Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 556

1.

Bilateral intracochlear schwannomas in a patient with no genetic or clinical features of neurofibromatosis type 2.

Withers S, Plontke SK, Boeddinghaus R, Kuthubutheen J, Atlas M.

HNO. 2019 Oct 9. doi: 10.1007/s00106-019-00752-9. [Epub ahead of print]

PMID:
31598774
2.

Perivascular Adipose Tissue Contributes to the Modulation of Vascular Tone in vivo.

Saxton SN, Withers SB, Nyvad J, Mazur A, Matchkov V, Heagerty AM, Aalkjær C.

J Vasc Res. 2019 Sep 24:1-13. doi: 10.1159/000502689. [Epub ahead of print]

PMID:
31550717
3.

Prospecting for α-N-acetylgalactosaminidases yields a new class of GH31 O-glycanase.

Rahfeld P, Wardman JF, Mehr K, Huff D, Morgan-Lang C, Chen HM, Hallam SJ, Withers SG.

J Biol Chem. 2019 Sep 17. pii: jbc.RA119.010628. doi: 10.1074/jbc.RA119.010628. [Epub ahead of print]

4.

Outcomes of hydrocephalus secondary to congenital toxoplasmosis.

McLone D, Frim D, Penn R, Swisher CN, Heydemann P, Boyer KM, Noble AG, Rabiah PK, Withers S, Wroblewski K, Karrison T, Hutson S, Wheeler K, Cohen W, Lykins J, McLeod R.

J Neurosurg Pediatr. 2019 Sep 6:1-8. doi: 10.3171/2019.6.PEDS18684. [Epub ahead of print]

PMID:
31491752
5.

Mechanistic Links Between Obesity, Diabetes, and Blood Pressure: Role of Perivascular Adipose Tissue.

Saxton SN, Clark BJ, Withers SB, Eringa EC, Heagerty AM.

Physiol Rev. 2019 Oct 1;99(4):1701-1763. doi: 10.1152/physrev.00034.2018.

PMID:
31339053
6.

Passaging of an influenza A(H1N1)pdm09 virus in a difluoro sialic acid inhibitor selects for a novel, but unfit I106M neuraminidase mutant.

McKimm-Breschkin JL, Barrett S, McKenzie-Kludas C, McAuley J, Streltsov VA, Withers SG.

Antiviral Res. 2019 Sep;169:104542. doi: 10.1016/j.antiviral.2019.104542. Epub 2019 Jun 22.

PMID:
31233807
7.

An enzymatic pathway in the human gut microbiome that converts A to universal O type blood.

Rahfeld P, Sim L, Moon H, Constantinescu I, Morgan-Lang C, Hallam SJ, Kizhakkedathu JN, Withers SG.

Nat Microbiol. 2019 Sep;4(9):1475-1485. doi: 10.1038/s41564-019-0469-7. Epub 2019 Jun 10.

PMID:
31182795
8.

Synthesis of modified 1,5-imino-d-xylitols as ligands for lysosomal β-glucocerebrosidase.

Zoidl M, Wolfsgruber A, Schalli M, Nasseri SA, Weber P, Stütz AE, Withers SG, Wrodnigg TM.

Monatsh Chem. 2019;150(5):831-842. doi: 10.1007/s00706-019-02427-1. Epub 2019 May 11.

9.

High-Throughput Recovery and Characterization of Metagenome-Derived Glycoside Hydrolase-Containing Clones as a Resource for Biocatalyst Development.

Armstrong Z, Liu F, Kheirandish S, Chen HM, Mewis K, Duo T, Morgan-Lang C, Hallam SJ, Withers SG.

mSystems. 2019 Jun 4;4(4). pii: e00082-19. doi: 10.1128/mSystems.00082-19.

10.

Publisher Correction: Toxoplasma Modulates Signature Pathways of Human Epilepsy, Neurodegeneration & Cancer.

Ngô HM, Zhou Y, Lorenzi H, Wang K, Kim TK, Zhou Y, El Bissati K, Mui E, Fraczek L, Rajagopala SV, Roberts CW, Henriquez FL, Montpetit A, Blackwell JM, Jamieson SE, Wheeler K, Begeman IJ, Naranjo-Galvis C, Alliey-Rodriguez N, Davis RG, Soroceanu L, Cobbs C, Steindler DA, Boyer K, Noble AG, Swisher CN, Heydemann PT, Rabiah P, Withers S, Soteropoulos P, Hood L, McLeod R.

