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Items: 1 to 50 of 54

1.

CRISPR/Cas9 mediated generation of an ovine model for infantile neuronal ceroid lipofuscinosis (CLN1 disease).

Eaton SL, Proudfoot C, Lillico SG, Skehel P, Kline RA, Hamer K, Rzechorzek NM, Clutton E, Gregson R, King T, O'Neill CA, Cooper JD, Thompson G, Whitelaw CB, Wishart TM.

Sci Rep. 2019 Jul 9;9(1):9891. doi: 10.1038/s41598-019-45859-9.

2.

Applying modern Omic technologies to the Neuronal Ceroid Lipofuscinoses.

Kline RA, Wishart TM, Mills K, Heywood WE.

Biochim Biophys Acta Mol Basis Dis. 2019 Jun 15. pii: S0925-4439(19)30211-X. doi: 10.1016/j.bbadis.2019.06.012. [Epub ahead of print] Review.

PMID:
31207290
3.

Altered mitochondrial bioenergetics are responsible for the delay in Wallerian degeneration observed in neonatal mice.

Kline RA, Dissanayake KN, Hurtado ML, Martínez NW, Ahl A, Mole AJ, Lamont DJ, Court FA, Ribchester RR, Wishart TM, Murray LM.

Neurobiol Dis. 2019 Oct;130:104496. doi: 10.1016/j.nbd.2019.104496. Epub 2019 Jun 6.

4.

Regional Molecular Mapping of Primate Synapses during Normal Healthy Aging.

Graham LC, Naldrett MJ, Kohama SG, Smith C, Lamont DJ, McColl BW, Gillingwater TH, Skehel P, Urbanski HF, Wishart TM.

Cell Rep. 2019 Apr 23;27(4):1018-1026.e4. doi: 10.1016/j.celrep.2019.03.096.

5.

UBA1/GARS-dependent pathways drive sensory-motor connectivity defects in spinal muscular atrophy.

Shorrock HK, van der Hoorn D, Boyd PJ, Llavero Hurtado M, Lamont DJ, Wirth B, Sleigh JN, Schiavo G, Wishart TM, Groen EJN, Gillingwater TH.

Brain. 2018 Oct 1;141(10):2878-2894. doi: 10.1093/brain/awy237.

6.

Cellular and Molecular Anatomy of the Human Neuromuscular Junction.

Jones RA, Harrison C, Eaton SL, Llavero Hurtado M, Graham LC, Alkhammash L, Oladiran OA, Gale A, Lamont DJ, Simpson H, Simmen MW, Soeller C, Wishart TM, Gillingwater TH.

Cell Rep. 2017 Nov 28;21(9):2348-2356. doi: 10.1016/j.celrep.2017.11.008.

7.

Molecular analysis of axonal-intrinsic and glial-associated co-regulation of axon degeneration.

Catenaccio A, Llavero Hurtado M, Diaz P, Lamont DJ, Wishart TM, Court FA.

Cell Death Dis. 2017 Nov 9;8(11):e3166. doi: 10.1038/cddis.2017.489.

8.

Proteomic profiling of neuronal mitochondria reveals modulators of synaptic architecture.

Graham LC, Eaton SL, Brunton PJ, Atrih A, Smith C, Lamont DJ, Gillingwater TH, Pennetta G, Skehel P, Wishart TM.

Mol Neurodegener. 2017 Oct 27;12(1):77. doi: 10.1186/s13024-017-0221-9.

9.

Proteomic mapping of differentially vulnerable pre-synaptic populations identifies regulators of neuronal stability in vivo.

Llavero Hurtado M, Fuller HR, Wong AMS, Eaton SL, Gillingwater TH, Pennetta G, Cooper JD, Wishart TM.

Sci Rep. 2017 Sep 29;7(1):12412. doi: 10.1038/s41598-017-12603-0.

10.

Pro-death NMDA receptor signaling is promoted by the GluN2B C-terminus independently of Dapk1.

McQueen J, Ryan TJ, McKay S, Marwick K, Baxter P, Carpanini SM, Wishart TM, Gillingwater TH, Manson JC, Wyllie DJA, Grant SGN, McColl BW, Komiyama NH, Hardingham GE.

