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Items: 1 to 50 of 131


Natural Language Processing of Clinical Notes for Improved Early Prediction of Septic Shock in the ICU.

Liu R, Greenstein JL, Sarma SV, Winslow RL.

Conf Proc IEEE Eng Med Biol Soc. 2019 Jul;2019:6103-6108. doi: 10.1109/EMBC.2019.8857819.


Please Welcome the New Team Member: The Algorithm.

Fackler JC, Rehman M, Winslow RL.

Pediatr Crit Care Med. 2019 Dec;20(12):1200-1201. doi: 10.1097/PCC.0000000000002149. No abstract available.


Data-driven discovery of a novel sepsis pre-shock state predicts impending septic shock in the ICU.

Liu R, Greenstein JL, Granite SJ, Fackler JC, Bembea MM, Sarma SV, Winslow RL.

Sci Rep. 2019 Apr 16;9(1):6145. doi: 10.1038/s41598-019-42637-5.


Na+ microdomains and sparks: Role in cardiac excitation-contraction coupling and arrhythmias in ankyrin-B deficiency.

Chu L, Greenstein JL, Winslow RL.

J Mol Cell Cardiol. 2019 Mar;128:145-157. doi: 10.1016/j.yjmcc.2019.02.001. Epub 2019 Feb 5.


A bilobal model of Ca2+-dependent inactivation to probe the physiology of L-type Ca2+ channels.

Limpitikul WB, Greenstein JL, Yue DT, Dick IE, Winslow RL.

J Gen Physiol. 2018 Dec 3;150(12):1688-1701. doi: 10.1085/jgp.201812115. Epub 2018 Nov 23.


Estimating the probabilities of rare arrhythmic events in multiscale computational models of cardiac cells and tissue.

Walker MA, Gurev V, Rice JJ, Greenstein JL, Winslow RL.

PLoS Comput Biol. 2017 Nov 16;13(11):e1005783. doi: 10.1371/journal.pcbi.1005783. eCollection 2017 Nov.


WaveformECG: A Platform for Visualizing, Annotating, and Analyzing ECG Data.

Winslow RL, Granite S, Jurado C.

Comput Sci Eng. 2016 Sep-Oct;18(5):36-46. doi: 10.1109/MCSE.2016.91. Epub 2016 Aug 24.


Mechanisms of the cyclic nucleotide cross-talk signaling network in cardiac L-type calcium channel regulation.

Zhao CY, Greenstein JL, Winslow RL.

J Mol Cell Cardiol. 2017 May;106:29-44. doi: 10.1016/j.yjmcc.2017.01.013. Epub 2017 Mar 29.


Immune Responses to Novel Adenovirus Type 26 and Modified Vaccinia Virus Ankara-Vectored Ebola Vaccines at 1 Year.

Winslow RL, Milligan ID, Voysey M, Luhn K, Shukarev G, Douoguih M, Snape MD.

JAMA. 2017 Mar 14;317(10):1075-1077. doi: 10.1001/jama.2016.20644. No abstract available.


Metadata-driven Clinical Data Loading into i2b2 for Clinical and Translational Science Institutes.

Post AR, Pai AK, Willard R, May BJ, West AC, Agravat S, Granite SJ, Winslow RL, Stephens DS.

AMIA Jt Summits Transl Sci Proc. 2016 Jul 20;2016:184-93. eCollection 2016.


Modeling Na+-Ca2+ exchange in the heart: Allosteric activation, spatial localization, sparks and excitation-contraction coupling.

Chu L, Greenstein JL, Winslow RL.

J Mol Cell Cardiol. 2016 Oct;99:174-187. doi: 10.1016/j.yjmcc.2016.06.068. Epub 2016 Jul 2.


Models and Simulations as a Service: Exploring the Use of Galaxy for Delivering Computational Models.

Walker MA, Madduri R, Rodriguez A, Greenstein JL, Winslow RL.

Biophys J. 2016 Mar 8;110(5):1038-43. doi: 10.1016/j.bpj.2015.12.041.


Roles of phosphodiesterases in the regulation of the cardiac cyclic nucleotide cross-talk signaling network.

Zhao CY, Greenstein JL, Winslow RL.

J Mol Cell Cardiol. 2016 Feb;91:215-27. doi: 10.1016/j.yjmcc.2016.01.004. Epub 2016 Jan 7.


Shape analysis of hypertrophic and hypertensive heart disease using MRI-based 3D surface models of left ventricular geometry.

Ardekani S, Jain S, Sanzi A, Corona-Villalobos CP, Abraham TP, Abraham MR, Zimmerman SL, Wu KC, Winslow RL, Miller MI, Younes L.

Med Image Anal. 2016 Apr;29:12-23. doi: 10.1016/ Epub 2015 Dec 10.


Modeling calcium regulation of contraction, energetics, signaling, and transcription in the cardiac myocyte.

Winslow RL, Walker MA, Greenstein JL.

Wiley Interdiscip Rev Syst Biol Med. 2016 Jan-Feb;8(1):37-67. doi: 10.1002/wsbm.1322. Epub 2015 Nov 12. Review.


On the Adjacency Matrix of RyR2 Cluster Structures.

Walker MA, Kohl T, Lehnart SE, Greenstein JL, Lederer WJ, Winslow RL.

PLoS Comput Biol. 2015 Nov 6;11(11):e1004521. doi: 10.1371/journal.pcbi.1004521. eCollection 2015 Nov.


Interaction between phosphodiesterases in the regulation of the cardiac ╬▓-adrenergic pathway.

Zhao CY, Greenstein JL, Winslow RL.

