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Items: 45


Beyond EZH2: is the polycomb protein CBX2 an emerging target for anti-cancer therapy?

Jangal M, Lebeau B, Witcher M.

Expert Opin Ther Targets. 2019 Jul;23(7):565-578. doi: 10.1080/14728222.2019.1627329. Epub 2019 Jun 10.


SWI/SNF-Compromised Cancers Are Susceptible to Bromodomain Inhibitors.

Shorstova T, Marques M, Su J, Johnston J, Kleinman CL, Hamel N, Huang S, Alaoui-Jamali MA, Foulkes WD, Witcher M.

Cancer Res. 2019 May 15;79(10):2761-2774. doi: 10.1158/0008-5472.CAN-18-1545. Epub 2019 Mar 15.


CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary.

Xue Y, Meehan B, Macdonald E, Venneti S, Wang XQD, Witkowski L, Jelinic P, Kong T, Martinez D, Morin G, Firlit M, Abedini A, Johnson RM, Cencic R, Patibandla J, Chen H, Papadakis AI, Auguste A, de Rink I, Kerkhoven RM, Bertos N, Gotlieb WH, Clarke BA, Leary A, Witcher M, Guiot MC, Pelletier J, Dostie J, Park M, Judkins AR, Hass R, Levine DA, Rak J, Vanderhyden B, Foulkes WD, Huang S.

Nat Commun. 2019 Feb 4;10(1):558. doi: 10.1038/s41467-018-06958-9.


MNK1/NODAL Signaling Promotes Invasive Progression of Breast Ductal Carcinoma In Situ.

Guo Q, Li VZ, Nichol JN, Huang F, Yang W, Preston SEJ, Talat Z, Lefrère H, Yu H, Zhang G, Basik M, Gonçalves C, Zhan Y, Plourde D, Su J, Torres J, Marques M, Habyan SA, Bijian K, Amant F, Witcher M, Behbod F, McCaffrey L, Alaoui-Jamali M, Giannakopoulos NV, Brackstone M, Postovit LM, Del Rincón SV, Miller WH Jr.

Cancer Res. 2019 Apr 1;79(7):1646-1657. doi: 10.1158/0008-5472.CAN-18-1602. Epub 2019 Jan 18.


Oncogenic activity of poly (ADP-ribose) glycohydrolase.

Marques M, Jangal M, Wang LC, Kazanets A, da Silva SD, Zhao T, Lovato A, Yu H, Jie S, Del Rincon S, Mackey J, Damaraju S, Alaoui-Jamali M, Witcher M.

Oncogene. 2019 Mar;38(12):2177-2191. doi: 10.1038/s41388-018-0568-6. Epub 2018 Nov 20.


Meckel Cave Epidermoid Cyst Presenting as Multiple Cranial Nerve Deficits Due to Indirect Tumoral Compression of the Cavernous Sinus: A Case Report and Literature Review.

Busch CM, Prickett JT, Stein R, Cuoco JA, Marvin EA, Witcher MR.

World Neurosurg. 2019 Jan;121:88-94. doi: 10.1016/j.wneu.2018.09.206. Epub 2018 Oct 9. Review.


HIV-1 Employs Multiple Mechanisms To Resist Cas9/Single Guide RNA Targeting the Viral Primer Binding Site.

Wang Z, Wang W, Cui YC, Pan Q, Zhu W, Gendron P, Guo F, Cen S, Witcher M, Liang C.

J Virol. 2018 Sep 26;92(20). pii: e01135-18. doi: 10.1128/JVI.01135-18. Print 2018 Oct 15.


Clinical Neuroscience in Practice: An Experiential Learning Course for Undergraduates Offered by Neurosurgeons and Neuroscientists.

Simonds GR, Marvin EA, Apfel LS, Elias Z, Howes GA, Witcher MR, Weaver EN, Fraser JC, Synkowski JJ, Prickett JT, Rogers CM, Busch CM, Benko MJ, Sou N, Churning MJ, Summers DC, Sontheimer H.

