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Items: 37


Characterization of P. falciparum dipeptidyl aminopeptidase 3 specificity identifies differences in amino acid preferences between peptide-based substrates and covalent inhibitors.

de Vries LE, Sanchez MI, Groborz K, Kuppens L, Poreba M, Lehmann C, Nevins N, Withers-Martinez C, Hirst DJ, Yuan F, Arastu-Kapur S, Horn M, Mares M, Bogyo M, Drag M, Deu E.

FEBS J. 2019 Oct;286(20):3998-4023. doi: 10.1111/febs.14953. Epub 2019 Jun 24.


Cyclic AMP signalling controls key components of malaria parasite host cell invasion machinery.

Patel A, Perrin AJ, Flynn HR, Bisson C, Withers-Martinez C, Treeck M, Flueck C, Nicastro G, Martin SR, Ramos A, Gilberger TW, Snijders AP, Blackman MJ, Baker DA.

PLoS Biol. 2019 May 10;17(5):e3000264. doi: 10.1371/journal.pbio.3000264. eCollection 2019 May.


Peptidomimetic plasmepsin inhibitors with potent anti-malarial activity and selectivity against cathepsin D.

Zogota R, Kinena L, Withers-Martinez C, Blackman MJ, Bobrovs R, Pantelejevs T, Kanepe-Lapsa I, Ozola V, Jaudzems K, Suna E, Jirgensons A.

Eur J Med Chem. 2019 Feb 1;163:344-352. doi: 10.1016/j.ejmech.2018.11.068. Epub 2018 Nov 29.


Essentiality of Plasmodium falciparum plasmepsin V.

Boonyalai N, Collins CR, Hackett F, Withers-Martinez C, Blackman MJ.

PLoS One. 2018 Dec 5;13(12):e0207621. doi: 10.1371/journal.pone.0207621. eCollection 2018.


Targeted Deletion of a Plasmodium Site-2 Protease Impairs Life Cycle Progression in the Mammalian Host.

Koussis K, Goulielmaki E, Chalari A, Withers-Martinez C, Siden-Kiamos I, Matuschewski K, Loukeris TG.

PLoS One. 2017 Jan 20;12(1):e0170260. doi: 10.1371/journal.pone.0170260. eCollection 2017.


Processing of Plasmodium falciparum Merozoite Surface Protein MSP1 Activates a Spectrin-Binding Function Enabling Parasite Egress from RBCs.

Das S, Hertrich N, Perrin AJ, Withers-Martinez C, Collins CR, Jones ML, Watermeyer JM, Fobes ET, Martin SR, Saibil HR, Wright GJ, Treeck M, Epp C, Blackman MJ.

Cell Host Microbe. 2015 Oct 14;18(4):433-44. doi: 10.1016/j.chom.2015.09.007.


Plasmodium falciparum SERA5 plays a non-enzymatic role in the malarial asexual blood-stage lifecycle.

Stallmach R, Kavishwar M, Withers-Martinez C, Hackett F, Collins CR, Howell SA, Yeoh S, Knuepfer E, Atid AJ, Holder AA, Blackman MJ.

Mol Microbiol. 2015 Apr;96(2):368-87. doi: 10.1111/mmi.12941. Epub 2015 Feb 11.


The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin.

Withers-Martinez C, Strath M, Hackett F, Haire LF, Howell SA, Walker PA, Christodoulou E, Dodson GG, Blackman MJ.

Nat Commun. 2014 May 2;5:3726. doi: 10.1038/ncomms4726. Erratum in: Nat Commun. 2014;5:4031. Evangelos, Christodoulou [corrected to Christodoulou, Evangelos].


Identification of a Plasmodium falciparum phospholipid transfer protein.

van Ooij C, Withers-Martinez C, Ringel A, Cockcroft S, Haldar K, Blackman MJ.

J Biol Chem. 2013 Nov 1;288(44):31971-83. doi: 10.1074/jbc.M113.474189. Epub 2013 Sep 16.


Molecular determinants for subcellular trafficking of the malarial sheddase PfSUB2.

Child MA, Harris PK, Collins CR, Withers-Martinez C, Yeoh S, Blackman MJ.

Traffic. 2013 Oct;14(10):1053-64. doi: 10.1111/tra.12092. Epub 2013 Jul 30.


Malaria parasite cGMP-dependent protein kinase regulates blood stage merozoite secretory organelle discharge and egress.

Collins CR, Hackett F, Strath M, Penzo M, Withers-Martinez C, Baker DA, Blackman MJ.

