bellve K, Craige B, Craft JM, Fogarty K, Lechtreck KF, Witman GB.

J Cell Sci. 2016 May 15;129(10):2106-19. doi: 10.1242/jcs.187120. Epub 2016 Apr 11.

6.

Corrigendum: TCTEX1D2 mutations underlie Jeune asphyxiating thoracic dystrophy with impaired retrograde intraflagellar transport.

Schmidts M, Hou Y, Cortés CR, Mans DA, Huber C, Boldt K, Patel M, van Reeuwijk J, Plaza JM, van Beersum SE, Yap ZM, Letteboer SJ, Taylor SP, Herridge W, Johnson CA, Scambler PJ, Ueffing M, Kayserili H, Krakow D, King SM; UK10K, Beales PL, Al-Gazali L, Wicking C, Cormier-Daire V, Roepman R, Mitchison HM, Witman GB.

Nat Commun. 2016 Mar 29;7:11270. doi: 10.1038/ncomms11270. No abstract available.

7.

Intraflagellar transport is essential for mammalian spermiogenesis but is absent in mature sperm.

San Agustin JT, Pazour GJ, Witman GB.

Mol Biol Cell. 2015 Dec 1;26(24):4358-72. doi: 10.1091/mbc.E15-08-0578. Epub 2015 Sep 30.

8.

Superresolution Pattern Recognition Reveals the Architectural Map of the Ciliary Transition Zone.

Yang TT, Su J, Wang WJ, Craige B, Witman GB, Tsou MF, Liao JC.

Sci Rep. 2015 Sep 14;5:14096. doi: 10.1038/srep14096.

9.

CFAP54 is required for proper ciliary motility and assembly of the central pair apparatus in mice.

McKenzie CW, Craige B, Kroeger TV, Finn R, Wyatt TA, Sisson JH, Pavlik JA, Strittmatter L, Hendricks GM, Witman GB, Lee L.

Mol Biol Cell. 2015 Sep 15;26(18):3140-9. doi: 10.1091/mbc.E15-02-0121. Epub 2015 Jul 29.

10.

Reduced tubulin polyglutamylation suppresses flagellar shortness in Chlamydomonas.

Kubo T, Hirono M, Aikawa T, Kamiya R, Witman GB.

Mol Biol Cell. 2015 Aug 1;26(15):2810-22. doi: 10.1091/mbc.E15-03-0182. Epub 2015 Jun 17.

11.

DRC3 connects the N-DRC to dynein g to regulate flagellar waveform.

Awata J, Song K, Lin J, King SM, Sanderson MJ, Nicastro D, Witman GB.

Mol Biol Cell. 2015 Aug 1;26(15):2788-800. doi: 10.1091/mbc.E15-01-0018. Epub 2015 Jun 10.

12.

Assembly of IFT trains at the ciliary base depends on IFT74.

Brown JM, Cochran DA, Craige B, Kubo T, Witman GB.

Curr Biol. 2015 Jun 15;25(12):1583-93. doi: 10.1016/j.cub.2015.04.060. Epub 2015 Jun 4.

13.

TCTEX1D2 mutations underlie Jeune asphyxiating thoracic dystrophy with impaired retrograde intraflagellar transport.

Schmidts M, Hou Y, Cortés CR, Mans DA, Huber C, Boldt K, Patel M, van Reeuwijk J, Plaza JM, van Beersum SE, Yap ZM, Letteboer SJ, Taylor SP, Herridge W, Johnson CA, Scambler PJ, Ueffing M, Kayserili H, Krakow D, King SM; UK10K, Beales PL, Al-Gazali L, Wicking C, Cormier-Daire V, Roepman R, Mitchison HM, Witman GB.

Nat Commun. 2015 Jun 5;6:7074. doi: 10.1038/ncomms8074. Erratum in: Nat Commun. 2016;7:11270.

14.

Cilia and Diseases.

Brown JM, Witman GB.

Bioscience. 2014 Dec 1;64(12):1126-1137.

15.

Novel Jbts17 mutant mouse model of Joubert syndrome with cilia transition zone defects and cerebellar and other ciliopathy related anomalies.

Damerla RR, Cui C, Gabriel GC, Liu X, Craige B, Gibbs BC, Francis R, Li Y, Chatterjee B, San Agustin JT, Eguether T, Subramanian R, Witman GB, Michaud JL, Pazour GJ, Lo CW.

