Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 377

1.

Tapping the therapeutic potential of protein tyrosine phosphatase 4A with small molecule inhibitors.

Tasker NR, Rastelli EJ, Burnett JC, Sharlow ER, Lazo JS, Wipf P.

Bioorg Med Chem Lett. 2019 Jun 27. pii: S0960-894X(19)30430-5. doi: 10.1016/j.bmcl.2019.06.048. [Epub ahead of print] Review.

PMID:
31307888
2.

Synthesis and Optimization of Kv7 (KCNQ) Potassium Channel Agonists: The Role of Fluorines in Potency and Selectivity.

Liu R, Tzounopoulos T, Wipf P.

ACS Med Chem Lett. 2019 May 8;10(6):929-935. doi: 10.1021/acsmedchemlett.9b00097. eCollection 2019 Jun 13.

PMID:
31223450
3.

Amelioration of Amyotrophic Lateral Sclerosis in SOD1G93A Mice by M2 Microglia from Transplanted Marrow.

Epperly MW, Fisher R, Rigatti L, Watkins S, Zhang X, Hou W, Shields D, Franicola D, Bayir H, Wang H, Thermozier S, Henderson A, Donnelly C, Wipf P, Greenberger JS.

In Vivo. 2019 May-Jun;33(3):675-688. doi: 10.21873/invivo.11526.

4.

Grob-Type Fragmentation Releases Paracyclophane Ring Strain in a Late-Stage Precursor of Haouamine A.

Cao L, Wang C, Wipf P.

Org Lett. 2019 Mar 1;21(5):1538-1541. doi: 10.1021/acs.orglett.9b00424. Epub 2019 Feb 19.

PMID:
30779589
5.

In-flow photooxygenation of aminothienopyridinones generates iminopyridinedione PTP4A3 phosphatase inhibitors.

Tasker NR, Rastelli EJ, Blanco IK, Burnett JC, Sharlow ER, Lazo JS, Wipf P.

Org Biomol Chem. 2019 Feb 27;17(9):2448-2466. doi: 10.1039/c9ob00025a.

PMID:
30746541
6.

Ferroptosis as a Novel Therapeutic Target for Friedreich's Ataxia.

Cotticelli MG, Xia S, Lin D, Lee T, Terrab L, Wipf P, Huryn DM, Wilson RB.

J Pharmacol Exp Ther. 2019 Apr;369(1):47-54. doi: 10.1124/jpet.118.252759. Epub 2019 Jan 11.

PMID:
30635474
7.

Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding.

Chiang AN, Liang M, Dominguez-Meijide A, Masaracchia C, Goeckeler-Fried JL, Mazzone CS, Newhouse DW, Kendsersky NM, Yates ME, Manos-Turvey A, Needham PG, Outeiro TF, Wipf P, Brodsky JL.

Bioorg Med Chem. 2019 Jan 1;27(1):79-91. doi: 10.1016/j.bmc.2018.11.011. Epub 2018 Nov 15.

PMID:
30528127
8.

Continuous One Year Oral Administration of the Radiation Mitigator, MMS350, after Total-Body Irradiation, Restores Bone Marrow Stromal Cell Proliferative Capacity and Reduces Senescence in Fanconi Anemia (Fanca-/-) Mice.

Sivananthan A, Shields D, Fisher R, Hou W, Zhang X, Franicola D, Epperly MW, Wipf P, Greenberger JS.

Radiat Res. 2019 Feb;191(2):139-153. doi: 10.1667/RR15199.1. Epub 2018 Nov 30.

PMID:
30499383
9.

Structural Basis of Polyketide Synthase O-Methylation.

Skiba MA, Bivins MM, Schultz JR, Bernard SM, Fiers WD, Dan Q, Kulkarni S, Wipf P, Gerwick WH, Sherman DH, Aldrich CC, Smith JL.

ACS Chem Biol. 2018 Dec 21;13(12):3221-3228. doi: 10.1021/acschembio.8b00687. Epub 2018 Dec 3.

PMID:
30489068
10.

Mitochondria are a substrate of cellular memory.

Cheikhi A, Wallace C, St Croix C, Cohen C, Tang WY, Wipf P, Benos PV, Ambrosio F, Barchowsky A.

Free Radic Biol Med. 2019 Jan;130:528-541. doi: 10.1016/j.freeradbiomed.2018.11.028. Epub 2018 Nov 22.

PMID:
30472365
11.

Mitochondrial energetics is impaired in very long-chain acyl-CoA dehydrogenase deficiency and can be rescued by treatment with mitochondria-targeted electron scavengers.

