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ADF/Cofilin-Mediated Actin Turnover Promotes Axon Regeneration in the Adult CNS.

Tedeschi A, Dupraz S, Curcio M, Laskowski CJ, Schaffran B, Flynn KC, Santos TE, Stern S, Hilton BJ, Larson MJE, Gurniak CB, Witke W, Bradke F.

Neuron. 2019 Sep 25;103(6):1073-1085.e6. doi: 10.1016/j.neuron.2019.07.007. Epub 2019 Aug 7.


Cell injury triggers actin polymerization to initiate epithelial restitution.

Aihara E, Medina-Candelaria NM, Hanyu H, Matthis AL, Engevik KA, Gurniak CB, Witke W, Turner JR, Zhang T, Montrose MH.

J Cell Sci. 2018 Aug 20;131(16). pii: jcs216317. doi: 10.1242/jcs.216317.


Cofilin1-dependent actin dynamics control DRP1-mediated mitochondrial fission.

Rehklau K, Hoffmann L, Gurniak CB, Ott M, Witke W, Scorrano L, Culmsee C, Rust MB.

Cell Death Dis. 2017 Oct 5;8(10):e3063. doi: 10.1038/cddis.2017.448.


Gelsolin dysfunction causes photoreceptor loss in induced pluripotent cell and animal retinitis pigmentosa models.

Megaw R, Abu-Arafeh H, Jungnickel M, Mellough C, Gurniak C, Witke W, Zhang W, Khanna H, Mill P, Dhillon B, Wright AF, Lako M, Ffrench-Constant C.

Nat Commun. 2017 Aug 16;8(1):271. doi: 10.1038/s41467-017-00111-8.


The actin-binding protein profilin 2 is a novel regulator of iron homeostasis.

Luscieti S, Galy B, Gutierrez L, Reinke M, Couso J, Shvartsman M, Di Pascale A, Witke W, Hentze MW, Pilo Boyl P, Sanchez M.

Blood. 2017 Oct 26;130(17):1934-1945. doi: 10.1182/blood-2016-11-754382. Epub 2017 Aug 3.


The Actin-Binding Protein Cofilin and Its Interaction With Cortactin Are Required for Podosome Patterning in Osteoclasts and Bone Resorption In Vivo and In Vitro.

Zalli D, Neff L, Nagano K, Shin NY, Witke W, Gori F, Baron R.

J Bone Miner Res. 2016 Sep;31(9):1701-12. doi: 10.1002/jbmr.2851. Epub 2016 May 27.


ADF and Cofilin1 Control Actin Stress Fibers, Nuclear Integrity, and Cell Survival.

Kanellos G, Zhou J, Patel H, Ridgway RA, Huels D, Gurniak CB, Sandilands E, Carragher NO, Sansom OJ, Witke W, Brunton VG, Frame MC.

Cell Rep. 2015 Dec 1;13(9):1949-64. doi: 10.1016/j.celrep.2015.10.056. Epub 2015 Nov 19.


Actin filament turnover drives leading edge growth during myelin sheath formation in the central nervous system.

Nawaz S, Sánchez P, Schmitt S, Snaidero N, Mitkovski M, Velte C, Brückner BR, Alexopoulos I, Czopka T, Jung SY, Rhee JS, Janshoff A, Witke W, Schaap IAT, Lyons DA, Simons M.

Dev Cell. 2015 Jul 27;34(2):139-151. doi: 10.1016/j.devcel.2015.05.013. Epub 2015 Jul 9.


Rho-kinase-dependent actin turnover and actomyosin disassembly are necessary for mouse spinal neural tube closure.

Escuin S, Vernay B, Savery D, Gurniak CB, Witke W, Greene ND, Copp AJ.

J Cell Sci. 2015 Jul 15;128(14):2468-81. doi: 10.1242/jcs.164574. Epub 2015 Jun 3.


Targeted downregulation of platelet CLEC-2 occurs through Syk-independent internalization.

Lorenz V, Stegner D, Stritt S, Vögtle T, Kiefer F, Witke W, Schymeinsky J, Watson SP, Walzog B, Nieswandt B.

Blood. 2015 Jun 25;125(26):4069-77. doi: 10.1182/blood-2014-11-611905. Epub 2015 Mar 20.


Corrigendum: Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect.

Bender M, Stritt S, Nurden P, van Eeuwijk JM, Zieger B, Kentouche K, Schulze H, Morbach H, Stegner D, Heinze KG, Dütting S, Gupta S, Witke W, Falet H, Fischer A, Hartwig JH, Nieswandt B.