Hum Mol Genet. 2015 Jul 15;24(14):3994-4005. doi: 10.1093/hmg/ddv137. Epub 2015 Apr 15.

16.

Dynein and intraflagellar transport.

Hou Y, Witman GB.

Exp Cell Res. 2015 May 15;334(1):26-34. doi: 10.1016/j.yexcr.2015.02.017. Epub 2015 Feb 25. Review. No abstract available.

17.

In situ localization of N and C termini of subunits of the flagellar nexin-dynein regulatory complex (N-DRC) using SNAP tag and cryo-electron tomography.

Song K, Awata J, Tritschler D, Bower R, Witman GB, Porter ME, Nicastro D.

J Biol Chem. 2015 Feb 27;290(9):5341-53. doi: 10.1074/jbc.M114.626556. Epub 2015 Jan 6.

18.

Flipping a phosphate switch on kinesin-II to turn IFT around.

Craige B, Witman GB.

Dev Cell. 2014 Sep 8;30(5):492-3. doi: 10.1016/j.devcel.2014.08.019.

19.

NPHP4 controls ciliary trafficking of membrane proteins and large soluble proteins at the transition zone.

Awata J, Takada S, Standley C, Lechtreck KF, Bellvé KD, Pazour GJ, Fogarty KE, Witman GB.

J Cell Sci. 2014 Nov 1;127(Pt 21):4714-27. doi: 10.1242/jcs.155275. Epub 2014 Aug 22.

20.

Cooperative binding of the outer arm-docking complex underlies the regular arrangement of outer arm dynein in the axoneme.

Owa M, Furuta A, Usukura J, Arisaka F, King SM, Witman GB, Kamiya R, Wakabayashi K.

Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9461-6. doi: 10.1073/pnas.1403101111. Epub 2014 Jun 16.

21.

Characterization of THB1, a Chlamydomonas reinhardtii truncated hemoglobin: linkage to nitrogen metabolism and identification of lysine as the distal heme ligand.

Johnson EA, Rice SL, Preimesberger MR, Nye DB, Gilevicius L, Wenke BB, Brown JM, Witman GB, Lecomte JT.

Biochemistry. 2014 Jul 22;53(28):4573-89. doi: 10.1021/bi5005206. Epub 2014 Jul 9.

22.

The Chlamydomonas genome project: a decade on.

Blaby IK, Blaby-Haas CE, Tourasse N, Hom EF, Lopez D, Aksoy M, Grossman A, Umen J, Dutcher S, Porter M, King S, Witman GB, Stanke M, Harris EH, Goodstein D, Grimwood J, Schmutz J, Vallon O, Merchant SS, Prochnik S.

Trends Plant Sci. 2014 Oct;19(10):672-80. doi: 10.1016/j.tplants.2014.05.008. Epub 2014 Jun 17. Review.

23.

Flagellar central pair assembly in Chlamydomonas reinhardtii.

Lechtreck KF, Gould TJ, Witman GB.

Cilia. 2013 Nov 27;2(1):15. doi: 10.1186/2046-2530-2-15.

24.

Isolation of Chlamydomonas flagella.

Craige B, Brown JM, Witman GB.

Curr Protoc Cell Biol. 2013 Jun;Chapter 3:Unit 3.41.1-9. doi: 10.1002/0471143030.cb0341s59.

25.

Cycling of the signaling protein phospholipase D through cilia requires the BBSome only for the export phase.

Lechtreck KF, Brown JM, Sampaio JL, Craft JM, Shevchenko A, Evans JE, Witman GB.

J Cell Biol. 2013 Apr 15;201(2):249-61. doi: 10.1083/jcb.201207139.

26.

Avalanche-like behavior in ciliary import.

Ludington WB, Wemmer KA, Lechtreck KF, Witman GB, Marshall WF.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3925-30. doi: 10.1073/pnas.1217354110. Epub 2013 Feb 19.

27.

The role of retrograde intraflagellar transport in flagellar assembly, maintenance, and function.

Engel BD, Ishikawa H, Wemmer KA, Geimer S, Wakabayashi K, Hirono M, Craige B, Pazour GJ, Witman GB, Kamiya R, Marshall WF.