Elife. 2017 Jul 21;6. pii: e17161. doi: 10.7554/eLife.17161.

11.

Bioenergetic status modulates motor neuron vulnerability and pathogenesis in a zebrafish model of spinal muscular atrophy.

Boyd PJ, Tu WY, Shorrock HK, Groen EJN, Carter RN, Powis RA, Thomson SR, Thomson D, Graham LC, Motyl AAL, Wishart TM, Highley JR, Morton NM, Becker T, Becker CG, Heath PR, Gillingwater TH.

PLoS Genet. 2017 Apr 20;13(4):e1006744. doi: 10.1371/journal.pgen.1006744. eCollection 2017 Apr.

12.

Bridging the gap: large animal models in neurodegenerative research.

Eaton SL, Wishart TM.

Mamm Genome. 2017 Aug;28(7-8):324-337. doi: 10.1007/s00335-017-9687-6. Epub 2017 Apr 4. Review.

13.

Analysis of gene expression in the nervous system identifies key genes and novel candidates for health and disease.

Carpanini SM, Wishart TM, Gillingwater TH, Manson JC, Summers KM.

Neurogenetics. 2017 Apr;18(2):81-95. doi: 10.1007/s10048-017-0509-5. Epub 2017 Feb 11.

14.

Sideroflexin 3 is an α-synuclein-dependent mitochondrial protein that regulates synaptic morphology.

Amorim IS, Graham LC, Carter RN, Morton NM, Hammachi F, Kunath T, Pennetta G, Carpanini SM, Manson JC, Lamont DJ, Wishart TM, Gillingwater TH.

J Cell Sci. 2017 Jan 15;130(2):325-331. doi: 10.1242/jcs.194241. Epub 2017 Jan 3.

15.

Systemic restoration of UBA1 ameliorates disease in spinal muscular atrophy.

Powis RA, Karyka E, Boyd P, Côme J, Jones RA, Zheng Y, Szunyogova E, Groen EJ, Hunter G, Thomson D, Wishart TM, Becker CG, Parson SH, Martinat C, Azzouz M, Gillingwater TH.

JCI Insight. 2016 Jul 21;1(11):e87908. doi: 10.1172/jci.insight.87908.

16.

Commonality amid diversity: Multi-study proteomic identification of conserved disease mechanisms in spinal muscular atrophy.

Fuller HR, Gillingwater TH, Wishart TM.

Neuromuscul Disord. 2016 Sep;26(9):560-9. doi: 10.1016/j.nmd.2016.06.004. Epub 2016 Jun 7. Review.

17.

Understanding the molecular consequences of inherited muscular dystrophies: advancements through proteomic experimentation.

Fuller HR, Graham LC, Llavero Hurtado M, Wishart TM.

Expert Rev Proteomics. 2016 Jul;13(7):659-71. doi: 10.1080/14789450.2016.1202768. Epub 2016 Jul 5. Review.

PMID:
27329572
18.

Molecular neuropathology of the synapse in sheep with CLN5 Batten disease.

Amorim IS, Mitchell NL, Palmer DN, Sawiak SJ, Mason R, Wishart TM, Gillingwater TH.

Brain Behav. 2015 Oct 9;5(11):e00401. doi: 10.1002/brb3.401. eCollection 2015 Nov.

19.

Equine grass sickness, but not botulism, causes autonomic and enteric neurodegeneration and increases soluble N-ethylmaleimide-sensitive factor attachment receptor protein expression within neuronal perikarya.

McGorum BC, Scholes S, Milne EM, Eaton SL, Wishart TM, Poxton IR, Moss S, Wernery U, Davey T, Harris JB, Pirie RS.

Equine Vet J. 2016 Nov;48(6):786-791. doi: 10.1111/evj.12543. Epub 2016 Jan 11.

PMID:
26640078
20.

Quantitative imaging of tissue sections using infrared scanning technology.

Eaton SL, Cumyn E, King D, Kline RA, Carpanini SM, Del-Pozo J, Barron R, Wishart TM.