Nat Commun. 2015 Mar 6;6:6507. doi: 10.1038/ncomms7507. No abstract available.


Small, smaller… dendritic spine.

Pilo Boyl P, Witke W.

EMBO J. 2014 Dec 1;33(23):2737-9. doi: 10.15252/embj.201490137. Epub 2014 Oct 16. No abstract available.


Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect.

Bender M, Stritt S, Nurden P, van Eeuwijk JM, Zieger B, Kentouche K, Schulze H, Morbach H, Stegner D, Heinze KG, Dütting S, Gupta S, Witke W, Falet H, Fischer A, Hartwig JH, Nieswandt B.

Nat Commun. 2014 Sep 4;5:4746. doi: 10.1038/ncomms5746. Erratum in: Nat Commun. 2015;6:6507. Heinze, Katrin [corrected to Heinze, Katrin G].


ADF/Cofilin Controls Synaptic Actin Dynamics and Regulates Synaptic Vesicle Mobilization and Exocytosis.

Wolf M, Zimmermann AM, Görlich A, Gurniak CB, Sassoè-Pognetto M, Friauf E, Witke W, Rust MB.

Cereb Cortex. 2015 Sep;25(9):2863-75. doi: 10.1093/cercor/bhu081. Epub 2014 Apr 25.


Attention-Deficit/Hyperactivity Disorder-like Phenotype in a Mouse Model with Impaired Actin Dynamics.

Zimmermann AM, Jene T, Wolf M, Görlich A, Gurniak CB, Sassoè-Pognetto M, Witke W, Friauf E, Rust MB.

Biol Psychiatry. 2015 Jul 15;78(2):95-106. doi: 10.1016/j.biopsych.2014.03.011. Epub 2014 Mar 21.


Severe protein aggregate myopathy in a knockout mouse model points to an essential role of cofilin2 in sarcomeric actin exchange and muscle maintenance.

Gurniak CB, Chevessier F, Jokwitz M, Jönsson F, Perlas E, Richter H, Matern G, Boyl PP, Chaponnier C, Fürst D, Schröder R, Witke W.

Eur J Cell Biol. 2014 May-Jun;93(5-6):252-66. doi: 10.1016/j.ejcb.2014.01.007. Epub 2014 Feb 11.


ADF/cofilin-mediated actin retrograde flow directs neurite formation in the developing brain.

Flynn KC, Hellal F, Neukirchen D, Jacob S, Tahirovic S, Dupraz S, Stern S, Garvalov BK, Gurniak C, Shaw AE, Meyn L, Wedlich-Söldner R, Bamburg JR, Small JV, Witke W, Bradke F.

Neuron. 2012 Dec 20;76(6):1091-107. doi: 10.1016/j.neuron.2012.09.038.


Cofilin-1: a modulator of anxiety in mice.

Goodson M, Rust MB, Witke W, Bannerman D, Mott R, Ponting CP, Flint J.

PLoS Genet. 2012;8(10):e1002970. doi: 10.1371/journal.pgen.1002970. Epub 2012 Oct 4.


Purkinje cell loss and motor coordination defects in profilin1 mutant mice.

Kullmann JA, Neumeyer A, Wickertsheim I, Böttcher RT, Costell M, Deitmer JW, Witke W, Friauf E, Rust MB.

Neuroscience. 2012 Oct 25;223:355-64. doi: 10.1016/j.neuroscience.2012.07.055. Epub 2012 Aug 3.


Role of the actin-binding protein profilin1 in radial migration and glial cell adhesion of granule neurons in the cerebellum.

Rust MB, Kullmann JA, Witke W.

Cell Adh Migr. 2012 Jan-Feb;6(1):13-7. doi: 10.4161/cam.19845.


Immunological responses and actin dynamics in macrophages are controlled by N-cofilin but are independent from ADF.

Jönsson F, Gurniak CB, Fleischer B, Kirfel G, Witke W.

PLoS One. 2012;7(4):e36034. doi: 10.1371/journal.pone.0036034. Epub 2012 Apr 27.


Defective erythroid maturation in gelsolin mutant mice.

Cantù C, Bosè F, Bianchi P, Reali E, Colzani MT, Cantù I, Barbarani G, Ottolenghi S, Witke W, Spinardi L, Ronchi AE.

Haematologica. 2012 Jul;97(7):980-8. doi: 10.3324/haematol.2011.052522. Epub 2012 Jan 22.


