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Quantitative 3D measurements of tibial plateau fractures.

Assink N, Kraeima J, Slump CH, Ten Duis K, de Vries JPPM, Meesters AML, van Ooijen P, Witjes MJH, IJpma FFA.

Sci Rep. 2019 Oct 7;9(1):14395. doi: 10.1038/s41598-019-50887-6.


Letter to the Editor on "Deek N.F. Al, Kao HK, Wei FC. The fibula osteoseptocutaneous flap: concise review, goal oriented surgical technique, and tips and tricks. Plast. Reconstruct. Surg. 142: 913e, 2018".

Stenekes MW, Witjes MJ, Van Der Lei BL.

Plast Reconstr Surg. 2019 Sep 9. doi: 10.1097/PRS.0000000000006250. [Epub ahead of print] No abstract available.


Splintless surgery using patient-specific osteosynthesis in Le Fort I osteotomies: a randomized controlled multi-centre trial.

Kraeima J, Schepers RH, Spijkervet FKL, Maal TJJ, Baan F, Witjes MJH, Jansma J.

Int J Oral Maxillofac Surg. 2019 Sep 7. pii: S0901-5027(19)31272-X. doi: 10.1016/j.ijom.2019.08.005. [Epub ahead of print]


Research Frontiers in Oral Toxicities of Cancer Therapies: Osteoradionecrosis of the Jaws.

Spijkervet FKL, Brennan MT, Peterson DE, Witjes MJH, Vissink A.

J Natl Cancer Inst Monogr. 2019 Aug 1;2019(53). pii: lgz006. doi: 10.1093/jncimonographs/lgz006.


The prognostic value of CT-based image-biomarkers for head and neck cancer patients treated with definitive (chemo-)radiation.

Zhai TT, Langendijk JA, van Dijk LV, Halmos GB, Witjes MJH, Oosting SF, Noordzij W, Sijtsema NM, Steenbakkers RJHM.

Oral Oncol. 2019 Aug;95:178-186. doi: 10.1016/j.oraloncology.2019.06.020. Epub 2019 Jun 26.


Automatic segmentation of the mandible from computed tomography scans for 3D virtual surgical planning using the convolutional neural network.

Qiu B, Guo J, Kraeima J, Glas HH, Borra RJH, Witjes MJH, van Ooijen PMA.

Phys Med Biol. 2019 Sep 5;64(17):175020. doi: 10.1088/1361-6560/ab2c95.


Introduction of a three-dimensional computed tomography measurement method for acetabular fractures.

Meesters AML, Kraeima J, Banierink H, Slump CH, de Vries JPPM, Ten Duis K, Witjes MJH, IJpma FFA.

PLoS One. 2019 Jun 19;14(6):e0218612. doi: 10.1371/journal.pone.0218612. eCollection 2019.


High rate of unexpected lymphatic drainage patterns and a high accuracy of the sentinel lymph node biopsy in oral cancer after previous neck treatment.

den Toom IJ, Boeve K, van Weert S, Bloemena E, Brouwers AH, Hoekstra OS, de Keizer B, van der Vegt B, Willems SM, Leemans CR, Witjes MJH, de Bree R.

Oral Oncol. 2019 Jul;94:68-72. doi: 10.1016/j.oraloncology.2019.05.007. Epub 2019 May 21.


Addition of tumour infiltration depth and extranodal extension improves the prognostic value of the pathological TNM classification for early-stage oral squamous cell carcinoma.

Boeve K, Melchers LJ, Schuuring E, Roodenburg JL, Halmos GB, van Dijk BA, van der Vegt B, Witjes MJ.

Histopathology. 2019 Sep;75(3):329-337. doi: 10.1111/his.13886. Epub 2019 Jul 29.


Light Up the Tissue and Brighten Your Patients' Odds.

Witjes MJH, Betz CS, van Dam GM.

Ann Surg Oncol. 2019 May;26(5):1184-1185. doi: 10.1245/s10434-019-07280-4. Epub 2019 Mar 7. No abstract available.


Functional Swallowing Units (FSUs) as organs-at-risk for radiotherapy. PART 2: Advanced delineation guidelines for FSUs.

Gawryszuk A, Bijl HP, Holwerda M, Halmos GB, Wedman J, Witjes MJH, van der Vliet AM, Dorgelo B, Langendijk JA.