Sci Rep. 2019 May 28;9(1):8110. doi: 10.1038/s41598-019-44545-0.

11.

Development and Application of a High-Throughput Functional Metagenomic Screen for Glycoside Phosphorylases.

Macdonald SS, Armstrong Z, Morgan-Lang C, Osowiecka M, Robinson K, Hallam SJ, Withers SG.

Cell Chem Biol. 2019 Jul 18;26(7):1001-1012.e5. doi: 10.1016/j.chembiol.2019.03.017. Epub 2019 May 9.

PMID:
31080075
12.

Probing the role of an invariant active site His in family GH1 β-glycosidases.

Strazzulli A, Perugino G, Mazzone M, Rossi M, Withers SG, Moracci M.

J Enzyme Inhib Med Chem. 2019 Dec;34(1):973-980. doi: 10.1080/14756366.2019.1608198.

13.

Directed evolution of bacterial polysialyltransferases.

Janesch B, Baumann L, Mark A, Thompson N, Rahmani S, Sim L, Withers SG, Wakarchuk WW.

Glycobiology. 2019 Jul 1;29(7):588-598. doi: 10.1093/glycob/cwz021.

PMID:
30976781
14.

Emerging Roles of Sympathetic Nerves and Inflammation in Perivascular Adipose Tissue.

Saxton SN, Withers SB, Heagerty AM.

Cardiovasc Drugs Ther. 2019 Apr;33(2):245-259. doi: 10.1007/s10557-019-06862-4.

15.

High-Throughput "FP-Tag" Assay for the Identification of Glycosyltransferase Inhibitors.

Gao Z, Ovchinnikova OG, Huang BS, Liu F, Williams DE, Andersen RJ, Lowary TL, Whitfield C, Withers SG.

J Am Chem Soc. 2019 Feb 13;141(6):2201-2204. doi: 10.1021/jacs.8b10940. Epub 2019 Feb 1.

PMID:
30698425
16.

Metastatic immune infiltrates correlate with those of the primary tumour in canine osteosarcoma.

Withers SS, York D, Choi JW, Woolard KD, Laufer-Amorim R, Sparger EE, Burton JH, McSorley SJ, Monjazeb AM, Murphy WJ, Canter RJ, Rebhun RB.

Vet Comp Oncol. 2019 Sep;17(3):242-252. doi: 10.1111/vco.12459. Epub 2019 Apr 8.

PMID:
30684301
17.

Efficacy of stabilized chlorine dioxide-based unflavored mouthwash in reducing oral malodor: An 8-week randomized controlled study.

Lee SS, Suprono MS, Stephens J, Withers SA, Li Y.

Am J Dent. 2018 Dec;31(6):309-312.

PMID:
30658377
18.

Facile Formation of β-thioGlcNAc Linkages to Thiol-Containing Sugars, Peptides, and Proteins using a Mutant GH20 Hexosaminidase.

Tegl G, Hanson J, Chen HM, Kwan DH, Santana AG, Withers SG.

Angew Chem Int Ed Engl. 2019 Feb 4;58(6):1632-1637. doi: 10.1002/anie.201809928. Epub 2019 Jan 9.

19.

The pKa values of the catalytic residues in the retaining glycoside hydrolase T26H mutant of T4 lysozyme.

Brockerman JA, Okon M, Withers SG, McIntosh LP.

Protein Sci. 2019 Mar;28(3):620-632. doi: 10.1002/pro.3562. Epub 2019 Jan 12.

PMID:
30537432
20.

A Bacterial Expression Platform for Production of Therapeutic Proteins Containing Human-like O-Linked Glycans.

Du T, Buenbrazo N, Kell L, Rahmani S, Sim L, Withers SG, DeFrees S, Wakarchuk W.

Cell Chem Biol. 2019 Feb 21;26(2):203-212.e5. doi: 10.1016/j.chembiol.2018.10.017. Epub 2018 Nov 29.

PMID:
30503285
21.

Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade.