Preserved morphology and physiology of excitatory synapses in profilin1-deficient mice.

Görlich A, Zimmermann AM, Schober D, Böttcher RT, Sassoè-Pognetto M, Friauf E, Witke W, Rust MB.

PLoS One. 2012;7(1):e30068. doi: 10.1371/journal.pone.0030068. Epub 2012 Jan 11.


Profilin1 is required for glial cell adhesion and radial migration of cerebellar granule neurons.

Kullmann JA, Neumeyer A, Gurniak CB, Friauf E, Witke W, Rust MB.

EMBO Rep. 2011 Dec 23;13(1):75-82. doi: 10.1038/embor.2011.211.


N-cofilin can compensate for the loss of ADF in excitatory synapses.

Görlich A, Wolf M, Zimmermann AM, Gurniak CB, Al Banchaabouchi M, Sassoè-Pognetto M, Witke W, Friauf E, Rust MB.

PLoS One. 2011;6(10):e26789. doi: 10.1371/journal.pone.0026789. Epub 2011 Oct 28.


Actin depolymerizing factors cofilin1 and destrin are required for ureteric bud branching morphogenesis.

Kuure S, Cebrian C, Machingo Q, Lu BC, Chi X, Hyink D, D'Agati V, Gurniak C, Witke W, Costantini F.

PLoS Genet. 2010 Oct 28;6(10):e1001176. doi: 10.1371/journal.pgen.1001176.


ADF/n-cofilin-dependent actin turnover determines platelet formation and sizing.

Bender M, Eckly A, Hartwig JH, Elvers M, Pleines I, Gupta S, Krohne G, Jeanclos E, Gohla A, Gurniak C, Gachet C, Witke W, Nieswandt B.

Blood. 2010 Sep 9;116(10):1767-75. doi: 10.1182/blood-2010-03-274340. Epub 2010 Jun 7.


Actin-depolymerizing factor cofilin-1 is necessary in maintaining mature podocyte architecture.

Garg P, Verma R, Cook L, Soofi A, Venkatareddy M, George B, Mizuno K, Gurniak C, Witke W, Holzman LB.

J Biol Chem. 2010 Jul 16;285(29):22676-88. doi: 10.1074/jbc.M110.122929. Epub 2010 May 15.


Learning, AMPA receptor mobility and synaptic plasticity depend on n-cofilin-mediated actin dynamics.

Rust MB, Gurniak CB, Renner M, Vara H, Morando L, Görlich A, Sassoè-Pognetto M, Banchaabouchi MA, Giustetto M, Triller A, Choquet D, Witke W.

EMBO J. 2010 Jun 2;29(11):1889-902. doi: 10.1038/emboj.2010.72. Epub 2010 Apr 20.


Gelsolin is required for macrophage recruitment during remyelination of the peripheral nervous system.

Gonçalves AF, Dias NG, Moransard M, Correia R, Pereira JA, Witke W, Suter U, Relvas JB.

Glia. 2010 Apr 15;58(6):706-15. doi: 10.1002/glia.20956.


Inactivation of Numb and Numblike in spermatogonial stem cells by cell-permeant Cre recombinase.

Grisanti L, Corallini S, Fera S, Muciaccia B, Stefanini M, Witke W, Vicini E.

Differentiation. 2009 Sep-Oct;78(2-3):131-6. doi: 10.1016/j.diff.2009.05.005. Epub 2009 Jun 21.


SMN, profilin IIa and plastin 3: a link between the deregulation of actin dynamics and SMA pathogenesis.

Bowerman M, Anderson CL, Beauvais A, Boyl PP, Witke W, Kothary R.

Mol Cell Neurosci. 2009 Sep;42(1):66-74. doi: 10.1016/j.mcn.2009.05.009. Epub 2009 Jun 1.


Gelsolin expression is necessary for the development of modelled pulmonary inflammation and fibrosis.

Oikonomou N, Thanasopoulou A, Tzouvelekis A, Harokopos V, Paparountas T, Nikitopoulou I, Witke W, Karameris A, Kotanidou A, Bouros D, Aidinis V.

Thorax. 2009 Jun;64(6):467-75. doi: 10.1136/thx.2008.107946. Epub 2009 Feb 12.


A critical role for gelsolin in ventilator-induced lung injury.

Maniatis NA, Harokopos V, Thanassopoulou A, Oikonomou N, Mersinias V, Witke W, Orfanos SE, Armaganidis A, Roussos C, Kotanidou A, Aidinis V.