Radiother Oncol. 2019 Jan;130:68-74. doi: 10.1016/j.radonc.2018.09.022. Epub 2018 Dec 11.


Variation in Integrated Head and Neck Cancer Care: Impact of Patient and Hospital Characteristics.

van Overveld LFJ, Takes RP, Braspenning JCC, Baatenburg de Jong RJ, de Boer JP, Brouns JJA, Bun RJ, Dik EA, van Dijk BAC, van Es RJJ, Hoebers FJP, Kolenaar B, Kropveld A, Langeveld TPM, Verschuur HP, de Visscher JGAM, van Weert S, Witjes MJH, Smeele LE, Merkx MAW, Hermens RPMG.

J Natl Compr Canc Netw. 2018 Dec;16(12):1491-1498. doi: 10.6004/jnccn.2018.7061.


Functional Swallowing Units (FSUs) as organs-at-risk for radiotherapy. PART 1: Physiology and anatomy.

Gawryszuk A, Bijl HP, Holwerda M, Halmos GB, Wedman J, Witjes MJH, van der Vliet AM, Dorgelo B, Langendijk JA.

Radiother Oncol. 2019 Jan;130:62-67. doi: 10.1016/j.radonc.2018.10.028. Epub 2018 Nov 9.


[Spontaneous numbness along with pre-existing deviations in the pigmentation of the lower lip].

Gareb B, Witjes MJH.

Ned Tijdschr Tandheelkd. 2018 Oct;125(10):517-523. doi: 10.5177/ntvt.2018.10.18142. Dutch.


Effect of adjuvant radiotherapy on the local recurrence of oral squamous cell carcinoma with perineural invasion: A systematic review.

Vonk J, Smit KA, Roodenburg JLN, van der Vegt B, Halmos GB, Vemer-van den Hoek JGM, Dijkstra PU, Witjes MJH.

Clin Otolaryngol. 2019 Mar;44(2):131-137. doi: 10.1111/coa.13239. Epub 2018 Oct 30.


Multi-modality 3D mandibular resection planning in head and neck cancer using CT and MRI data fusion: A clinical series.

Kraeima J, Dorgelo B, Gulbitti HA, Steenbakkers RJHM, Schepman KP, Roodenburg JLN, Spijkervet FKL, Schepers RH, Witjes MJH.

Oral Oncol. 2018 Jun;81:22-28. doi: 10.1016/j.oraloncology.2018.03.013. Epub 2018 Apr 11.


Epidermal growth factor receptor (EGFR) density may not be the only determinant for the efficacy of EGFR-targeted photoimmunotherapy in human head and neck cancer cell lines.

Peng W, de Bruijn HS, Farrell E, Sioud M, Mashayekhi V, Oliveira S, van Dam GM, Roodenburg JLN, Witjes MJH, Robinson DJ.

Lasers Surg Med. 2018 Jul;50(5):513-522. doi: 10.1002/lsm.22930. Epub 2018 May 19.


Patient-specific pre-contouring of osteosynthesis plates for mandibular reconstruction: Using a three-dimensional key printed solution.

Kraeima J, Glas HH, Witjes MJH, Schepman KP.

J Craniomaxillofac Surg. 2018 Jun;46(6):1037-1040. doi: 10.1016/j.jcms.2018.03.022. Epub 2018 Apr 6.


Optimisation of three-dimensional lower jaw resection margin planning using a novel Black Bone magnetic resonance imaging protocol.

Hoving AM, Kraeima J, Schepers RH, Dijkstra H, Potze JH, Dorgelo B, Witjes MJH.

PLoS One. 2018 Apr 20;13(4):e0196059. doi: 10.1371/journal.pone.0196059. eCollection 2018.


Accuracy Assessment of Pedicle and Lateral Mass Screw Insertion Assisted by Customized 3D-Printed Drill Guides: A Human Cadaver Study.

Pijpker PAJ, Kraeima J, Witjes MJH, Oterdoom DLM, Coppes MH, Groen RJM, Kuijlen JMA.

Oper Neurosurg (Hagerstown). 2019 Jan 1;16(1):94-102. doi: 10.1093/ons/opy060.


Development of a patient-specific temporomandibular joint prosthesis according to the Groningen principle through a cadaver test series.