J Cell Biol. 2012 Oct 1;199(1):151-67. doi: 10.1083/jcb.201206068.

28.

A FAP46 mutant provides new insights into the function and assembly of the C1d complex of the ciliary central apparatus.

Brown JM, Dipetrillo CG, Smith EF, Witman GB.

J Cell Sci. 2012 Aug 15;125(Pt 16):3904-13. doi: 10.1242/jcs.107151. Epub 2012 May 8.

29.

A unified taxonomy for ciliary dyneins.

Hom EF, Witman GB, Harris EH, Dutcher SK, Kamiya R, Mitchell DR, Pazour GJ, Porter ME, Sale WS, Wirschell M, Yagi T, King SM.

Cytoskeleton (Hoboken). 2011 Oct;68(10):555-65. doi: 10.1002/cm.20533.

30.

Regulation of flagellar motility by the conserved flagellar protein CG34110/Ccdc135/FAP50.

Yang Y, Cochran DA, Gargano MD, King I, Samhat NK, Burger BP, Sabourin KR, Hou Y, Awata J, Parry DA, Marshall WF, Witman GB, Lu X.

Mol Biol Cell. 2011 Apr;22(7):976-87. doi: 10.1091/mbc.E10-04-0331. Epub 2011 Feb 2.

31.

CEP290 tethers flagellar transition zone microtubules to the membrane and regulates flagellar protein content.

Craige B, Tsao CC, Diener DR, Hou Y, Lechtreck KF, Rosenbaum JL, Witman GB.

J Cell Biol. 2010 Sep 6;190(5):927-40. doi: 10.1083/jcb.201006105.

32.

The Chlamydomonas reinhardtii BBSome is an IFT cargo required for export of specific signaling proteins from flagella.

Lechtreck KF, Johnson EC, Sakai T, Cochran D, Ballif BA, Rush J, Pazour GJ, Ikebe M, Witman GB.

J Cell Biol. 2009 Dec 28;187(7):1117-32. doi: 10.1083/jcb.200909183.

33.

IC97 is a novel intermediate chain of I1 dynein that interacts with tubulin and regulates interdoublet sliding.

Wirschell M, Yang C, Yang P, Fox L, Yanagisawa HA, Kamiya R, Witman GB, Porter ME, Sale WS.

Mol Biol Cell. 2009 Jul;20(13):3044-54. doi: 10.1091/mbc.E09-04-0276. Epub 2009 May 6. Erratum in: Mol Biol Cell. 2009 Aug;20(15):3617.

34.

HA-tagging of putative flagellar proteins in Chlamydomonas reinhardtii identifies a novel protein of intraflagellar transport complex B.

Lechtreck KF, Luro S, Awata J, Witman GB.

Cell Motil Cytoskeleton. 2009 Aug;66(8):469-82. doi: 10.1002/cm.20369.

35.

Total internal reflection fluorescence (TIRF) microscopy of Chlamydomonas flagella.

Engel BD, Lechtreck KF, Sakai T, Ikebe M, Witman GB, Marshall WF.

Methods Cell Biol. 2009;93:157-77. doi: 10.1016/S0091-679X(08)93009-0. Epub 2009 Dec 4.

36.

High-speed digital imaging of ependymal cilia in the murine brain.

Lechtreck KF, Sanderson MJ, Witman GB.

Methods Cell Biol. 2009;91:255-64. doi: 10.1016/S0091-679X(08)91013-X. Epub 2009 Dec 1.

37.

Mutations in Hydin impair ciliary motility in mice.

Lechtreck KF, Delmotte P, Robinson ML, Sanderson MJ, Witman GB.

J Cell Biol. 2008 Feb 11;180(3):633-43. doi: 10.1083/jcb.200710162. Epub 2008 Feb 4.

38.

Function and dynamics of PKD2 in Chlamydomonas reinhardtii flagella.

Huang K, Diener DR, Mitchell A, Pazour GJ, Witman GB, Rosenbaum JL.

J Cell Biol. 2007 Nov 5;179(3):501-14.

39.

The Chlamydomonas genome reveals the evolution of key animal and plant functions.

