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Items: 1 to 50 of 784

1.

Development of a sprayable hydrogel formulation for the skin application of therapeutic antibodies.

Geh KJ, Stelzl A, Gröne A, Wagner L, Förster B, Winter G.

Eur J Pharm Biopharm. 2019 Jun 14. pii: S0939-6411(18)31402-4. doi: 10.1016/j.ejpb.2019.06.015. [Epub ahead of print]

PMID:
31207297
2.

Identification and characterization of cancer vulnerabilities via targeted protein degradation.

Mayor-Ruiz C, Winter GE.

Drug Discov Today Technol. 2019 Apr;31:81-90. doi: 10.1016/j.ddtec.2018.12.003. Epub 2019 Jan 2. Review.

PMID:
31200863
3.

Do interactions between Protein and Phospholipids influence the release behavior from lipid-based exenatide depot systems?

Breitsamer M, Stulz A, Heerklotz HH, Winter G.

Eur J Pharm Biopharm. 2019 Jun 10. pii: S0939-6411(19)30007-4. doi: 10.1016/j.ejpb.2019.06.007. [Epub ahead of print]

PMID:
31195130
4.

Immunomodulatory asthma therapy in the equine animal model: A dose-response study and evaluation of a long-term effect.

Klier J, Bartl C, Geuder S, Geh KJ, Reese S, Goehring LS, Winter G, Gehlen H.

Immun Inflamm Dis. 2019 May 29. doi: 10.1002/iid3.252. [Epub ahead of print]

5.

MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation.

Sdelci S, Rendeiro AF, Rathert P, You W, Lin JG, Ringler A, Hofstätter G, Moll HP, Gürtl B, Farlik M, Schick S, Klepsch F, Oldach M, Buphamalai P, Schischlik F, Májek P, Parapatics K, Schmidl C, Schuster M, Penz T, Buckley DL, Hudecz O, Imre R, Wang SY, Maric HM, Kralovics R, Bennett KL, Müller AC, Mechtler K, Menche J, Bradner JE, Winter GE, Klavins K, Casanova E, Bock C, Zuber J, Kubicek S.

Nat Genet. 2019 Jun;51(6):990-998. doi: 10.1038/s41588-019-0413-z. Epub 2019 May 27.

PMID:
31133746
6.

Application of interpretable artificial neural networks to early monoclonal antibodies development.

Gentiluomo L, Roessner D, Augustijn D, Svilenov H, Kulakova A, Mahapatra S, Winter G, Streicher W, Rinnan Å, Peters GHJ, Harris P, Frieß W.

Eur J Pharm Biopharm. 2019 May 18. pii: S0939-6411(19)30318-2. doi: 10.1016/j.ejpb.2019.05.017. [Epub ahead of print]

PMID:
31112768
7.

Structural Studies Reveal Enantiospecific Recognition of a DNA G-Quadruplex by a Ruthenium Polypyridyl Complex.

McQuaid K, Abell H, Gurung SP, Allan DR, Winter G, Sorensen T, Cardin DJ, Brazier JA, Cardin CJ, Hall JP.

Angew Chem Int Ed Engl. 2019 Apr 8. doi: 10.1002/anie.201814502. [Epub ahead of print]

PMID:
30958918
8.

How best to use photons.

Winter G, Gildea RJ, Paterson NG, Beale J, Gerstel M, Axford D, Vollmar M, McAuley KE, Owen RL, Flaig R, Ashton AW, Hall DR.

Acta Crystallogr D Struct Biol. 2019 Mar 1;75(Pt 3):242-261. doi: 10.1107/S2059798319003528. Epub 2019 Mar 19.

9.

Locus-Specific Knock-In of a Degradable Tag for Target Validation Studies.

Brand M, Winter GE.

Methods Mol Biol. 2019;1953:105-119. doi: 10.1007/978-1-4939-9145-7_7.

PMID:
30912018
10.

Rapid sample-saving biophysical characterisation and long-term storage stability of liquid interferon alpha2a formulations: Is there a correlation?

Svilenov H, Winter G.

