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Recent Advances in the Drug Treatment of Dravet Syndrome.

Wirrell EC, Nabbout R.

CNS Drugs. 2019 Sep;33(9):867-881. doi: 10.1007/s40263-019-00666-8. Review.


The co-occurrence of epilepsy and autism: A systematic review.

Lukmanji S, Manji SA, Kadhim S, Sauro KM, Wirrell EC, Kwon CS, Jetté N.

Epilepsy Behav. 2019 Sep;98(Pt A):238-248. doi: 10.1016/j.yebeh.2019.07.037. Epub 2019 Aug 6. Review.


Seizure Rescue Medication Use among US Pediatric Epilepsy Providers: A Survey of the Pediatric Epilepsy Research Consortium.

Wallace A, Wirrell E, Payne E.

J Pediatr. 2019 Sep;212:111-116. doi: 10.1016/j.jpeds.2019.05.034. Epub 2019 Jun 14.


Immediate outcomes in early life epilepsy: A contemporary account.

Berg AT, Wusthoff C, Shellhaas RA, Loddenkemper T, Grinspan ZM, Saneto RP, Knupp KG, Patel A, Sullivan JE, Kossoff EH, Chu CJ, Massey S, Valencia I, Keator C, Wirrell EC, Coryell J, Millichap JJ, Gaillard WD.

Epilepsy Behav. 2019 Aug;97:44-50. doi: 10.1016/j.yebeh.2019.05.011. Epub 2019 Jun 7.


Correspondence Reply to Madaan et al.

Jagadish S, Payne ET, Wong-Kisiel L, Nickels KC, Eckert S, Wirrell EC.

Pediatr Neurol. 2019 Jun;95:92-93. doi: 10.1016/j.pediatrneurol.2019.01.004. Epub 2019 Feb 2. No abstract available.


The Ketogenic and Modified Atkins Diet Therapy for Children With Refractory Epilepsy of Genetic Etiology.

Jagadish S, Payne ET, Wong-Kisiel L, Nickels KC, Eckert S, Wirrell EC.

Pediatr Neurol. 2019 May;94:32-37. doi: 10.1016/j.pediatrneurol.2018.12.012. Epub 2018 Dec 29.


How can transition to adult care be best orchestrated for adolescents with epilepsy?

Camfield PR, Andrade D, Camfield CS, Carrizosa-Moog J, Appleton R, Baulac M, Brown L, Menachem EB, Cross H, Desguerre I, Grant C, Hosny H, Jurasek L, Mula M, Pfäfflin M, Rheims S, Ring H, Shellhaas RA, Vinayan KP, Wirrell E, Nabbout R.

Epilepsy Behav. 2019 Apr;93:138-147. doi: 10.1016/j.yebeh.2018.12.015. Epub 2019 Jan 12. Review.


Systematic review of the screening, diagnosis, and management of ADHD in children with epilepsy. Consensus paper of the Task Force on Comorbidities of the ILAE Pediatric Commission.

Auvin S, Wirrell E, Donald KA, Berl M, Hartmann H, Valente KD, Van Bogaert P, Cross JH, Osawa M, Kanemura H, Aihara M, Guerreiro MM, Samia P, Vinayan KP, Smith ML, Carmant L, Kerr M, Hermann B, Dunn D, Wilmshurst JM.

Epilepsia. 2018 Oct;59(10):1867-1880. doi: 10.1111/epi.14549. Epub 2018 Sep 3.


Neuroimaging of Early Life Epilepsy.

Coryell J, Gaillard WD, Shellhaas RA, Grinspan ZM, Wirrell EC, Knupp KG, Wusthoff CJ, Keator C, Sullivan JE, Loddenkemper T, Patel A, Chu CJ, Massey S, Novotny EJ Jr, Saneto RP, Berg AT.

Pediatrics. 2018 Sep;142(3). pii: e20180672. doi: 10.1542/peds.2018-0672. Epub 2018 Aug 8.


Jeavons Syndrome: Clinical Features and Response to Treatment.

Smith KM, Youssef PE, Wirrell EC, Nickels KC, Payne ET, Britton JW, Shin C, Cascino GD, Patterson MC, Wong-Kisiel LC.

Pediatr Neurol. 2018 Sep;86:46-51. doi: 10.1016/j.pediatrneurol.2018.06.001. Epub 2018 Jul 10.


