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Analysis of an Integrated Human Multiorgan Microphysiological System for Combined Tolcapone Metabolism and Brain Metabolomics.

Wang X, Cirit M, Wishnok JS, Griffith LG, Tannenbaum SR.

Anal Chem. 2019 Jul 2;91(13):8667-8675. doi: 10.1021/acs.analchem.9b02224. Epub 2019 Jun 21.


S-nitrosylation of E3 ubiquitin-protein ligase RNF213 alters non-canonical Wnt/Ca+2 signaling in the P301S mouse model of tauopathy.

Amal H, Gong G, Gjoneska E, Lewis SM, Wishnok JS, Tsai LH, Tannenbaum SR.

Transl Psychiatry. 2019 Jan 29;9(1):44. doi: 10.1038/s41398-019-0388-7.


Magnetic silica nanoparticles for use in matrix-assisted laser desorption ionization mass spectrometry of labile biomolecules such as oligosaccharides, amino acids, peptides and nucleosides.

Yang H, Su R, Wishnok JS, Liu N, Chen C, Liu S, Tannenbaum SR.

Mikrochim Acta. 2019 Jan 12;186(2):104. doi: 10.1007/s00604-018-3208-5.


Shank3 mutation in a mouse model of autism leads to changes in the S-nitroso-proteome and affects key proteins involved in vesicle release and synaptic function.

Amal H, Barak B, Bhat V, Gong G, Joughin BA, Wang X, Wishnok JS, Feng G, Tannenbaum SR.

Mol Psychiatry. 2018 Jul 9. doi: 10.1038/s41380-018-0113-6. [Epub ahead of print]


Chemoproteomics of matrix metalloproteases in a model of cartilage degeneration suggests functional biomarkers associated with posttraumatic osteoarthritis.

Ravindra KC, Ahrens CC, Wang Y, Ramseier JY, Wishnok JS, Griffith LG, Grodzinsky AJ, Tannenbaum SR.

J Biol Chem. 2018 Jul 20;293(29):11459-11469. doi: 10.1074/jbc.M117.818542. Epub 2018 May 23.


Automated Online Solid-Phase Derivatization for Sensitive Quantification of Endogenous S-Nitrosoglutathione and Rapid Capture of Other Low-Molecular-Mass S-Nitrosothiols.

Wang X, Garcia CT, Gong G, Wishnok JS, Tannenbaum SR.

Anal Chem. 2018 Feb 6;90(3):1967-1975. doi: 10.1021/acs.analchem.7b04049. Epub 2018 Jan 9.


Integrated Assessment of Diclofenac Biotransformation, Pharmacokinetics, and Omics-Based Toxicity in a Three-Dimensional Human Liver-Immunocompetent Coculture System.

Sarkar U, Ravindra KC, Large E, Young CL, Rivera-Burgos D, Yu J, Cirit M, Hughes DJ, Wishnok JS, Lauffenburger DA, Griffith LG, Tannenbaum SR.

Drug Metab Dispos. 2017 Jul;45(7):855-866. doi: 10.1124/dmd.116.074005. Epub 2017 Apr 27.


S-nitrosation of proteins relevant to Alzheimer's disease during early stages of neurodegeneration.

Seneviratne U, Nott A, Bhat VB, Ravindra KC, Wishnok JS, Tsai LH, Tannenbaum SR.

Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):4152-7. doi: 10.1073/pnas.1521318113. Epub 2016 Mar 24.


Hydroxyphenylation of Histone Lysines: Post-translational Modification by Quinone Imines.

Ravindra KC, Trudel LJ, Wishnok JS, Wogan GN, Tannenbaum SR, Skipper PL.

ACS Chem Biol. 2016 May 20;11(5):1230-7. doi: 10.1021/acschembio.5b00923. Epub 2016 Feb 18.


Glucocorticoid Clearance and Metabolite Profiling in an In Vitro Human Airway Epithelium Lung Model.

Rivera-Burgos D, Sarkar U, Lever AR, Avram MJ, Coppeta JR, Wishnok JS, Borenstein JT, Tannenbaum SR.

Drug Metab Dispos. 2016 Feb;44(2):220-6. doi: 10.1124/dmd.115.066365. Epub 2015 Nov 19.


Quantitative Systems Pharmacology Approaches Applied to Microphysiological Systems (MPS): Data Interpretation and Multi-MPS Integration.

Yu J, Cilfone NA, Large EM, Sarkar U, Wishnok JS, Tannenbaum SR, Hughes DJ, Lauffenburger DA, Griffith LG, Stokes CL, Cirit M.