Int J Pharm. 2019 May 1;562:42-50. doi: 10.1016/j.ijpharm.2019.03.025. Epub 2019 Mar 14.

PMID:
30878589
11.

The ReFOLD assay for protein formulation studies and prediction of protein aggregation during long-term storage.

Svilenov H, Winter G.

Eur J Pharm Biopharm. 2019 Apr;137:131-139. doi: 10.1016/j.ejpb.2019.02.018. Epub 2019 Feb 25.

PMID:
30818009
12.

Evaluation of a 3D Human Artificial Lymph Node as Test Model for the Assessment of Immunogenicity of Protein Aggregates.

Kraus T, Lubitz A, Schließer U, Giese C, Reuschel J, Brecht R, Engert J, Winter G.

J Pharm Sci. 2019 Feb 21. pii: S0022-3549(19)30096-6. doi: 10.1016/j.xphs.2019.02.011. [Epub ahead of print]

PMID:
30797781
13.

Polypropylene crystallization at an alumina interface using single walled carbon nanotubes.

Faust JL, Winter GA, Minus ML, Erb RM.

J Colloid Interface Sci. 2019 May 1;543:9-16. doi: 10.1016/j.jcis.2019.02.020. Epub 2019 Feb 7.

PMID:
30772536
14.

Test models for the evaluation of immunogenicity of protein aggregates.

Kraus T, Winter G, Engert J.

Int J Pharm. 2019 Mar 25;559:192-200. doi: 10.1016/j.ijpharm.2019.01.015. Epub 2019 Jan 18. Review.

PMID:
30665000
15.

Comparison of ice fog methods and monitoring of controlled nucleation success after freeze-drying.

Vollrath I, Friess W, Freitag A, Hawe A, Winter G.

Int J Pharm. 2019 Mar 10;558:18-28. doi: 10.1016/j.ijpharm.2018.12.056. Epub 2018 Dec 28.

PMID:
30597272
16.

Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML.

Brand M, Jiang B, Bauer S, Donovan KA, Liang Y, Wang ES, Nowak RP, Yuan JC, Zhang T, Kwiatkowski N, Müller AC, Fischer ES, Gray NS, Winter GE.

Cell Chem Biol. 2019 Feb 21;26(2):300-306.e9. doi: 10.1016/j.chembiol.2018.11.006. Epub 2018 Dec 27.

PMID:
30595531
17.

Vesicular phospholipid gels as drug delivery systems for small molecular weight drugs, peptides and proteins: State of the art review.

Breitsamer M, Winter G.

Int J Pharm. 2019 Feb 25;557:1-8. doi: 10.1016/j.ijpharm.2018.12.030. Epub 2018 Dec 18. Review.

PMID:
30572079
18.

New studies on leachables in commercial scale protein drug filling lines using stir bar sorptive extraction coupled with TD-GC-MS and UPLC/QTOF-MS/MS analytics.

Scherer N, Marcseková K, Posset T, Winter G.

Int J Pharm. 2019 Jan 30;555:404-419. doi: 10.1016/j.ijpharm.2018.11.033. Epub 2018 Nov 27.

PMID:
30500460
19.

Pharmacological Modulation of the Psychiatric Risk Factor FKBP51 Alters Efficiency of Common Antidepressant Drugs.

Pöhlmann ML, Häusl AS, Harbich D, Balsevich G, Engelhardt C, Feng X, Breitsamer M, Hausch F, Winter G, Schmidt MV.

Front Behav Neurosci. 2018 Nov 12;12:262. doi: 10.3389/fnbeh.2018.00262. eCollection 2018.

20.

Structure determination and crystal chemistry of large repeat mixed-layer hexaferrites.

Delacotte C, Whitehead GFS, Pitcher MJ, Robertson CM, Sharp PM, Dyer MS, Alaria J, Claridge JB, Darling GR, Allan DR, Winter G, Rosseinsky MJ.

IUCrJ. 2018 Sep 12;5(Pt 6):681-698. doi: 10.1107/S2052252518011351. eCollection 2018 Nov 1.

21.

LZTR1 is a regulator of RAS ubiquitination and signaling.

