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Cytosolic PCNA interacts with p47phox and controls NADPH oxidase NOX2 activation in neutrophils.

Ohayon D, De Chiara A, Dang PM, Thieblemont N, Chatfield S, Marzaioli V, Burgener SS, Mocek J, Candalh C, Pintard C, Tacnet-Delorme P, Renault G, Lagoutte I, Favier M, Walker F, Hurtado-Nedelec M, Desplancq D, Weiss E, Benarafa C, Housset D, Marie JC, Frachet P, El-Benna J, Witko-Sarsat V.

J Exp Med. 2019 Sep 6. pii: jem.20180371. doi: 10.1084/jem.20180371. [Epub ahead of print]


Proteomic analysis of neutrophils in ANCA-associated vasculitis reveals a dysregulation in proteinase 3-associated proteins such as annexin-A1 involved in apoptotic cell clearance.

Everts-Graber J, Martin KR, Thieblemont N, Mocek J, Roccabianca A, Chafey P, Le Gall M, Tacnet-Delorme P, Reutelingsperger CP, Naccache JM, Bonnotte B, Karras A, Puéchal X, Guillevin L, Terrier B, Frachet P, Perretti M, Mouthon L, Witko-Sarsat V.

Kidney Int. 2019 Aug;96(2):397-408. doi: 10.1016/j.kint.2019.02.017. Epub 2019 Mar 4.


Inflammasome activation: Neutrophils go their own way.

Tourneur L, Witko-Sarsat V.

J Leukoc Biol. 2019 Mar;105(3):433-436. doi: 10.1002/JLB.3CE1118-433R. Epub 2019 Feb 5.


Expanding Neutrophil Horizons: New Concepts in Inflammation.

Chatfield SM, Thieblemont N, Witko-Sarsat V.

J Innate Immun. 2018;10(5-6):422-431. doi: 10.1159/000493101. Epub 2018 Sep 26. Review.


Regulation of macrophage activation by proteins expressed on apoptotic neutrophils: Subversion towards autoimmunity by proteinase 3.

Thieblemont N, Witko-Sarsat V, Ariel A.

Eur J Clin Invest. 2018 Nov;48 Suppl 2:e12990. doi: 10.1111/eci.12990. Review.


Proteinase 3 Interferes With C1q-Mediated Clearance of Apoptotic Cells.

Tacnet-Delorme P, Gabillet J, Chatfield S, Thieblemont N, Frachet P, Witko-Sarsat V.

Front Immunol. 2018 Apr 25;9:818. doi: 10.3389/fimmu.2018.00818. eCollection 2018.


mTOR pathway is activated in endothelial cells from patients with Takayasu arteritis and is modulated by serum immunoglobulin G.

Hadjadj J, Canaud G, Mirault T, Samson M, Bruneval P, Régent A, Goulvestre C, Witko-Sarsat V, Costedoat-Chalumeau N, Guillevin L, Mouthon L, Terrier B; French Vasculitis Study Group.

Rheumatology (Oxford). 2018 Jun 1;57(6):1011-1020. doi: 10.1093/rheumatology/key017.


Transgenic Mice Expressing Human Proteinase 3 Exhibit Sustained Neutrophil-Associated Peritonitis.

Martin KR, Pederzoli-Ribeil M, Pacreau E, Burgener SS, Dahdah A, Candalh C, Lauret E, Foretz M, Mouthon L, Lucas B, Thieblemont N, Benarafa C, Launay P, Witko-Sarsat V.

J Immunol. 2017 Dec 1;199(11):3914-3924. doi: 10.4049/jimmunol.1601522. Epub 2017 Oct 27.


Harnessing Neutrophil Survival Mechanisms during Chronic Infection by Pseudomonas aeruginosa: Novel Therapeutic Targets to Dampen Inflammation in Cystic Fibrosis.

Marteyn BS, Burgel PR, Meijer L, Witko-Sarsat V.

Front Cell Infect Microbiol. 2017 Jun 30;7:243. doi: 10.3389/fcimb.2017.00243. eCollection 2017. Review.


Proteinase 3: the odd one out that became an autoantigen.

Martin KR, Witko-Sarsat V.

J Leukoc Biol. 2017 Sep;102(3):689-698. doi: 10.1189/jlb.3MR0217-069R. Epub 2017 May 25. Review.


Granulomatosis with polyangiitis (Wegener granulomatosis): A proteinase-3 driven disease?

Witko-Sarsat V, Thieblemont N.

Joint Bone Spine. 2018 Mar;85(2):185-189. doi: 10.1016/j.jbspin.2017.05.004. Epub 2017 May 8.


Molecular analysis of vascular smooth muscle cells from patients with giant cell arteritis: Targeting endothelin-1 receptor to control proliferation.