CPT Pharmacometrics Syst Pharmacol. 2015 Oct;4(10):585-94. doi: 10.1002/psp4.12010. Epub 2015 Oct 5.


Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells.

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR.

Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21.


Metabolite profiling and pharmacokinetic evaluation of hydrocortisone in a perfused three-dimensional human liver bioreactor.

Sarkar U, Rivera-Burgos D, Large EM, Hughes DJ, Ravindra KC, Dyer RL, Ebrahimkhani MR, Wishnok JS, Griffith LG, Tannenbaum SR.

Drug Metab Dispos. 2015 Jul;43(7):1091-9. doi: 10.1124/dmd.115.063495. Epub 2015 Apr 29.


Cytotoxic and pathogenic properties of Klebsiella oxytoca isolated from laboratory animals.

Darby A, Lertpiriyapong K, Sarkar U, Seneviratne U, Park DS, Gamazon ER, Batchelder C, Cheung C, Buckley EM, Taylor NS, Shen Z, Tannenbaum SR, Wishnok JS, Fox JG.

PLoS One. 2014 Jul 24;9(7):e100542. doi: 10.1371/journal.pone.0100542. eCollection 2014.


Gut microbiome phenotypes driven by host genetics affect arsenic metabolism.

Lu K, Mahbub R, Cable PH, Ru H, Parry NM, Bodnar WM, Wishnok JS, Styblo M, Swenberg JA, Fox JG, Tannenbaum SR.

Chem Res Toxicol. 2014 Feb 17;27(2):172-4. doi: 10.1021/tx400454z. Epub 2014 Feb 3.


Arsenic exposure perturbs the gut microbiome and its metabolic profile in mice: an integrated metagenomics and metabolomics analysis.

Lu K, Abo RP, Schlieper KA, Graffam ME, Levine S, Wishnok JS, Swenberg JA, Tannenbaum SR, Fox JG.

Environ Health Perspect. 2014 Mar;122(3):284-91. doi: 10.1289/ehp.1307429. Epub 2014 Jan 10.


Tunable membranes for free-flow zone electrophoresis in PDMS microchip using guided self-assembly of silica microbeads.

Song YA, Wu L, Tannenbaum SR, Wishnok JS, Han J.

Anal Chem. 2013 Dec 17;85(24):11695-9. doi: 10.1021/ac402169x. Epub 2013 Nov 25.


Gut microbiome perturbations induced by bacterial infection affect arsenic biotransformation.

Lu K, Cable PH, Abo RP, Ru H, Graffam ME, Schlieper KA, Parry NM, Levine S, Bodnar WM, Wishnok JS, Styblo M, Swenberg JA, Fox JG, Tannenbaum SR.

Chem Res Toxicol. 2013 Dec 16;26(12):1893-903. doi: 10.1021/tx4002868. Epub 2013 Nov 18.


Chemical and cytokine features of innate immunity characterize serum and tissue profiles in inflammatory bowel disease.

Knutson CG, Mangerich A, Zeng Y, Raczynski AR, Liberman RG, Kang P, Ye W, Prestwich EG, Lu K, Wishnok JS, Korzenik JR, Wogan GN, Fox JG, Dedon PC, Tannenbaum SR.

Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):E2332-41. doi: 10.1073/pnas.1222669110. Epub 2013 Jun 10.


Mechanism-based triarylphosphine-ester probes for capture of endogenous RSNOs.

Seneviratne U, Godoy LC, Wishnok JS, Wogan GN, Tannenbaum SR.

J Am Chem Soc. 2013 May 22;135(20):7693-704. doi: 10.1021/ja401565w. Epub 2013 May 8.


Comparative analysis of four oxidized guanine lesions from reactions of DNA with peroxynitrite, singlet oxygen, and γ-radiation.

Cui L, Ye W, Prestwich EG, Wishnok JS, Taghizadeh K, Dedon PC, Tannenbaum SR.

Chem Res Toxicol. 2013 Feb 18;26(2):195-202. doi: 10.1021/tx300294d. Epub 2013 Jan 24.


In situ analysis of 8-oxo-7,8-dihydro-2'-deoxyguanosine oxidation reveals sequence- and agent-specific damage spectra.

Lim KS, Cui L, Taghizadeh K, Wishnok JS, Chan W, DeMott MS, Babu IR, Tannenbaum SR, Dedon PC.