Bigenzahn JW, Collu GM, Kartnig F, Pieraks M, Vladimer GI, Heinz LX, Sedlyarov V, Schischlik F, Fauster A, Rebsamen M, Parapatics K, Blomen VA, Müller AC, Winter GE, Kralovics R, Brummelkamp TR, Mlodzik M, Superti-Furga G.

Science. 2018 Dec 7;362(6419):1171-1177. doi: 10.1126/science.aap8210. Epub 2018 Nov 15.

PMID:
30442766
22.

Silicone Oil-Free Polymer Syringes for the Storage of Therapeutic Proteins.

Werner BP, Schöneich C, Winter G.

J Pharm Sci. 2019 Mar;108(3):1148-1160. doi: 10.1016/j.xphs.2018.10.049. Epub 2018 Nov 2.

PMID:
30391415
23.

Improving signal strength in serial crystallography with DIALS geometry refinement.

Brewster AS, Waterman DG, Parkhurst JM, Gildea RJ, Young ID, O'Riordan LJ, Yano J, Winter G, Evans G, Sauter NK.

Acta Crystallogr D Struct Biol. 2018 Sep 1;74(Pt 9):877-894. doi: 10.1107/S2059798318009191. Epub 2018 Sep 3.

24.

A New Approach to Study the Physical Stability of Monoclonal Antibody Formulations-Dilution From a Denaturant.

Svilenov H, Gentiluomo L, Friess W, Roessner D, Winter G.

J Pharm Sci. 2018 Dec;107(12):3007-3013. doi: 10.1016/j.xphs.2018.08.004. Epub 2018 Aug 16.

PMID:
30121313
25.

Expanding Bedside Filtration-A Powerful Tool to Protect Patients From Protein Aggregates.

Werner BP, Winter G.

J Pharm Sci. 2018 Nov;107(11):2775-2788. doi: 10.1016/j.xphs.2018.07.022. Epub 2018 Jul 27.

PMID:
30059660
26.

A Comparison of Controlled Ice Nucleation Techniques for Freeze-Drying of a Therapeutic Antibody.

Gitter JH, Geidobler R, Presser I, Winter G.

J Pharm Sci. 2018 Nov;107(11):2748-2754. doi: 10.1016/j.xphs.2018.07.019. Epub 2018 Jul 25.

PMID:
30055225
27.

Zn2+-triggered self-assembly of Gonadorelin [6-D-Phe] to produce nanostructures and fibrils.

Yordanova Y, Vanderlinden W, Stoll R, Rüdiger D, Tosstorff A, Zaremba W, Winter G, Zahler S, Friess W.

Sci Rep. 2018 Jul 26;8(1):11280. doi: 10.1038/s41598-018-29529-w.

28.

Intrathecal Baclofen Therapy-Practical Approach: Clinical Benefits and Complication Management.

Winter G, Beni-Adani L, Ben-Pazi H.

J Child Neurol. 2018 Oct;33(11):734-741. doi: 10.1177/0883073818785074. Epub 2018 Jul 16.

PMID:
30009656
29.

Immune responses induced by nano-self-assembled lipid adjuvants based on a monomycoloyl glycerol analogue after vaccination with the Chlamydia trachomatis major outer membrane protein.

Rodrigues L, Raftopoulos KN, Tandrup Schmidt S, Schneider F, Dietz H, Rades T, Franzyk H, Pedersen AE, Papadakis CM, Christensen D, Winter G, Foged C, Hubert M.

J Control Release. 2018 Sep 10;285:12-22. doi: 10.1016/j.jconrel.2018.06.028. Epub 2018 Jun 28.

PMID:
29964134
30.

Binding of HSA to Macromolecular pHPMA Based Nanoparticles for Drug Delivery: An Investigation Using Fluorescence Methods.

Zhang X, Chytil P, Etrych T, Liu W, Rodrigues L, Winter G, Filippov SK, Papadakis CM.

Langmuir. 2018 Jul 10;34(27):7998-8006. doi: 10.1021/acs.langmuir.8b01015. Epub 2018 Jun 27.

PMID:
29949376
31.

New insights into process understanding of solid lipid extrusion (SLE) of extruded lipid implants for sustained protein delivery.