Régent A, Ly KH, Groh M, Khifer C, Lofek S, Clary G, Chafey P, Baud V, Broussard C, Federici C, Labrousse F, Mesturoux L, Le Jeunne C, Vidal E, Brezin A, Witko-Sarsat V, Guillevin L, Mouthon L.

Autoimmun Rev. 2017 Apr;16(4):398-406. doi: 10.1016/j.autrev.2017.02.006. Epub 2017 Feb 14. Review.


Cytoplasmic proliferating cell nuclear antigen connects glycolysis and cell survival in acute myeloid leukemia.

Ohayon D, De Chiara A, Chapuis N, Candalh C, Mocek J, Ribeil JA, Haddaoui L, Ifrah N, Hermine O, Bouillaud F, Frachet P, Bouscary D, Witko-Sarsat V.

Sci Rep. 2016 Oct 19;6:35561. doi: 10.1038/srep35561.


Proliferating cell nuclear antigen in neutrophil fate.

Witko-Sarsat V, Ohayon D.

Immunol Rev. 2016 Sep;273(1):344-56. doi: 10.1111/imr.12449. Review.


Anoxia and glucose supplementation preserve neutrophil viability and function.

Monceaux V, Chiche-Lapierre C, Chaput C, Witko-Sarsat V, Prevost MC, Taylor CT, Ungeheuer MN, Sansonetti PJ, Marteyn BS.

Blood. 2016 Aug 18;128(7):993-1002. doi: 10.1182/blood-2015-11-680918. Epub 2016 Jul 8.


[Proteinase 3: a new danger signal and a double agent in vasculitis].

Witko-Sarsat V, Perruche S.

Med Sci (Paris). 2016 May;32(5):450-2. doi: 10.1051/medsci/20163205008. Epub 2016 May 25. French. No abstract available.


From Starfish Oocytes to Inflammation: The Unforeseeable Destiny of Roscovitine in Cystic Fibrosis.

Witko-Sarsat V.

J Innate Immun. 2016;8(4):327-9. doi: 10.1159/000445967. Epub 2016 Apr 26. No abstract available.


Human neutrophils in auto-immunity.

Thieblemont N, Wright HL, Edwards SW, Witko-Sarsat V.

Semin Immunol. 2016 Apr;28(2):159-73. doi: 10.1016/j.smim.2016.03.004. Epub 2016 Mar 29. Review.


Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis.

Meijer L, Nelson DJ, Riazanski V, Gabdoulkhakova AG, Hery-Arnaud G, Le Berre R, Loaëc N, Oumata N, Galons H, Nowak E, Gueganton L, Dorothée G, Prochazkova M, Hall B, Kulkarni AB, Gray RD, Rossi AG, Witko-Sarsat V, Norez C, Becq F, Ravel D, Mottier D, Rault G.

J Innate Immun. 2016;8(4):330-49. doi: 10.1159/000444256. Epub 2016 Mar 18. Review.


Proteinase 3 Is a Phosphatidylserine-binding Protein That Affects the Production and Function of Microvesicles.

Martin KR, Kantari-Mimoun C, Yin M, Pederzoli-Ribeil M, Angelot-Delettre F, Ceroi A, Grauffel C, Benhamou M, Reuter N, Saas P, Frachet P, Boulanger CM, Witko-Sarsat V.

J Biol Chem. 2016 May 13;291(20):10476-89. doi: 10.1074/jbc.M115.698639. Epub 2016 Mar 9.


Neutrophil-Expressed p21/waf1 Favors Inflammation Resolution in Pseudomonas aeruginosa Infection.

Martin C, Ohayon D, Alkan M, Mocek J, Pederzoli-Ribeil M, Candalh C, Thevenot G, Millet A, Tamassia N, Cassatella MA, Thieblemont N, Burgel PR, Witko-Sarsat V.

Am J Respir Cell Mol Biol. 2016 May;54(5):740-50. doi: 10.1165/rcmb.2015-0047OC.


Dividing the Janus vasculitis? Pathophysiology of eosinophilic granulomatosis with polyangitis.

Chaigne B, Terrier B, Thieblemont N, Witko-Sarsat V, Mouthon L.

Autoimmun Rev. 2016 Feb;15(2):139-45. doi: 10.1016/j.autrev.2015.10.006. Epub 2015 Oct 23. Review.


Proteinase 3 on apoptotic cells disrupts immune silencing in autoimmune vasculitis.

Millet A, Martin KR, Bonnefoy F, Saas P, Mocek J, Alkan M, Terrier B, Kerstein A, Tamassia N, Satyanarayanan SK, Ariel A, Ribeil JA, Guillevin L, Cassatella MA, Mueller A, Thieblemont N, Lamprecht P, Mouthon L, Perruche S, Witko-Sarsat V.