J Anat. 2016 Jan;228(1):203-13. doi: 10.1111/joa.12398. Epub 2015 Oct 29.

21.

Proteomic Profiling of Cranial (Superior) Cervical Ganglia Reveals Beta-Amyloid and Ubiquitin Proteasome System Perturbations in an Equine Multiple System Neuropathy.

McGorum BC, Pirie RS, Eaton SL, Keen JA, Cumyn EM, Arnott DM, Chen W, Lamont DJ, Graham LC, Llavero Hurtado M, Pemberton A, Wishart TM.

Mol Cell Proteomics. 2015 Nov;14(11):3072-86. doi: 10.1074/mcp.M115.054635. Epub 2015 Sep 13.

22.

A guide to modern quantitative fluorescent western blotting with troubleshooting strategies.

Eaton SL, Hurtado ML, Oldknow KJ, Graham LC, Marchant TW, Gillingwater TH, Farquharson C, Wishart TM.

J Vis Exp. 2014 Nov 20;(93):e52099. doi: 10.3791/52099.

23.

Loss of glial neurofascin155 delays developmental synapse elimination at the neuromuscular junction.

Roche SL, Sherman DL, Dissanayake K, Soucy G, Desmazieres A, Lamont DJ, Peles E, Julien JP, Wishart TM, Ribchester RR, Brophy PJ, Gillingwater TH.

J Neurosci. 2014 Sep 17;34(38):12904-18. doi: 10.1523/JNEUROSCI.1725-14.2014.

24.

Label-free quantitative proteomic profiling identifies disruption of ubiquitin homeostasis as a key driver of Schwann cell defects in spinal muscular atrophy.

Aghamaleky Sarvestany A, Hunter G, Tavendale A, Lamont DJ, Llavero Hurtado M, Graham LC, Wishart TM, Gillingwater TH.

J Proteome Res. 2014 Nov 7;13(11):4546-57. doi: 10.1021/pr500492j. Epub 2014 Aug 29.

PMID:
25151848
25.

Increased levels of UCHL1 are a compensatory response to disrupted ubiquitin homeostasis in spinal muscular atrophy and do not represent a viable therapeutic target.

Powis RA, Mutsaers CA, Wishart TM, Hunter G, Wirth B, Gillingwater TH.

Neuropathol Appl Neurobiol. 2014 Dec;40(7):873-87. doi: 10.1111/nan.12168.

26.

The rat striatum responds to nigro-striatal degeneration via the increased expression of proteins associated with growth and regeneration of neuronal circuitry.

Fuller HR, Hurtado ML, Wishart TM, Gates MA.

Proteome Sci. 2014 Apr 28;12:20. doi: 10.1186/1477-5956-12-20. eCollection 2014.

27.

A novel mouse model of Warburg Micro syndrome reveals roles for RAB18 in eye development and organisation of the neuronal cytoskeleton.

Carpanini SM, McKie L, Thomson D, Wright AK, Gordon SL, Roche SL, Handley MT, Morrison H, Brownstein D, Wishart TM, Cousin MA, Gillingwater TH, Aligianis IA, Jackson IJ.

Dis Model Mech. 2014 Jun;7(6):711-22. doi: 10.1242/dmm.015222. Epub 2014 Apr 24.

28.

Dysregulation of ubiquitin homeostasis and β-catenin signaling promote spinal muscular atrophy.

Wishart TM, Mutsaers CA, Riessland M, Reimer MM, Hunter G, Hannam ML, Eaton SL, Fuller HR, Roche SL, Somers E, Morse R, Young PJ, Lamont DJ, Hammerschmidt M, Joshi A, Hohenstein P, Morris GE, Parson SH, Skehel PA, Becker T, Robinson IM, Becker CG, Wirth B, Gillingwater TH.

J Clin Invest. 2014 Apr;124(4):1821-34. doi: 10.1172/JCI71318. Epub 2014 Mar 3.

29.

Label-free proteomics identifies Calreticulin and GRP75/Mortalin as peripherally accessible protein biomarkers for spinal muscular atrophy.

Mutsaers CA, Lamont DJ, Hunter G, Wishart TM, Gillingwater TH.

