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Items: 1 to 50 of 68

1.

Itraconazole targets cell cycle heterogeneity in colorectal cancer.

Buczacki SJA, Popova S, Biggs E, Koukorava C, Buzzelli J, Vermeulen L, Hazelwood L, Francies H, Garnett MJ, Winton DJ.

J Exp Med. 2018 Jul 2;215(7):1891-1912. doi: 10.1084/jem.20171385. Epub 2018 May 31.

2.

Fixation and Spread of Somatic Mutations in Adult Human Colonic Epithelium.

Nicholson AM, Olpe C, Hoyle A, Thorsen AS, Rus T, Colombé M, Brunton-Sim R, Kemp R, Marks K, Quirke P, Malhotra S, Ten Hoopen R, Ibrahim A, Lindskog C, Myers MB, Parsons B, Tavaré S, Wilkinson M, Morrissey E, Winton DJ.

Cell Stem Cell. 2018 Jun 1;22(6):909-918.e8. doi: 10.1016/j.stem.2018.04.020. Epub 2018 May 17.

3.

Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells.

Huels DJ, Bruens L, Hodder MC, Cammareri P, Campbell AD, Ridgway RA, Gay DM, Solar-Abboud M, Faller WJ, Nixon C, Zeiger LB, McLaughlin ME, Morrissey E, Winton DJ, Snippert HJ, van Rheenen J, Sansom OJ.

Nat Commun. 2018 Mar 19;9(1):1132. doi: 10.1038/s41467-018-03426-2.

4.

Metaplastic Cdx2-depleted cells can be very disruptive neighbors.

Lourenço FC, Winton DJ.

J Exp Med. 2018 Mar 5;215(3):725-727. doi: 10.1084/jem.20180215. Epub 2018 Feb 12.

PMID:
29440363
5.

Mex3a Marks a Slowly Dividing Subpopulation of Lgr5+ Intestinal Stem Cells.

Barriga FM, Montagni E, Mana M, Mendez-Lago M, Hernando-Momblona X, Sevillano M, Guillaumet-Adkins A, Rodriguez-Esteban G, Buczacki SJA, Gut M, Heyn H, Winton DJ, Yilmaz OH, Attolini CS, Gut I, Batlle E.

Cell Stem Cell. 2017 Jun 1;20(6):801-816.e7. doi: 10.1016/j.stem.2017.02.007. Epub 2017 Mar 9.

6.

Single-cell lineage tracing in the mammary gland reveals stochastic clonal dispersion of stem/progenitor cell progeny.

Davis FM, Lloyd-Lewis B, Harris OB, Kozar S, Winton DJ, Muresan L, Watson CJ.

Nat Commun. 2016 Oct 25;7:13053. doi: 10.1038/ncomms13053.

7.

Turning off the BCL-2 switch to prevent intestinal tumorigenesis.

van der Heijden M, Winton DJ, Vermeulen L.

Oncotarget. 2016 May 17;7(20):28763-4. doi: 10.18632/oncotarget.8757. No abstract available.

8.

Detection of colorectal dysplasia using fluorescently labelled lectins.

Kuo JC, Ibrahim AE, Dawson S, Parashar D, Howat WJ, Guttula K, Miller R, Fearnhead NS, Winton DJ, Neves AA, Brindle KM.

Sci Rep. 2016 Apr 13;6:24231. doi: 10.1038/srep24231.

9.

Bcl-2 is a critical mediator of intestinal transformation.

van der Heijden M, Zimberlin CD, Nicholson AM, Colak S, Kemp R, Meijer SL, Medema JP, Greten FR, Jansen M, Winton DJ, Vermeulen L.

Nat Commun. 2016 Mar 9;7:10916. doi: 10.1038/ncomms10916.

10.

Isolation of Human Colon Stem Cells Using Surface Expression of PTK7.

Jung P, Sommer C, Barriga FM, Buczacki SJ, Hernando-Momblona X, Sevillano M, Duran-Frigola M, Aloy P, Selbach M, Winton DJ, Batlle E.

Stem Cell Reports. 2015 Dec 8;5(6):979-987. doi: 10.1016/j.stemcr.2015.10.003. Epub 2015 Nov 5.

11.

Lineage selection and plasticity in the intestinal crypt.

Philpott A, Winton DJ.

Curr Opin Cell Biol. 2014 Dec;31:39-45. doi: 10.1016/j.ceb.2014.07.002. Epub 2014 Sep 15. Review.

