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Items: 1 to 50 of 179

1.

Growth and accumulation dynamics of poly(3-hydroxyalkanoate) (PHA) in Pseudomonas putida GPo1 cultivated in continuous culture under transient feed conditions.

Zinn M, Durner R, Zinn H, Ren Q, Egli T, Witholt B.

Biotechnol J. 2011 Oct;6(10):1240-52. doi: 10.1002/biot.201100219. Epub 2011 Aug 10.

PMID:
21751398
2.

Influence of growth stage on activities of polyhydroxyalkanoate (PHA) polymerase and PHA depolymerase in Pseudomonas putida U.

Ren Q, de Roo G, Witholt B, Zinn M, Thöny-Meyer L.

BMC Microbiol. 2010 Oct 11;10:254. doi: 10.1186/1471-2180-10-254.

3.

Simultaneous biosynthesis of two copolymers in Pseudomonas putida GPo1 using a two-stage continuous culture system.

Hartmann R, Hany R, Witholt B, Zinn M.

Biomacromolecules. 2010 Jun 14;11(6):1488-93. doi: 10.1021/bm100118t.

PMID:
20459087
4.

Overexpression and characterization of medium-chain-length polyhydroxyalkanoate granule bound polymerases from Pseudomonas putida GPo1.

Ren Q, de Roo G, Witholt B, Zinn M, Thöny-Meyer L.

Microb Cell Fact. 2009 Nov 19;8:60. doi: 10.1186/1475-2859-8-60.

5.

Simultaneous accumulation and degradation of polyhydroxyalkanoates: futile cycle or clever regulation?

Ren Q, de Roo G, Ruth K, Witholt B, Zinn M, Thöny-Meyer L.

Biomacromolecules. 2009 Apr 13;10(4):916-22. doi: 10.1021/bm801431c.

PMID:
19267463
6.

Carbon metabolism and product inhibition determine the epoxidation efficiency of solvent-tolerant Pseudomonas sp. strain VLB120DeltaC.

Park JB, Bühler B, Panke S, Witholt B, Schmid A.

Biotechnol Bioeng. 2007 Dec 15;98(6):1219-29.

PMID:
17514751
7.

CYP153A6, a soluble P450 oxygenase catalyzing terminal-alkane hydroxylation.

Funhoff EG, Bauer U, García-Rubio I, Witholt B, van Beilen JB.

J Bacteriol. 2006 Jul;188(14):5220-7.

8.

The efficiency of recombinant Escherichia coli as biocatalyst for stereospecific epoxidation.

Park JB, Bühler B, Habicher T, Hauer B, Panke S, Witholt B, Schmid A.

Biotechnol Bioeng. 2006 Oct 20;95(3):501-12.

PMID:
16767777
9.
10.

Selection of biocatalysts for chemical synthesis.

van Sint Fiet S, van Beilen JB, Witholt B.

Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1693-8. Epub 2006 Jan 30.

11.

Cytochrome P450 alkane hydroxylases of the CYP153 family are common in alkane-degrading eubacteria lacking integral membrane alkane hydroxylases.

van Beilen JB, Funhoff EG, van Loon A, Just A, Kaysser L, Bouza M, Holtackers R, Röthlisberger M, Li Z, Witholt B.

Appl Environ Microbiol. 2006 Jan;72(1):59-65.

13.

Tailor-made olefinic medium-chain-length poly[(R)-3-hydroxyalkanoates] by Pseudomonas putida GPo1: batch versus chemostat production.

Hartmann R, Hany R, Pletscher E, Ritter A, Witholt B, Zinn M.

Biotechnol Bioeng. 2006 Mar 5;93(4):737-46.

PMID:
16255038
14.

Poly(3-hydroxyalkanoate) polymerase synthesis and in vitro activity in recombinant Escherichia coli and Pseudomonas putida.

Ren Q, de Roo G, van Beilen JB, Zinn M, Kessler B, Witholt B.

Appl Microbiol Biotechnol. 2005 Dec;69(3):286-92. Epub 2005 Nov 15.

PMID:
15846484
15.

Biocatalytic production of perillyl alcohol from limonene by using a novel Mycobacterium sp. cytochrome P450 alkane hydroxylase expressed in Pseudomonas putida.

van Beilen JB, Holtackers R, Lüscher D, Bauer U, Witholt B, Duetz WA.

Appl Environ Microbiol. 2005 Apr;71(4):1737-44.