LGI1 and CASPR2 neurological autoimmunity in children.

López-Chiriboga AS, Klein C, Zekeridou A, McKeon A, Dubey D, Flanagan EP, Lennon VA, Tillema JM, Wirrell EC, Patterson MC, Gadoth A, Aaen JG, Brenton JN, Bui JD, Moen A, Otten C, Piquet A, Pittock SJ.

Ann Neurol. 2018 Sep;84(3):473-480. doi: 10.1002/ana.25310.


Correction to: Treatment Strategies for Dravet Syndrome.

Knupp KG, Wirrell EC.

CNS Drugs. 2018 Aug;32(8):783. doi: 10.1007/s40263-018-0546-0.


A Novel Phenotype in a Previously Described Epilepsy-Aphasia Disorder.

Fine AL, Wong-Kisiel LC, Wirrell EC.

Semin Pediatr Neurol. 2018 Jul;26:21-24. doi: 10.1016/j.spen.2018.04.004.


Optimal clinical management of children receiving dietary therapies for epilepsy: Updated recommendations of the International Ketogenic Diet Study Group.

Kossoff EH, Zupec-Kania BA, Auvin S, Ballaban-Gil KR, Christina Bergqvist AG, Blackford R, Buchhalter JR, Caraballo RH, Cross JH, Dahlin MG, Donner EJ, Guzel O, Jehle RS, Klepper J, Kang HC, Lambrechts DA, Liu YMC, Nathan JK, Nordli DR Jr, Pfeifer HH, Rho JM, Scheffer IE, Sharma S, Stafstrom CE, Thiele EA, Turner Z, Vaccarezza MM, van der Louw EJTM, Veggiotti P, Wheless JW, Wirrell EC; Charlie Foundation; Matthew's Friends; Practice Committee of the Child Neurology Society.

Epilepsia Open. 2018 May 21;3(2):175-192. doi: 10.1002/epi4.12225. eCollection 2018 Jun.


De Novo DNM1L Variant in a Teenager With Progressive Paroxysmal Dystonia and Lethal Super-refractory Myoclonic Status Epilepticus.

Ryan CS, Fine AL, Cohen AL, Schiltz BM, Renaud DL, Wirrell EC, Patterson MC, Boczek NJ, Liu R, Babovic-Vuksanovic D, Chan DC, Payne ET.

J Child Neurol. 2018 Sep;33(10):651-658. doi: 10.1177/0883073818778203. Epub 2018 Jun 7. Review.


Challenges in managing epilepsy associated with focal cortical dysplasia in children.

Wong-Kisiel LC, Blauwblomme T, Ho ML, Boddaert N, Parisi J, Wirrell E, Nabbout R.

Epilepsy Res. 2018 Sep;145:1-17. doi: 10.1016/j.eplepsyres.2018.05.006. Epub 2018 May 14. Review.


Effect of Cannabidiol on Drop Seizures in the Lennox-Gastaut Syndrome.

Devinsky O, Patel AD, Cross JH, Villanueva V, Wirrell EC, Privitera M, Greenwood SM, Roberts C, Checketts D, VanLandingham KE, Zuberi SM; GWPCARE3 Study Group.

N Engl J Med. 2018 May 17;378(20):1888-1897. doi: 10.1056/NEJMoa1714631.


Impact of Prior Authorization of Antiepileptic Drugs in Children With Epilepsy.

Wirrell EC, Vanderwiel AJ, Nickels L, Vanderwiel SL, Nickels KC.

Pediatr Neurol. 2018 Jun;83:38-41. doi: 10.1016/j.pediatrneurol.2018.03.006. Epub 2018 Apr 3.


How do we diagnose and treat epilepsy with myoclonic-atonic seizures (Doose syndrome)? Results of the Pediatric Epilepsy Research Consortium survey.

Nickels K, Thibert R, Rau S, Demarest S, Wirrell E, Kossoff EH, Joshi C, Nangia S, Shellhaas R; Pediatric Epilepsy Research Consortium.

Epilepsy Res. 2018 Aug;144:14-19. doi: 10.1016/j.eplepsyres.2018.04.010. Epub 2018 Apr 25.


Ketogenic Diet Therapy in Infants: Efficacy and Tolerability.

Wirrell E, Eckert S, Wong-Kisiel L, Payne E, Nickels K.