Kraeima J, Merema BJ, Witjes MJH, Spijkervet FKL.

J Craniomaxillofac Surg. 2018 May;46(5):779-784. doi: 10.1016/j.jcms.2018.03.004. Epub 2018 Mar 14.


High sensitivity and negative predictive value of sentinel lymph node biopsy in a retrospective early stage oral cavity cancer cohort in the Northern Netherlands.

Boeve K, Schepman KP, Schuuring E, Roodenburg JLN, Halmos GB, van Dijk BAC, Boorsma RAC, de Visscher JGAM, Brouwers AH, van der Vegt B, Witjes MJH.

Clin Otolaryngol. 2018 Mar 25. doi: 10.1111/coa.13107. [Epub ahead of print]


A clinicopathological study and prognostic factor analysis of 177 salivary duct carcinoma patients from The Netherlands.

Boon E, Bel M, van Boxtel W, van der Graaf WTA, van Es RJJ, Eerenstein SEJ, Baatenburg de Jong RJ, van den Brekel MWM, van der Velden LA, Witjes MJH, Hoeben A, Willems SM, Bloemena E, Smit LA, Oosting SF; PALGA Group, Jonker MA, Flucke UE, van Herpen CML.

Int J Cancer. 2018 Aug 15;143(4):758-766. doi: 10.1002/ijc.31353. Epub 2018 Mar 23.


Impact of 3D virtual planning on reconstruction of mandibular and maxillary surgical defects in head and neck oncology.

Witjes MJH, Schepers RH, Kraeima J.

Curr Opin Otolaryngol Head Neck Surg. 2018 Apr;26(2):108-114. doi: 10.1097/MOO.0000000000000437. Review.


Virtual 3D planning of tracheostomy placement and clinical applicability of 3D cannula design: a three-step study.

de Kleijn BJ, Kraeima J, Wachters JE, van der Laan BFAM, Wedman J, Witjes MJH, Halmos GB.

Eur Arch Otorhinolaryngol. 2018 Feb;275(2):451-457. doi: 10.1007/s00405-017-4819-x. Epub 2017 Nov 24.


Patients with advanced periodontal disease before intensity-modulated radiation therapy are prone to develop bone healing problems: a 2-year prospective follow-up study.

Schuurhuis JM, Stokman MA, Witjes MJH, Reintsema H, Langendijk JA, Vissink A, Spijkervet FKL.

Support Care Cancer. 2018 Apr;26(4):1133-1142. doi: 10.1007/s00520-017-3934-y. Epub 2017 Oct 31.


The design, production and clinical application of 3D patient-specific implants with drilling guides for acetabular surgery.

Merema BJ, Kraeima J, Ten Duis K, Wendt KW, Warta R, Vos E, Schepers RH, Witjes MJH, IJpma FFA.

Injury. 2017 Nov;48(11):2540-2547. doi: 10.1016/j.injury.2017.08.059. Epub 2017 Aug 30.


Secondary surgical management of osteoradionecrosis using three-dimensional isodose curve visualization: a report of three cases.

Kraeima J, Steenbakkers RJHM, Spijkervet FKL, Roodenburg JLN, Witjes MJH.

Int J Oral Maxillofac Surg. 2018 Feb;47(2):214-219. doi: 10.1016/j.ijom.2017.08.002. Epub 2017 Sep 4.


Improving the prediction of overall survival for head and neck cancer patients using image biomarkers in combination with clinical parameters.

Zhai TT, van Dijk LV, Huang BT, Lin ZX, Ribeiro CO, Brouwer CL, Oosting SF, Halmos GB, Witjes MJH, Langendijk JA, Steenbakkers RJHM, Sijtsema NM.

Radiother Oncol. 2017 Aug;124(2):256-262. doi: 10.1016/j.radonc.2017.07.013. Epub 2017 Jul 29.


Tyrosine kinase inhibitor induced growth factor receptor upregulation enhances the efficacy of near-infrared targeted photodynamic therapy in esophageal adenocarcinoma cell lines.

Hartmans E, Linssen MD, Sikkens C, Levens A, Witjes MJH, van Dam GM, Nagengast WB.

Oncotarget. 2017 May 2;8(18):29846-29856. doi: 10.18632/oncotarget.16165.


Lymphatic drainage patterns of oral maxillary tumors: Approachable locations of sentinel lymph nodes mainly at the cervical neck level.

