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Items: 33

1.

Conformationally constrained farnesoid X receptor (FXR) agonists: alternative replacements of the stilbene.

Akwabi-Ameyaw A, Caravella JA, Chen L, Creech KL, Deaton DN, Madauss KP, Marr HB, Miller AB, Navas F 3rd, Parks DJ, Spearing PK, Todd D, Williams SP, Wisely GB.

Bioorg Med Chem Lett. 2011 Oct 15;21(20):6154-60. doi: 10.1016/j.bmcl.2011.08.034. Epub 2011 Aug 11.

PMID:
21890356
2.

Conformationally constrained farnesoid X receptor (FXR) agonists: heteroaryl replacements of the naphthalene.

Bass JY, Caravella JA, Chen L, Creech KL, Deaton DN, Madauss KP, Marr HB, McFadyen RB, Miller AB, Mills WY, Navas F 3rd, Parks DJ, Smalley TL Jr, Spearing PK, Todd D, Williams SP, Wisely GB.

Bioorg Med Chem Lett. 2011 Feb 15;21(4):1206-13. doi: 10.1016/j.bmcl.2010.12.089. Epub 2010 Dec 23.

PMID:
21256005
3.

GSK4112, a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbĪ±.

Grant D, Yin L, Collins JL, Parks DJ, Orband-Miller LA, Wisely GB, Joshi S, Lazar MA, Willson TM, Zuercher WJ.

ACS Chem Biol. 2010 Oct 15;5(10):925-32. doi: 10.1021/cb100141y.

PMID:
20677822
4.

Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064.

Bass JY, Caldwell RD, Caravella JA, Chen L, Creech KL, Deaton DN, Madauss KP, Marr HB, McFadyen RB, Miller AB, Parks DJ, Todd D, Williams SP, Wisely GB.

Bioorg Med Chem Lett. 2009 Jun 1;19(11):2969-73. doi: 10.1016/j.bmcl.2009.04.047. Epub 2009 Apr 18.

PMID:
19410460
5.

Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064.

Akwabi-Ameyaw A, Bass JY, Caldwell RD, Caravella JA, Chen L, Creech KL, Deaton DN, Jones SA, Kaldor I, Liu Y, Madauss KP, Marr HB, McFadyen RB, Miller AB, Navas F III, Parks DJ, Spearing PK, Todd D, Williams SP, Wisely GB.

Bioorg Med Chem Lett. 2008 Aug 1;18(15):4339-43. doi: 10.1016/j.bmcl.2008.06.073. Epub 2008 Jun 28.

PMID:
18621523
6.

Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways.

Yin L, Wu N, Curtin JC, Qatanani M, Szwergold NR, Reid RA, Waitt GM, Parks DJ, Pearce KH, Wisely GB, Lazar MA.

Science. 2007 Dec 14;318(5857):1786-9. Epub 2007 Nov 15.

7.

Automated in-line gel filtration for native state mass spectrometry.

Waitt GM, Xu R, Wisely GB, Williams JD.

J Am Soc Mass Spectrom. 2008 Feb;19(2):239-45. Epub 2007 May 23.

8.

Crystallization of protein-ligand complexes.

Hassell AM, An G, Bledsoe RK, Bynum JM, Carter HL 3rd, Deng SJ, Gampe RT, Grisard TE, Madauss KP, Nolte RT, Rocque WJ, Wang L, Weaver KL, Williams SP, Wisely GB, Xu R, Shewchuk LM.

Acta Crystallogr D Biol Crystallogr. 2007 Jan;63(Pt 1):72-9. Epub 2006 Dec 13. Review.

9.

Human PXR forms a tryptophan zipper-mediated homodimer.

Noble SM, Carnahan VE, Moore LB, Luntz T, Wang H, Ittoop OR, Stimmel JB, Davis-Searles PR, Watkins RE, Wisely GB, LeCluyse E, Tripathy A, McDonnell DP, Redinbo MR.