Seminotti B, Leipnitz G, Karunanidhi A, Kochersperger C, Roginskaya VY, Basu S, Wang Y, Wipf P, Van Houten B, Mohsen AW, Vockley J.

Hum Mol Genet. 2019 Mar 15;28(6):928-941. doi: 10.1093/hmg/ddy403.

12.

Optimization of Phenyl Indole Inhibitors of the AAA+ ATPase p97.

LaPorte MG, Burnett JC, Colombo R, Bulfer SL, Alverez C, Chou TF, Neitz RJ, Green N, Moore WJ, Yue Z, Li S, Arkin MR, Wipf P, Huryn DM.

ACS Med Chem Lett. 2018 Sep 18;9(11):1075-1081. doi: 10.1021/acsmedchemlett.8b00372. eCollection 2018 Nov 8.

13.

2,2,6,6-Tetramethylpiperidin-1-yloxycarbonyl: A Protecting Group for Primary, Secondary, and Heterocyclic Amines.

Lizza JR, Bremerich M, McCabe SR, Wipf P.

Org Lett. 2018 Nov 2;20(21):6760-6764. doi: 10.1021/acs.orglett.8b02874. Epub 2018 Oct 17.

PMID:
30350679
14.

Hsp70 Binds to the Androgen Receptor N-terminal Domain and Modulates the Receptor Function in Prostate Cancer Cells.

Dong J, Wu Z, Wang D, Pascal LE, Nelson JB, Wipf P, Wang Z.

Mol Cancer Ther. 2019 Jan;18(1):39-50. doi: 10.1158/1535-7163.MCT-18-0432. Epub 2018 Oct 8.

PMID:
30297360
15.

A Five-Component Biginelli-Diels-Alder Cascade Reaction.

Maskrey TS, Frischling MC, Rice ML, Wipf P.

Front Chem. 2018 Aug 24;6:376. doi: 10.3389/fchem.2018.00376. eCollection 2018.

16.

Synthesis and Evaluation of a Mitochondria-Targeting Poly(ADP-ribose) Polymerase-1 Inhibitor.

Krainz T, Lamade AM, Du L, Maskrey TS, Calderon MJ, Watkins SC, Epperly MW, Greenberger JS, Bayır H, Wipf P, Clark RSB.

ACS Chem Biol. 2018 Oct 19;13(10):2868-2879. doi: 10.1021/acschembio.8b00423. Epub 2018 Sep 14.

PMID:
30184433
17.

Targeting Mitochondrial Oxidative Stress to Mitigate UV-Induced Skin Damage.

Brand RM, Wipf P, Durham A, Epperly MW, Greenberger JS, Falo LD Jr.

Front Pharmacol. 2018 Aug 20;9:920. doi: 10.3389/fphar.2018.00920. eCollection 2018. Review.

18.

Evaluation of Different Formulations and Routes for the Delivery of the Ionizing Radiation Mitigator GS-Nitroxide (JP4-039).

Epperly MW, Wipf P, Fisher R, Franicola D, Beumer J, Li S, Brand RM, Falo LD Jr, Erdos G, Greenberger JS.

In Vivo. 2018 Sep-Oct;32(5):1009-1023. doi: 10.21873/invivo.11341.

19.

Compensatory increases of select proteostasis networks after Hsp70 inhibition in cancer cells.

Sannino S, Guerriero CJ, Sabnis AJ, Stolz DB, Wallace CT, Wipf P, Watkins SC, Bivona TG, Brodsky JL.

J Cell Sci. 2018 Sep 5;131(17). pii: jcs217760. doi: 10.1242/jcs.217760.

20.

A High-Content Screen Reveals New Small-Molecule Enhancers of Ras/Mapk Signaling as Probes for Zebrafish Heart Development.

Saydmohammed M, Vollmer LL, Onuoha EO, Maskrey TS, Gibson G, Watkins SC, Wipf P, Vogt A, Tsang M.

Molecules. 2018 Jul 11;23(7). pii: E1691. doi: 10.3390/molecules23071691.

21.

Genetic re-engineering of polyunsaturated phospholipid profile of Saccharomyces cerevisiae identifies a novel role for Cld1 in mitigating the effects of cardiolipin peroxidation.

Lou W, Ting HC, Reynolds CA, Tyurina YY, Tyurin VA, Li Y, Ji J, Yu W, Liang Z, Stoyanovsky DA, Anthonymuthu TS, Frasso MA, Wipf P, Greenberger JS, Bayır H, Kagan VE, Greenberg ML.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Oct;1863(10):1354-1368. doi: 10.1016/j.bbalip.2018.06.016. Epub 2018 Jun 20.

