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Items: 1 to 50 of 804

1.

Exploring Chemical Space for new Substances to stabilize a therapeutic Monoclonal Antibody.

Tosstorff A, Menzen T, Winter G.

J Pharm Sci. 2019 Nov 4. pii: S0022-3549(19)30729-4. doi: 10.1016/j.xphs.2019.10.057. [Epub ahead of print]

PMID:
31697947
2.

Orthogonal techniques to study the effect of pH, sucrose and arginine salts on monoclonal antibody physical stability and aggregation during long-term storage.

Svilenov HL, Kulakova A, Zalar M, Golovanov AP, Harris P, Winter G.

J Pharm Sci. 2019 Nov 2. pii: S0022-3549(19)30737-3. doi: 10.1016/j.xphs.2019.10.065. [Epub ahead of print]

PMID:
31689429
3.

Genome-scale CRISPR screens are efficient in non-homologous end-joining deficient cells.

Ferreira da Silva J, Salic S, Wiedner M, Datlinger P, Essletzbichler P, Hanzl A, Superti-Furga G, Bock C, Winter G, Loizou JI.

Sci Rep. 2019 Oct 31;9(1):15751. doi: 10.1038/s41598-019-52078-9.

4.

Development and implementation of ISAR, a new synthesis platform for radiopharmaceutical production.

Frank C, Winter G, Rensei F, Samper V, Brooks AF, Hockley BG, Henderson BD, Rensch C, Scott PJH.

EJNMMI Radiopharm Chem. 2019 Sep 18;4(1):24. doi: 10.1186/s41181-019-0077-0.

5.

Overcoming challenges in co-formulation of proteins with contradicting stability profiles - EPO plus G-CSF.

Krieg D, Svilenov H, Gitter JH, Winter G.

Eur J Pharm Sci. 2020 Jan 1;141:105073. doi: 10.1016/j.ejps.2019.105073. Epub 2019 Oct 23.

PMID:
31655209
6.

Intrinsic Differential Scanning Fluorimetry for Fast and Easy Identification of AAV Serotypes.

Rieser R, Penaud-Budloo M, Bouzelha M, Rossi A, Menzen T, Biel M, Büning H, Ayuso E, Winter G, Michalakis S.

J Pharm Sci. 2019 Oct 19. pii: S0022-3549(19)30668-9. doi: 10.1016/j.xphs.2019.10.031. [Epub ahead of print]

PMID:
31639391
7.

In conversation with Greg Winter.

Dhillon P, Winter G.

FEBS J. 2019 Oct;286(19):3742-3744. doi: 10.1111/febs.15064.

PMID:
31588669
8.

A review of the antimicrobial side of antidepressants and its putative implications on the gut microbiome.

McGovern AS, Hamlin AS, Winter G.

Aust N Z J Psychiatry. 2019 Dec;53(12):1151-1166. doi: 10.1177/0004867419877954. Epub 2019 Sep 26.

PMID:
31558039
9.

The role of germline mutation profiling in the selection of related donors for haematopoietic stem cell transplantation.

Zebisch A, Winter G, Kashofer K, Hatzl S, Uhl B, Wurm S, Wölfler A, Greinix HT, Hoefler G, Sill H.

Bone Marrow Transplant. 2019 Sep 25. doi: 10.1038/s41409-019-0691-1. [Epub ahead of print] No abstract available.

PMID:
31554930
10.

Harnessing Evolution to Make Medicines (Nobel Lecture).

Winter G.

Angew Chem Int Ed Engl. 2019 Oct 7;58(41):14438-14445. doi: 10.1002/anie.201909343. Epub 2019 Sep 17. Review.

PMID:
31529671
11.

Structure-based discovery of a new protein-aggregation breaking excipient.

Tosstorff A, Svilenov H, Peters GHJ, Harris P, Winter G.

Eur J Pharm Biopharm. 2019 Nov;144:207-216. doi: 10.1016/j.ejpb.2019.09.010. Epub 2019 Sep 12.