Am J Respir Cell Mol Biol. 2009 Oct;41(4):426-32. doi: 10.1165/rcmb.2008-0144OC. Epub 2009 Feb 6.


The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP.

Napoli I, Mercaldo V, Boyl PP, Eleuteri B, Zalfa F, De Rubeis S, Di Marino D, Mohr E, Massimi M, Falconi M, Witke W, Costa-Mattioli M, Sonenberg N, Achsel T, Bagni C.

Cell. 2008 Sep 19;134(6):1042-54. doi: 10.1016/j.cell.2008.07.031.


Gelsolin and diseases.

Spinardi L, Witke W.

Subcell Biochem. 2007;45:55-69. Review.


High-resolution structural analysis of mammalian profilin 2a complex formation with two physiological ligands: the formin homology 1 domain of mDia1 and the proline-rich domain of VASP.

Kursula P, Kursula I, Massimi M, Song YH, Downer J, Stanley WA, Witke W, Wilmanns M.

J Mol Biol. 2008 Jan 4;375(1):270-90. Epub 2007 Oct 24.


N-cofilin is associated with neuronal migration disorders and cell cycle control in the cerebral cortex.

Bellenchi GC, Gurniak CB, Perlas E, Middei S, Ammassari-Teule M, Witke W.

Genes Dev. 2007 Sep 15;21(18):2347-57.


Profilin2 contributes to synaptic vesicle exocytosis, neuronal excitability, and novelty-seeking behavior.

Pilo Boyl P, Di Nardo A, Mulle C, Sassoè-Pognetto M, Panzanelli P, Mele A, Kneussel M, Costantini V, Perlas E, Massimi M, Vara H, Giustetto M, Witke W.

EMBO J. 2007 Jun 20;26(12):2991-3002. Epub 2007 May 31.


Inhibition of HIV-1 replication by siRNA targeting conserved regions of gag/pol.

Morris KV, Chung CH, Witke W, Looney DJ.

RNA Biol. 2005 Jan;2(1):17-20. Epub 2005 Jan 27.


HuGE, a novel GFP-actin-expressing mouse line for studying cytoskeletal dynamics.

Gurniak CB, Witke W.

Eur J Cell Biol. 2007 Jan;86(1):3-12. Epub 2006 Oct 16.


Mouse profilin 2 regulates endocytosis and competes with SH3 ligand binding to dynamin 1.

Gareus R, Di Nardo A, Rybin V, Witke W.

J Biol Chem. 2006 Feb 3;281(5):2803-11. Epub 2005 Nov 29.


Cytoskeletal rearrangements in synovial fibroblasts as a novel pathophysiological determinant of modeled rheumatoid arthritis.

Aidinis V, Carninci P, Armaka M, Witke W, Harokopos V, Pavelka N, Koczan D, Argyropoulos C, Thwin MM, Möller S, Waki K, Gopalakrishnakone P, Ricciardi-Castagnoli P, Thiesen HJ, Hayashizaki Y, Kollias G.

PLoS Genet. 2005 Oct;1(4):e48. Epub 2005 Oct 28. Erratum in: PLoS Genet. 2005 Nov;1(5):e73. Kazunori, Waki [corrected to Waki, Kazunori].


The actin-binding protein profilin I is localized at synaptic sites in an activity-regulated manner.

Neuhoff H, Sassoè-Pognetto M, Panzanelli P, Maas C, Witke W, Kneussel M.

Eur J Neurosci. 2005 Jan;21(1):15-25.


The role of profilin complexes in cell motility and other cellular processes.

Witke W.

Trends Cell Biol. 2004 Aug;14(8):461-9. Review.


Altered dopamine signaling and MPTP resistance in mice lacking the Parkinson's disease-associated GPR37/parkin-associated endothelin-like receptor.

Marazziti D, Golini E, Mandillo S, Magrelli A, Witke W, Matteoni R, Tocchini-Valentini GP.

Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):10189-94. Epub 2004 Jun 24.


RhoA/ROCK regulation of neuritogenesis via profilin IIa-mediated control of actin stability.

Da Silva JS, Medina M, Zuliani C, Di Nardo A, Witke W, Dotti CG.

J Cell Biol. 2003 Sep 29;162(7):1267-79.


Profilin I is essential for cell survival and cell division in early mouse development.

Witke W, Sutherland JD, Sharpe A, Arai M, Kwiatkowski DJ.

Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3832-6. Epub 2001 Mar 13.

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