PMID:
29935382
22.

Relaxin-2 therapy reverses radiation-induced fibrosis and restores bladder function in mice.

Ikeda Y, Zabbarova IV, Birder LA, Wipf P, Getchell SE, Tyagi P, Fry CH, Drake MJ, Kanai AJ.

Neurourol Urodyn. 2018 Nov;37(8):2441-2451. doi: 10.1002/nau.23721. Epub 2018 May 28.

23.

Targeting p75 neurotrophin receptors ameliorates spinal cord injury-induced detrusor sphincter dyssynergia in mice.

Zabbarova IV, Ikeda Y, Carder EJ, Wipf P, Wolf-Johnston AS, Birder LA, Yoshimura N, Getchell SE, Almansoori K, Tyagi P, Fry CH, Drake MJ, Kanai AJ.

Neurourol Urodyn. 2018 Nov;37(8):2452-2461. doi: 10.1002/nau.23722. Epub 2018 May 28.

24.

Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging.

Robinson AR, Yousefzadeh MJ, Rozgaja TA, Wang J, Li X, Tilstra JS, Feldman CH, Gregg SQ, Johnson CH, Skoda EM, Frantz MC, Bell-Temin H, Pope-Varsalona H, Gurkar AU, Nasto LA, Robinson RAS, Fuhrmann-Stroissnigg H, Czerwinska J, McGowan SJ, Cantu-Medellin N, Harris JB, Maniar S, Ross MA, Trussoni CE, LaRusso NF, Cifuentes-Pagano E, Pagano PJ, Tudek B, Vo NV, Rigatti LH, Opresko PL, Stolz DB, Watkins SC, Burd CE, Croix CMS, Siuzdak G, Yates NA, Robbins PD, Wang Y, Wipf P, Kelley EE, Niedernhofer LJ.

Redox Biol. 2018 Jul;17:259-273. doi: 10.1016/j.redox.2018.04.007. Epub 2018 Apr 13.

25.

A chemical genetics approach identifies PTP4A3 as a regulator of colon cancer cell adhesion.

McQueeney KE, Salamoun JM, Ahn JG, Pekic P, Blanco IK, Struckman HL, Sharlow ER, Wipf P, Lazo JS.

FASEB J. 2018 Oct;32(10):5661-5673. doi: 10.1096/fj.201701446R. Epub 2018 May 10.

PMID:
29746167
26.

ATF4 Regulates CD4+ T Cell Immune Responses through Metabolic Reprogramming.

Yang X, Xia R, Yue C, Zhai W, Du W, Yang Q, Cao H, Chen X, Obando D, Zhu Y, Chen X, Chen JJ, Piganelli J, Wipf P, Jiang Y, Xiao G, Wu C, Jiang J, Lu B.

Cell Rep. 2018 May 8;23(6):1754-1766. doi: 10.1016/j.celrep.2018.04.032.

27.

XJB-5-131-mediated improvement in physiology and behaviour of the R6/2 mouse model of Huntington's disease is age- and sex- dependent.

Polyzos AA, Wood NI, Williams P, Wipf P, Morton AJ, McMurray CT.

PLoS One. 2018 Apr 9;13(4):e0194580. doi: 10.1371/journal.pone.0194580. eCollection 2018.

28.

Amelioration of Head and Neck Radiation-Induced Mucositis and Distant Marrow Suppression in Fanca-/- and Fancg-/- Mice by Intraoral Administration of GS-Nitroxide (JP4-039).

Willis J, Epperly MW, Fisher R, Zhang X, Shields D, Hou W, Wang H, Li S, Wipf P, Parmar K, Guinan E, Steinman J, Greenberger JS.

Radiat Res. 2018 Jun;189(6):560-578. doi: 10.1667/RR14878.1. Epub 2018 Mar 27.

29.

Targeting ovarian cancer and endothelium with an allosteric PTP4A3 phosphatase inhibitor.

McQueeney KE, Salamoun JM, Burnett JC, Barabutis N, Pekic P, Lewandowski SL, Llaneza DC, Cornelison R, Bai Y, Zhang ZY, Catravas JD, Landen CN, Wipf P, Lazo JS, Sharlow ER.

Oncotarget. 2017 Dec 30;9(9):8223-8240. doi: 10.18632/oncotarget.23787. eCollection 2018 Feb 2.

30.