Vollrath M, Engert J, Winter G.

Eur J Pharm Biopharm. 2018 Sep;130:11-21. doi: 10.1016/j.ejpb.2018.06.016. Epub 2018 Jun 18.

PMID:
29913270
32.

Significant Drying Time Reduction Using Microwave-Assisted Freeze-Drying for a Monoclonal Antibody.

Gitter JH, Geidobler R, Presser I, Winter G.

J Pharm Sci. 2018 Oct;107(10):2538-2543. doi: 10.1016/j.xphs.2018.05.023. Epub 2018 Jun 8.

PMID:
29890173
33.

Does controlled nucleation impact the properties and stability of lyophilized monoclonal antibody formulations?

Vollrath I, Friess W, Freitag A, Hawe A, Winter G.

Eur J Pharm Biopharm. 2018 Aug;129:134-144. doi: 10.1016/j.ejpb.2018.05.025. Epub 2018 May 22.

PMID:
29800618
34.

Progress in formulation development and sterilisation of freeze-dried oligodeoxynucleotide-loaded gelatine nanoparticles.

Geh KJ, Hubert M, Winter G.

Eur J Pharm Biopharm. 2018 Aug;129:10-20. doi: 10.1016/j.ejpb.2018.05.016. Epub 2018 May 16.

PMID:
29777773
35.

Targetable BET proteins- and E2F1-dependent transcriptional program maintains the malignancy of glioblastoma.

Xu L, Chen Y, Mayakonda A, Koh L, Chong YK, Buckley DL, Sandanaraj E, Lim SW, Lin RY, Ke XY, Huang ML, Chen J, Sun W, Wang LZ, Goh BC, Dinh HQ, Kappei D, Winter GE, Ding LW, Ang BT, Berman BP, Bradner JE, Tang C, Koeffler HP.

Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5086-E5095. doi: 10.1073/pnas.1712363115. Epub 2018 May 15.

36.

Taste as a marker for behavioral energy regulation:Replication and extension of meal pattern evidence from selectively bred rats.

Dess NK, Schreiber KR, Winter GM, Chapman CD.

Behav Processes. 2018 Aug;153:9-15. doi: 10.1016/j.beproc.2018.05.006. Epub 2018 May 7.

PMID:
29747044
37.

Engineered hybrid spider silk particles as delivery system for peptide vaccines.

Lucke M, Mottas I, Herbst T, Hotz C, Römer L, Schierling M, Herold HM, Slotta U, Spinetti T, Scheibel T, Winter G, Bourquin C, Engert J.

Biomaterials. 2018 Jul;172:105-115. doi: 10.1016/j.biomaterials.2018.04.008. Epub 2018 Apr 21.

PMID:
29723755
38.

Determination of Patterson group symmetry from sparse multi-crystal data sets in the presence of an indexing ambiguity.

Gildea RJ, Winter G.

Acta Crystallogr D Struct Biol. 2018 May 1;74(Pt 5):405-410. doi: 10.1107/S2059798318002978. Epub 2018 Apr 24.

39.

A pilot study using a novel pyrotechnically driven prototype applicator for epidermal powder immunization in piglets.

Engert J, Anamur C, Engelke L, Fellner C, Lell P, Henke S, Stadler J, Zöls S, Ritzmann M, Winter G.

Int J Pharm. 2018 Jul 10;545(1-2):215-228. doi: 10.1016/j.ijpharm.2018.04.039. Epub 2018 Apr 20.

PMID:
29684561
40.

Application of water-soluble polyvinyl alcohol-based film patches on laser microporated skin facilitates intradermal macromolecule and nanoparticle delivery.

Engelke L, Winter G, Engert J.

Eur J Pharm Biopharm. 2018 Jul;128:119-130. doi: 10.1016/j.ejpb.2018.04.008. Epub 2018 Apr 13.

PMID:
29660407
41.

The dTAG system for immediate and target-specific protein degradation.

Nabet B, Roberts JM, Buckley DL, Paulk J, Dastjerdi S, Yang A, Leggett AL, Erb MA, Lawlor MA, Souza A, Scott TG, Vittori S, Perry JA, Qi J, Winter GE, Wong KK, Gray NS, Bradner JE.