Pediatr Neurol. 2018 May;82:13-18. doi: 10.1016/j.pediatrneurol.2017.10.018. Epub 2018 Jan 31.


Treatment Strategies for Dravet Syndrome.

Knupp KG, Wirrell EC.

CNS Drugs. 2018 Apr;32(4):335-350. doi: 10.1007/s40263-018-0511-y. Review. Erratum in: CNS Drugs. 2018 Aug;32(8):783. Abstract corrected.


Why West? Comparisons of clinical, genetic and molecular features of infants with and without spasms.

Berg AT, Chakravorty S, Koh S, Grinspan ZM, Shellhaas RA, Saneto RP, Wirrell EC, Coryell J, Chu CJ, Mytinger JR, Gaillard WD, Valencia I, Knupp KG, Loddenkemper T, Sullivan JE, Poduri A, Millichap JJ, Keator C, Wusthoff C, Ryan N, Dobyns WB, Hegde M.

PLoS One. 2018 Mar 8;13(3):e0193599. doi: 10.1371/journal.pone.0193599. eCollection 2018.


Comparative Effectiveness of Levetiracetam vs Phenobarbital for Infantile Epilepsy.

Grinspan ZM, Shellhaas RA, Coryell J, Sullivan JE, Wirrell EC, Mytinger JR, Gaillard WD, Kossoff EH, Valencia I, Knupp KG, Wusthoff C, Keator C, Ryan N, Loddenkemper T, Chu CJ, Novotny EJ Jr, Millichap J, Berg AT.

JAMA Pediatr. 2018 Apr 1;172(4):352-360. doi: 10.1001/jamapediatrics.2017.5211.


Cognitive and Social Outcomes of Epileptic Encephalopathies.

Nickels KC, Wirrell EC.

Semin Pediatr Neurol. 2017 Nov;24(4):264-275. doi: 10.1016/j.spen.2017.10.001. Epub 2017 Oct 7. Review.


The impact of hypsarrhythmia on infantile spasms treatment response: Observational cohort study from the National Infantile Spasms Consortium.

Demarest ST, Shellhaas RA, Gaillard WD, Keator C, Nickels KC, Hussain SA, Loddenkemper T, Patel AD, Saneto RP, Wirrell E, Sánchez Fernández I, Chu CJ, Grinspan Z, Wusthoff CJ, Joshi S, Mohamed IS, Stafstrom CE, Stack CV, Yozawitz E, Bluvstein JS, Singh RK, Knupp KG; Pediatric Epilepsy Research Consortium.

Epilepsia. 2017 Dec;58(12):2098-2103. doi: 10.1111/epi.13937. Epub 2017 Nov 3.


Initial Treatment for Nonsyndromic Early-Life Epilepsy: An Unexpected Consensus.

Shellhaas RA, Berg AT, Grinspan ZM, Wusthoff CJ, Millichap JJ, Loddenkemper T, Coryell J, Saneto RP, Chu CJ, Joshi SM, Sullivan JE, Knupp KG, Kossoff EH, Keator C, Wirrell EC, Mytinger JR, Valencia I, Massey S, Gaillard WD.

Pediatr Neurol. 2017 Oct;75:73-79. doi: 10.1016/j.pediatrneurol.2017.06.011. Epub 2017 Jun 27.


Not all SCN1A epileptic encephalopathies are Dravet syndrome: Early profound Thr226Met phenotype.

Sadleir LG, Mountier EI, Gill D, Davis S, Joshi C, DeVile C, Kurian MA; DDD Study, Mandelstam S, Wirrell E, Nickels KC, Murali HR, Carvill G, Myers CT, Mefford HC, Scheffer IE.

Neurology. 2017 Sep 5;89(10):1035-1042. doi: 10.1212/WNL.0000000000004331. Epub 2017 Aug 9.


Early-Life Epilepsies and the Emerging Role of Genetic Testing.

Berg AT, Coryell J, Saneto RP, Grinspan ZM, Alexander JJ, Kekis M, Sullivan JE, Wirrell EC, Shellhaas RA, Mytinger JR, Gaillard WD, Kossoff EH, Valencia I, Knupp KG, Wusthoff C, Keator C, Dobyns WB, Ryan N, Loddenkemper T, Chu CJ, Novotny EJ Jr, Koh S.

JAMA Pediatr. 2017 Sep 1;171(9):863-871. doi: 10.1001/jamapediatrics.2017.1743.