Combination of a thioxodihydroquinazolinone with cisplatin eliminates ovarian cancer stem cell-like cells (CSC-LCs) and shows preclinical potential.

Ma J, Salamoun J, Wipf P, Edwards R, Van Houten B, Qian W.

Oncotarget. 2017 Dec 26;9(5):6042-6054. doi: 10.18632/oncotarget.23679. eCollection 2018 Jan 19.

31.

The GS-nitroxide JP4-039 improves intestinal barrier and stem cell recovery in irradiated mice.

Wei L, Leibowitz BJ, Epperly M, Bi C, Li A, Steinman J, Wipf P, Li S, Zhang L, Greenberger J, Yu J.

Sci Rep. 2018 Feb 1;8(1):2072. doi: 10.1038/s41598-018-20370-9.

32.

Evaluation of mitochondrial bioenergetics, dynamics, endoplasmic reticulum-mitochondria crosstalk, and reactive oxygen species in fibroblasts from patients with complex I deficiency.

Leipnitz G, Mohsen AW, Karunanidhi A, Seminotti B, Roginskaya VY, Markantone DM, Grings M, Mihalik SJ, Wipf P, Van Houten B, Vockley J.

Sci Rep. 2018 Jan 18;8(1):1165. doi: 10.1038/s41598-018-19543-3.

33.

Structure-based virtual screening identifies a small-molecule inhibitor of the profilin 1-actin interaction.

Gau D, Lewis T, McDermott L, Wipf P, Koes D, Roy P.

J Biol Chem. 2018 Feb 16;293(7):2606-2616. doi: 10.1074/jbc.M117.809137. Epub 2017 Dec 27.

34.

New Cav2 calcium channel gating modifiers with agonist activity and therapeutic potential to treat neuromuscular disease.

Wu M, White HV, Boehm BA, Meriney CJ, Kerrigan K, Frasso M, Liang M, Gotway EM, Wilcox MR, Johnson JW, Wipf P, Meriney SD.

Neuropharmacology. 2018 Mar 15;131:176-189. doi: 10.1016/j.neuropharm.2017.12.022. Epub 2017 Dec 12.

35.

Liquid chromatography-tandem mass spectrometric assay for the quantitation of the novel radiation protective agent and radiation mitigator JP4-039 in murine plasma.

Christner S, Guo J, Parise RA, Ringeval M, Hoye AT, Wipf P, Epperly MW, Greenberger JS, Beumer JH, Eiseman JL.

J Pharm Biomed Anal. 2018 Feb 20;150:169-175. doi: 10.1016/j.jpba.2017.12.023. Epub 2017 Dec 12.

36.

Improved Total-Body Irradiation Survival by Delivery of Two Radiation Mitigators that Target Distinct Cell Death Pathways.

Steinman J, Epperly M, Hou W, Willis J, Wang H, Fisher R, Liu B, Bahar I, McCaw T, Kagan V, Bayir H, Yu J, Wipf P, Li S, Huq MS, Greenberger JS.

Radiat Res. 2018 Jan;189(1):68-83. doi: 10.1667/RR14787.1. Epub 2017 Nov 15.

37.

Lambert-Eaton myasthenic syndrome: mouse passive-transfer model illuminates disease pathology and facilitates testing therapeutic leads.

Meriney SD, Tarr TB, Ojala KS, Wu M, Li Y, Lacomis D, Garcia-Ocaña A, Liang M, Valdomir G, Wipf P.

Ann N Y Acad Sci. 2018 Jan;1412(1):73-81. doi: 10.1111/nyas.13512. Epub 2017 Nov 10. Review.

38.

Inhibition of Androgen Receptor Function and Level in Castration-Resistant Prostate Cancer Cells by 2-[(isoxazol-4-ylmethyl)thio]-1-(4-phenylpiperazin-1-yl)ethanone.

Masoodi KZ, Eisermann K, Yang Z, Dar JA, Pascal LE, Nguyen M, O'Malley K, Parrinello E, Feturi FG, Kenefake AN, Nelson JB, Johnston PA, Wipf P, Wang Z.

Endocrinology. 2017 Oct 1;158(10):3152-3161. doi: 10.1210/en.2017-00408.

39.

t-BuOOH induces ferroptosis in human and murine cell lines.

Wenz C, Faust D, Linz B, Turmann C, Nikolova T, Bertin J, Gough P, Wipf P, Schröder AS, Krautwald S, Dietrich C.

Arch Toxicol. 2018 Feb;92(2):759-775. doi: 10.1007/s00204-017-2066-y. Epub 2017 Oct 3.