Wang Z, Aguilar EG, Luna JI, Dunai C, Khuat LT, Le CT, Mirsoian A, Minnar CM, Stoffel KM, Sturgill IR, Grossenbacher SK, Withers SS, Rebhun RB, Hartigan-O'Connor DJ, Méndez-Lagares G, Tarantal AF, Isseroff RR, Griffith TS, Schalper KA, Merleev A, Saha A, Maverakis E, Kelly K, Aljumaily R, Ibrahimi S, Mukherjee S, Machiorlatti M, Vesely SK, Longo DL, Blazar BR, Canter RJ, Murphy WJ, Monjazeb AM.

Nat Med. 2019 Jan;25(1):141-151. doi: 10.1038/s41591-018-0221-5. Epub 2018 Nov 12.

22.

Endo-fucoidan hydrolases from glycoside hydrolase family 107 (GH107) display structural and mechanistic similarities to α-l-fucosidases from GH29.

Vickers C, Liu F, Abe K, Salama-Alber O, Jenkins M, Springate CMK, Burke JE, Withers SG, Boraston AB.

J Biol Chem. 2018 Nov 23;293(47):18296-18308. doi: 10.1074/jbc.RA118.005134. Epub 2018 Oct 3.

PMID:
30282808
23.

Proximity Ligation-Based Fluorogenic Imaging Agents for Neuraminidases.

Gao Z, Thompson AJ, Paulson JC, Withers SG.

Angew Chem Int Ed Engl. 2018 Oct 8;57(41):13538-13541. doi: 10.1002/anie.201808196. Epub 2018 Sep 14.

24.

Identity and role of the non-conserved acid/base catalytic residue in the GH29 fucosidase from the spider Nephilingis cruentata.

Perrella NN, Withers SG, Lopes AR.

Glycobiology. 2018 Dec 1;28(12):925-932. doi: 10.1093/glycob/cwy083.

PMID:
30204861
25.

Structural Dissection of Helianthamide Reveals the Basis of Its Potent Inhibition of Human Pancreatic α-Amylase.

Tysoe C, Withers SG.

Biochemistry. 2018 Sep 18;57(37):5384-5387. doi: 10.1021/acs.biochem.8b00825. Epub 2018 Sep 7.

PMID:
30180544
26.

Association of macrophage and lymphocyte infiltration with outcome in canine osteosarcoma.

Withers SS, Skorupski KA, York D, Choi JW, Woolard KD, Laufer-Amorim R, Sparger EE, Rodriguez CO, McSorley SJ, Monjazeb AM, Murphy WJ, Canter RJ, Rebhun RB.

Vet Comp Oncol. 2019 Mar;17(1):49-60. doi: 10.1111/vco.12444. Epub 2018 Sep 19.

PMID:
30156029
27.

Insights into Heptosyltransferase I Catalysis and Inhibition through the Structure of Its Ternary Complex.

Blaukopf M, Worrall L, Kosma P, Strynadka NCJ, Withers SG.

Structure. 2018 Oct 2;26(10):1399-1407.e5. doi: 10.1016/j.str.2018.07.001. Epub 2018 Aug 16.

28.

In vitro and in vivo activity of liposome-encapsulated curcumin for naturally occurring canine cancers.

Withers SS, York D, Johnson E, Al-Nadaf S, Skorupski KA, Rodriguez CO Jr, Burton JH, Guerrero T, Sein K, Wittenburg L, Rebhun RB.

Vet Comp Oncol. 2018 Dec;16(4):571-579. doi: 10.1111/vco.12424. Epub 2018 Aug 8.

PMID:
30088848
29.

Synthesis of azido-deoxy and amino-deoxy glycosides and glycosyl fluorides for screening of glycosidase libraries and assembly of substituted glycosides.

Chen HM, Withers SG.

Carbohydr Res. 2018 Sep;467:33-44. doi: 10.1016/j.carres.2018.07.007. Epub 2018 Jul 27.

PMID:
30075363
30.

Metagenomics reveals functional synergy and novel polysaccharide utilization loci in the Castor canadensis fecal microbiome.

Armstrong Z, Mewis K, Liu F, Morgan-Lang C, Scofield M, Durno E, Chen HM, Mehr K, Withers SG, Hallam SJ.