PLoS Pathog. 2013 May;9(5):e1003344. doi: 10.1371/journal.ppat.1003344. Epub 2013 May 9.


Molecular determinants of binding to the Plasmodium subtilisin-like protease 1.

Fulle S, Withers-Martinez C, Blackman MJ, Morris GM, Finn PW.

J Chem Inf Model. 2013 Mar 25;53(3):573-83. doi: 10.1021/ci300581z. Epub 2013 Mar 4.


Proteolytic activation of the essential parasitophorous vacuole cysteine protease SERA6 accompanies malaria parasite egress from its host erythrocyte.

Ruecker A, Shea M, Hackett F, Suarez C, Hirst EM, Milutinovic K, Withers-Martinez C, Blackman MJ.

J Biol Chem. 2012 Nov 2;287(45):37949-63. doi: 10.1074/jbc.M112.400820. Epub 2012 Sep 14.


Plasmodium subtilisin-like protease 1 (SUB1): insights into the active-site structure, specificity and function of a pan-malaria drug target.

Withers-Martinez C, Suarez C, Fulle S, Kher S, Penzo M, Ebejer JP, Koussis K, Hackett F, Jirgensons A, Finn P, Blackman MJ.

Int J Parasitol. 2012 May 15;42(6):597-612. doi: 10.1016/j.ijpara.2012.04.005. Epub 2012 Apr 27.


Juxtamembrane shedding of Plasmodium falciparum AMA1 is sequence independent and essential, and helps evade invasion-inhibitory antibodies.

Olivieri A, Collins CR, Hackett F, Withers-Martinez C, Marshall J, Flynn HR, Skehel JM, Blackman MJ.

PLoS Pathog. 2011 Dec;7(12):e1002448. doi: 10.1371/journal.ppat.1002448. Epub 2011 Dec 15. Erratum in: PLoS Pathog. 2012 Feb;8(2). doi:10.1371/annotation/72b02b2e-460a-44f4-bc87-067cfe76bfdb.


Global identification of multiple substrates for Plasmodium falciparum SUB1, an essential malarial processing protease.

Silmon de Monerri NC, Flynn HR, Campos MG, Hackett F, Koussis K, Withers-Martinez C, Skehel JM, Blackman MJ.

Infect Immun. 2011 Mar;79(3):1086-97. doi: 10.1128/IAI.00902-10. Epub 2011 Jan 10.


A multifunctional serine protease primes the malaria parasite for red blood cell invasion.

Koussis K, Withers-Martinez C, Yeoh S, Child M, Hackett F, Knuepfer E, Juliano L, Woehlbier U, Bujard H, Blackman MJ.

EMBO J. 2009 Mar 18;28(6):725-35. doi: 10.1038/emboj.2009.22. Epub 2009 Feb 12.


An inhibitory antibody blocks interactions between components of the malarial invasion machinery.

Collins CR, Withers-Martinez C, Hackett F, Blackman MJ.

PLoS Pathog. 2009 Jan;5(1):e1000273. doi: 10.1371/journal.ppat.1000273. Epub 2009 Jan 23.


Subcellular discharge of a serine protease mediates release of invasive malaria parasites from host erythrocytes.

Yeoh S, O'Donnell RA, Koussis K, Dluzewski AR, Ansell KH, Osborne SA, Hackett F, Withers-Martinez C, Mitchell GH, Bannister LH, Bryans JS, Kettleborough CA, Blackman MJ.

Cell. 2007 Dec 14;131(6):1072-83.


Malarial EBA-175 region VI crystallographic structure reveals a KIX-like binding interface.

Withers-Martinez C, Haire LF, Hackett F, Walker PA, Howell SA, Smerdon SJ, Dodson GG, Blackman MJ.

J Mol Biol. 2008 Jan 18;375(3):773-81. Epub 2007 Nov 1.


Molecules incorporating a benzothiazole core scaffold inhibit the N-myristoyltransferase of Plasmodium falciparum.

Bowyer PW, Gunaratne RS, Grainger M, Withers-Martinez C, Wickramsinghe SR, Tate EW, Leatherbarrow RJ, Brown KA, Holder AA, Smith DF.

Biochem J. 2007 Dec 1;408(2):173-80.


Fine mapping of an epitope recognized by an invasion-inhibitory monoclonal antibody on the malaria vaccine candidate apical membrane antigen 1.

Collins CR, Withers-Martinez C, Bentley GA, Batchelor AH, Thomas AW, Blackman MJ.