16.

Expression of PHA polymerase genes of Pseudomonas putida in Escherichia coli and its effect on PHA formation.

Ren Q, van Beilen JB, Sierro N, Zinn M, Kessler B, Witholt B.

Antonie Van Leeuwenhoek. 2005 Feb;87(2):91-100.

PMID:
15793618
17.

Identification of an amino acid position that determines the substrate range of integral membrane alkane hydroxylases.

van Beilen JB, Smits TH, Roos FF, Brunner T, Balada SB, Röthlisberger M, Witholt B.

J Bacteriol. 2005 Jan;187(1):85-91.

18.

Dual nutrient limited growth: models, experimental observations, and applications.

Zinn M, Witholt B, Egli T.

J Biotechnol. 2004 Sep 30;113(1-3):263-79. Review.

PMID:
15380660
19.

Rapid identification of new bacterial alcohol dehydrogenases for (R)- and (S)-enantioselective reduction of ss-ketoesters.

Zhang J, Duetz WA, Witholt B, Li Z.

Chem Commun (Camb). 2004 Sep 21;(18):2120-1. Epub 2004 Aug 6.

PMID:
15368004
20.
21.

Biochemical characterization of StyAB from Pseudomonas sp. strain VLB120 as a two-component flavin-diffusible monooxygenase.

Otto K, Hofstetter K, Röthlisberger M, Witholt B, Schmid A.

J Bacteriol. 2004 Aug;186(16):5292-302.

22.

Coupling of biocatalytic asymmetric epoxidation with NADH regeneration in organic-aqueous emulsions.

Hofstetter K, Lutz J, Lang I, Witholt B, Schmid A.

Angew Chem Int Ed Engl. 2004 Apr 13;43(16):2163-6. No abstract available.

PMID:
15083473
23.

High-throughput measurement of the enantiomeric excess of chiral alcohols by using two enzymes.

Li Z, Bütikofer L, Witholt B.

Angew Chem Int Ed Engl. 2004 Mar 19;43(13):1698-702. No abstract available.

PMID:
15038041
24.

Characterization of two alkane hydroxylase genes from the marine hydrocarbonoclastic bacterium Alcanivorax borkumensis.

van Beilen JB, Marín MM, Smits TH, Röthlisberger M, Franchini AG, Witholt B, Rojo F.

Environ Microbiol. 2004 Mar;6(3):264-73.

PMID:
14871210
25.
26.

Functional characterization of genes involved in alkane oxidation by Pseudomonas aeruginosa.

Smits TH, Witholt B, van Beilen JB.

Antonie Van Leeuwenhoek. 2003;84(3):193-200.

PMID:
14574114
27.

Production of 6-phenylacetylene picolinic acid from diphenylacetylene by a toluene-degrading Acinetobacter strain.

Spain JC, Nishino SF, Witholt B, Tan LS, Duetz WA.

Appl Environ Microbiol. 2003 Jul;69(7):4037-42.

28.

Stereospecific biocatalytic epoxidation: the first example of direct regeneration of a FAD-dependent monooxygenase for catalysis.

Hollmann F, Lin PC, Witholt B, Schmid A.

J Am Chem Soc. 2003 Jul 9;125(27):8209-17.

PMID:
12837091
29.
30.

Biotransformation of limonene by bacteria, fungi, yeasts, and plants.

Duetz WA, Bouwmeester H, van Beilen JB, Witholt B.

Appl Microbiol Biotechnol. 2003 May;61(4):269-77. Epub 2003 Mar 15. Review.

PMID:
12743755
31.

Chemical biotechnology for the specific oxyfunctionalization of hydrocarbons on a technical scale.

Bühler B, Bollhalder I, Hauer B, Witholt B, Schmid A.

Biotechnol Bioeng. 2003 Jun 30;82(7):833-42.

PMID:
12701150
32.

Practical issues in the application of oxygenases.

van Beilen JB, Duetz WA, Schmid A, Witholt B.

Trends Biotechnol. 2003 Apr;21(4):170-7. Review.

PMID:
12679065
33.

Crystallization and preliminary X-ray analysis of native and selenomethionine 2-hydroxybiphenyl 3-monooxygenase.

Meyer A, Tanner D, Schmid A, Sargent DF, Kohler HP, Witholt B.

Acta Crystallogr D Biol Crystallogr. 2003 Apr;59(Pt 4):741-3. Epub 2003 Mar 25.