PMID:
31521717
12.

Shape Characterization of Subvisible Particles Using Dynamic Imaging Analysis.

Mathaes R, Manning MC, Winter G, Engert J, Wilson GA.

J Pharm Sci. 2019 Aug 30. pii: S0022-3549(19)30556-8. doi: 10.1016/j.xphs.2019.08.023. [Epub ahead of print]

PMID:
31476311
13.

Plasticity of the Cullin-RING Ligase Repertoire Shapes Sensitivity to Ligand-Induced Protein Degradation.

Mayor-Ruiz C, Jaeger MG, Bauer S, Brand M, Sin C, Hanzl A, Mueller AC, Menche J, Winter GE.

Mol Cell. 2019 Aug 22;75(4):849-858.e8. doi: 10.1016/j.molcel.2019.07.013.

PMID:
31442425
14.

Nonspherical Nanoparticle Shape Stability Is Affected by Complex Manufacturing Aspects: Its Implications for Drug Delivery and Targeting.

Haryadi BM, Hafner D, Amin I, Schubel R, Jordan R, Winter G, Engert J.

Adv Healthc Mater. 2019 Sep;8(18):e1900352. doi: 10.1002/adhm.201900352. Epub 2019 Aug 13. Review.

PMID:
31410996
15.

Storage and handling of human faecal samples affect the gut microbiome composition: A feasibility study.

Ezzy AC, Hagstrom AD, George C, Hamlin AS, Pereg L, Murphy AJ, Winter G.

J Microbiol Methods. 2019 Sep;164:105668. doi: 10.1016/j.mimet.2019.105668. Epub 2019 Jul 11.

PMID:
31302202
16.

Cellular uptake of self-assembled phytantriol-based hexosomes is independent of major endocytic machineries.

Rodrigues L, Schneider F, Zhang X, Larsson E, Moodie LWK, Dietz H, Papadakis CM, Winter G, Lundmark R, Hubert M.

J Colloid Interface Sci. 2019 Oct 1;553:820-833. doi: 10.1016/j.jcis.2019.06.045. Epub 2019 Jun 19.

PMID:
31284226
17.

Modelling the internalisation process of prostate cancer cells for PSMA-specific ligands.

Winter G, Vogt A, Jiménez-Franco LD, Rinscheid A, Yousefzadeh-Nowshahr E, Solbach C, Beer AJ, Glatting G, Kletting P.

Nucl Med Biol. 2019 May - Jun;72-73:20-25. doi: 10.1016/j.nucmedbio.2019.05.003. Epub 2019 May 29.

PMID:
31260881
18.

Generation, Characterization, and Quantitative Bioanalysis of Drug/Anti-drug Antibody Immune Complexes to Facilitate Dedicated In Vivo Studies.

Hoffmann E, Jordan G, Lauer M, Ringler P, Kusznir EA, Rufer AC, Huber S, Jochner A, Winter G, Staack RF.

Pharm Res. 2019 Jun 28;36(9):129. doi: 10.1007/s11095-019-2661-0.

19.

DEG10 contributes to mitochondrial proteostasis, root growth, and seed yield in Arabidopsis.

Huber CV, Jakobs BD, Mishra LS, Niedermaier S, Stift M, Winter G, Adamska I, Funk C, Huesgen PF, Funck D.

J Exp Bot. 2019 Oct 15;70(19):5423-5436. doi: 10.1093/jxb/erz294.

20.

Stick it to E3s.

Brand M, Winter GE.

Nat Chem Biol. 2019 Jul;15(7):655-656. doi: 10.1038/s41589-019-0312-8. No abstract available.

PMID:
31209352
21.

Development of a sprayable hydrogel formulation for the skin application of therapeutic antibodies.

Geh KJ, Stelzl A, Gröne A, Wagner L, Förster B, Winter G.

Eur J Pharm Biopharm. 2019 Sep;142:123-132. doi: 10.1016/j.ejpb.2019.06.015. Epub 2019 Jun 14.

