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Deletion of myeloid IRS2 enhances adipose tissue sympathetic nerve function and limits obesity.

Rached MT, Millership SJ, Pedroni SMA, Choudhury AI, Costa ASH, Hardy DG, Glegola JA, Irvine EE, Selman C, Woodberry MC, Yadav VK, Khadayate S, Vidal-Puig A, Virtue S, Frezza C, Withers DJ.

Mol Metab. 2019 Feb;20:38-50. doi: 10.1016/j.molmet.2018.11.010. Epub 2018 Nov 28.


nNOS-Expressing Neurons in the Ventral Tegmental Area and Substantia Nigra Pars Compacta.

Paul EJ, Kalk E, Tossell K, Irvine EE, Franks NP, Wisden W, Withers DJ, Leiper J, Ungless MA.

eNeuro. 2018 Nov 16;5(5). pii: ENEURO.0381-18.2018. doi: 10.1523/ENEURO.0381-18.2018. eCollection 2018 Sep-Oct.


Calcium Channel CaV2.3 Subunits Regulate Hepatic Glucose Production by Modulating Leptin-Induced Excitation of Arcuate Pro-opiomelanocortin Neurons.

Smith MA, Katsouri L, Virtue S, Choudhury AI, Vidal-Puig A, Ashford MLJ, Withers DJ.

Cell Rep. 2018 Oct 9;25(2):278-287.e4. doi: 10.1016/j.celrep.2018.09.024.


Neuronatin deletion causes postnatal growth restriction and adult obesity in 129S2/Sv mice.

Millership SJ, Tunster SJ, Van de Pette M, Choudhury AI, Irvine EE, Christian M, Fisher AG, John RM, Scott J, Withers DJ.

Mol Metab. 2018 Dec;18:97-106. doi: 10.1016/j.molmet.2018.09.001. Epub 2018 Sep 15.


Neuronatin regulates pancreatic β cell insulin content and secretion.

Millership SJ, Da Silva Xavier G, Choudhury AI, Bertazzo S, Chabosseau P, Pedroni SM, Irvine EE, Montoya A, Faull P, Taylor WR, Kerr-Conte J, Pattou F, Ferrer J, Christian M, John RM, Latreille M, Liu M, Rutter GA, Scott J, Withers DJ.

J Clin Invest. 2018 Aug 1;128(8):3369-3381. doi: 10.1172/JCI120115. Epub 2018 Jul 9.


Common and unique transcriptional responses to dietary restriction and loss of insulin receptor substrate 1 (IRS1) in mice.

Page MM, Schuster EF, Mudaliar M, Herzyk P, Withers DJ, Selman C.

Aging (Albany NY). 2018 May 20;10(5):1027-1052. doi: 10.18632/aging.101446.


Phasic Stimulation of Midbrain Dopamine Neuron Activity Reduces Salt Consumption.

Sandhu EC, Fernando ABP, Irvine EE, Tossell K, Kokkinou M, Glegola J, Smith MA, Howes OD, Withers DJ, Ungless MA.

eNeuro. 2018 May 15;5(2). pii: ENEURO.0064-18.2018. doi: 10.1523/ENEURO.0064-18.2018. eCollection 2018 Mar-Apr.


Evidence that S6K1, but not 4E-BP1, mediates skeletal muscle pathology associated with loss of A-type lamins.

Liao CY, Anderson SS, Chicoine NH, Mayfield JR, Garrett BJ, Kwok CS, Academia EC, Hsu YM, Miller DM, Bair AM, Wilson JA, Tannady G, Stewart EM, Adamson SS, Wang J, Withers DJ, Kennedy BK.

Cell Discov. 2017 Oct 31;3:17039. doi: 10.1038/celldisc.2017.39. eCollection 2017.


Modulation of SF1 Neuron Activity Coordinately Regulates Both Feeding Behavior and Associated Emotional States.

Viskaitis P, Irvine EE, Smith MA, Choudhury AI, Alvarez-Curto E, Glegola JA, Hardy DG, Pedroni SMA, Paiva Pessoa MR, Fernando ABP, Katsouri L, Sardini A, Ungless MA, Milligan G, Withers DJ.

