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Items: 10

1.

Genomic profiling of human vascular cells identifies TWIST1 as a causal gene for common vascular diseases.

Nurnberg ST, Guerraty MA, Wirka RC, Rao HS, Pjanic M, Norton S, Serrano F, Perisic L, Elwyn S, Pluta J, Zhao W, Testa S, Park Y, Nguyen T, Ko YA, Wang T, Hedin U, Sinha S, Barash Y, Brown CD, Quertermous T, Rader DJ.

PLoS Genet. 2020 Jan 9;16(1):e1008538. doi: 10.1371/journal.pgen.1008538. eCollection 2020 Jan.

2.

PCSK6 Is a Key Protease in the Control of Smooth Muscle Cell Function in Vascular Remodeling.

Rykaczewska U, Suur BE, Röhl S, Razuvaev A, Lengquist M, Sabater-Lleal M, van der Laan SW, Miller CL, Wirka RC, Kronqvist M, Gonzalez Diez M, Vesterlund M, Gillgren P, Odeberg J, Lindeman JH, Veglia F, Humphries SE, de Faire U, Baldassarre D, Tremoli E, Lehtiö J, Hansson GK, Paulsson-Berne G, Pasterkamp G, Quertermous T, Hamsten A, Eriksson P, Hedin U, Matic L.

Circ Res. 2020 Jan 2. doi: 10.1161/CIRCRESAHA.119.316063. [Epub ahead of print]

PMID:
31893970
3.

Coronary Disease Associated Gene TCF21 Inhibits Smooth Muscle Cell Differentiation by Blocking the Myocardin-Serum Response Factor Pathway.

Nagao M, Lyu Q, Zhao Q, Wirka RC, Bagga J, Nguyen T, Cheng P, Kim JB, Pjanic M, Miano JM, Quertermous T.

Circ Res. 2019 Dec 9. doi: 10.1161/CIRCRESAHA.119.315968. [Epub ahead of print]

PMID:
31815603
4.

Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis.

Wirka RC, Wagh D, Paik DT, Pjanic M, Nguyen T, Miller CL, Kundu R, Nagao M, Coller J, Koyano TK, Fong R, Woo YJ, Liu B, Montgomery SB, Wu JC, Zhu K, Chang R, Alamprese M, Tallquist MD, Kim JB, Quertermous T.

Nat Med. 2019 Aug;25(8):1280-1289. doi: 10.1038/s41591-019-0512-5. Epub 2019 Jul 29.

PMID:
31359001
5.

Large-Scale Single-Cell RNA-Seq Reveals Molecular Signatures of Heterogeneous Populations of Human Induced Pluripotent Stem Cell-Derived Endothelial Cells.

Paik DT, Tian L, Lee J, Sayed N, Chen IY, Rhee S, Rhee JW, Kim Y, Wirka RC, Buikema JW, Wu SM, Red-Horse K, Quertermous T, Wu JC.

Circ Res. 2018 Aug 3;123(4):443-450. doi: 10.1161/CIRCRESAHA.118.312913.

6.

Advances in Transcriptomics: Investigating Cardiovascular Disease at Unprecedented Resolution.

Wirka RC, Pjanic M, Quertermous T.

Circ Res. 2018 Apr 27;122(9):1200-1220. doi: 10.1161/CIRCRESAHA.117.310910. Review.

PMID:
29700068
7.

Circulating peptide prevents preeclampsia.

Wirka RC, Quertermous T.

Science. 2017 Aug 18;357(6352):643-644. doi: 10.1126/science.aao2642. No abstract available.

PMID:
28818928
8.

The ESCRT-III pathway facilitates cardiomyocyte release of cBIN1-containing microparticles.

Xu B, Fu Y, Liu Y, Agvanian S, Wirka RC, Baum R, Zhou K, Shaw RM, Hong T.

PLoS Biol. 2017 Aug 14;15(8):e2002354. doi: 10.1371/journal.pbio.2002354. eCollection 2017 Aug.

9.

Low prevalence of connexin-40 gene variants in atrial tissues and blood from atrial fibrillation subjects.

Tchou GD, Wirka RC, Van Wagoner DR, Barnard J, Chung MK, Smith JD.

BMC Med Genet. 2012 Nov 7;13:102. doi: 10.1186/1471-2350-13-102.

10.

A common connexin-40 gene promoter variant affects connexin-40 expression in human atria and is associated with atrial fibrillation.

Wirka RC, Gore S, Van Wagoner DR, Arking DE, Lubitz SA, Lunetta KL, Benjamin EJ, Alonso A, Ellinor PT, Barnard J, Chung MK, Smith JD.

Circ Arrhythm Electrophysiol. 2011 Feb;4(1):87-93. doi: 10.1161/CIRCEP.110.959726. Epub 2010 Nov 13.

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