PMID:
31207297
22.

Identification and characterization of cancer vulnerabilities via targeted protein degradation.

Mayor-Ruiz C, Winter GE.

Drug Discov Today Technol. 2019 Apr;31:81-90. doi: 10.1016/j.ddtec.2018.12.003. Epub 2019 Jan 2. Review.

PMID:
31200863
23.

Do interactions between protein and phospholipids influence the release behavior from lipid-based exenatide depot systems?

Breitsamer M, Stulz A, Heerklotz HH, Winter G.

Eur J Pharm Biopharm. 2019 Sep;142:61-69. doi: 10.1016/j.ejpb.2019.06.007. Epub 2019 Jun 10.

PMID:
31195130
24.

Immunomodulatory asthma therapy in the equine animal model: A dose-response study and evaluation of a long-term effect.

Klier J, Bartl C, Geuder S, Geh KJ, Reese S, Goehring LS, Winter G, Gehlen H.

Immun Inflamm Dis. 2019 Sep;7(3):130-149. doi: 10.1002/iid3.252. Epub 2019 May 29.

25.

MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation.

Sdelci S, Rendeiro AF, Rathert P, You W, Lin JG, Ringler A, Hofstätter G, Moll HP, Gürtl B, Farlik M, Schick S, Klepsch F, Oldach M, Buphamalai P, Schischlik F, Májek P, Parapatics K, Schmidl C, Schuster M, Penz T, Buckley DL, Hudecz O, Imre R, Wang SY, Maric HM, Kralovics R, Bennett KL, Müller AC, Mechtler K, Menche J, Bradner JE, Winter GE, Klavins K, Casanova E, Bock C, Zuber J, Kubicek S.

Nat Genet. 2019 Jun;51(6):990-998. doi: 10.1038/s41588-019-0413-z. Epub 2019 May 27.

PMID:
31133746
26.

Application of interpretable artificial neural networks to early monoclonal antibodies development.

Gentiluomo L, Roessner D, Augustijn D, Svilenov H, Kulakova A, Mahapatra S, Winter G, Streicher W, Rinnan Å, Peters GHJ, Harris P, Frieß W.

Eur J Pharm Biopharm. 2019 Aug;141:81-89. doi: 10.1016/j.ejpb.2019.05.017. Epub 2019 May 18.

PMID:
31112768
27.

Structural Studies Reveal Enantiospecific Recognition of a DNA G-Quadruplex by a Ruthenium Polypyridyl Complex.

McQuaid K, Abell H, Gurung SP, Allan DR, Winter G, Sorensen T, Cardin DJ, Brazier JA, Cardin CJ, Hall JP.

Angew Chem Int Ed Engl. 2019 Jul 15;58(29):9881-9885. doi: 10.1002/anie.201814502. Epub 2019 Jun 12.

PMID:
30958918
28.

How best to use photons.

Winter G, Gildea RJ, Paterson NG, Beale J, Gerstel M, Axford D, Vollmar M, McAuley KE, Owen RL, Flaig R, Ashton AW, Hall DR.

Acta Crystallogr D Struct Biol. 2019 Mar 1;75(Pt 3):242-261. doi: 10.1107/S2059798319003528. Epub 2019 Mar 19.

29.

Locus-Specific Knock-In of a Degradable Tag for Target Validation Studies.

Brand M, Winter GE.

Methods Mol Biol. 2019;1953:105-119. doi: 10.1007/978-1-4939-9145-7_7.

PMID:
30912018
30.

Rapid sample-saving biophysical characterisation and long-term storage stability of liquid interferon alpha2a formulations: Is there a correlation?

Svilenov H, Winter G.

Int J Pharm. 2019 May 1;562:42-50. doi: 10.1016/j.ijpharm.2019.03.025. Epub 2019 Mar 14.

PMID:
30878589
31.

The ReFOLD assay for protein formulation studies and prediction of protein aggregation during long-term storage.