Cell Rep. 2017 Dec 19;21(12):3559-3572. doi: 10.1016/j.celrep.2017.11.089.


Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production.

Hine C, Kim HJ, Zhu Y, Harputlugil E, Longchamp A, Matos MS, Ramadoss P, Bauerle K, Brace L, Asara JM, Ozaki CK, Cheng SY, Singha S, Ahn KH, Kimmelman A, Fisher FM, Pissios P, Withers DJ, Selman C, Wang R, Yen K, Longo VD, Cohen P, Bartke A, Kopchick JJ, Miller R, Hollenberg AN, Mitchell JR.

Cell Metab. 2017 Jun 6;25(6):1320-1333.e5. doi: 10.1016/j.cmet.2017.05.003.


Physiology: An atypical switch for metabolism and ageing.

Selman C, Withers DJ.

Nature. 2017 Feb 16;542(7641):299-300. doi: 10.1038/nature21500. Epub 2017 Feb 8. No abstract available.


Visualizing Changes in Cdkn1c Expression Links Early-Life Adversity to Imprint Mis-regulation in Adults.

Van de Pette M, Abbas A, Feytout A, McNamara G, Bruno L, To WK, Dimond A, Sardini A, Webster Z, McGinty J, Paul EJ, Ungless MA, French PMW, Withers DJ, Uren A, Ferguson-Smith AC, Merkenschlager M, John RM, Fisher AG.

Cell Rep. 2017 Jan 31;18(5):1090-1099. doi: 10.1016/j.celrep.2017.01.010.


A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs.

Raffan E, Dennis RJ, O'Donovan CJ, Becker JM, Scott RA, Smith SP, Withers DJ, Wood CJ, Conci E, Clements DN, Summers KM, German AJ, Mellersh CS, Arendt ML, Iyemere VP, Withers E, Söder J, Wernersson S, Andersson G, Lindblad-Toh K, Yeo GS, O'Rahilly S.

Cell Metab. 2016 May 10;23(5):893-900. doi: 10.1016/j.cmet.2016.04.012. Epub 2016 May 3.


Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function.

Yavari A, Stocker CJ, Ghaffari S, Wargent ET, Steeples V, Czibik G, Pinter K, Bellahcene M, Woods A, Martínez de Morentin PB, Cansell C, Lam BY, Chuster A, Petkevicius K, Nguyen-Tu MS, Martinez-Sanchez A, Pullen TJ, Oliver PL, Stockenhuber A, Nguyen C, Lazdam M, O'Dowd JF, Harikumar P, Tóth M, Beall C, Kyriakou T, Parnis J, Sarma D, Katritsis G, Wortmann DD, Harper AR, Brown LA, Willows R, Gandra S, Poncio V, de Oliveira Figueiredo MJ, Qi NR, Peirson SN, McCrimmon RJ, Gereben B, Tretter L, Fekete C, Redwood C, Yeo GS, Heisler LK, Rutter GA, Smith MA, Withers DJ, Carling D, Sternick EB, Arch JR, Cawthorne MA, Watkins H, Ashrafian H.

Cell Metab. 2016 May 10;23(5):821-36. doi: 10.1016/j.cmet.2016.04.003. Epub 2016 Apr 28.


Evidence that hematopoietic stem cell function is preserved during aging in long-lived S6K1 mutant mice.

Selman C, Sinclair A, Pedroni SM, Irvine EE, Michie AM, Withers DJ.

Oncotarget. 2016 May 24;7(21):29937-43. doi: 10.18632/oncotarget.8729.


Ageing: Out with the old.

Gil J, Withers DJ.

Nature. 2016 Feb 11;530(7589):164-5. doi: 10.1038/nature16875. Epub 2016 Feb 3. No abstract available.


Ribosomal S6K1 in POMC and AgRP Neurons Regulates Glucose Homeostasis but Not Feeding Behavior in Mice.

Smith MA, Katsouri L, Irvine EE, Hankir MK, Pedroni SM, Voshol PJ, Gordon MW, Choudhury AI, Woods A, Vidal-Puig A, Carling D, Withers DJ.

Cell Rep. 2015 Apr 21;11(3):335-43. doi: 10.1016/j.celrep.2015.03.029. Epub 2015 Apr 9.