ISME J. 2018 Nov;12(11):2757-2769. doi: 10.1038/s41396-018-0215-9. Epub 2018 Jul 16.

31.

A Mechanism-Based Approach to Screening Metagenomic Libraries for Discovery of Unconventional Glycosidases.

Nasseri SA, Betschart L, Opaleva D, Rahfeld P, Withers SG.

Angew Chem Int Ed Engl. 2018 Aug 27;57(35):11359-11364. doi: 10.1002/anie.201806792. Epub 2018 Aug 1.

PMID:
30001477
32.

β3 -Adrenoceptor stimulation of perivascular adipocytes leads to increased fat cell-derived NO and vascular relaxation in small arteries.

Bussey CE, Withers SB, Saxton SN, Bodagh N, Aldous RG, Heagerty AM.

Br J Pharmacol. 2018 Sep;175(18):3685-3698. doi: 10.1111/bph.14433. Epub 2018 Aug 10.

33.

Discovery of UDP-Glycosyltransferases and BAHD-Acyltransferases Involved in the Biosynthesis of the Antidiabetic Plant Metabolite Montbretin A.

Irmisch S, Jo S, Roach CR, Jancsik S, Man Saint Yuen M, Madilao LL, O'Neil-Johnson M, Williams R, Withers SG, Bohlmann J.

Plant Cell. 2018 Aug;30(8):1864-1886. doi: 10.1105/tpc.18.00406. Epub 2018 Jul 2.

34.

Cochlear Patency After Translabyrinthine Vestibular Schwannoma Surgery.

Hill FCE, Grenness A, Withers S, Iseli C, Briggs R.

Otol Neurotol. 2018 Aug;39(7):e575-e578. doi: 10.1097/MAO.0000000000001858.

PMID:
29912821
35.

Modulating the Nucleophile of a Glycoside Hydrolase through Site-Specific Incorporation of Fluoroglutamic Acids.

Kötzler MP, Robinson K, Chen HM, Okon M, McIntosh LP, Withers SG.

J Am Chem Soc. 2018 Jul 5;140(26):8268-8276. doi: 10.1021/jacs.8b04235. Epub 2018 Jun 26.

PMID:
29894173
36.

Multi-color flow cytometry for evaluating age-related changes in memory lymphocyte subsets in dogs.

Withers SS, Moore PF, Chang H, Choi JW, McSorley SJ, Kent MS, Monjazeb AM, Canter RJ, Murphy WJ, Sparger EE, Rebhun RB.

Dev Comp Immunol. 2018 Oct;87:64-74. doi: 10.1016/j.dci.2018.05.022. Epub 2018 May 31.

37.

Modulation of Vascular Reactivity by Perivascular Adipose Tissue (PVAT).

Agabiti-Rosei C, Paini A, De Ciuceis C, Withers S, Greenstein A, Heagerty AM, Rizzoni D.

Curr Hypertens Rep. 2018 May 7;20(5):44. doi: 10.1007/s11906-018-0835-5. Review.

PMID:
29736674
38.

Personalizing Hypertension Treatment?

Withers SB, Saxton SN, Heagerty AM.

Hypertension. 2018 Jun;71(6):1028-1029. doi: 10.1161/HYPERTENSIONAHA.118.11107. Epub 2018 Apr 23. No abstract available.

PMID:
29686010
39.

The Molecular Basis of Polysaccharide Sulfatase Activity and a Nomenclature for Catalytic Subsites in this Class of Enzyme.

Hettle AG, Vickers C, Robb CS, Liu F, Withers SG, Hehemann JH, Boraston AB.

Structure. 2018 May 1;26(5):747-758.e4. doi: 10.1016/j.str.2018.03.012. Epub 2018 Apr 19.

40.

Oversized galactosides as a probe for conformational dynamics in LacY.

Smirnova I, Kasho V, Jiang X, Chen HM, Withers SG, Kaback HR.

Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):4146-4151. doi: 10.1073/pnas.1800706115. Epub 2018 Mar 30.

41.

Potent GH20 N-Acetyl-β-d-hexosaminidase Inhibitors: N-Substituted 3-acetamido-4-amino-5-hydroxymethyl-cyclopentanediols.

