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Items: 34


Radiation-induced pulmonary gene expression changes are attenuated by the CTGF antibody Pamrevlumab.

Sternlicht MD, Wirkner U, Bickelhaupt S, Lopez Perez R, Tietz A, Lipson KE, Seeley TW, Huber PE.

Respir Res. 2018 Jan 18;19(1):14. doi: 10.1186/s12931-018-0720-4.


Effects of CTGF Blockade on Attenuation and Reversal of Radiation-Induced Pulmonary Fibrosis.

Bickelhaupt S, Erbel C, Timke C, Wirkner U, Dadrich M, Flechsig P, Tietz A, Pföhler J, Gross W, Peschke P, Hoeltgen L, Katus HA, Gröne HJ, Nicolay NH, Saffrich R, Debus J, Sternlicht MD, Seeley TW, Lipson KE, Huber PE.

J Natl Cancer Inst. 2017 Aug 1;109(8). doi: 10.1093/jnci/djw339.


Combined inhibition of TGFβ and PDGF signaling attenuates radiation-induced pulmonary fibrosis.

Dadrich M, Nicolay NH, Flechsig P, Bickelhaupt S, Hoeltgen L, Roeder F, Hauser K, Tietz A, Jenne J, Lopez R, Roehrich M, Wirkner U, Lahn M, Huber PE.

Oncoimmunology. 2015 Dec 29;5(5):e1123366. doi: 10.1080/2162402X.2015.1123366. eCollection 2016 May.


Mesenchymal stem cells are sensitive to treatment with kinase inhibitors and ionizing radiation.

Nicolay NH, Sommer E, Perez RL, Wirkner U, Bostel T, Ho AD, Lahn M, Debus J, Saffrich R, Huber PE.

Strahlenther Onkol. 2014 Oct;190(11):1037-45. doi: 10.1007/s00066-014-0686-1. Epub 2014 May 27.


Mesenchymal stem cells retain their defining stem cell characteristics after exposure to ionizing radiation.

Nicolay NH, Sommer E, Lopez R, Wirkner U, Trinh T, Sisombath S, Debus J, Ho AD, Saffrich R, Huber PE.

Int J Radiat Oncol Biol Phys. 2013 Dec 1;87(5):1171-8. doi: 10.1016/j.ijrobp.2013.09.003. Epub 2013 Oct 23.


LY2109761 attenuates radiation-induced pulmonary murine fibrosis via reversal of TGF-β and BMP-associated proinflammatory and proangiogenic signals.

Flechsig P, Dadrich M, Bickelhaupt S, Jenne J, Hauser K, Timke C, Peschke P, Hahn EW, Gröne HJ, Yingling J, Lahn M, Wirkner U, Huber PE.

Clin Cancer Res. 2012 Jul 1;18(13):3616-27. doi: 10.1158/1078-0432.CCR-11-2855. Epub 2012 Apr 30.


Blockade of TGF-β signaling by the TGFβR-I kinase inhibitor LY2109761 enhances radiation response and prolongs survival in glioblastoma.

Zhang M, Kleber S, Röhrich M, Timke C, Han N, Tuettenberg J, Martin-Villalba A, Debus J, Peschke P, Wirkner U, Lahn M, Huber PE.

Cancer Res. 2011 Dec 1;71(23):7155-67. doi: 10.1158/0008-5472.CAN-11-1212. Epub 2011 Oct 17.


Trimodal glioblastoma treatment consisting of concurrent radiotherapy, temozolomide, and the novel TGF-β receptor I kinase inhibitor LY2109761.

Zhang M, Herion TW, Timke C, Han N, Hauser K, Weber KJ, Peschke P, Wirkner U, Lahn M, Huber PE.

Neoplasia. 2011 Jun;13(6):537-49.


Investigation of tumor hypoxia using a two-enzyme system for in vitro generation of oxygen deficiency.

Askoxylakis V, Millonig G, Wirkner U, Schwager C, Rana S, Altmann A, Haberkorn U, Debus J, Mueller S, Huber PE.

Radiat Oncol. 2011 Apr 10;6:35. doi: 10.1186/1748-717X-6-35.


Organ-, inflammation- and cancer specific transcriptional fingerprints of pancreatic and hepatic stellate cells.

Erkan M, Weis N, Pan Z, Schwager C, Samkharadze T, Jiang X, Wirkner U, Giese NA, Ansorge W, Debus J, Huber PE, Friess H, Abdollahi A, Kleeff J.

Mol Cancer. 2010 Apr 23;9:88. doi: 10.1186/1476-4598-9-88.


MicroRNA expression after ionizing radiation in human endothelial cells.

Wagner-Ecker M, Schwager C, Wirkner U, Abdollahi A, Huber PE.

Radiat Oncol. 2010 Mar 26;5:25. doi: 10.1186/1748-717X-5-25.


Gene expression signatures in the peripheral blood after radiosurgery of human cerebral arteriovenous malformations.

Zabel-du Bois A, Wagner-Ecker M, Milker-Zabel S, Schwager C, Wirkner U, Debus J, Abdollahi A, Huber PE.

Strahlenther Onkol. 2010 Feb;186(2):91-98. doi: 10.1007/s00066-010-2034-4. Epub 2010 Jan 28.


Genome-wide transcriptome profile of the human osteosarcoma Sa OS and U-2 OS cell lines.

Trougakos IP, Chondrogianni N, Amarantos I, Blake J, Schwager C, Wirkner U, Ansorge W, Gonos ES.

Cancer Genet Cytogenet. 2010 Jan 15;196(2):109-18. doi: 10.1016/j.cancergencyto.2009.09.012.


TableButler - a Windows based tool for processing large data tables generated with high-throughput methods.