Fibroblasts derived from long-lived insulin receptor substrate 1 null mice are not resistant to multiple forms of stress.

Page MM, Sinclair A, Robb EL, Stuart JA, Withers DJ, Selman C.

Aging Cell. 2014 Oct;13(5):962-4. doi: 10.1111/acel.12255. Epub 2014 Jul 24.


Caloric restriction reveals a metabolomic and lipidomic signature in liver of male mice.

Jové M, Naudí A, Ramírez-Núñez O, Portero-Otín M, Selman C, Withers DJ, Pamplona R.

Aging Cell. 2014 Oct;13(5):828-37. doi: 10.1111/acel.12241. Epub 2014 Jul 23.


PINK1 deficiency in β-cells increases basal insulin secretion and improves glucose tolerance in mice.

Deas E, Piipari K, Machhada A, Li A, Gutierrez-del-Arroyo A, Withers DJ, Wood NW, Abramov AY.

Open Biol. 2014 May 7;4:140051. doi: 10.1098/rsob.140051.


Peripheral activation of the Y2-receptor promotes secretion of GLP-1 and improves glucose tolerance.

Chandarana K, Gelegen C, Irvine EE, Choudhury AI, Amouyal C, Andreelli F, Withers DJ, Batterham RL.

Mol Metab. 2013 Mar 14;2(3):142-52. doi: 10.1016/j.molmet.2013.03.001. eCollection 2013.


Differential effects of laparoscopic sleeve gastrectomy and laparoscopic gastric bypass on appetite, circulating acyl-ghrelin, peptide YY3-36 and active GLP-1 levels in non-diabetic humans.

Yousseif A, Emmanuel J, Karra E, Millet Q, Elkalaawy M, Jenkinson AD, Hashemi M, Adamo M, Finer N, Fiennes AG, Withers DJ, Batterham RL.

Obes Surg. 2014 Feb;24(2):241-52. doi: 10.1007/s11695-013-1066-0.


A link between FTO, ghrelin, and impaired brain food-cue responsivity.

Karra E, O'Daly OG, Choudhury AI, Yousseif A, Millership S, Neary MT, Scott WR, Chandarana K, Manning S, Hess ME, Iwakura H, Akamizu T, Millet Q, Gelegen C, Drew ME, Rahman S, Emmanuel JJ, Williams SC, Rüther UU, Brüning JC, Withers DJ, Zelaya FO, Batterham RL.

J Clin Invest. 2013 Aug;123(8):3539-51. doi: 10.1172/JCI44403. Epub 2013 Jul 15.


Differential pre-mRNA splicing regulates Nnat isoforms in the hypothalamus after gastric bypass surgery in mice.

Scott WR, Gelegen C, Chandarana K, Karra E, Yousseif A, Amouyal C, Choudhury AI, Andreelli F, Withers DJ, Batterham RL.

PLoS One. 2013;8(3):e59407. doi: 10.1371/journal.pone.0059407. Epub 2013 Mar 20.


Long-term p110α PI3K inactivation exerts a beneficial effect on metabolism.

Foukas LC, Bilanges B, Bettedi L, Pearce W, Ali K, Sancho S, Withers DJ, Vanhaesebroeck B.

EMBO Mol Med. 2013 Apr;5(4):563-71. doi: 10.1002/emmm.201201953. Epub 2013 Mar 11.


Experimental analysis of risk factors for ulcerative dermatitis in mice.

Neuhaus B, Niessen CM, Mesaros A, Withers DJ, Krieg T, Partridge L.

Exp Dermatol. 2012 Sep;21(9):712-3. doi: 10.1111/j.1600-0625.2012.01558.x.


Regulation of hindbrain Pyy expression by acute food deprivation, prolonged caloric restriction, and weight loss surgery in mice.

Gelegen C, Chandarana K, Choudhury AI, Al-Qassab H, Evans IM, Irvine EE, Hyde CB, Claret M, Andreelli F, Sloan SE, Leiter AB, Withers DJ, Batterham RL.

Am J Physiol Endocrinol Metab. 2012 Sep 1;303(5):E659-68. doi: 10.1152/ajpendo.00033.2012. Epub 2012 Jul 3.