J Am Chem Soc. 2012 Oct 31;134(43):18053-64. doi: 10.1021/ja307525h. Epub 2012 Oct 22.


Serum metabolomics in a Helicobacter hepaticus mouse model of inflammatory bowel disease reveal important changes in the microbiome, serum peptides, and intermediary metabolism.

Lu K, Knutson CG, Wishnok JS, Fox JG, Tannenbaum SR.

J Proteome Res. 2012 Oct 5;11(10):4916-26. doi: 10.1021/pr300429x. Epub 2012 Sep 27.


Infection-induced colitis in mice causes dynamic and tissue-specific changes in stress response and DNA damage leading to colon cancer.

Mangerich A, Knutson CG, Parry NM, Muthupalani S, Ye W, Prestwich E, Cui L, McFaline JL, Mobley M, Ge Z, Taghizadeh K, Wishnok JS, Wogan GN, Fox JG, Tannenbaum SR, Dedon PC.

Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):E1820-9. doi: 10.1073/pnas.1207829109. Epub 2012 Jun 11.


Sequence-dependent variation in the reactivity of 8-Oxo-7,8-dihydro-2'-deoxyguanosine toward oxidation.

Lim KS, Taghizadeh K, Wishnok JS, Babu IR, Shafirovich V, Geacintov NE, Dedon PC.

Chem Res Toxicol. 2012 Feb 20;25(2):366-73. doi: 10.1021/tx200422g. Epub 2011 Dec 2.


Site-specific and redox-controlled S-nitrosation of thioredoxin.

Barglow KT, Knutson CG, Wishnok JS, Tannenbaum SR, Marletta MA.

Proc Natl Acad Sci U S A. 2011 Aug 30;108(35):E600-6. doi: 10.1073/pnas.1110736108. Epub 2011 Aug 17.


A filtered database search algorithm for endogenous serum protein carbonyl modifications in a mouse model of inflammation.

Slade PG, Williams MV, Chiang A, Iffrig E, Tannenbaum SR, Wishnok JS.

Mol Cell Proteomics. 2011 Oct;10(10):M111.007658. doi: 10.1074/mcp.M111.007658. Epub 2011 Jul 18.


Helicobacter hepaticus--induced liver tumor promotion is associated with increased serum bile acid and a persistent microbial-induced immune response.

García A, Zeng Y, Muthupalani S, Ge Z, Potter A, Mobley MW, Boussahmain C, Feng Y, Wishnok JS, Fox JG.

Cancer Res. 2011 Apr 1;71(7):2529-40. doi: 10.1158/0008-5472.CAN-10-1975. Epub 2011 Feb 18.


PGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury.

North TE, Babu IR, Vedder LM, Lord AM, Wishnok JS, Tannenbaum SR, Zon LI, Goessling W.

Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17315-20. doi: 10.1073/pnas.1008209107. Epub 2010 Sep 20.


Free-flow zone electrophoresis of peptides and proteins in PDMS microchip for narrow pI range sample prefractionation coupled with mass spectrometry.

Song YA, Chan M, Celio C, Tannenbaum SR, Wishnok JS, Han J.

Anal Chem. 2010 Mar 15;82(6):2317-25. doi: 10.1021/ac9025219.


Proteins modified by the lipid peroxidation aldehyde 9,12-dioxo-10(E)-dodecenoic acid in MCF7 breast cancer cells.

Slade PG, Williams MV, Brahmbhatt V, Dash A, Wishnok JS, Tannenbaum SR.

Chem Res Toxicol. 2010 Mar 15;23(3):557-67. doi: 10.1021/tx9002808.


Human exposure to selected animal neurocarcinogens: a biomarker-based assessment and implications for brain tumor epidemiology.

Il'yasova D, McCarthy BJ, Erdal S, Shimek J, Goldstein J, Doerge DR, Myers SR, Vineis P, Wishnok JS, Swenberg JA, Bigner DD, Davis FG.

J Toxicol Environ Health B Crit Rev. 2009 Mar;12(3):175-87. doi: 10.1080/10937400902894152. Review.


Mechanical injury and cytokines cause loss of cartilage integrity and upregulate proteins associated with catabolism, immunity, inflammation, and repair.

Stevens AL, Wishnok JS, White FM, Grodzinsky AJ, Tannenbaum SR.

Mol Cell Proteomics. 2009 Jul;8(7):1475-89. doi: 10.1074/mcp.M800181-MCP200. Epub 2009 Feb 4.


Identification of adducts formed by reaction of N-acetoxy-3,5-dimethylaniline with DNA.