Biochemistry. 2006 Jul 18;45(28):8579-89.

10.

Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin.

Chrencik JE, Orans J, Moore LB, Xue Y, Peng L, Collins JL, Wisely GB, Lambert MH, Kliewer SA, Redinbo MR.

Mol Endocrinol. 2005 May;19(5):1125-34. Epub 2005 Feb 10.

PMID:
15705662
11.

Helix 1/8 interactions influence the activity of nuclear receptor ligand-binding domains.

Holt JA, Consler TG, Williams SP, Ayscue AH, Leesnitzer LM, Wisely GB, Billin AN.

Mol Endocrinol. 2003 Sep;17(9):1704-14. Epub 2003 Jun 19.

PMID:
12817079
12.

2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin.

Watkins RE, Maglich JM, Moore LB, Wisely GB, Noble SM, Davis-Searles PR, Lambert MH, Kliewer SA, Redinbo MR.

Biochemistry. 2003 Feb 18;42(6):1430-8.

PMID:
12578355
13.

A new series of estrogen receptor modulators that display selectivity for estrogen receptor beta.

Henke BR, Consler TG, Go N, Hale RL, Hohman DR, Jones SA, Lu AT, Moore LB, Moore JT, Orband-Miller LA, Robinett RG, Shearin J, Spearing PK, Stewart EL, Turnbull PS, Weaver SL, Williams SP, Wisely GB, Lambert MH.

J Med Chem. 2002 Dec 5;45(25):5492-505.

PMID:
12459017
14.

Use of in vitro pregnane X receptor assays to assess CYP3A4 induction potential of drug candidates.

Jones SA, Moore LB, Wisely GB, Kliewer SA.

Methods Enzymol. 2002;357:161-70. No abstract available.

PMID:
12424907
15.

Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids.

Wisely GB, Miller AB, Davis RG, Thornquest AD Jr, Johnson R, Spitzer T, Sefler A, Shearer B, Moore JT, Miller AB, Willson TM, Williams SP.

Structure. 2002 Sep;10(9):1225-34.

16.

The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity.

Watkins RE, Wisely GB, Moore LB, Collins JL, Lambert MH, Williams SP, Willson TM, Kliewer SA, Redinbo MR.

Science. 2001 Jun 22;292(5525):2329-33. Epub 2001 Jun 14.

17.

Production and characterization of an estrogen receptor beta subtype-specific mouse monoclonal antibody.

Su JL, McKee DD, Ellis B, Kadwell SH, Wisely GB, Moore LB, Triantafillou JA, Kost TA, Fuqua S, Moore JT.

Hybridoma. 2000 Dec;19(6):481-7.

PMID:
11152400
18.

Structural basis for autorepression of retinoid X receptor by tetramer formation and the AF-2 helix.

Gampe RT Jr, Montana VG, Lambert MH, Wisely GB, Milburn MV, Xu HE.

Genes Dev. 2000 Sep 1;14(17):2229-41.

19.

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor.

Moore LB, Goodwin B, Jones SA, Wisely GB, Serabjit-Singh CJ, Willson TM, Collins JL, Kliewer SA.

Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7500-2.

20.

Production of monoclonal antibodies using recombinant baculovirus displaying gp64-fusion proteins.

Lindley KM, Su JL, Hodges PK, Wisely GB, Bledsoe RK, Condreay JP, Winegar DA, Hutchins JT, Kost TA.

J Immunol Methods. 2000 Feb 3;234(1-2):123-35.

PMID:
10669777
21.

The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution.

Jones SA, Moore LB, Shenk JL, Wisely GB, Hamilton GA, McKee DD, Tomkinson NC, LeCluyse EL, Lambert MH, Willson TM, Kliewer SA, Moore JT.

Mol Endocrinol. 2000 Jan;14(1):27-39.

PMID:
10628745
22.