Schwager C, Wirkner U, Abdollahi A, Huber PE.

BMC Bioinformatics. 2009 Jul 29;10:235. doi: 10.1186/1471-2105-10-235.


Identification of cholesterol-regulating genes by targeted RNAi screening.

Bartz F, Kern L, Erz D, Zhu M, Gilbert D, Meinhof T, Wirkner U, Erfle H, Muckenthaler M, Pepperkok R, Runz H.

Cell Metab. 2009 Jul;10(1):63-75. doi: 10.1016/j.cmet.2009.05.009.


Molecular mechanisms of the antiangiogenic and antitumor effects of mycophenolic acid.

Domhan S, Muschal S, Schwager C, Morath C, Wirkner U, Ansorge W, Maercker C, Zeier M, Huber PE, Abdollahi A.

Mol Cancer Ther. 2008 Jun;7(6):1656-68. doi: 10.1158/1535-7163.MCT-08-0193.


Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood.

Wagner W, Wein F, Seckinger A, Frankhauser M, Wirkner U, Krause U, Blake J, Schwager C, Eckstein V, Ansorge W, Ho AD.

Exp Hematol. 2005 Nov;33(11):1402-16.


Hematopoietic progenitor cells and cellular microenvironment: behavioral and molecular changes upon interaction.

Wagner W, Saffrich R, Wirkner U, Eckstein V, Blake J, Ansorge A, Schwager C, Wein F, Miesala K, Ansorge W, Ho AD.

Stem Cells. 2005 Sep;23(8):1180-91. Epub 2005 Jun 13.


Genome-wide gene expression profiling of testicular carcinoma in situ progression into overt tumours.

Almstrup K, Hoei-Hansen CE, Nielsen JE, Wirkner U, Ansorge W, Skakkebaek NE, Rajpert-De Meyts E, Leffers H.

Br J Cancer. 2005 May 23;92(10):1934-41.


Embryonic stem cell-like features of testicular carcinoma in situ revealed by genome-wide gene expression profiling.

Almstrup K, Hoei-Hansen CE, Wirkner U, Blake J, Schwager C, Ansorge W, Nielsen JE, Skakkebaek NE, Rajpert-De Meyts E, Leffers H.

Cancer Res. 2004 Jul 15;64(14):4736-43.


A neutral model of transcriptome evolution.

Khaitovich P, Weiss G, Lachmann M, Hellmann I, Enard W, Muetzel B, Wirkner U, Ansorge W, Pääbo S.

PLoS Biol. 2004 May;2(5):E132. Epub 2004 May 11.


Molecular evidence for stem cell function of the slow-dividing fraction among human hematopoietic progenitor cells by genome-wide analysis.

Wagner W, Ansorge A, Wirkner U, Eckstein V, Schwager C, Blake J, Miesala K, Selig J, Saffrich R, Ansorge W, Ho AD.

Blood. 2004 Aug 1;104(3):675-86. Epub 2004 Apr 13.


Ets1 is a common element in directing transcription of the alpha and beta genes of human protein kinase CK2.

Krehan A, Schmalzbauer R, Böcher O, Ackermann K, Wirkner U, Brouwers S, Pyerin W.

Eur J Biochem. 2001 Jun;268(11):3243-52.


Transcription factors ets1, NF-kappa B, and Sp1 are major determinants of the promoter activity of the human protein kinase CK2alpha gene.

Krehan A, Ansuini H, Bocher O, Grein S, Wirkner U, Pyerin W.

J Biol Chem. 2000 Jun 16;275(24):18327-36.


Prediction of nonsynonymous single nucleotide polymorphisms in human disease-associated genes.

Sunyaev S, Hanke J, Aydin A, Wirkner U, Zastrow I, Reich J, Bork P.

J Mol Med (Berl). 1999 Nov;77(11):754-60.


CK2alpha loci in the human genome: structure and transcriptional activity.

Wirkner U, Pyerin W.

Mol Cell Biochem. 1999 Jan;191(1-2):59-64.


The Genexpress IMAGE knowledge base of the human brain transcriptome: a prototype integrated resource for functional and computational genomics.

Piétu G, Mariage-Samson R, Fayein NA, Matingou C, Eveno E, Houlgatte R, Decraene C, Vandenbrouck Y, Tahi F, Devignes MD, Wirkner U, Ansorge W, Cox D, Nagase T, Nomura N, Auffray C.

Genome Res. 1999 Feb;9(2):195-209.


Human protein kinase CK2 genes.

Wirkner U, Voss H, Lichter P, Pyerin W.

Cell Mol Biol Res. 1994;40(5-6):489-99.


Human casein kinase II subunit alpha: sequence of a processed (pseudo)gene and its localization on chromosome 11.

Wirkner U, Voss H, Lichter P, Weitz S, Ansorge W, Pyerin W.

Biochim Biophys Acta. 1992 Jun 15;1131(2):220-2.


Structure of the gene encoding human casein kinase II subunit beta.

Voss H, Wirkner U, Jakobi R, Hewitt NA, Schwager C, Zimmermann J, Ansorge W, Pyerin W.

J Biol Chem. 1991 Jul 25;266(21):13706-11.


Direct genomic fluorescent on-line sequencing and analysis using in vitro amplification of DNA.

Voss H, Schwager C, Wirkner U, Sproat B, Zimmermann J, Rosenthal A, Erfle H, Stegemann J, Ansorge W.

Nucleic Acids Res. 1989 Apr 11;17(7):2517-27.


Automated Sanger DNA sequencing with one label in less than four lanes on gel.

Ansorge W, Voss H, Wirkner U, Schwager C, Stegemann J, Pepperkok R, Zimmermann J, Erfle H.

J Biochem Biophys Methods. 1989;20(1):47-52.


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