Cui L, Sun HL, Wishnok JS, Tannenbaum SR, Skipper PL.

Chem Res Toxicol. 2007 Nov;20(11):1730-6.


Phosphorothioation of DNA in bacteria by dnd genes.

Wang L, Chen S, Xu T, Taghizadeh K, Wishnok JS, Zhou X, You D, Deng Z, Dedon PC.

Nat Chem Biol. 2007 Nov;3(11):709-10. Epub 2007 Oct 14.


Covalent adducts arising from the decomposition products of lipid hydroperoxides in the presence of cytochrome c.

Williams MV, Wishnok JS, Tannenbaum SR.

Chem Res Toxicol. 2007 May;20(5):767-75. Epub 2007 Apr 4.


Comparative time-dependent analysis of potential inflammation biomarkers in lymphoma-bearing SJL mice.

Kristiansson MH, Bhat VB, Babu IR, Wishnok JS, Tannenbaum SR.

J Proteome Res. 2007 May;6(5):1735-44. Epub 2007 Mar 28.


Lipid peroxidation dominates the chemistry of DNA adduct formation in a mouse model of inflammation.

Pang B, Zhou X, Yu H, Dong M, Taghizadeh K, Wishnok JS, Tannenbaum SR, Dedon PC.

Carcinogenesis. 2007 Aug;28(8):1807-13. Epub 2007 Mar 7.


Hydroxyl-specific fluorescence labeling of ABP-deoxyguanosine, PhIP-deoxyguanosine, and AFB1-formamidopyrimidine with BODIPY-FL.

Jang HG, Park M, Wishnok JS, Tannenbaum SR, Wogan GN.

Anal Biochem. 2006 Dec 15;359(2):151-60. Epub 2006 Nov 1.


Detection and quantification of 4-ABP adducts in DNA from bladder cancer patients.

Zayas B, Stillwell SW, Wishnok JS, Trudel LJ, Skipper P, Yu MC, Tannenbaum SR, Wogan GN.

Carcinogenesis. 2007 Feb;28(2):342-9. Epub 2006 Aug 21.


DNA adducts formed by a novel antitumor agent 11beta-dichloro in vitro and in vivo.

Hillier SM, Marquis JC, Zayas B, Wishnok JS, Liberman RG, Skipper PL, Tannenbaum SR, Essigmann JM, Croy RG.

Mol Cancer Ther. 2006 Apr;5(4):977-84.


Renal injury is a consistent finding in Dutch Belted rabbits experimentally infected with enterohemorrhagic Escherichia coli.

Garcia A, Bosques CJ, Wishnok JS, Feng Y, Karalius BJ, Butterton JR, Schauer DB, Rogers AB, Fox JG.

J Infect Dis. 2006 Apr 15;193(8):1125-34. Epub 2006 Mar 6.


Quantitation of four guanine oxidation products from reaction of DNA with varying doses of peroxynitrite.

Yu H, Venkatarangan L, Wishnok JS, Tannenbaum SR.

Chem Res Toxicol. 2005 Dec;18(12):1849-57.


Peroxynitrite-induced oxidation and nitration products of guanine and 8-oxoguanine: structures and mechanisms of product formation.

Niles JC, Wishnok JS, Tannenbaum SR.

Nitric Oxide. 2006 Mar;14(2):109-21. Epub 2005 Dec 13. Review.


Comparative plasma proteome analysis of lymphoma-bearing SJL mice.

Bhat VB, Choi MH, Wishnok JS, Tannenbaum SR.

J Proteome Res. 2005 Sep-Oct;4(5):1814-25.


AlkB reverses etheno DNA lesions caused by lipid oxidation in vitro and in vivo.

Delaney JC, Smeester L, Wong C, Frick LE, Taghizadeh K, Wishnok JS, Drennan CL, Samson LD, Essigmann JM.

Nat Struct Mol Biol. 2005 Oct;12(10):855-60. Epub 2005 Oct 2.


Characterization of the secreted proteome of rat hepatocytes cultured in collagen sandwiches.

Farkas D, Bhat VB, Mandapati S, Wishnok JS, Tannenbaum SR.

Chem Res Toxicol. 2005 Jul;18(7):1132-9.


Characterization of testosterone 11 beta-hydroxylation catalyzed by human liver microsomal cytochromes P450.

Choi MH, Skipper PL, Wishnok JS, Tannenbaum SR.

Drug Metab Dispos. 2005 Jun;33(6):714-8. Epub 2005 Mar 11.


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