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Items: 10

1.

Human STAT5b mutation causes dysregulated human natural killer cell maturation and impaired lytic function.

Vargas-Hernández A, Witalisz-Siepracka A, Prchal-Murphy M, Klein K, Mahapatra S, Al-Herz W, Mace EM, Carisey AF, Orange JS, Sexl V, Forbes LR.

J Allergy Clin Immunol. 2019 Oct 7. pii: S0091-6749(19)31252-7. doi: 10.1016/j.jaci.2019.09.016. [Epub ahead of print]

PMID:
31600547
2.

CDK8-Novel Therapeutic Opportunities.

Menzl I, Witalisz-Siepracka A, Sexl V.

Pharmaceuticals (Basel). 2019 Jun 19;12(2). pii: E92. doi: 10.3390/ph12020092. Review.

3.

STAT5BN642H drives transformation of NKT cells: a novel mouse model for CD56+ T-LGL leukemia.

Klein K, Witalisz-Siepracka A, Maurer B, Prinz D, Heller G, Leidenfrost N, Prchal-Murphy M, Suske T, Moriggl R, Sexl V.

Leukemia. 2019 Sep;33(9):2336-2340. doi: 10.1038/s41375-019-0471-3. Epub 2019 Apr 9. No abstract available.

4.

NK Cells Require Cell-Extrinsic and -Intrinsic TYK2 for Full Functionality in Tumor Surveillance and Antibacterial Immunity.

Simonović N, Witalisz-Siepracka A, Meissl K, Lassnig C, Reichart U, Kolbe T, Farlik M, Bock C, Sexl V, Müller M, Strobl B.

J Immunol. 2019 Mar 15;202(6):1724-1734. doi: 10.4049/jimmunol.1701649. Epub 2019 Feb 4.

5.

Loss of JAK1 Drives Innate Immune Deficiency.

Witalisz-Siepracka A, Klein K, Prinz D, Leidenfrost N, Schabbauer G, Dohnal A, Sexl V.

Front Immunol. 2019 Jan 8;9:3108. doi: 10.3389/fimmu.2018.03108. eCollection 2018.

6.

NK Cell-Specific CDK8 Deletion Enhances Antitumor Responses.

Witalisz-Siepracka A, Gotthardt D, Prchal-Murphy M, Didara Z, Menzl I, Prinz D, Edlinger L, Putz EM, Sexl V.

Cancer Immunol Res. 2018 Apr;6(4):458-466. doi: 10.1158/2326-6066.CIR-17-0183. Epub 2018 Jan 31.

7.

Effect of heme oxygenase-1 on ochratoxin A-induced nephrotoxicity in mice.

Loboda A, Stachurska A, Podkalicka P, Sobczak M, Mucha O, Witalisz-Siepracka A, Jozkowicz A, Dulak J.

Int J Biochem Cell Biol. 2017 Mar;84:46-57. doi: 10.1016/j.biocel.2017.01.003. Epub 2017 Jan 9.

PMID:
28089712
8.

STAT5 Is a Key Regulator in NK Cells and Acts as a Molecular Switch from Tumor Surveillance to Tumor Promotion.

Gotthardt D, Putz EM, Grundschober E, Prchal-Murphy M, Straka E, Kudweis P, Heller G, Bago-Horvath Z, Witalisz-Siepracka A, Cumaraswamy AA, Gunning PT, Strobl B, Müller M, Moriggl R, Stockmann C, Sexl V.

Cancer Discov. 2016 Apr;6(4):414-29. doi: 10.1158/2159-8290.CD-15-0732. Epub 2016 Feb 12.

9.

Tyrosine kinase 2 - Surveillant of tumours and bona fide oncogene.

Leitner NR, Witalisz-Siepracka A, Strobl B, Müller M.

Cytokine. 2017 Jan;89:209-218. doi: 10.1016/j.cyto.2015.10.015. Epub 2015 Nov 26. Review.

10.

In vivo tumor surveillance by NK cells requires TYK2 but not TYK2 kinase activity.

Prchal-Murphy M, Witalisz-Siepracka A, Bednarik KT, Putz EM, Gotthardt D, Meissl K, Sexl V, Müller M, Strobl B.

Oncoimmunology. 2015 May 26;4(11):e1047579. eCollection 2015 Nov.

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