Brain deletion of insulin receptor substrate 2 disrupts hippocampal synaptic plasticity and metaplasticity.

Costello DA, Claret M, Al-Qassab H, Plattner F, Irvine EE, Choudhury AI, Giese KP, Withers DJ, Pedarzani P.

PLoS One. 2012;7(2):e31124. doi: 10.1371/journal.pone.0031124. Epub 2012 Feb 27.


Longevity of insulin receptor substrate1 null mice is not associated with increased basal antioxidant protection or reduced oxidative damage.

Page MM, Withers DJ, Selman C.

Age (Dordr). 2013 Jun;35(3):647-58. doi: 10.1007/s11357-012-9395-9. Epub 2012 Feb 29.


Metabotyping of long-lived mice using 1H NMR spectroscopy.

Wijeyesekera A, Selman C, Barton RH, Holmes E, Nicholson JK, Withers DJ.

J Proteome Res. 2012 Apr 6;11(4):2224-35. doi: 10.1021/pr2010154. Epub 2012 Feb 27.


Insulin receptor substrate 2 is a negative regulator of memory formation.

Irvine EE, Drinkwater L, Radwanska K, Al-Qassab H, Smith MA, O'Brien M, Kielar C, Choudhury AI, Krauss S, Cooper JD, Withers DJ, Giese KP.

Learn Mem. 2011 May 19;18(6):375-83. doi: 10.1101/lm.2111311. Print 2011 Jun.


Diet and gastrointestinal bypass-induced weight loss: the roles of ghrelin and peptide YY.

Chandarana K, Gelegen C, Karra E, Choudhury AI, Drew ME, Fauveau V, Viollet B, Andreelli F, Withers DJ, Batterham RL.

Diabetes. 2011 Mar;60(3):810-8. doi: 10.2337/db10-0566. Epub 2011 Feb 3.


Replication of extended lifespan phenotype in mice with deletion of insulin receptor substrate 1.

Selman C, Partridge L, Withers DJ.

PLoS One. 2011 Jan 25;6(1):e16144. doi: 10.1371/journal.pone.0016144.


Deletion of Lkb1 in pro-opiomelanocortin neurons impairs peripheral glucose homeostasis in mice.

Claret M, Smith MA, Knauf C, Al-Qassab H, Woods A, Heslegrave A, Piipari K, Emmanuel JJ, Colom A, Valet P, Cani PD, Begum G, White A, Mucket P, Peters M, Mizuno K, Batterham RL, Giese KP, Ashworth A, Burcelin R, Ashford ML, Carling D, Withers DJ.

Diabetes. 2011 Mar;60(3):735-45. doi: 10.2337/db10-1055. Epub 2011 Jan 24.


Bio-informatics analysis of a gene co-expression module in adipose tissue containing the diet-responsive gene Nnat.

Li X, Thomason PA, Withers DJ, Scott J.

BMC Syst Biol. 2010 Dec 27;4:175. doi: 10.1186/1752-0509-4-175.


LKB1 is required for hepatic bile acid transport and canalicular membrane integrity in mice.

Woods A, Heslegrave AJ, Muckett PJ, Levene AP, Clements M, Mobberley M, Ryder TA, Abu-Hayyeh S, Williamson C, Goldin RD, Ashworth A, Withers DJ, Carling D.

Biochem J. 2011 Feb 15;434(1):49-60. doi: 10.1042/BJ20101721.


Mammalian models of extended healthy lifespan.

Selman C, Withers DJ.

Philos Trans R Soc Lond B Biol Sci. 2011 Jan 12;366(1561):99-107. doi: 10.1098/rstb.2010.0243. Review.


The hypoxia response pathway and β-cell function.

Cantley J, Grey ST, Maxwell PH, Withers DJ.

Diabetes Obes Metab. 2010 Oct;12 Suppl 2:159-67. doi: 10.1111/j.1463-1326.2010.01276.x. Review.


Phosphoinositide signalling pathways in metabolic regulation.

Foukas LC, Withers DJ.

Curr Top Microbiol Immunol. 2010;346:115-41. doi: 10.1007/82_2010_59. Review.