J Undergrad Neurosci Educ. 2018 Jun 15;16(2):A112-A119. eCollection 2018 Spring.


Peroxisomes and cancer: The role of a metabolic specialist in a disease of aberrant metabolism.

Dahabieh MS, Di Pietro E, Jangal M, Goncalves C, Witcher M, Braverman NE, Del Rincón SV.

Biochim Biophys Acta Rev Cancer. 2018 Aug;1870(1):103-121. doi: 10.1016/j.bbcan.2018.07.004. Epub 2018 Aug 6. Review.


Developing a hippocampal neural prosthetic to facilitate human memory encoding and recall.

Hampson RE, Song D, Robinson BS, Fetterhoff D, Dakos AS, Roeder BM, She X, Wicks RT, Witcher MR, Couture DE, Laxton AW, Munger-Clary H, Popli G, Sollman MJ, Whitlow CT, Marmarelis VZ, Berger TW, Deadwyler SA.

J Neural Eng. 2018 Jun;15(3):036014. doi: 10.1088/1741-2552/aaaed7. Epub 2018 Mar 28.


Designing Patient-Specific Optimal Neurostimulation Patterns for Seizure Suppression.

Sandler RA, Geng K, Song D, Hampson RE, Witcher MR, Deadwyler SA, Berger TW, Marmarelis VZ.

Neural Comput. 2018 May;30(5):1180-1208. doi: 10.1162/NECO_a_01075. Epub 2018 Mar 22.


A Novel Approach for Responsive Neural Stimulator Implantation With Infraclavicular Placement of the Internal Pulse Generator.

Philipp LR, Witcher MR, Gross RE.

Oper Neurosurg (Hagerstown). 2018 Dec 1;15(6):711-719. doi: 10.1093/ons/opy025.


The Protective Action Encoding of Serotonin Transients in the Human Brain.

Moran RJ, Kishida KT, Lohrenz T, Saez I, Laxton AW, Witcher MR, Tatter SB, Ellis TL, Phillips PE, Dayan P, Montague PR.

Neuropsychopharmacology. 2018 May;43(6):1425-1435. doi: 10.1038/npp.2017.304. Epub 2018 Jan 3.


Competition between translation initiation factor eIF5 and its mimic protein 5MP determines non-AUG initiation rate genome-wide.

Tang L, Morris J, Wan J, Moore C, Fujita Y, Gillaspie S, Aube E, Nanda J, Marques M, Jangal M, Anderson A, Cox C, Hiraishi H, Dong L, Saito H, Singh CR, Witcher M, Topisirovic I, Qian SB, Asano K.

Nucleic Acids Res. 2017 Nov 16;45(20):11941-11953. doi: 10.1093/nar/gkx808.


CTCF facilitates DNA double-strand break repair by enhancing homologous recombination repair.

Hilmi K, Jangal M, Marques M, Zhao T, Saad A, Zhang C, Luo VM, Syme A, Rejon C, Yu Z, Krum A, Fabian MR, Richard S, Alaoui-Jamali M, Orthwein A, McCaffrey L, Witcher M.

Sci Adv. 2017 May 24;3(5):e1601898. doi: 10.1126/sciadv.1601898. eCollection 2017 May.


Insights into a novel nuclear function for Fascin in the regulation of the amino-acid transporter SLC3A2.

Saad A, Bijian K, Qiu D, da Silva SD, Marques M, Chang CH, Nassour H, Ramotar D, Damaraju S, Mackey J, Bismar T, Witcher M, Alaoui-Jamali MA.

Sci Rep. 2016 Nov 7;6:36699. doi: 10.1038/srep36699.


Haploinsufficiency of the ESCRT Component HD-PTP Predisposes to Cancer.

Manteghi S, Gingras MC, Kharitidi D, Galarneau L, Marques M, Yan M, Cencic R, Robert F, Paquet M, Witcher M, Pelletier J, Pause A.