J Clin Invest. 2015 Nov 2;125(11):4107-21. doi: 10.1172/JCI78182. Epub 2015 Oct 5.


Promoting apoptosis of neutrophils and phagocytosis by macrophages: novel strategies in the resolution of inflammation.

Martin KR, Ohayon D, Witko-Sarsat V.

Swiss Med Wkly. 2015 Feb 21;145:w14056. doi: 10.4414/smw.2015.14056. eCollection 2015. Review.


Neurotrophins are expressed in giant cell arteritis lesions and may contribute to vascular remodeling.

Ly KH, Régent A, Molina E, Saada S, Sindou P, Le-Jeunne C, Brézin A, Witko-Sarsat V, Labrousse F, Robert PY, Bertin P, Bourges JL, Fauchais AL, Vidal E, Mouthon L, Jauberteau MO.

Arthritis Res Ther. 2014 Nov 24;16(6):487. doi: 10.1186/s13075-014-0487-z.


Republished: Antineutrophil cytoplasmic antibody-associated vasculitides: is it time to split up the group?

Millet A, Pederzoli-Ribeil M, Guillevin L, Witko-Sarsat V, Mouthon L.

Postgrad Med J. 2014 May;90(1063):290-6. doi: 10.1136/postgradmedj-2013-203255rep. Review.


Characterization of cytosolic proliferating cell nuclear antigen (PCNA) in neutrophils: antiapoptotic role of the monomer.

De Chiara A, Pederzoli-Ribeil M, Mocek J, Candalh C, Mayeux P, Millet A, Witko-Sarsat V.

J Leukoc Biol. 2013 Oct;94(4):723-31. doi: 10.1189/jlb.1212637. Epub 2013 Jul 3.


Autophagy and innate immunity.

Witko-Sarsat V, Codogno P.

J Innate Immun. 2013;5(5):425-6. doi: 10.1159/000353153. Epub 2013 Jun 15. No abstract available.


Antineutrophil cytoplasmic antibody-associated vasculitides: is it time to split up the group?

Millet A, Pederzoli-Ribeil M, Guillevin L, Witko-Sarsat V, Mouthon L.

Ann Rheum Dis. 2013 Aug;72(8):1273-9. doi: 10.1136/annrheumdis-2013-203255. Epub 2013 Apr 20. Review.


Neutrophils in the innate immunity conundrum of cystic fibrosis: a CFTR-related matter?

Witko-Sarsat V.

J Innate Immun. 2013;5(3):195-6. doi: 10.1159/000350215. Epub 2013 Mar 23. No abstract available.


L34. Neutrophils in ANCA-associated vasculitis: still under investigation.

Witko-Sarsat V.

Presse Med. 2013 Apr;42(4 Pt 2):595-7. doi: 10.1016/j.lpm.2013.01.034. Epub 2013 Mar 6. Review. No abstract available.


Targeting cytosolic proliferating cell nuclear antigen in neutrophil-dominated inflammation.

Chiara AD, Pederzoli-Ribeil M, Burgel PR, Danel C, Witko-Sarsat V.

Front Immunol. 2012 Oct 9;3:311. doi: 10.3389/fimmu.2012.00311. eCollection 2012.


[Pathophysiology of ANCA-associated vasculitides].

Mouthon L, Millet A, Régent A, Pederzoli-Ribeil M, Witko-Sarsat V.

Presse Med. 2012 Oct;41(10):996-1003. doi: 10.1016/j.lpm.2012.07.007. Epub 2012 Aug 23. Review. French.


Proteomes of umbilical vein and microvascular endothelial cells reflect distinct biological properties and influence immune recognition.

Dib H, Chafey P, Clary G, Federici C, Le Gall M, Dwyer J, Gavard J, Tamas N, Bussone G, Broussard C, Camoin L, Witko-Sarsat V, Tamby MC, Mouthon L.

Proteomics. 2012 Aug;12(15-16):2547-55. doi: 10.1002/pmic.201200060.


Proteinase 3, the autoantigen in granulomatosis with polyangiitis, associates with calreticulin on apoptotic neutrophils, impairs macrophage phagocytosis, and promotes inflammation.

Gabillet J, Millet A, Pederzoli-Ribeil M, Tacnet-Delorme P, Guillevin L, Mouthon L, Frachet P, Witko-Sarsat V.

J Immunol. 2012 Sep 1;189(5):2574-83. doi: 10.4049/jimmunol.1200600. Epub 2012 Jul 27.


IgG from patients with pulmonary arterial hypertension and/or systemic sclerosis binds to vascular smooth muscle cells and induces cell contraction.