Genome Med. 2013 Oct 18;5(10):95. doi: 10.1186/gm498. eCollection 2013.

30.

Total protein analysis as a reliable loading control for quantitative fluorescent Western blotting.

Eaton SL, Roche SL, Llavero Hurtado M, Oldknow KJ, Farquharson C, Gillingwater TH, Wishart TM.

PLoS One. 2013 Aug 30;8(8):e72457. doi: 10.1371/journal.pone.0072457. eCollection 2013.

31.

Mechanisms underlying synaptic vulnerability and degeneration in neurodegenerative disease.

Gillingwater TH, Wishart TM.

Neuropathol Appl Neurobiol. 2013 Jun;39(4):320-34. doi: 10.1111/nan.12014.

PMID:
23289367
32.

Combining comparative proteomics and molecular genetics uncovers regulators of synaptic and axonal stability and degeneration in vivo.

Wishart TM, Rooney TM, Lamont DJ, Wright AK, Morton AJ, Jackson M, Freeman MR, Gillingwater TH.

PLoS Genet. 2012;8(8):e1002936. doi: 10.1371/journal.pgen.1002936. Epub 2012 Aug 30.

33.

WldS prevents axon degeneration through increased mitochondrial flux and enhanced mitochondrial Ca2+ buffering.

Avery MA, Rooney TM, Pandya JD, Wishart TM, Gillingwater TH, Geddes JW, Sullivan PG, Freeman MR.

Curr Biol. 2012 Apr 10;22(7):596-600. doi: 10.1016/j.cub.2012.02.043. Epub 2012 Mar 15.

34.

Density, calibre and ramification of muscle capillaries are altered in a mouse model of severe spinal muscular atrophy.

Somers E, Stencel Z, Wishart TM, Gillingwater TH, Parson SH.

Neuromuscul Disord. 2012 May;22(5):435-42. doi: 10.1016/j.nmd.2011.10.021. Epub 2011 Dec 7.

PMID:
22153987
35.

Using induced pluripotent stem cells (iPSC) to model human neuromuscular connectivity: promise or reality?

Thomson SR, Wishart TM, Patani R, Chandran S, Gillingwater TH.

J Anat. 2012 Feb;220(2):122-30. doi: 10.1111/j.1469-7580.2011.01459.x. Epub 2011 Dec 2. Review.

36.

Reversible molecular pathology of skeletal muscle in spinal muscular atrophy.

Mutsaers CA, Wishart TM, Lamont DJ, Riessland M, Schreml J, Comley LH, Murray LM, Parson SH, Lochmüller H, Wirth B, Talbot K, Gillingwater TH.

Hum Mol Genet. 2011 Nov 15;20(22):4334-44. doi: 10.1093/hmg/ddr360. Epub 2011 Aug 12.

PMID:
21840928
37.

ApoE isoform-specific regulation of regeneration in the peripheral nervous system.

Comley LH, Fuller HR, Wishart TM, Mutsaers CA, Thomson D, Wright AK, Ribchester RR, Morris GE, Parson SH, Horsburgh K, Gillingwater TH.

Hum Mol Genet. 2011 Jun 15;20(12):2406-21. doi: 10.1093/hmg/ddr147. Epub 2011 Apr 8.

38.

Induction of cell stress in neurons from transgenic mice expressing yellow fluorescent protein: implications for neurodegeneration research.

Comley LH, Wishart TM, Baxter B, Murray LM, Nimmo A, Thomson D, Parson SH, Gillingwater TH.

PLoS One. 2011 Mar 8;6(3):e17639. doi: 10.1371/journal.pone.0017639.

39.

Retinoid-independent motor neurogenesis from human embryonic stem cells reveals a medial columnar ground state.

Patani R, Hollins AJ, Wishart TM, Puddifoot CA, Alvarez S, de Lera AR, Wyllie DJ, Compston DA, Pedersen RA, Gillingwater TH, Hardingham GE, Allen ND, Chandran S.

Nat Commun. 2011;2:214. doi: 10.1038/ncomms1216.

40.