Cell Rep. 2016 May 31;15(9):1893-900. doi: 10.1016/j.celrep.2016.04.076. Epub 2016 May 19.


Epigenetic silencing of tumor suppressor genes: Paradigms, puzzles, and potential.

Kazanets A, Shorstova T, Hilmi K, Marques M, Witcher M.

Biochim Biophys Acta. 2016 Apr;1865(2):275-88. doi: 10.1016/j.bbcan.2016.04.001. Epub 2016 Apr 13. Review.


Dilated cardiomyopathy mutations in δ-sarcoglycan exert a dominant-negative effect on cardiac myocyte mechanical stability.

Campbell MD, Witcher M, Gopal A, Michele DE.

Am J Physiol Heart Circ Physiol. 2016 May 1;310(9):H1140-50. doi: 10.1152/ajpheart.00521.2015. Epub 2016 Mar 11.


Subsecond dopamine fluctuations in human striatum encode superposed error signals about actual and counterfactual reward.

Kishida KT, Saez I, Lohrenz T, Witcher MR, Laxton AW, Tatter SB, White JP, Ellis TL, Phillips PE, Montague PR.

Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):200-5. doi: 10.1073/pnas.1513619112. Epub 2015 Nov 23.


Analysis of changes to mRNA levels and CTCF occupancy upon TFII-I knockdown.

Marques M, Hernández RP, Witcher M.

Genom Data. 2014 Oct 18;4:17-21. doi: 10.1016/j.gdata.2014.09.012. eCollection 2015 Jun.


Chemotherapy reduces PARP1 in cancers of the ovary: implications for future clinical trials involving PARP inhibitors.

Marques M, Beauchamp MC, Fleury H, Laskov I, Qiang S, Pelmus M, Provencher D, Mes-Masson AM, Gotlieb WH, Witcher M.

BMC Med. 2015 Sep 9;13:217. doi: 10.1186/s12916-015-0454-9.


Anticancer Properties of Phyllanthus emblica (Indian Gooseberry).

Zhao T, Sun Q, Marques M, Witcher M.

Oxid Med Cell Longev. 2015;2015:950890. doi: 10.1155/2015/950890. Epub 2015 Jun 9. Review.


Genome-wide targeting of the epigenetic regulatory protein CTCF to gene promoters by the transcription factor TFII-I.

Peña-Hernández R, Marques M, Hilmi K, Zhao T, Saad A, Alaoui-Jamali MA, del Rincon SV, Ashworth T, Roy AL, Emerson BM, Witcher M.

Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):E677-86. doi: 10.1073/pnas.1416674112. Epub 2015 Feb 2.


Neuronal oscillations in Parkinson's disease.

Witcher M, Moran R, Tatter SB, Laxton AW.

Front Biosci (Landmark Ed). 2014 Jun 1;19:1291-9. Review.


Gallotannin imposes S phase arrest in breast cancer cells and suppresses the growth of triple-negative tumors in vivo.

Zhao T, Sun Q, del Rincon SV, Lovato A, Marques M, Witcher M.

PLoS One. 2014 Mar 21;9(3):e92853. doi: 10.1371/journal.pone.0092853. eCollection 2014.


In vitro correction of disorders of lysosomal transport by microvesicles derived from baculovirus-infected Spodoptera cells.

Thoene J, Goss T, Witcher M, Mullet J, N'Kuli F, Van Der Smissen P, Courtoy P, Hahn SH.

Mol Genet Metab. 2013 May;109(1):77-85. doi: 10.1016/j.ymgme.2013.01.014. Epub 2013 Feb 4.


Is there an epigenetic component underlying the resistance of triple-negative breast cancers to parp inhibitors?

Lovato A, Panasci L, Witcher M.

Front Pharmacol. 2012 Dec 27;3:202. doi: 10.3389/fphar.2012.00202. eCollection 2012.