Predictive models in the diagnosis and treatment of autoimmune epilepsy.

Dubey D, Singh J, Britton JW, Pittock SJ, Flanagan EP, Lennon VA, Tillema JM, Wirrell E, Shin C, So E, Cascino GD, Wingerchuk DM, Hoerth MT, Shih JJ, Nickels KC, McKeon A.

Epilepsia. 2017 Jul;58(7):1181-1189. doi: 10.1111/epi.13797. Epub 2017 May 26.


Stiripentol in the Management of Epilepsy.

Nickels KC, Wirrell EC.

CNS Drugs. 2017 May;31(5):405-416. doi: 10.1007/s40263-017-0432-1. Review.


Optimizing the Diagnosis and Management of Dravet Syndrome: Recommendations From a North American Consensus Panel.

Wirrell EC, Laux L, Donner E, Jette N, Knupp K, Meskis MA, Miller I, Sullivan J, Welborn M, Berg AT.

Pediatr Neurol. 2017 Mar;68:18-34.e3. doi: 10.1016/j.pediatrneurol.2017.01.025. Epub 2017 Feb 4.


Epidemiology and Outcomes of Arterial Ischemic Stroke in Children: The Canadian Pediatric Ischemic Stroke Registry.

deVeber GA, Kirton A, Booth FA, Yager JY, Wirrell EC, Wood E, Shevell M, Surmava AM, McCusker P, Massicotte MP, MacGregor D, MacDonald EA, Meaney B, Levin S, Lemieux BG, Jardine L, Humphreys P, David M, Chan AK, Buckley DJ, Bjornson BH.

Pediatr Neurol. 2017 Apr;69:58-70. doi: 10.1016/j.pediatrneurol.2017.01.016. Epub 2017 Jan 26.


Understanding Death in Children With Epilepsy.

Donner EJ, Camfield P, Brooks L, Buchhalter J, Camfield C, Loddenkemper T, Wirrell E.

Pediatr Neurol. 2017 May;70:7-15. doi: 10.1016/j.pediatrneurol.2017.01.011. Epub 2017 Jan 31. Review.


False ictal-appearing EEG from a frontal sinus pseudomeningocele.

Wallace A, Shin C, Wirrell EC, Burkholder DB.

Neurology. 2016 Dec 13;87(24):2600-2601. No abstract available.


Prevalence and Risk Factors of Peri-ictal Autonomic Changes in Children With Temporal Lobe Seizures.

Whealy M, Wirrell E, Wong-Kisiel L, Nickels K, Payne ET.

Pediatr Neurol. 2017 Feb;67:36-39. doi: 10.1016/j.pediatrneurol.2016.09.017. Epub 2016 Oct 11.


Mortality in Dravet syndrome.

Cooper MS, Mcintosh A, Crompton DE, McMahon JM, Schneider A, Farrell K, Ganesan V, Gill D, Kivity S, Lerman-Sagie T, McLellan A, Pelekanos J, Ramesh V, Sadleir L, Wirrell E, Scheffer IE.

Epilepsy Res. 2016 Dec;128:43-47. doi: 10.1016/j.eplepsyres.2016.10.006. Epub 2016 Oct 26.


Febrile infection-related epilepsy syndrome treated with anakinra.

Kenney-Jung DL, Vezzani A, Kahoud RJ, LaFrance-Corey RG, Ho ML, Muskardin TW, Wirrell EC, Howe CL, Payne ET.

Ann Neurol. 2016 Dec;80(6):939-945. doi: 10.1002/ana.24806. Epub 2016 Nov 14.


Response to second treatment after initial failed treatment in a multicenter prospective infantile spasms cohort.

Knupp KG, Leister E, Coryell J, Nickels KC, Ryan N, Juarez-Colunga E, Gaillard WD, Mytinger JR, Berg AT, Millichap J, Nordli DR Jr, Joshi S, Shellhaas RA, Loddenkemper T, Dlugos D, Wirrell E, Sullivan J, Hartman AL, Kossoff EH, Grinspan ZM, Hamikawa L; Pediatric Epilepsy Research Consortium.

Epilepsia. 2016 Nov;57(11):1834-1842. doi: 10.1111/epi.13557. Epub 2016 Sep 12.


Patient and caregiver view on seizure detection devices: A survey study.

Tovar Quiroga DF, Britton JW, Wirrell EC.