Boeve K, Schepman KP, Vegt BV, Schuuring E, Roodenburg JL, Brouwers AH, Witjes MJ.

Head Neck. 2017 Mar;39(3):486-491. doi: 10.1002/hed.24628. Epub 2016 Dec 22.


Meta-analysis of 701 published cases of sinonasal neuroendocrine carcinoma: The importance of differentiation grade in determining treatment strategy.

van der Laan TP, Iepsma R, Witjes MJ, van der Laan BF, Plaat BE, Halmos GB.

Oral Oncol. 2016 Dec;63:1-9. doi: 10.1016/j.oraloncology.2016.10.002. Epub 2016 Oct 31. Review.


Amplification and protein overexpression of cyclin D1: Predictor of occult nodal metastasis in early oral cancer.

Noorlag R, Boeve K, Witjes MJ, Koole R, Peeters TL, Schuuring E, Willems SM, van Es RJ.

Head Neck. 2017 Feb;39(2):326-333. doi: 10.1002/hed.24584. Epub 2016 Sep 21.


Impact of chemotherapy on the outcome of osteosarcoma of the head and neck in adults.

Boon E, van der Graaf WT, Gelderblom H, Tesselaar ME, van Es RJ, Oosting SF, de Bree R, van Meerten E, Hoeben A, Smeele LE, Willems SM, Witjes MJ, Buter J, Baatenburg de Jong RJ, Flucke UE, Peer PG, Bovée JV, Van Herpen CM.

Head Neck. 2017 Jan;39(1):140-146. doi: 10.1002/hed.24556. Epub 2016 Aug 10.


A comparison of weekly versus 3-weekly cisplatin during adjuvant radiotherapy for high-risk head and neck cancer.

Oosting SF, Chen TWW, Huang SH, Wang L, Waldron J, Gilbert R, Goldstein D, Halmos GB, Witjes MJH, Gietema JA, O'Sullivan B, Langendijk JA, Siu LL, Hansen AR.

Oral Oncol. 2016 Aug;59:43-49. doi: 10.1016/j.oraloncology.2016.05.016.


Management of the clinically N0 neck in squamous cell carcinoma of the maxillary alveolus and hard palate.

Os AD, Karakullukcu B, Leemans CR, Halmos GB, Roodenburg JL, Weert SV, Karagozoglu KH, Witjes MJ.

Head Neck. 2016 Dec;38(12):1794-1798. doi: 10.1002/hed.24511. Epub 2016 Jul 4.


Head and neck intensity modulated radiation therapy leads to an increase of opportunistic oral pathogens.

Schuurhuis JM, Stokman MA, Witjes MJ, Langendijk JA, van Winkelhoff AJ, Vissink A, Spijkervet FK.

Oral Oncol. 2016 Jul;58:32-40. doi: 10.1016/j.oraloncology.2016.05.005. Epub 2016 May 27.


A systematic review of functional outcome and quality of life following reconstruction of maxillofacial defects using vascularized free fibula flaps and dental rehabilitation reveals poor data quality.

Wijbenga JG, Schepers RH, Werker PM, Witjes MJ, Dijkstra PU.

J Plast Reconstr Aesthet Surg. 2016 Aug;69(8):1024-36. doi: 10.1016/j.bjps.2016.05.003. Epub 2016 May 13. Review.


Human Salivary Gland Stem Cells Functionally Restore Radiation Damaged Salivary Glands.

Pringle S, Maimets M, van der Zwaag M, Stokman MA, van Gosliga D, Zwart E, Witjes MJ, de Haan G, van Os R, Coppes RP.

Stem Cells. 2016 Mar;34(3):640-52. doi: 10.1002/stem.2278.


Accuracy of secondary maxillofacial reconstruction with prefabricated fibula grafts using 3D planning and guided reconstruction.

Schepers RH, Kraeima J, Vissink A, Lahoda LU, Roodenburg JL, Reintsema H, Raghoebar GM, Witjes MJ.

J Craniomaxillofac Surg. 2016 Apr;44(4):392-9. doi: 10.1016/j.jcms.2015.12.008. Epub 2016 Jan 6.


mTHPC mediated, systemic photodynamic therapy (PDT) for nonmelanoma skin cancers: Case and literature review.

Horlings RK, Terra JB, Witjes MJ.