Astroglial networks and implications for therapeutic neuromodulation of epilepsy.

Witcher MR, Ellis TL.

Front Comput Neurosci. 2012 Aug 29;6:61. doi: 10.3389/fncom.2012.00061. eCollection 2012.


Functional and molecular characterization of the role of CTCF in human embryonic stem cell biology.

Balakrishnan SK, Witcher M, Berggren TW, Emerson BM.

PLoS One. 2012;7(8):e42424. doi: 10.1371/journal.pone.0042424. Epub 2012 Aug 3.


Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock.

DiTacchio L, Le HD, Vollmers C, Hatori M, Witcher M, Secombe J, Panda S.

Science. 2011 Sep 30;333(6051):1881-5. doi: 10.1126/science.1206022.


The redox status of cystinotic fibroblasts.

Vitvitsky V, Witcher M, Banerjee R, Thoene J.

Mol Genet Metab. 2010 Apr;99(4):384-8. doi: 10.1016/j.ymgme.2009.12.010. Epub 2009 Dec 21.


Three-dimensional relationships between perisynaptic astroglia and human hippocampal synapses.

Witcher MR, Park YD, Lee MR, Sharma S, Harris KM, Kirov SA.

Glia. 2010 Apr;58(5):572-87. doi: 10.1002/glia.20946.


Postoperative pain management with tramadol after craniotomy: evaluation and cost analysis.

Rahimi SY, Alleyne CH, Vernier E, Witcher MR, Vender JR.

J Neurosurg. 2010 Feb;112(2):268-72. doi: 10.3171/2008.9.17689.


Epigenetic silencing of the p16(INK4a) tumor suppressor is associated with loss of CTCF binding and a chromatin boundary.

Witcher M, Emerson BM.

Mol Cell. 2009 May 15;34(3):271-84. doi: 10.1016/j.molcel.2009.04.001.


Retinoic acid modulates chromatin to potentiate tumor necrosis factor alpha signaling on the DIF2 promoter.

Witcher M, Pettersson F, Dupéré-Richer D, Padovani A, Summers-Deluca L, Baldwin AS, Miller WH Jr.

Nucleic Acids Res. 2008 Feb;36(2):435-43. Epub 2007 Nov 26.


Corpus callosotomy for treatment of pediatric epilepsy in the modern era.

Rahimi SY, Park YD, Witcher MR, Lee KH, Marrufo M, Lee MR.

Pediatr Neurosurg. 2007;43(3):202-8.


Plasticity of perisynaptic astroglia during synaptogenesis in the mature rat hippocampus.

Witcher MR, Kirov SA, Harris KM.

Glia. 2007 Jan 1;55(1):13-23.


Cytokines and retinoic acid therapy for APL: new tricks from an old combination.

Witcher M, Miller WH Jr.

Leuk Res. 2004 May;28(5):447-8. No abstract available.


Synergy between all-trans retinoic acid and tumor necrosis factor pathways in acute leukemia cells.

Witcher M, Ross DT, Rousseau C, Deluca L, Miller WH Jr.

Blood. 2003 Jul 1;102(1):237-45. Epub 2003 Feb 13.


BAG-1 p50 isoform interacts with the vitamin D receptor and its cellular overexpression inhibits the vitamin D pathway.

Witcher M, Yang X, Pater A, Tang SC.

Exp Cell Res. 2001 Apr 15;265(1):167-73.


Biotechnology: an introduction to recombinant DNA technology and product availability.

Evens RP, Witcher M.

Ther Drug Monit. 1993 Dec;15(6):514-20. Review.


Application of office ultrasound in the management of the spinal cord injury patient.

Bodner DR, Witcher M, Resnick MI.

J Urol. 1990 May;143(5):969-72.


Urologic changes after cauda equina compression in dogs.

Bodner DR, Delamarter RB, Bohlman HH, Witcher M, Biro C, Resnick MI.

J Urol. 1990 Jan;143(1):186-90.


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