Seizure. 2016 Oct;41:179-81. doi: 10.1016/j.seizure.2016.08.004. Epub 2016 Aug 24.


Usefulness of repeat review of head magnetic resonance images during presurgical epilepsy conferences.

Kenney DL, Kelly-Williams KM, Krecke KN, Witte RJ, Watson RE Jr, Kotsenas AL, Wirrell EC, Nickels KC, Wong-Kisiel LC, So E.

Epilepsy Res. 2016 Oct;126:106-8. doi: 10.1016/j.eplepsyres.2016.06.005. Epub 2016 Jul 1.


Cognitive and neurodevelopmental comorbidities in paediatric epilepsy.

Nickels KC, Zaccariello MJ, Hamiwka LD, Wirrell EC.

Nat Rev Neurol. 2016 Aug;12(8):465-76. doi: 10.1038/nrneurol.2016.98. Epub 2016 Jul 22. Review.


A microRNA-328 binding site in PAX6 is associated with centrotemporal spikes of rolandic epilepsy.

Panjwani N, Wilson MD, Addis L, Crosbie J, Wirrell E, Auvin S, Caraballo RH, Kinali M, McCormick D, Oren C, Taylor J, Trounce J, Clarke T, Akman CI, Kugler SL, Mandelbaum DE, McGoldrick P, Wolf SM, Arnold P, Schachar R, Pal DK, Strug LJ.

Ann Clin Transl Neurol. 2016 Jun 2;3(7):512-22. doi: 10.1002/acn3.320. eCollection 2016 Jul.


Treatment of Dravet Syndrome.

Wirrell EC.

Can J Neurol Sci. 2016 Jun;43 Suppl 3:S13-8. doi: 10.1017/cjn.2016.249. Review.


Focal photoparoxysmal response in the Heidenhain variant of CJD: Hidden from view!

Feyissa AM, Wirrell EC, Jones DT, Young NP, Britton JW.

Neurology. 2016 Apr 26;86(17):1647-8. doi: 10.1212/WNL.0000000000002617. No abstract available.


Routine vs extended outpatient EEG for the detection of interictal epileptiform discharges.

Burkholder DB, Britton JW, Rajasekaran V, Fabris RR, Cherian PJ, Kelly-Williams KM, So EL, Nickels KC, Wong-Kisiel LC, Lagerlund TD, Cascino GD, Worrell GA, Wirrell EC.

Neurology. 2016 Apr 19;86(16):1524-30. doi: 10.1212/WNL.0000000000002592. Epub 2016 Mar 16.


Pharmacotherapy for Dravet Syndrome.

Wallace A, Wirrell E, Kenney-Jung DL.

Paediatr Drugs. 2016 Jun;18(3):197-208. doi: 10.1007/s40272-016-0171-7. Review.


Infantile, Childhood, and Adolescent Epilepsies.

Wirrell E.

Continuum (Minneap Minn). 2016 Feb;22(1 Epilepsy):60-93. doi: 10.1212/CON.0000000000000269. Review.


Response to treatment in a prospective national infantile spasms cohort.

Knupp KG, Coryell J, Nickels KC, Ryan N, Leister E, Loddenkemper T, Grinspan Z, Hartman AL, Kossoff EH, Gaillard WD, Mytinger JR, Joshi S, Shellhaas RA, Sullivan J, Dlugos D, Hamikawa L, Berg AT, Millichap J, Nordli DR Jr, Wirrell E; Pediatric Epilepsy Research Consortium.

Ann Neurol. 2016 Mar;79(3):475-84. doi: 10.1002/ana.24594. Epub 2016 Feb 13.


Seizure Freedom in Children With Pathology-Confirmed Focal Cortical Dysplasia.

Mrelashvili A, Witte RJ, Wirrell EC, Nickels KC, Wong-Kisiel LC.

Pediatr Neurol. 2015 Dec;53(6):513-8. doi: 10.1016/j.pediatrneurol.2015.09.004. Epub 2015 Sep 12.


Delivery of epilepsy care to adults with intellectual and developmental disabilities.

Devinsky O, Asato M, Camfield P, Geller E, Kanner AM, Keller S, Kerr M, Kossoff EH, Lau H, Kothare S, Singh BK, Wirrell E.

Neurology. 2015 Oct 27;85(17):1512-21. doi: 10.1212/WNL.0000000000002060. Epub 2015 Sep 30. Review.

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