Loss of AMP-activated protein kinase alpha2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia.

Beall C, Piipari K, Al-Qassab H, Smith MA, Parker N, Carling D, Viollet B, Withers DJ, Ashford ML.

Biochem J. 2010 Jul 15;429(2):323-33. doi: 10.1042/BJ20100231.


Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk.

Slack C, Werz C, Wieser D, Alic N, Foley A, Stocker H, Withers DJ, Thornton JM, Hafen E, Partridge L.

PLoS Genet. 2010 Mar 19;6(3):e1000881. doi: 10.1371/journal.pgen.1000881.


Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons.

Al-Qassab H, Smith MA, Irvine EE, Guillermet-Guibert J, Claret M, Choudhury AI, Selman C, Piipari K, Clements M, Lingard S, Chandarana K, Bell JD, Barsh GS, Smith AJ, Batterham RL, Ashford ML, Vanhaesebroeck B, Withers DJ.

Cell Metab. 2009 Nov;10(5):343-54. doi: 10.1016/j.cmet.2009.09.008.


Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.

Selman C, Tullet JM, Wieser D, Irvine E, Lingard SJ, Choudhury AI, Claret M, Al-Qassab H, Carmignac D, Ramadani F, Woods A, Robinson IC, Schuster E, Batterham RL, Kozma SC, Thomas G, Carling D, Okkenhaug K, Thornton JM, Partridge L, Gems D, Withers DJ.

Science. 2009 Oct 2;326(5949):140-4. doi: 10.1126/science.1177221. Erratum in: Science. 2011 Oct 7;334(6052):39.


Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice.

Killick R, Scales G, Leroy K, Causevic M, Hooper C, Irvine EE, Choudhury AI, Drinkwater L, Kerr F, Al-Qassab H, Stephenson J, Yilmaz Z, Giese KP, Brion JP, Withers DJ, Lovestone S.

Biochem Biophys Res Commun. 2009 Aug 14;386(1):257-62. doi: 10.1016/j.bbrc.2009.06.032. Epub 2009 Jun 10.


5-HT inhibition of rat insulin 2 promoter Cre recombinase transgene and proopiomelanocortin neuron excitability in the mouse arcuate nucleus.

Hisadome K, Smith MA, Choudhury AI, Claret M, Withers DJ, Ashford ML.

Neuroscience. 2009 Mar 3;159(1):83-93. doi: 10.1016/j.neuroscience.2008.12.003. Epub 2008 Dec 14.


Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice.

Cantley J, Selman C, Shukla D, Abramov AY, Forstreuter F, Esteban MA, Claret M, Lingard SJ, Clements M, Harten SK, Asare-Anane H, Batterham RL, Herrera PL, Persaud SJ, Duchen MR, Maxwell PH, Withers DJ.

J Clin Invest. 2009 Jan;119(1):125-35. doi: 10.1172/JCI26934. Epub 2008 Dec 8.


Comment on "Brain IRS2 signaling coordinates life span and nutrient homeostasis".

Selman C, Lingard S, Gems D, Partridge L, Withers DJ.

Science. 2008 May 23;320(5879):1012; author reply 1012. doi: 10.1126/science.1152366.


PYY modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humans.

Batterham RL, ffytche DH, Rosenthal JM, Zelaya FO, Barker GJ, Withers DJ, Williams SC.

Nature. 2007 Nov 1;450(7166):106-9. Epub 2007 Oct 14.


Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice.

Selman C, Lingard S, Choudhury AI, Batterham RL, Claret M, Clements M, Ramadani F, Okkenhaug K, Schuster E, Blanc E, Piper MD, Al-Qassab H, Speakman JR, Carmignac D, Robinson IC, Thornton JM, Gems D, Partridge L, Withers DJ.

FASEB J. 2008 Mar;22(3):807-18. Epub 2007 Oct 10.


AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons.

Claret M, Smith MA, Batterham RL, Selman C, Choudhury AI, Fryer LG, Clements M, Al-Qassab H, Heffron H, Xu AW, Speakman JR, Barsh GS, Viollet B, Vaulont S, Ashford ML, Carling D, Withers DJ.

J Clin Invest. 2007 Aug;117(8):2325-36.

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