Lasers Surg Med. 2015 Dec;47(10):779-87. doi: 10.1002/lsm.22429. Epub 2015 Oct 14. Review.


Sparing the region of the salivary gland containing stem cells preserves saliva production after radiotherapy for head and neck cancer.

van Luijk P, Pringle S, Deasy JO, Moiseenko VV, Faber H, Hovan A, Baanstra M, van der Laan HP, Kierkels RG, van der Schaaf A, Witjes MJ, Schippers JM, Brandenburg S, Langendijk JA, Wu J, Coppes RP.

Sci Transl Med. 2015 Sep 16;7(305):305ra147. doi: 10.1126/scitranslmed.aac4441.


Integration of oncologic margins in three-dimensional virtual planning for head and neck surgery, including a validation of the software pathway.

Kraeima J, Schepers RH, van Ooijen PM, Steenbakkers RJ, Roodenburg JL, Witjes MJ.

J Craniomaxillofac Surg. 2015 Oct;43(8):1374-9. doi: 10.1016/j.jcms.2015.07.015. Epub 2015 Jul 30.


Accuracy of fibula reconstruction using patient-specific CAD/CAM reconstruction plates and dental implants: A new modality for functional reconstruction of mandibular defects.

Schepers RH, Raghoebar GM, Vissink A, Stenekes MW, Kraeima J, Roodenburg JL, Reintsema H, Witjes MJ.

J Craniomaxillofac Surg. 2015 Jun;43(5):649-57. doi: 10.1016/j.jcms.2015.03.015. Epub 2015 Mar 27.


Detection of HPV-associated oropharyngeal tumours in a 16-year cohort: more than meets the eye.

Melchers LJ, Mastik MF, Samaniego Cameron B, van Dijk BA, de Bock GH, van der Laan BF, van der Vegt B, Speel EJ, Roodenburg JL, Witjes MJ, Schuuring E.

Br J Cancer. 2015 Apr 14;112(8):1349-57. doi: 10.1038/bjc.2015.99. Epub 2015 Mar 17.


Predictive value of the Groningen Frailty Indicator for treatment outcomes in elderly patients after head and neck, or skin cancer surgery in a retrospective cohort.

Bras L, Peters TT, Wedman J, Plaat BE, Witjes MJ, van Leeuwen BL, van der Laan BF, Halmos GB.

Clin Otolaryngol. 2015 Oct;40(5):474-82. doi: 10.1111/coa.12409.


Evidence supporting pre-radiation elimination of oral foci of infection in head and neck cancer patients to prevent oral sequelae. A systematic review.

Schuurhuis JM, Stokman MA, Witjes MJ, Dijkstra PU, Vissink A, Spijkervet FK.

Oral Oncol. 2015 Mar;51(3):212-20. doi: 10.1016/j.oraloncology.2014.11.017. Epub 2014 Dec 15. Review.


Photochemical internalization (PCI)-mediated enhancement of bleomycin cytotoxicity by liposomal mTHPC formulations in human head and neck cancer cells.

Peng W, Samplonius DF, de Visscher S, Roodenburg JL, Helfrich W, Witjes MJ.

Lasers Surg Med. 2014 Oct;46(8):650-8. doi: 10.1002/lsm.22281. Epub 2014 Aug 30.


Overdentures on primary mandibular implants in patients with oral cancer: a follow-up study over 14 years.

Korfage A, Raghoebar GM, Slater JJ, Roodenburg JL, Witjes MJ, Vissink A, Reintsema H.

Br J Oral Maxillofac Surg. 2014 Nov;52(9):798-805. doi: 10.1016/j.bjoms.2014.05.013. Epub 2014 Jun 17. Erratum in: Br J Oral Maxillofac Surg. 2015 Apr;53(4):e23-5.


Localization of liposomal mTHPC formulations within normal epithelium, dysplastic tissue, and carcinoma of oral epithelium in the 4NQO-carcinogenesis rat model.

de Visscher SA, Witjes MJ, van der Vegt B, de Bruijn HS, van der Ploeg-van den Heuvel A, Amelink A, Sterenborg HJ, Roodenburg JL, Robinson DJ.

Lasers Surg Med. 2013 Dec;45(10):668-78. doi: 10.1002/lsm.22197. Epub 2013 Oct 30.


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