Nat Chem Biol. 2018 May;14(5):431-441. doi: 10.1038/s41589-018-0021-8. Epub 2018 Mar 26.

42.

The stress regulator FKBP51: a novel and promising druggable target for the treatment of persistent pain states across sexes.

Maiarù M, Morgan OB, Mao T, Breitsamer M, Bamber H, Pöhlmann M, Schmidt MV, Winter G, Hausch F, Géranton SM.

Pain. 2018 Jul;159(7):1224-1234. doi: 10.1097/j.pain.0000000000001204.

43.

DIALS: implementation and evaluation of a new integration package.

Winter G, Waterman DG, Parkhurst JM, Brewster AS, Gildea RJ, Gerstel M, Fuentes-Montero L, Vollmar M, Michels-Clark T, Young ID, Sauter NK, Evans G.

Acta Crystallogr D Struct Biol. 2018 Feb 1;74(Pt 2):85-97. doi: 10.1107/S2059798317017235. Epub 2018 Feb 1.

44.

Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands.

Gechijian LN, Buckley DL, Lawlor MA, Reyes JM, Paulk J, Ott CJ, Winter GE, Erb MA, Scott TG, Xu M, Seo HS, Dhe-Paganon S, Kwiatkowski NP, Perry JA, Qi J, Gray NS, Bradner JE.

Nat Chem Biol. 2018 Apr;14(4):405-412. doi: 10.1038/s41589-018-0010-y. Epub 2018 Mar 5.

45.

Evaluation of stir-bar sorptive extraction coupled with thermal desorption GC-MS for the detection of leachables from polymer single use systems to drugs.

Scherer N, Marcseková K, Posset T, Winter G.

J Pharm Biomed Anal. 2018 Apr 15;152:66-73. doi: 10.1016/j.jpba.2018.01.045. Epub 2018 Feb 3.

PMID:
29414020
46.

Gut microbiome and depression: what we know and what we need to know.

Winter G, Hart RA, Charlesworth RPG, Sharpley CF.

Rev Neurosci. 2018 Aug 28;29(6):629-643. doi: 10.1515/revneuro-2017-0072. Review.

PMID:
29397391
47.

Enhancer invasion shapes MYCN-dependent transcriptional amplification in neuroblastoma.

Zeid R, Lawlor MA, Poon E, Reyes JM, Fulciniti M, Lopez MA, Scott TG, Nabet B, Erb MA, Winter GE, Jacobson Z, Polaski DR, Karlin KL, Hirsch RA, Munshi NP, Westbrook TF, Chesler L, Lin CY, Bradner JE.

Nat Genet. 2018 Apr;50(4):515-523. doi: 10.1038/s41588-018-0044-9. Epub 2018 Jan 29.

48.

Acute Pharmacologic Degradation of a Stable Antigen Enhances Its Direct Presentation on MHC Class I Molecules.

Moser SC, Voerman JSA, Buckley DL, Winter GE, Schliehe C.

Front Immunol. 2018 Jan 8;8:1920. doi: 10.3389/fimmu.2017.01920. eCollection 2017.

49.

Translation Termination Factor GSPT1 Is a Phenotypically Relevant Off-Target of Heterobifunctional Phthalimide Degraders.

Ishoey M, Chorn S, Singh N, Jaeger MG, Brand M, Paulk J, Bauer S, Erb MA, Parapatics K, Müller AC, Bennett KL, Ecker GF, Bradner JE, Winter GE.

ACS Chem Biol. 2018 Mar 16;13(3):553-560. doi: 10.1021/acschembio.7b00969. Epub 2018 Jan 29.

PMID:
29356495
50.

Isothermal chemical denaturation as a complementary tool to overcome limitations of thermal differential scanning fluorimetry in predicting physical stability of protein formulations.

Svilenov H, Markoja U, Winter G.

Eur J Pharm Biopharm. 2018 Apr;125:106-113. doi: 10.1016/j.ejpb.2018.01.004. Epub 2018 Jan 9.

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