Svilenov H, Winter G.

Eur J Pharm Biopharm. 2019 Apr;137:131-139. doi: 10.1016/j.ejpb.2019.02.018. Epub 2019 Feb 25.

PMID:
30818009
32.

Evaluation of a 3D Human Artificial Lymph Node as Test Model for the Assessment of Immunogenicity of Protein Aggregates.

Kraus T, Lubitz A, Schließer U, Giese C, Reuschel J, Brecht R, Engert J, Winter G.

J Pharm Sci. 2019 Jul;108(7):2358-2366. doi: 10.1016/j.xphs.2019.02.011. Epub 2019 Feb 21.

PMID:
30797781
33.

Polypropylene crystallization at an alumina interface using single walled carbon nanotubes.

Faust JL, Winter GA, Minus ML, Erb RM.

J Colloid Interface Sci. 2019 May 1;543:9-16. doi: 10.1016/j.jcis.2019.02.020. Epub 2019 Feb 7.

PMID:
30772536
34.

Test models for the evaluation of immunogenicity of protein aggregates.

Kraus T, Winter G, Engert J.

Int J Pharm. 2019 Mar 25;559:192-200. doi: 10.1016/j.ijpharm.2019.01.015. Epub 2019 Jan 18. Review.

PMID:
30665000
35.

Comparison of ice fog methods and monitoring of controlled nucleation success after freeze-drying.

Vollrath I, Friess W, Freitag A, Hawe A, Winter G.

Int J Pharm. 2019 Mar 10;558:18-28. doi: 10.1016/j.ijpharm.2018.12.056. Epub 2018 Dec 28.

PMID:
30597272
36.

Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML.

Brand M, Jiang B, Bauer S, Donovan KA, Liang Y, Wang ES, Nowak RP, Yuan JC, Zhang T, Kwiatkowski N, Müller AC, Fischer ES, Gray NS, Winter GE.

Cell Chem Biol. 2019 Feb 21;26(2):300-306.e9. doi: 10.1016/j.chembiol.2018.11.006. Epub 2018 Dec 27.

PMID:
30595531
37.

Vesicular phospholipid gels as drug delivery systems for small molecular weight drugs, peptides and proteins: State of the art review.

Breitsamer M, Winter G.

Int J Pharm. 2019 Feb 25;557:1-8. doi: 10.1016/j.ijpharm.2018.12.030. Epub 2018 Dec 18. Review.

PMID:
30572079
38.

New studies on leachables in commercial scale protein drug filling lines using stir bar sorptive extraction coupled with TD-GC-MS and UPLC/QTOF-MS/MS analytics.

Scherer N, Marcseková K, Posset T, Winter G.

Int J Pharm. 2019 Jan 30;555:404-419. doi: 10.1016/j.ijpharm.2018.11.033. Epub 2018 Nov 27.

PMID:
30500460
39.

Pharmacological Modulation of the Psychiatric Risk Factor FKBP51 Alters Efficiency of Common Antidepressant Drugs.

Pöhlmann ML, Häusl AS, Harbich D, Balsevich G, Engelhardt C, Feng X, Breitsamer M, Hausch F, Winter G, Schmidt MV.

Front Behav Neurosci. 2018 Nov 12;12:262. doi: 10.3389/fnbeh.2018.00262. eCollection 2018.

40.

Structure determination and crystal chemistry of large repeat mixed-layer hexaferrites.

Delacotte C, Whitehead GFS, Pitcher MJ, Robertson CM, Sharp PM, Dyer MS, Alaria J, Claridge JB, Darling GR, Allan DR, Winter G, Rosseinsky MJ.

IUCrJ. 2018 Sep 12;5(Pt 6):681-698. doi: 10.1107/S2052252518011351. eCollection 2018 Nov 1.

41.

LZTR1 is a regulator of RAS ubiquitination and signaling.