PMID:
12657798
34.

Cloning of Baeyer-Villiger monooxygenases from Comamonas, Xanthobacter and Rhodococcus using polymerase chain reaction with highly degenerate primers.

Van Beilen JB, Mourlane F, Seeger MA, Kovac J, Li Z, Smits TH, Fritsche U, Witholt B.

Environ Microbiol. 2003 Mar;5(3):174-82.

PMID:
12588297
35.

Use of the two-liquid phase concept to exploit kinetically controlled multistep biocatalysis.

Bühler B, Bollhalder I, Hauer B, Witholt B, Schmid A.

Biotechnol Bioeng. 2003 Mar 20;81(6):683-94.

PMID:
12529882
36.

Synthesis of 3-tert-butylcatechol by an engineered monooxygenase.

Meyer A, Held M, Schmid A, Kohler HP, Witholt B.

Biotechnol Bioeng. 2003 Mar 5;81(5):518-24.

PMID:
12514800
37.

Alkane hydroxylase homologues in Gram-positive strains.

van Beilen JB, Smits TH, Whyte LG, Schorcht S, Röthlisberger M, Plaggemeier T, Engesser KH, Witholt B.

Environ Microbiol. 2002 Nov;4(11):676-82.

PMID:
12460275
38.

Gene cloning and characterization of multiple alkane hydroxylase systems in Rhodococcus strains Q15 and NRRL B-16531.

Whyte LG, Smits TH, Labbé D, Witholt B, Greer CW, van Beilen JB.

Appl Environ Microbiol. 2002 Dec;68(12):5933-42.

39.

Pilot-scale production of (S)-styrene oxide from styrene by recombinant Escherichia coli synthesizing styrene monooxygenase.

Panke S, Held M, Wubbolts MG, Witholt B, Schmid A.

Biotechnol Bioeng. 2002 Oct 5;80(1):33-41.

PMID:
12209784
40.

Hydroxylation of indole by laboratory-evolved 2-hydroxybiphenyl 3-monooxygenase.

Meyer A, Würsten M, Schmid A, Kohler HP, Witholt B.

J Biol Chem. 2002 Sep 13;277(37):34161-7. Epub 2002 Jul 8.

41.

Oxidative biotransformations using oxygenases.

Li Z, van Beilen JB, Duetz WA, Schmid A, de Raadt A, Griengl H, Witholt B.

Curr Opin Chem Biol. 2002 Apr;6(2):136-44. Review.

PMID:
12038996
42.

Practical syntheses of N-substituted 3-hydroxyazetidines and 4-hydroxypiperidines by hydroxylation with Sphingomonas sp. HXN-200.

Chang D, Feiten HJ, Engesser KH, van Beilen JB, Witholt B, Li Z.

Org Lett. 2002 May 30;4(11):1859-62.

PMID:
12027632
43.

Functional analysis of alkane hydroxylases from gram-negative and gram-positive bacteria.

Smits TH, Balada SB, Witholt B, van Beilen JB.

J Bacteriol. 2002 Mar;184(6):1733-42.

44.

Rubredoxins involved in alkane oxidation.

van Beilen JB, Neuenschwander M, Smits TH, Roth C, Balada SB, Witholt B.

J Bacteriol. 2002 Mar;184(6):1722-32.

45.

Characterization and application of xylene monooxygenase for multistep biocatalysis.

Bühler B, Witholt B, Hauer B, Schmid A.

Appl Environ Microbiol. 2002 Feb;68(2):560-8.

46.
47.

Changing the substrate reactivity of 2-hydroxybiphenyl 3-monooxygenase from Pseudomonas azelaica HBP1 by directed evolution.

Meyer A, Schmid A, Held M, Westphal AH, Rothlisberger M, Kohler HP, van Berkel WJ, Witholt B.

J Biol Chem. 2002 Feb 15;277(7):5575-82. Epub 2001 Dec 3.

48.
49.

Occurrence, synthesis and medical application of bacterial polyhydroxyalkanoate.

Zinn M, Witholt B, Egli T.

Adv Drug Deliv Rev. 2001 Dec 3;53(1):5-21. Review.

PMID:
11733115
50.

Using proteins in their natural environment: potential and limitations of microbial whole-cell hydroxylations in applied biocatalysis.

Duetz WA, van Beilen JB, Witholt B.

Curr Opin Biotechnol. 2001 Aug;12(4):419-25. Review.

PMID:
11551473

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