Synaptic protection in the brain of WldS mice occurs independently of age but is sensitive to gene-dose.

Wright AK, Wishart TM, Ingham CA, Gillingwater TH.

PLoS One. 2010 Nov 29;5(11):e15108. doi: 10.1371/journal.pone.0015108.

41.

SMN deficiency disrupts brain development in a mouse model of severe spinal muscular atrophy.

Wishart TM, Huang JP, Murray LM, Lamont DJ, Mutsaers CA, Ross J, Geldsetzer P, Ansorge O, Talbot K, Parson SH, Gillingwater TH.

Hum Mol Genet. 2010 Nov 1;19(21):4216-28. doi: 10.1093/hmg/ddq340. Epub 2010 Aug 12.

42.

Expression of the neuroprotective slow Wallerian degeneration (WldS) gene in non-neuronal tissues.

Wishart TM, Brownstein DG, Thomson D, Tabakova AM, Boothe KM, Tsao JW, Gillingwater TH.

BMC Neurosci. 2009 Dec 16;10:148. doi: 10.1186/1471-2202-10-148.

43.

Molecular correlates of axonal and synaptic pathology in mouse models of Batten disease.

Kielar C, Wishart TM, Palmer A, Dihanich S, Wong AM, Macauley SL, Chan CH, Sands MS, Pearce DA, Cooper JD, Gillingwater TH.

Hum Mol Genet. 2009 Nov 1;18(21):4066-80. doi: 10.1093/hmg/ddp355. Epub 2009 Jul 29.

44.

Protein product of CLN6 gene responsible for variant late-onset infantile neuronal ceroid lipofuscinosis interacts with CRMP-2.

Benedict JW, Getty AL, Wishart TM, Gillingwater TH, Pearce DA.

J Neurosci Res. 2009 Jul;87(9):2157-66. doi: 10.1002/jnr.22032.

45.

Loss of translation elongation factor (eEF1A2) expression in vivo differentiates between Wallerian degeneration and dying-back neuronal pathology.

Murray LM, Thomson D, Conklin A, Wishart TM, Gillingwater TH.

J Anat. 2008 Dec;213(6):633-45. doi: 10.1111/j.1469-7580.2008.01007.x.

46.

Modified cell cycle status in a mouse model of altered neuronal vulnerability (slow Wallerian degeneration; Wlds).

Wishart TM, Pemberton HN, James SR, McCabe CJ, Gillingwater TH.

Genome Biol. 2008;9(6):R101. doi: 10.1186/gb-2008-9-6-r101. Epub 2008 Jun 20.

47.

VCP binding influences intracellular distribution of the slow Wallerian degeneration protein, Wld(S).

Wilbrey AL, Haley JE, Wishart TM, Conforti L, Morreale G, Beirowski B, Babetto E, Adalbert R, Gillingwater TH, Smith T, Wyllie DJ, Ribchester RR, Coleman MP.

Mol Cell Neurosci. 2008 Jul;38(3):325-40. doi: 10.1016/j.mcn.2008.03.004. Epub 2008 Mar 25.

PMID:
18468455
48.

Design of a novel quantitative PCR (QPCR)-based protocol for genotyping mice carrying the neuroprotective Wallerian degeneration slow (Wlds) gene.

Wishart TM, Macdonald SH, Chen PE, Shipston MJ, Coleman MP, Gillingwater TH, Ribchester RR.

Mol Neurodegener. 2007 Oct 30;2:21.

49.

Differential proteomics analysis of synaptic proteins identifies potential cellular targets and protein mediators of synaptic neuroprotection conferred by the slow Wallerian degeneration (Wlds) gene.

Wishart TM, Paterson JM, Short DM, Meredith S, Robertson KA, Sutherland C, Cousin MA, Dutia MB, Gillingwater TH.

Mol Cell Proteomics. 2007 Aug;6(8):1318-30. Epub 2007 Apr 29.

50.

Synaptic vulnerability in neurodegenerative disease.

Wishart TM, Parson SH, Gillingwater TH.

J Neuropathol Exp Neurol. 2006 Aug;65(8):733-9. Review.

PMID:
16896307

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