Merchant SS, Prochnik SE, Vallon O, Harris EH, Karpowicz SJ, Witman GB, Terry A, Salamov A, Fritz-Laylin LK, Maréchal-Drouard L, Marshall WF, Qu LH, Nelson DR, Sanderfoot AA, Spalding MH, Kapitonov VV, Ren Q, Ferris P, Lindquist E, Shapiro H, Lucas SM, Grimwood J, Schmutz J, Cardol P, Cerutti H, Chanfreau G, Chen CL, Cognat V, Croft MT, Dent R, Dutcher S, Fernández E, Fukuzawa H, González-Ballester D, González-Halphen D, Hallmann A, Hanikenne M, Hippler M, Inwood W, Jabbari K, Kalanon M, Kuras R, Lefebvre PA, Lemaire SD, Lobanov AV, Lohr M, Manuell A, Meier I, Mets L, Mittag M, Mittelmeier T, Moroney JV, Moseley J, Napoli C, Nedelcu AM, Niyogi K, Novoselov SV, Paulsen IT, Pazour G, Purton S, Ral JP, Riaño-Pachón DM, Riekhof W, Rymarquis L, Schroda M, Stern D, Umen J, Willows R, Wilson N, Zimmer SL, Allmer J, Balk J, Bisova K, Chen CJ, Elias M, Gendler K, Hauser C, Lamb MR, Ledford H, Long JC, Minagawa J, Page MD, Pan J, Pootakham W, Roje S, Rose A, Stahlberg E, Terauchi AM, Yang P, Ball S, Bowler C, Dieckmann CL, Gladyshev VN, Green P, Jorgensen R, Mayfield S, Mueller-Roeber B, Rajamani S, Sayre RT, Brokstein P, Dubchak I, Goodstein D, Hornick L, Huang YW, Jhaveri J, Luo Y, Martínez D, Ngau WC, Otillar B, Poliakov A, Porter A, Szajkowski L, Werner G, Zhou K, Grigoriev IV, Rokhsar DS, Grossman AR.

Science. 2007 Oct 12;318(5848):245-50.

40.

Functional analysis of an individual IFT protein: IFT46 is required for transport of outer dynein arms into flagella.

Hou Y, Qin H, Follit JA, Pazour GJ, Rosenbaum JL, Witman GB.

J Cell Biol. 2007 Feb 26;176(5):653-65. Epub 2007 Feb 20.

41.
42.

Radial spoke proteins of Chlamydomonas flagella.

Yang P, Diener DR, Yang C, Kohno T, Pazour GJ, Dienes JM, Agrin NS, King SM, Sale WS, Kamiya R, Rosenbaum JL, Witman GB.

J Cell Sci. 2006 Mar 15;119(Pt 6):1165-74. Epub 2006 Feb 28.

43.

Cytoplasmic dynein nomenclature.

Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB.

J Cell Biol. 2005 Nov 7;171(3):411-3. Epub 2005 Oct 31.

44.

Differential light chain assembly influences outer arm dynein motor function.

DiBella LM, Gorbatyuk O, Sakato M, Wakabayashi K, Patel-King RS, Pazour GJ, Witman GB, King SM.

Mol Biol Cell. 2005 Dec;16(12):5661-74. Epub 2005 Sep 29.

45.

Proteomic analysis of a eukaryotic cilium.

Pazour GJ, Agrin N, Leszyk J, Witman GB.

J Cell Biol. 2005 Jul 4;170(1):103-13.

46.

Identification of predicted human outer dynein arm genes: candidates for primary ciliary dyskinesia genes.

Pazour GJ, Agrin N, Walker BL, Witman GB.

J Med Genet. 2006 Jan;43(1):62-73. Epub 2005 Jun 3.

47.

Novel role for a sterol response element binding protein in directing spermatogenic cell-specific gene expression.

Wang H, San Agustin JT, Witman GB, Kilpatrick DL.

Mol Cell Biol. 2004 Dec;24(24):10681-8.

48.

A dynein light intermediate chain, D1bLIC, is required for retrograde intraflagellar transport.

Hou Y, Pazour GJ, Witman GB.

Mol Biol Cell. 2004 Oct;15(10):4382-94. Epub 2004 Jul 21.

49.

Oda5p, a novel axonemal protein required for assembly of the outer dynein arm and an associated adenylate kinase.

Wirschell M, Pazour G, Yoda A, Hirono M, Kamiya R, Witman GB.

Mol Biol Cell. 2004 Jun;15(6):2729-41. Epub 2004 Apr 2.

50.

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