Weber P, Nasseri SA, Pabst BM, Torvisco A, Müller P, Paschke E, Tschernutter M, Windischhofer W, Withers SG, Wrodnigg TM, Stütz AE.

Molecules. 2018 Mar 20;23(3). pii: E708. doi: 10.3390/molecules23030708.

42.

Role of Sympathetic Nerves and Adipocyte Catecholamine Uptake in the Vasorelaxant Function of Perivascular Adipose Tissue.

Saxton SN, Ryding KE, Aldous RG, Withers SB, Ohanian J, Heagerty AM.

Arterioscler Thromb Vasc Biol. 2018 Apr;38(4):880-891. doi: 10.1161/ATVBAHA.118.310777. Epub 2018 Mar 1.

PMID:
29496660
43.

Structural and mechanistic analysis of a β-glycoside phosphorylase identified by screening a metagenomic library.

Macdonald SS, Patel A, Larmour VLC, Morgan-Lang C, Hallam SJ, Mark BL, Withers SG.

J Biol Chem. 2018 Mar 2;293(9):3451-3467. doi: 10.1074/jbc.RA117.000948. Epub 2018 Jan 9.

44.

Remarkable Reactivity Differences between Glucosides with Identical Leaving Groups.

Duo T, Robinson K, Greig IR, Chen HM, Patrick BO, Withers SG.

J Am Chem Soc. 2017 Nov 8;139(44):15994-15999. doi: 10.1021/jacs.7b09645. Epub 2017 Oct 24.

PMID:
29035043
45.

Characterization of a thermostable endoglucanase from Cellulomonas fimi ATCC484.

Saxena H, Hsu B, de Asis M, Zierke M, Sim L, Withers SG, Wakarchuk W.

Biochem Cell Biol. 2018 Feb;96(1):68-76. doi: 10.1139/bcb-2017-0150. Epub 2017 Oct 5.

PMID:
28982013
46.

Discovery of New Glycosidases From Metagenomic Libraries.

Armstrong Z, Rahfeld P, Withers SG.

Methods Enzymol. 2017;597:3-23. doi: 10.1016/bs.mie.2017.06.001. Epub 2017 Jul 29.

PMID:
28935108
47.

Toxoplasma Modulates Signature Pathways of Human Epilepsy, Neurodegeneration & Cancer.

Ngô HM, Zhou Y, Lorenzi H, Wang K, Kim TK, Zhou Y, El Bissati K, Mui E, Fraczek L, Rajagopala SV, Roberts CW, Henriquez FL, Montpetit A, Blackwell JM, Jamieson SE, Wheeler K, Begeman IJ, Naranjo-Galvis C, Alliey-Rodriguez N, Davis RG, Soroceanu L, Cobbs C, Steindler DA, Boyer K, Noble AG, Swisher CN, Heydemann PT, Rabiah P, Withers S, Soteropoulos P, Hood L, McLeod R.

Sci Rep. 2017 Sep 13;7(1):11496. doi: 10.1038/s41598-017-10675-6. Erratum in: Sci Rep. 2019 May 28;9(1):8110.

48.

A Conifer UDP-Sugar Dependent Glycosyltransferase Contributes to Acetophenone Metabolism and Defense against Insects.

Mageroy MH, Jancsik S, Man Saint Yuen M, Fischer M, Withers SG, Paetz C, Schneider B, Mackay J, Bohlmann J.

Plant Physiol. 2017 Oct;175(2):641-651. doi: 10.1104/pp.17.00611. Epub 2017 Aug 9.

49.

Structural basis of Notch O-glucosylation and O-xylosylation by mammalian protein-O-glucosyltransferase 1 (POGLUT1).

Li Z, Fischer M, Satkunarajah M, Zhou D, Withers SG, Rini JM.

Nat Commun. 2017 Aug 4;8(1):185. doi: 10.1038/s41467-017-00255-7.

50.

Glycosyl Cations versus Allylic Cations in Spontaneous and Enzymatic Hydrolysis.

Danby PM, Withers SG.

J Am Chem Soc. 2017 Aug 9;139(31):10629-10632. doi: 10.1021/jacs.7b05628. Epub 2017 Jul 26.

PMID:
28737389

Supplemental Content

Loading ...
Support Center