Bussone G, Tamby MC, Calzas C, Kherbeck N, Sahbatou Y, Sanson C, Ghazal K, Dib H, Weksler BB, Broussard C, Verrecchia F, Yaici A, Witko-Sarsat V, Simonneau G, Guillevin L, Humbert M, Mouthon L.

Ann Rheum Dis. 2012 Apr;71(4):596-605. doi: 10.1136/annrheumdis-2011-200195. Epub 2011 Nov 14.


Targets of anti-endothelial cell antibodies in pulmonary hypertension and scleroderma.

Dib H, Tamby MC, Bussone G, Regent A, Berezné A, Lafine C, Broussard C, Simonneau G, Guillevin L, Witko-Sarsat V, Humbert M, Mouthon L.

Eur Respir J. 2012 Jun;39(6):1405-14. doi: 10.1183/09031936.00181410. Epub 2011 Oct 17.


Molecular analysis of the membrane insertion domain of proteinase 3, the Wegener's autoantigen, in RBL cells: implication for its pathogenic activity.

Kantari C, Millet A, Gabillet J, Hajjar E, Broemstrup T, Pluta P, Reuter N, Witko-Sarsat V.

J Leukoc Biol. 2011 Nov;90(5):941-50. doi: 10.1189/jlb.1210695. Epub 2011 Aug 5.


Regulating neutrophil apoptosis: new players enter the game.

Witko-Sarsat V, Pederzoli-Ribeil M, Hirsch E, Sozzani S, Cassatella MA.

Trends Immunol. 2011 Mar;32(3):117-24. doi: 10.1016/ Epub 2011 Feb 12. Review. Erratum in: Trends Immunol. 2011 May;32(5):187. Hirsh, Emilio [corrected to Hirsch, Emilio].


Proliferating cell nuclear antigen acts as a cytoplasmic platform controlling human neutrophil survival.

Witko-Sarsat V, Mocek J, Bouayad D, Tamassia N, Ribeil JA, Candalh C, Davezac N, Reuter N, Mouthon L, Hermine O, Pederzoli-Ribeil M, Cassatella MA.

J Exp Med. 2010 Nov 22;207(12):2631-45. doi: 10.1084/jem.20092241. Epub 2010 Oct 25.


Structures of human proteinase 3 and neutrophil elastase--so similar yet so different.

Hajjar E, Broemstrup T, Kantari C, Witko-Sarsat V, Reuter N.

FEBS J. 2010 May;277(10):2238-54. doi: 10.1111/j.1742-4658.2010.07659.x. Review.


Apoptosis, cell death and inflammation.

Witko-Sarsat V.

J Innate Immun. 2010;2(3):201-3. doi: 10.1159/000296505. Epub 2010 Mar 16. No abstract available.


Interaction of proteinase 3 with its associated partners: implications in the pathogenesis of Wegener's granulomatosis.

Witko-Sarsat V, Reuter N, Mouthon L.

Curr Opin Rheumatol. 2010 Jan;22(1):1-7. doi: 10.1097/BOR.0b013e3283331594. Review.


Neutrophils and B lymphocytes in ANCA-associated vasculitis.

Witko-Sarsat V, Daniel S, Noël LH, Mouthon L.

APMIS Suppl. 2009 Jun;(127):27-31. doi: 10.1111/j.1600-0463.2009.02473.x. Review.


Coronin-1 is associated with neutrophil survival and is cleaved during apoptosis: potential implication in neutrophils from cystic fibrosis patients.

Moriceau S, Kantari C, Mocek J, Davezac N, Gabillet J, Guerrera IC, Brouillard F, Tondelier D, Sermet-Gaudelus I, Danel C, Lenoir G, Daniel S, Edelman A, Witko-Sarsat V.

J Immunol. 2009 Jun 1;182(11):7254-63. doi: 10.4049/jimmunol.0803312.


The role of neutrophils and monocytes in innate immunity.

Kantari C, Pederzoli-Ribeil M, Witko-Sarsat V.

Contrib Microbiol. 2008;15:118-146. doi: 10.1159/000136335. Review.


Computational prediction of the binding site of proteinase 3 to the plasma membrane.

Hajjar E, Mihajlovic M, Witko-Sarsat V, Lazaridis T, Reuter N.

Proteins. 2008 Jun;71(4):1655-69.


Proteinase 3, the Wegener autoantigen, is externalized during neutrophil apoptosis: evidence for a functional association with phospholipid scramblase 1 and interference with macrophage phagocytosis.

Kantari C, Pederzoli-Ribeil M, Amir-Moazami O, Gausson-Dorey V, Moura IC, Lecomte MC, Benhamou M, Witko-Sarsat V.

Blood. 2007 Dec 1;110(12):4086-95. Epub 2007 Aug 21.

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