Bigenzahn JW, Collu GM, Kartnig F, Pieraks M, Vladimer GI, Heinz LX, Sedlyarov V, Schischlik F, Fauster A, Rebsamen M, Parapatics K, Blomen VA, Müller AC, Winter GE, Kralovics R, Brummelkamp TR, Mlodzik M, Superti-Furga G.

Science. 2018 Dec 7;362(6419):1171-1177. doi: 10.1126/science.aap8210. Epub 2018 Nov 15.

42.

Silicone Oil-Free Polymer Syringes for the Storage of Therapeutic Proteins.

Werner BP, Schöneich C, Winter G.

J Pharm Sci. 2019 Mar;108(3):1148-1160. doi: 10.1016/j.xphs.2018.10.049. Epub 2018 Nov 2.

PMID:
30391415
43.

Improving signal strength in serial crystallography with DIALS geometry refinement.

Brewster AS, Waterman DG, Parkhurst JM, Gildea RJ, Young ID, O'Riordan LJ, Yano J, Winter G, Evans G, Sauter NK.

Acta Crystallogr D Struct Biol. 2018 Sep 1;74(Pt 9):877-894. doi: 10.1107/S2059798318009191. Epub 2018 Sep 3.

44.

A New Approach to Study the Physical Stability of Monoclonal Antibody Formulations-Dilution From a Denaturant.

Svilenov H, Gentiluomo L, Friess W, Roessner D, Winter G.

J Pharm Sci. 2018 Dec;107(12):3007-3013. doi: 10.1016/j.xphs.2018.08.004. Epub 2018 Aug 16.

PMID:
30121313
45.

Expanding Bedside Filtration-A Powerful Tool to Protect Patients From Protein Aggregates.

Werner BP, Winter G.

J Pharm Sci. 2018 Nov;107(11):2775-2788. doi: 10.1016/j.xphs.2018.07.022. Epub 2018 Jul 27.

PMID:
30059660
46.

A Comparison of Controlled Ice Nucleation Techniques for Freeze-Drying of a Therapeutic Antibody.

Gitter JH, Geidobler R, Presser I, Winter G.

J Pharm Sci. 2018 Nov;107(11):2748-2754. doi: 10.1016/j.xphs.2018.07.019. Epub 2018 Jul 25.

PMID:
30055225
47.

Zn2+-triggered self-assembly of Gonadorelin [6-D-Phe] to produce nanostructures and fibrils.

Yordanova Y, Vanderlinden W, Stoll R, Rüdiger D, Tosstorff A, Zaremba W, Winter G, Zahler S, Friess W.

Sci Rep. 2018 Jul 26;8(1):11280. doi: 10.1038/s41598-018-29529-w.

48.

Intrathecal Baclofen Therapy-Practical Approach: Clinical Benefits and Complication Management.

Winter G, Beni-Adani L, Ben-Pazi H.

J Child Neurol. 2018 Oct;33(11):734-741. doi: 10.1177/0883073818785074. Epub 2018 Jul 16. Review.

PMID:
30009656
49.

Immune responses induced by nano-self-assembled lipid adjuvants based on a monomycoloyl glycerol analogue after vaccination with the Chlamydia trachomatis major outer membrane protein.

Rodrigues L, Raftopoulos KN, Tandrup Schmidt S, Schneider F, Dietz H, Rades T, Franzyk H, Pedersen AE, Papadakis CM, Christensen D, Winter G, Foged C, Hubert M.

J Control Release. 2018 Sep 10;285:12-22. doi: 10.1016/j.jconrel.2018.06.028. Epub 2018 Jun 28.

PMID:
29964134
50.

Binding of HSA to Macromolecular pHPMA Based Nanoparticles for Drug Delivery: An Investigation Using Fluorescence Methods.

Zhang X, Chytil P, Etrych T, Liu W, Rodrigues L, Winter G, Filippov SK, Papadakis CM.

Langmuir. 2018 Jul 10;34(27):7998-8006. doi: 10.1021/acs.langmuir.8b01015. Epub 2018 Jun 27.

PMID:
29949376

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