12.

Side population sorting separates subfractions of cycling and non-cycling intestinal stem cells.

von Furstenberg RJ, Buczacki SJ, Smith BJ, Seiler KM, Winton DJ, Henning SJ.

Stem Cell Res. 2014 Mar;12(2):364-75. doi: 10.1016/j.scr.2013.10.012. Epub 2013 Nov 9.

13.

Defining stem cell dynamics in models of intestinal tumor initiation.

Vermeulen L, Morrissey E, van der Heijden M, Nicholson AM, Sottoriva A, Buczacki S, Kemp R, Tavaré S, Winton DJ.

Science. 2013 Nov 22;342(6161):995-8. doi: 10.1126/science.1243148.

14.

Continuous clonal labeling reveals small numbers of functional stem cells in intestinal crypts and adenomas.

Kozar S, Morrissey E, Nicholson AM, van der Heijden M, Zecchini HI, Kemp R, Tavaré S, Vermeulen L, Winton DJ.

Cell Stem Cell. 2013 Nov 7;13(5):626-33. doi: 10.1016/j.stem.2013.08.001. Epub 2013 Sep 12.

15.

miR-34a sets the "sweet spot" for notch in colorectal cancer stem cells.

Winton DJ.

Cell Stem Cell. 2013 May 2;12(5):499-501. doi: 10.1016/j.stem.2013.04.018.

16.

Intestinal label-retaining cells are secretory precursors expressing Lgr5.

Buczacki SJ, Zecchini HI, Nicholson AM, Russell R, Vermeulen L, Kemp R, Winton DJ.

Nature. 2013 Mar 7;495(7439):65-9. doi: 10.1038/nature11965. Epub 2013 Feb 27.

PMID:
23446353
17.

Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation.

Wilson CH, Crombie C, van der Weyden L, Poulogiannis G, Rust AG, Pardo M, Gracia T, Yu L, Choudhary J, Poulin GB, McIntyre RE, Winton DJ, March HN, Arends MJ, Fraser AG, Adams DJ.

EMBO J. 2012 May 30;31(11):2486-97. doi: 10.1038/emboj.2012.91. Epub 2012 Apr 17.

18.

Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling.

Wong VW, Stange DE, Page ME, Buczacki S, Wabik A, Itami S, van de Wetering M, Poulsom R, Wright NA, Trotter MW, Watt FM, Winton DJ, Clevers H, Jensen KB.

Nat Cell Biol. 2012 Mar 4;14(4):401-8. doi: 10.1038/ncb2464.

19.

Cdx2 determines the fate of postnatal intestinal endoderm.

Stringer EJ, Duluc I, Saandi T, Davidson I, Bialecka M, Sato T, Barker N, Clevers H, Pritchard CA, Winton DJ, Wright NA, Freund JN, Deschamps J, Beck F.

Development. 2012 Feb;139(3):465-74. doi: 10.1242/dev.070722. Epub 2011 Dec 21.

20.

Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis.

March HN, Rust AG, Wright NA, ten Hoeve J, de Ridder J, Eldridge M, van der Weyden L, Berns A, Gadiot J, Uren A, Kemp R, Arends MJ, Wessels LF, Winton DJ, Adams DJ.

Nat Genet. 2011 Nov 6;43(12):1202-9. doi: 10.1038/ng.990.

21.

Stem cells, quiescence and rectal carcinoma: an unexplored relationship and potential therapeutic target.

Buczacki S, Davies RJ, Winton DJ.

Br J Cancer. 2011 Oct 25;105(9):1253-9. doi: 10.1038/bjc.2011.362. Epub 2011 Sep 20. Review.

22.

Delta1 expression, cell cycle exit, and commitment to a specific secretory fate coincide within a few hours in the mouse intestinal stem cell system.

Stamataki D, Holder M, Hodgetts C, Jeffery R, Nye E, Spencer-Dene B, Winton DJ, Lewis J.

PLoS One. 2011;6(9):e24484. doi: 10.1371/journal.pone.0024484. Epub 2011 Sep 7.

23.

mTOR regulation by JNK: rescuing the starving intestinal cancer cell?

March HN, Winton DJ.

Gastroenterology. 2011 May;140(5):1387-91. doi: 10.1053/j.gastro.2011.03.027. Epub 2011 Mar 25. No abstract available.

PMID:
21440581
24.

V600EBraf induces gastrointestinal crypt senescence and promotes tumour progression through enhanced CpG methylation of p16INK4a.

Carragher LA, Snell KR, Giblett SM, Aldridge VS, Patel B, Cook SJ, Winton DJ, Marais R, Pritchard CA.

EMBO Mol Med. 2010 Nov;2(11):458-71. doi: 10.1002/emmm.201000099.

25.

Intestinal stem cell replacement follows a pattern of neutral drift.

Lopez-Garcia C, Klein AM, Simons BD, Winton DJ.

Science. 2010 Nov 5;330(6005):822-5. doi: 10.1126/science.1196236. Epub 2010 Sep 23.

26.

β-Catenin activation synergizes with PTEN loss to cause bladder cancer formation.

Ahmad I, Morton JP, Singh LB, Radulescu SM, Ridgway RA, Patel S, Woodgett J, Winton DJ, Taketo MM, Wu XR, Leung HY, Sansom OJ.

Oncogene. 2011 Jan 13;30(2):178-89. doi: 10.1038/onc.2010.399. Epub 2010 Sep 6.

27.

Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling.

Ashton GH, Morton JP, Myant K, Phesse TJ, Ridgway RA, Marsh V, Wilkins JA, Athineos D, Muncan V, Kemp R, Neufeld K, Clevers H, Brunton V, Winton DJ, Wang X, Sears RC, Clarke AR, Frame MC, Sansom OJ.

Dev Cell. 2010 Aug 17;19(2):259-69. doi: 10.1016/j.devcel.2010.07.015.

28.

Loss of Indian Hedgehog activates multiple aspects of a wound healing response in the mouse intestine.

van Dop WA, Heijmans J, Büller NV, Snoek SA, Rosekrans SL, Wassenberg EA, van den Bergh Weerman MA, Lanske B, Clarke AR, Winton DJ, Wijgerde M, Offerhaus GJ, Hommes DW, Hardwick JC, de Jonge WJ, Biemond I, van den Brink GR.

Gastroenterology. 2010 Nov;139(5):1665-76, 1676.e1-10. doi: 10.1053/j.gastro.2010.07.045. Epub 2010 Aug 1.

PMID:
20682322
29.

Dvl2 promotes intestinal length and neoplasia in the ApcMin mouse model for colorectal cancer.

Metcalfe C, Ibrahim AE, Graeb M, de la Roche M, Schwarz-Romond T, Fiedler M, Winton DJ, Corfield A, Bienz M.

Cancer Res. 2010 Aug 15;70(16):6629-38. doi: 10.1158/0008-5472.CAN-10-1616. Epub 2010 Jul 27.

30.

Characterization of a heat resistant beta-glucosidase as a new reporter in cells and mice.

McCutcheon SC, Jones K, Cumming SA, Kemp R, Ireland-Zecchini H, Saunders JC, Houghton CA, Howard LA, Winton DJ.

BMC Biol. 2010 Jun 22;8:89. doi: 10.1186/1741-7007-8-89.

31.

E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells.

Chong JL, Wenzel PL, Sáenz-Robles MT, Nair V, Ferrey A, Hagan JP, Gomez YM, Sharma N, Chen HZ, Ouseph M, Wang SH, Trikha P, Culp B, Mezache L, Winton DJ, Sansom OJ, Chen D, Bremner R, Cantalupo PG, Robinson ML, Pipas JM, Leone G.

Nature. 2009 Dec 17;462(7275):930-4. doi: 10.1038/nature08677.

32.

Mutated K-ras(Asp12) promotes tumourigenesis in Apc(Min) mice more in the large than the small intestines, with synergistic effects between K-ras and Wnt pathways.

Luo F, Brooks DG, Ye H, Hamoudi R, Poulogiannis G, Patek CE, Winton DJ, Arends MJ.

Int J Exp Pathol. 2009 Oct;90(5):558-74. doi: 10.1111/j.1365-2613.2009.00667.x.

33.

Lkb1 deficiency alters goblet and paneth cell differentiation in the small intestine.

Shorning BY, Zabkiewicz J, McCarthy A, Pearson HB, Winton DJ, Sansom OJ, Ashworth A, Clarke AR.

PLoS One. 2009;4(1):e4264. doi: 10.1371/journal.pone.0004264. Epub 2009 Jan 23. Erratum in: PLoS One.2009;4(2). doi: 10.1371/annotation/7750701a-2069-4810-820b-b0a02b674a06.

34.

Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation.

Marsh V, Winton DJ, Williams GT, Dubois N, Trumpp A, Sansom OJ, Clarke AR.

Nat Genet. 2008 Dec;40(12):1436-44. doi: 10.1038/ng.256. Epub 2008 Nov 16.

PMID:
19011632
35.

A historical analysis of herpes simplex virus promoter activation in vivo reveals distinct populations of latently infected neurones.

Proença JT, Coleman HM, Connor V, Winton DJ, Efstathiou S.

J Gen Virol. 2008 Dec;89(Pt 12):2965-74. doi: 10.1099/vir.0.2008/005066-0.

36.

A single type of progenitor cell maintains normal epidermis.

Clayton E, Doupé DP, Klein AM, Winton DJ, Simons BD, Jones PH.

Nature. 2007 Mar 8;446(7132):185-9. Epub 2007 Feb 28.

PMID:
17330052
37.

Conditional expression of mutated K-ras accelerates intestinal tumorigenesis in Msh2-deficient mice.

Luo F, Brooks DG, Ye H, Hamoudi R, Poulogiannis G, Patek CE, Winton DJ, Arends MJ.

Oncogene. 2007 Jun 28;26(30):4415-27. Epub 2007 Feb 5.

PMID:
17297472
38.

Apc deficiency predisposes to renal carcinoma in the mouse.

Sansom OJ, Griffiths DF, Reed KR, Winton DJ, Clarke AR.

Oncogene. 2005 Dec 8;24(55):8205-10.

PMID:
16116480
39.

Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells.

van Es JH, van Gijn ME, Riccio O, van den Born M, Vooijs M, Begthel H, Cozijnsen M, Robine S, Winton DJ, Radtke F, Clevers H.

Nature. 2005 Jun 16;435(7044):959-63.

PMID:
15959515
40.

Cyclin D1 is not an immediate target of beta-catenin following Apc loss in the intestine.

Sansom OJ, Reed KR, van de Wetering M, Muncan V, Winton DJ, Clevers H, Clarke AR.

J Biol Chem. 2005 Aug 5;280(31):28463-7. Epub 2005 Jun 9.

41.
42.

PPARdelta status and Apc-mediated tumourigenesis in the mouse intestine.

Reed KR, Sansom OJ, Hayes AJ, Gescher AJ, Winton DJ, Peters JM, Clarke AR.

Oncogene. 2004 Nov 25;23(55):8992-6.

PMID:
15480419
43.

Elimination of background recombination: somatic induction of Cre by combined transcriptional regulation and hormone binding affinity.

Kemp R, Ireland H, Clayton E, Houghton C, Howard L, Winton DJ.

Nucleic Acids Res. 2004 Jul 1;32(11):e92. Print 2004.

44.

Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration.

Sansom OJ, Reed KR, Hayes AJ, Ireland H, Brinkmann H, Newton IP, Batlle E, Simon-Assmann P, Clevers H, Nathke IS, Clarke AR, Winton DJ.

Genes Dev. 2004 Jun 15;18(12):1385-90.

45.

Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin.

Ireland H, Kemp R, Houghton C, Howard L, Clarke AR, Sansom OJ, Winton DJ.

Gastroenterology. 2004 May;126(5):1236-46.

PMID:
15131783
46.

C-cell and thyroid epithelial tumours and altered follicular development in transgenic mice expressing the long isoform of MEN 2A RET.

Reynolds L, Jones K, Winton DJ, Cranston A, Houghton C, Howard L, Ponder BA, Smith DP.

Oncogene. 2001 Jul 5;20(30):3986-94.

47.

Msh-2 suppresses in vivo mutation in a gene dose and lesion dependent manner.

Sansom OJ, Toft NJ, Winton DJ, Clarke AR.

Oncogene. 2001 Jun 14;20(27):3580-4.

48.
49.

Msh2 status modulates both apoptosis and mutation frequency in the murine small intestine.

Toft NJ, Winton DJ, Kelly J, Howard LA, Dekker M, te Riele H, Arends MJ, Wyllie AH, Margison GP, Clarke AR.

Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3911-5.

50.

The mutagenicity of benzo[a]pyrene in mouse small intestine.

Brooks RA, Gooderham NJ, Edwards RJ, Boobis AR, Winton DJ.

Carcinogenesis. 1999 Jan;20(1):109-14.

PMID:
9934857

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