Use of a PPAR gamma-specific monoclonal antibody to demonstrate thiazolidinediones induce PPAR gamma receptor expression in vitro.

Su JL, Winegar DA, Wisely GB, Sigel CS, Hull-Ryde EA.

Hybridoma. 1999 Jun;18(3):273-80.

PMID:
10475242
23.

Molecular recognition of fatty acids by peroxisome proliferator-activated receptors.

Xu HE, Lambert MH, Montana VG, Parks DJ, Blanchard SG, Brown PJ, Sternbach DD, Lehmann JM, Wisely GB, Willson TM, Kliewer SA, Milburn MV.

Mol Cell. 1999 Mar;3(3):397-403.

24.

Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta.

Janowski BA, Grogan MJ, Jones SA, Wisely GB, Kliewer SA, Corey EJ, Mangelsdorf DJ.

Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):266-71.

25.

Interactions controlling the assembly of nuclear-receptor heterodimers and co-activators.

Westin S, Kurokawa R, Nolte RT, Wisely GB, McInerney EM, Rose DW, Milburn MV, Rosenfeld MG, Glass CK.

Nature. 1998 Sep 10;395(6698):199-202.

PMID:
9744281
26.

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma.

Nolte RT, Wisely GB, Westin S, Cobb JE, Lambert MH, Kurokawa R, Rosenfeld MG, Willson TM, Glass CK, Milburn MV.

Nature. 1998 Sep 10;395(6698):137-43.

PMID:
9744270
27.

Human recombinant phosphodiesterase 4B2B binds (R)-rolipram at a single site with two affinities.

Rocque WJ, Tian G, Wiseman JS, Holmes WD, Zajac-Thompson I, Willard DH, Patel IR, Wisely GB, Clay WC, Kadwell SH, Hoffman CR, Luther MA.

Biochemistry. 1997 Nov 18;36(46):14250-61.

PMID:
9369498
28.

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma.

Kliewer SA, Sundseth SS, Jones SA, Brown PJ, Wisely GB, Koble CS, Devchand P, Wahli W, Willson TM, Lenhard JM, Lehmann JM.

Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4318-23.

29.

Detailed characterization of a purified type 4 phosphodiesterase, HSPDE4B2B: differentiation of high- and low-affinity (R)-rolipram binding.

Rocque WJ, Holmes WD, Patel IR, Dougherty RW, Ittoop O, Overton L, Hoffman CR, Wisely GB, Willard DH, Luther MA.

Protein Expr Purif. 1997 Mar;9(2):191-202.

PMID:
9056484
30.

NF-kappa B regulates IL-1 beta transcription through a consensus NF-kappa B binding site and a nonconsensus CRE-like site.

Cogswell JP, Godlevski MM, Wisely GB, Clay WC, Leesnitzer LM, Ways JP, Gray JG.

J Immunol. 1994 Jul 15;153(2):712-23.

PMID:
8021507
31.

A CRE/ATF-like site in the upstream regulatory sequence of the human interleukin 1 beta gene is necessary for induction in U937 and THP-1 monocytic cell lines.

Gray JG, Chandra G, Clay WC, Stinnett SW, Haneline SA, Lorenz JJ, Patel IR, Wisely GB, Furdon PJ, Taylor JD, et al.

Mol Cell Biol. 1993 Nov;13(11):6678-89.

32.

Molecular and genetic organization of the suppressor of sable and minute (1) 1B region in Drosophila melanogaster.

Voelker RA, Huang SM, Wisely GB, Sterling JF, Bainbridge SP, Hiraizumi K.

Genetics. 1989 Jul;122(3):625-42.

33.

Frequent Imprecise Excision among Reversions of a P Element-Caused Lethal Mutation in Drosophila.

Voelker RA, Greenleaf AL, Gyurkovics H, Wisely GB, Huang SM, Searles LL.

Genetics. 1984 Jun;107(2):279-94.

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