J Biol Chem. 2007 Mar 9;282(10):7431-41. Epub 2006 Dec 27.


Intramembrane proteolysis mediates shedding of a key adhesin during erythrocyte invasion by the malaria parasite.

O'Donnell RA, Hackett F, Howell SA, Treeck M, Struck N, Krnajski Z, Withers-Martinez C, Gilberger TW, Blackman MJ.

J Cell Biol. 2006 Sep 25;174(7):1023-33.


Molecular identification of a malaria merozoite surface sheddase.

Harris PK, Yeoh S, Dluzewski AR, O'Donnell RA, Withers-Martinez C, Hackett F, Bannister LH, Mitchell GH, Blackman MJ.

PLoS Pathog. 2005 Nov;1(3):241-51. Epub 2005 Nov 25.


Unique insertions within Plasmodium falciparum subtilisin-like protease-1 are crucial for enzyme maturation and activity.

Jean L, Withers-Martinez C, Hackett F, Blackman MJ.

Mol Biochem Parasitol. 2005 Dec;144(2):187-97. Epub 2005 Sep 8.


Distinct mechanisms govern proteolytic shedding of a key invasion protein in apicomplexan pathogens.

Howell SA, Hackett F, Jongco AM, Withers-Martinez C, Kim K, Carruthers VB, Blackman MJ.

Mol Microbiol. 2005 Sep;57(5):1342-56.


Crystal structure of the malaria vaccine candidate apical membrane antigen 1.

Pizarro JC, Vulliez-Le Normand B, Chesne-Seck ML, Collins CR, Withers-Martinez C, Hackett F, Blackman MJ, Faber BW, Remarque EJ, Kocken CH, Thomas AW, Bentley GA.

Science. 2005 Apr 15;308(5720):408-11. Epub 2005 Feb 24.


Subtilisin-like proteases of the malaria parasite.

Withers-Martinez C, Jean L, Blackman MJ.

Mol Microbiol. 2004 Jul;53(1):55-63. Review.


High-level expression of the malaria blood-stage vaccine candidate Plasmodium falciparum apical membrane antigen 1 and induction of antibodies that inhibit erythrocyte invasion.

Kocken CH, Withers-Martinez C, Dubbeld MA, van der Wel A, Hackett F, Valderrama A, Blackman MJ, Thomas AW.

Infect Immun. 2002 Aug;70(8):4471-6. Erratum in: Infect Immun 2002 Oct;70(10):5901.


Expression of recombinant Plasmodium falciparum subtilisin-like protease-1 in insect cells. Characterization, comparison with the parasite protease, and homology modeling.

Withers-Martinez C, Saldanha JW, Ely B, Hackett F, O'Connor T, Blackman MJ.

J Biol Chem. 2002 Aug 16;277(33):29698-709. Epub 2002 Jun 6.


Proteolytic processing and primary structure of Plasmodium falciparum apical membrane antigen-1.

Howell SA, Withers-Martinez C, Kocken CH, Thomas AW, Blackman MJ.

J Biol Chem. 2001 Aug 17;276(33):31311-20. Epub 2001 Jun 8.


PCR-based gene synthesis as an efficient approach for expression of the A+T-rich malaria genome.

Withers-Martinez C, Carpenter EP, Hackett F, Ely B, Sajid M, Grainger M, Blackman MJ.

Protein Eng. 1999 Dec;12(12):1113-20.


PfSUB-2: a second subtilisin-like protein in Plasmodium falciparum merozoites.

Hackett F, Sajid M, Withers-Martinez C, Grainger M, Blackman MJ.

Mol Biochem Parasitol. 1999 Oct 15;103(2):183-95.


Structural basis for the substrate selectivity of pancreatic lipases and some related proteins.

Carrière F, Withers-Martinez C, van Tilbeurgh H, Roussel A, Cambillau C, Verger R.

Biochim Biophys Acta. 1998 Nov 10;1376(3):417-32. Review.


Pancreatic lipase structure-function relationships by domain exchange.

Carrière F, Thirstrup K, Hjorth S, Ferrato F, Nielsen PF, Withers-Martinez C, Cambillau C, Boel E, Thim L, Verger R.

Biochemistry. 1997 Jan 7;36(1):239-48.


A pancreatic lipase with a phospholipase A1 activity: crystal structure of a chimeric pancreatic lipase-related protein 2 from guinea pig.

Withers-Martinez C, Carrière F, Verger R, Bourgeois D, Cambillau C.

Structure. 1996 Nov 15;4(11):1363-74.

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