J Mol Cell Cardiol. 2015 Nov;88:29-38. doi: 10.1016/j.yjmcc.2015.09.011. Epub 2015 Sep 23.


Mechanistic Investigation of the Arrhythmogenic Role of Oxidized CaMKII in the Heart.

Foteinou PT, Greenstein JL, Winslow RL.

Biophys J. 2015 Aug 18;109(4):838-49. doi: 10.1016/j.bpj.2015.06.064.


Computing network-based features from physiological time series: application to sepsis detection.

Santaniello S, Granite SJ, Sarma SV, Winslow RL.

Conf Proc IEEE Eng Med Biol Soc. 2014;2014:3825-6. doi: 10.1109/EMBC.2014.6944457.


Superresolution modeling of calcium release in the heart.

Walker MA, Williams GSB, Kohl T, Lehnart SE, Jafri MS, Greenstein JL, Lederer WJ, Winslow RL.

Biophys J. 2014 Dec 16;107(12):3018-3029. doi: 10.1016/j.bpj.2014.11.003.


Modeling CaMKII-mediated regulation of L-type Ca(2+) channels and ryanodine receptors in the heart.

Greenstein JL, Foteinou PT, Hashambhoy-Ramsay YL, Winslow RL.

Front Pharmacol. 2014 Apr 3;5:60. doi: 10.3389/fphar.2014.00060. eCollection 2014. Review.


Systems biology approaches to understanding the cause and treatment of heart, lung, blood, and sleep disorders.

Winslow RL.

Front Physiol. 2014 Mar 28;5:107. doi: 10.3389/fphys.2014.00107. eCollection 2014. No abstract available.


An integrated mitochondrial ROS production and scavenging model: implications for heart failure.

Gauthier LD, Greenstein JL, O'Rourke B, Winslow RL.

Biophys J. 2013 Dec 17;105(12):2832-42. doi: 10.1016/j.bpj.2013.11.007.


A computational model of reactive oxygen species and redox balance in cardiac mitochondria.

Gauthier LD, Greenstein JL, Cortassa S, O'Rourke B, Winslow RL.

Biophys J. 2013 Aug 20;105(4):1045-56. doi: 10.1016/j.bpj.2013.07.006.


Extinguishing the sparks.

Winslow RL, Greenstein JL.

Biophys J. 2013 May 21;104(10):2115-7. doi: 10.1016/j.bpj.2013.04.010. No abstract available.


Cardiac resynchronization therapy improves altered Na channel gating in canine model of dyssynchronous heart failure.

Aiba T, Barth AS, Hesketh GG, Hashambhoy YL, Chakir K, Tunin RS, Greenstein JL, Winslow RL, Kass DA, Tomaselli GF.

Circ Arrhythm Electrophysiol. 2013 Jun;6(3):546-54. doi: 10.1161/CIRCEP.113.000400. Epub 2013 May 6.


Integrating mitochondrial energetics, redox and ROS metabolic networks: a two-compartment model.

Kembro JM, Aon MA, Winslow RL, O'Rourke B, Cortassa S.

Biophys J. 2013 Jan 22;104(2):332-43. doi: 10.1016/j.bpj.2012.11.3808.


Computational medicine: translating models to clinical care.

Winslow RL, Trayanova N, Geman D, Miller MI.

Sci Transl Med. 2012 Oct 31;4(158):158rv11. doi: 10.1126/scitranslmed.3003528.


Toward an integrative computational model of the Guinea pig cardiac myocyte.

Gauthier LD, Greenstein JL, Winslow RL.

Front Physiol. 2012 Jul 5;3:244. doi: 10.3389/fphys.2012.00244. eCollection 2012.


Dynamics of matrix-free Ca2+ in cardiac mitochondria: two components of Ca2+ uptake and role of phosphate buffering.

Wei AC, Liu T, Winslow RL, O'Rourke B.

J Gen Physiol. 2012 Jun;139(6):465-78. doi: 10.1085/jgp.201210784.


Ontological labels for automated location of anatomical shape differences.

Steinert-Threlkeld S, Ardekani S, Mejino JL, Detwiler LT, Brinkley JF, Halle M, Kikinis R, Winslow RL, Miller MI, Ratnanather JT.

J Biomed Inform. 2012 Jun;45(3):522-7. doi: 10.1016/j.jbi.2012.02.013. Epub 2012 Apr 3.


Metabolic control analysis applied to mitochondrial networks.

Cortassa S, Aon MA, O'Rourke B, Winslow RL.

Conf Proc IEEE Eng Med Biol Soc. 2011;2011:4673-6. doi: 10.1109/IEMBS.2011.6091157.


CaMKII-dependent activation of late INa contributes to cellular arrhythmia in a model of the cardiac myocyte.

Hashambhoy YL, Winslow RL, Greenstein JL.

Conf Proc IEEE Eng Med Biol Soc. 2011;2011:4665-8. doi: 10.1109/IEMBS.2011.6091155.


Model interactions: 'It is the simple, which is so difficult'.

Kohl P, Hunter PJ, Winslow RL.

Prog Biophys Mol Biol. 2011 Oct;107(1):1-3. doi: 10.1016/j.pbiomolbio.2011.07.003. Epub 2011 Jul 13. No abstract available.


Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): standardised reporting for model reproducibility, interoperability, and data sharing.

Quinn TA, Granite S, Allessie MA, Antzelevitch C, Bollensdorff C, Bub G, Burton RA, Cerbai E, Chen PS, Delmar M, Difrancesco D, Earm YE, Efimov IR, Egger M, Entcheva E, