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Items: 1 to 50 of 88

1.

Improving folding properties of computationally designed proteins.

Bjerre B, Nissen J, Madsen M, Fahrig-Kamarauskaitė J, Norrild RK, Holm PC, Nordentoft MK, O'Shea C, Willemoës M, Johansson KE, Winther JR.

Protein Eng Des Sel. 2019 Dec 13;32(3):145-151. doi: 10.1093/protein/gzz025.

PMID:
31553452
2.

Steady state kinetic analysis of O-linked GalNAc glycan release catalyzed by endo-α-N-acetylgalactosaminidase.

Hansen DK, Winther JR, Willemoës M.

Carbohydr Res. 2019 Jul 1;480:54-60. doi: 10.1016/j.carres.2019.05.009. Epub 2019 May 21.

PMID:
31176190
3.

Pulmonary effects of nanofibrillated celluloses in mice suggest that carboxylation lowers the inflammatory and acute phase responses.

Hadrup N, Knudsen KB, Berthing T, Wolff H, Bengtson S, Kofoed C, Espersen R, Højgaard C, Winther JR, Willemoës M, Wedin I, Nuopponen M, Alenius H, Norppa H, Wallin H, Vogel U.

Environ Toxicol Pharmacol. 2019 Feb;66:116-125. doi: 10.1016/j.etap.2019.01.003. Epub 2019 Jan 14.

PMID:
30665014
4.

Can a Charged Surfactant Unfold an Uncharged Protein?

Højgaard C, Sørensen HV, Pedersen JS, Winther JR, Otzen DE.

Biophys J. 2018 Dec 4;115(11):2081-2086. doi: 10.1016/j.bpj.2018.10.022. Epub 2018 Nov 15.

5.

A Robust Proton Flux (pHlux) Assay for Studying the Function and Inhibition of the Influenza A M2 Proton Channel.

Santner P, Martins JMDS, Laursen JS, Behrendt L, Riber L, Olsen CA, Arkin IT, Winther JR, Willemoës M, Lindorff-Larsen K.

Biochemistry. 2018 Oct 16;57(41):5949-5956. doi: 10.1021/acs.biochem.8b00721. Epub 2018 Oct 3.

PMID:
30230312
6.

Random Mutagenesis Analysis of the Influenza A M2 Proton Channel Reveals Novel Resistance Mutants.

Santner P, Martins JMDS, Kampmeyer C, Hartmann-Petersen R, Laursen JS, Stein A, Olsen CA, Arkin IT, Winther JR, Willemoës M, Lindorff-Larsen K.

Biochemistry. 2018 Oct 16;57(41):5957-5968. doi: 10.1021/acs.biochem.8b00722. Epub 2018 Oct 3.

PMID:
30230310
7.

Nanofibrillated cellulose causes acute pulmonary inflammation that subsides within a month.

Ilves M, Vilske S, Aimonen K, Lindberg HK, Pesonen S, Wedin I, Nuopponen M, Vanhala E, Højgaard C, Winther JR, Willemoës M, Vogel U, Wolff H, Norppa H, Savolainen K, Alenius H.

Nanotoxicology. 2018 Sep;12(7):729-746. doi: 10.1080/17435390.2018.1472312. Epub 2018 May 30.

PMID:
29848128
8.

Editorial overview: A perspective on protein evolution.

Höcker B, Winther JR.

Curr Opin Struct Biol. 2018 Feb;48:viii-ix. doi: 10.1016/j.sbi.2018.01.013. No abstract available.

PMID:
29475491
9.

Protein evolution: Hacking an enzyme.

Johansson KE, Winther JR.

Nat Chem Biol. 2018 Feb 14;14(3):202-204. doi: 10.1038/nchembio.2574. No abstract available.

PMID:
29443977
10.

Endoplasmic Reticulum Transport of Glutathione by Sec61 Is Regulated by Ero1 and Bip.

Ponsero AJ, Igbaria A, Darch MA, Miled S, Outten CE, Winther JR, Palais G, D'Autréaux B, Delaunay-Moisan A, Toledano MB.

Mol Cell. 2017 Sep 21;67(6):962-973.e5. doi: 10.1016/j.molcel.2017.08.012. Epub 2017 Sep 14.

11.

Exploring the antigenic response to multiplexed immunizations in a chicken model of antibody production.

Kousted TM, Kalliokoski O, Christensen SK, Winther JR, Hau J.

Heliyon. 2017 Mar 16;3(3):e00267. doi: 10.1016/j.heliyon.2017.e00267. eCollection 2017 Mar.

12.

Positive staining for cellulose in oral pulse granuloma.

Virkkunen S, Wolff H, Haglund C, Højgaard C, Winther JR, Willemoës M, Vogel U, Hagström J.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2017 Apr;123(4):464-467. doi: 10.1016/j.oooo.2016.11.022. Epub 2016 Dec 9.

PMID:
28189527
13.

Computational Redesign of Thioredoxin Is Hypersensitive toward Minor Conformational Changes in the Backbone Template.

Johansson KE, Tidemand Johansen N, Christensen S, Horowitz S, Bardwell JCA, Olsen JG, Willemoës M, Lindorff-Larsen K, Ferkinghoff-Borg J, Hamelryck T, Winther JR.

J Mol Biol. 2016 Oct 23;428(21):4361-4377. doi: 10.1016/j.jmb.2016.09.013. Epub 2016 Sep 20.

14.

Genotoxic and inflammatory effects of nanofibrillated cellulose in murine lungs.

Catalán J, Rydman E, Aimonen K, Hannukainen KS, Suhonen S, Vanhala E, Moreno C, Meyer V, Perez DD, Sneck A, Forsström U, Højgaard C, Willemoes M, Winther JR, Vogel U, Wolff H, Alenius H, Savolainen KM, Norppa H.

Mutagenesis. 2017 Jan;32(1):23-31. doi: 10.1093/mutage/gew035. Epub 2016 Jul 28.

PMID:
27470699
15.

A Soluble, Folded Protein without Charged Amino Acid Residues.

Højgaard C, Kofoed C, Espersen R, Johansson KE, Villa M, Willemoës M, Lindorff-Larsen K, Teilum K, Winther JR.

Biochemistry. 2016 Jul 19;55(28):3949-56. doi: 10.1021/acs.biochem.6b00269. Epub 2016 Jul 6.

PMID:
27307139
16.

Visualization of Nanofibrillar Cellulose in Biological Tissues Using a Biotinylated Carbohydrate Binding Module of β-1,4-Glycanase.

Knudsen KB, Kofoed C, Espersen R, Højgaard C, Winther JR, Willemoës M, Wedin I, Nuopponen M, Vilske S, Aimonen K, Weydahl IE, Alenius H, Norppa H, Wolff H, Wallin H, Vogel U.

Chem Res Toxicol. 2015 Aug 17;28(8):1627-35. doi: 10.1021/acs.chemrestox.5b00271. Epub 2015 Aug 6.

PMID:
26208679
17.

Mutational analysis of divalent metal ion binding in the active site of class II α-mannosidase from Sulfolobus solfataricus.

Hansen DK, Webb H, Nielsen JW, Harris P, Winther JR, Willemoës M.

Biochemistry. 2015 Mar 24;54(11):2032-9. doi: 10.1021/acs.biochem.5b00090. Epub 2015 Mar 12.

PMID:
25751413
18.

In silico prediction of mutant HIV-1 proteases cleaving a target sequence.

Jensen JH, Willemoës M, Winther JR, De Vico L.

PLoS One. 2014 May 5;9(5):e95833. doi: 10.1371/journal.pone.0095833. eCollection 2014.

19.

The pKa value and accessibility of cysteine residues are key determinants for protein substrate discrimination by glutaredoxin.

Jensen KS, Pedersen JT, Winther JR, Teilum K.

Biochemistry. 2014 Apr 22;53(15):2533-40. doi: 10.1021/bi4016633. Epub 2014 Apr 9.

PMID:
24673564
20.

Rapid TaqMan-based quantification of chlorophyll d-containing cyanobacteria in the genus Acaryochloris.

Behrendt L, Nielsen JL, Sørensen SJ, Larkum AW, Winther JR, Kühl M.

Appl Environ Microbiol. 2014 May;80(10):3244-9. doi: 10.1128/AEM.00334-14. Epub 2014 Mar 14.

21.

Non-invasive in-cell determination of free cytosolic [NAD+]/[NADH] ratios using hyperpolarized glucose show large variations in metabolic phenotypes.

Christensen CE, Karlsson M, Winther JR, Jensen PR, Lerche MH.

J Biol Chem. 2014 Jan 24;289(4):2344-52. doi: 10.1074/jbc.M113.498626. Epub 2013 Dec 3.

22.

Catalytic site interactions in yeast OMP synthase.

Hansen MR, Barr EW, Jensen KF, Willemoës M, Grubmeyer C, Winther JR.

Arch Biochem Biophys. 2014 Jan 15;542:28-38. doi: 10.1016/j.abb.2013.11.004. Epub 2013 Nov 18.

PMID:
24262852
23.

Quantifying Changes in the Cellular Thiol-Disulfide Status during Differentiation of B Cells into Antibody-Secreting Plasma Cells.

Hansen RE, Otsu M, Braakman I, Winther JR.

Int J Cell Biol. 2013;2013:898563. doi: 10.1155/2013/898563. Epub 2013 Sep 24.

24.

Quantification of thiols and disulfides.

Winther JR, Thorpe C.

Biochim Biophys Acta. 2014 Feb;1840(2):838-46. doi: 10.1016/j.bbagen.2013.03.031. Epub 2013 Apr 6. Review.

25.

Redox control: A black hole for oxidized glutathione.

Winther JR, Jakob U.

Nat Chem Biol. 2013 Feb;9(2):69-70. doi: 10.1038/nchembio.1161. No abstract available.

26.

Metal-ion dependent catalytic properties of Sulfolobus solfataricus class ii α-mannosidase.

Nielsen JW, Poulsen NR, Johnsson A, Winther JR, Stipp SL, Willemoës M.

Biochemistry. 2012 Oct 9;51(40):8039-46. doi: 10.1021/bi301096a. Epub 2012 Sep 28.

PMID:
22989181
27.

The human selenoprotein VCP-interacting membrane protein (VIMP) is non-globular and harbors a reductase function in an intrinsically disordered region.

Christensen LC, Jensen NW, Vala A, Kamarauskaite J, Johansson L, Winther JR, Hofmann K, Teilum K, Ellgaard L.

J Biol Chem. 2012 Jul 27;287(31):26388-99. doi: 10.1074/jbc.M112.346775. Epub 2012 Jun 14.

28.

A fluorescent probe which allows highly specific thiol labeling at low pH.

Nielsen JW, Jensen KS, Hansen RE, Gotfredsen CH, Winther JR.

Anal Biochem. 2012 Feb 1;421(1):115-20. doi: 10.1016/j.ab.2011.11.027. Epub 2011 Dec 1.

PMID:
22178918
29.

Millisecond dynamics in glutaredoxin during catalytic turnover is dependent on substrate binding and absent in the resting states.

Jensen KS, Winther JR, Teilum K.

J Am Chem Soc. 2011 Mar 9;133(9):3034-42. doi: 10.1021/ja1096539. Epub 2011 Feb 16.

PMID:
21323311
30.

Trisulfides in proteins.

Nielsen RW, Tachibana C, Hansen NE, Winther JR.

Antioxid Redox Signal. 2011 Jul 1;15(1):67-75. doi: 10.1089/ars.2010.3677. Epub 2011 Apr 13. Review.

PMID:
20977350
31.

Kinetic and thermodynamic properties of two barley thioredoxin h isozymes, HvTrxh1 and HvTrxh2.

Maeda K, Hägglund P, Björnberg O, Winther JR, Svensson B.

FEBS Lett. 2010 Aug 4;584(15):3376-80. doi: 10.1016/j.febslet.2010.06.028. Epub 2010 Jun 23.

32.

Thiol-disulfide exchange between glutaredoxin and glutathione.

Iversen R, Andersen PA, Jensen KS, Winther JR, Sigurskjold BW.

Biochemistry. 2010 Feb 2;49(4):810-20. doi: 10.1021/bi9015956.

PMID:
19968277
33.

An introduction to methods for analyzing thiols and disulfides: Reactions, reagents, and practical considerations.

Hansen RE, Winther JR.

Anal Biochem. 2009 Nov 15;394(2):147-58. doi: 10.1016/j.ab.2009.07.051. Epub 2009 Aug 5. Review. No abstract available.

PMID:
19664585
34.

Quantifying the global cellular thiol-disulfide status.

Hansen RE, Roth D, Winther JR.

Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):422-7. doi: 10.1073/pnas.0812149106. Epub 2009 Jan 2.

35.

Kinetic and thermodynamic aspects of cellular thiol-disulfide redox regulation.

Jensen KS, Hansen RE, Winther JR.

Antioxid Redox Signal. 2009 May;11(5):1047-58. doi: 10.1089/ARS.2008.2297. Review.

PMID:
19014315
36.

High-resolution imaging of redox signaling in live cells through an oxidation-sensitive yellow fluorescent protein.

Maulucci G, Labate V, Mele M, Panieri E, Arcovito G, Galeotti T, Østergaard H, Winther JR, De Spirito M, Pani G.

Sci Signal. 2008 Oct 28;1(43):pl3. doi: 10.1126/scisignal.143pl3.

PMID:
18957692
37.

Mutations in the RAM network confer resistance to the thiol oxidant 4,4'-dipyridyl disulfide.

López-Mirabal HR, Winther JR, Thorsen M, Kielland-Brandt MC.

Mol Genet Genomics. 2008 Jun;279(6):629-42. doi: 10.1007/s00438-008-0339-0. Epub 2008 Mar 21.

PMID:
18357467
38.

Oxidant resistance in a yeast mutant deficient in the Sit4 phosphatase.

López-Mirabal HR, Winther JR, Kielland-Brandt MC.

Curr Genet. 2008 May;53(5):275-86. doi: 10.1007/s00294-008-0184-z. Epub 2008 Mar 21.

PMID:
18357452
39.

Genetic interaction between the ero1-1 and leu2 mutations in Saccharomyces cerevisiae.

López-Mirabal HR, Winther JR, Kielland-Brandt MC.

Biosci Biotechnol Biochem. 2007 Dec;71(12):2934-42. Epub 2007 Dec 7.

40.

Redox characteristics of the eukaryotic cytosol.

López-Mirabal HR, Winther JR.

Biochim Biophys Acta. 2008 Apr;1783(4):629-40. Epub 2007 Nov 7. Review.

41.

The thiol oxidant dipyridyl disulfide can supply the PDI-Ero1p pathway with additional oxidative equivalents.

López-Mirabal HR, Winther JR.

Antonie Van Leeuwenhoek. 2007 Nov;92(4):463-72. Epub 2007 Jun 13.

PMID:
17564811
42.

Structure of glutaredoxin Grx1p C30S mutant from yeast.

Håkansson KO, Winther JR.

Acta Crystallogr D Biol Crystallogr. 2007 Mar;63(Pt 3):288-94. Epub 2007 Feb 21.

PMID:
17327665
43.

Erv2p: characterization of the redox behavior of a yeast sulfhydryl oxidase.

Wang W, Winther JR, Thorpe C.

Biochemistry. 2007 Mar 20;46(11):3246-54. Epub 2007 Feb 14.

44.

Quantification of protein thiols and dithiols in the picomolar range using sodium borohydride and 4,4'-dithiodipyridine.

Hansen RE, Østergaard H, Nørgaard P, Winther JR.

Anal Biochem. 2007 Apr 1;363(1):77-82. Epub 2007 Jan 8.

PMID:
17286954
45.

Cytoplasmic glutathione redox status determines survival upon exposure to the thiol-oxidant 4,4'-dipyridyl disulfide.

López-Mirabal HR, Thorsen M, Kielland-Brandt MC, Toledano MB, Winther JR.

FEMS Yeast Res. 2007 May;7(3):391-403. Epub 2007 Jan 24.

46.

Crystallization of mutant forms of glutaredoxin Grx1p from yeast.

Håkansson KO, Østergaard H, Winther JR.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Sep 1;62(Pt 9):920-2. Epub 2006 Aug 26.

47.

Evidence that translation reinitiation leads to a partially functional Menkes protein containing two copper-binding sites.

Paulsen M, Lund C, Akram Z, Winther JR, Horn N, Møller LB.

Am J Hum Genet. 2006 Aug;79(2):214-29. Epub 2006 Jun 5.

48.

Measuring intracellular redox conditions using GFP-based sensors.

Björnberg O, Ostergaard H, Winther JR.

Antioxid Redox Signal. 2006 Mar-Apr;8(3-4):354-61. Review.

PMID:
16677081
49.

Mechanistic insight provided by glutaredoxin within a fusion to redox-sensitive yellow fluorescent protein.

Björnberg O, Østergaard H, Winther JR.

Biochemistry. 2006 Feb 21;45(7):2362-71.

PMID:
16475825
50.

Increasing the reactivity of an artificial dithiol-disulfide pair through modification of the electrostatic milieu.

Hansen RE, Østergaard H, Winther JR.

Biochemistry. 2005 Apr 19;44(15):5899-906.

PMID:
15823049

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