PMID:
28975372
40.

Small molecule targeting of PTPs in cancer.

Lazo JS, McQueeney KE, Burnett JC, Wipf P, Sharlow ER.

Int J Biochem Cell Biol. 2018 Mar;96:171-181. doi: 10.1016/j.biocel.2017.09.011. Epub 2017 Sep 21. Review.

PMID:
28943273
41.

N-Acetyl-l-Cysteine Protects Astrocytes against Proteotoxicity without Recourse to Glutathione.

Gleixner AM, Hutchison DF, Sannino S, Bhatia TN, Leak LC, Flaherty PT, Wipf P, Brodsky JL, Leak RK.

Mol Pharmacol. 2017 Nov;92(5):564-575. doi: 10.1124/mol.117.109926. Epub 2017 Aug 22.

42.

Indole synthesis by palladium-catalyzed tandem allylic isomerization - furan Diels-Alder reaction.

Xu J, Wipf P.

Org Biomol Chem. 2017 Aug 30;15(34):7093-7096. doi: 10.1039/c7ob01654a.

PMID:
28813061
43.

Mechanism of action of selective inhibitors of IL-6 induced STAT3 pathway in head and neck cancer cell lines.

Sen M, Johnston PA, Pollock NI, DeGrave K, Joyce SC, Freilino ML, Hua Y, Camarco DP, Close DA, Huryn DM, Wipf P, Grandis JR.

J Chem Biol. 2017 May 11;10(3):129-141. doi: 10.1007/s12154-017-0169-9. eCollection 2017 Jul.

44.

Inhibition of Androgen Receptor Nuclear Localization and Castration-Resistant Prostate Tumor Growth by Pyrroloimidazole-based Small Molecules.

Masoodi KZ, Xu Y, Dar JA, Eisermann K, Pascal LE, Parrinello E, Ai J, Johnston PA, Nelson JB, Wipf P, Wang Z.

Mol Cancer Ther. 2017 Oct;16(10):2120-2129. doi: 10.1158/1535-7163.MCT-17-0176. Epub 2017 Jun 27.

45.

Induction of TGF-β by Irradiation or Chemotherapy in Fanconi Anemia (FA) Mouse Bone Marrow Is Modulated by Small Molecule Radiation Mitigators JP4-039 and MMS350.

Epperly MW, Rhieu BH, Franicola D, Dixon T, Cao S, Zhang X, Shields D, Wang H, Wipf P, Greenberger JS.

In Vivo. 2017 Mar-Apr;31(2):159-168.

46.

A threonine turnstile defines a dynamic amphiphilic binding motif in the AAA ATPase p97 allosteric binding site.

Burnett JC, Lim C, Peyser BD, Samankumara LP, Kovaliov M, Colombo R, Bulfer SL, LaPorte MG, Hermone AR, McGrath CF, Arkin MR, Gussio R, Huryn DM, Wipf P.

Org Biomol Chem. 2017 May 16;15(19):4096-4114. doi: 10.1039/c7ob00526a.

47.

A structure-activity relationship study of ABCC2 inhibitors.

Wissel G, Deng F, Kudryavtsev P, Ghemtio L, Wipf P, Xhaard H, Kidron H.

Eur J Pharm Sci. 2017 May 30;103:60-69. doi: 10.1016/j.ejps.2017.02.005. Epub 2017 Feb 7.

48.

ACS Medicinal Chemistry Letters: Technology Notes.

Wipf P.

ACS Med Chem Lett. 2017 Jan 12;8(1):1-2. doi: 10.1021/acsmedchemlett.6b00484. eCollection 2017 Jan 12. No abstract available.

49.

Effectiveness of Analogs of the GS-Nitroxide, JP4-039, as Total Body Irradiation Mitigators.

Epperly MW, Sacher JR, Krainz T, Zhang X, Wipf P, Liang M, Fisher R, Li S, Wang H, Greenberger JS.

In Vivo. 2017 Jan 2;31(1):39-43.

50.

Lipidomics Characterization of Biosynthetic and Remodeling Pathways of Cardiolipins in Genetically and Nutritionally Manipulated Yeast Cells.

Tyurina YY, Lou W, Qu F, Tyurin VA, Mohammadyani D, Liu J, Hüttemann M, Frasso MA, Wipf P, Bayir H, Greenberg ML, Kagan VE.

ACS Chem Biol. 2017 Jan 20;12(1):265-281. doi: 10.1021/acschembio.6b00995. Epub 2016 Dec 16.

Supplemental Content

Support Center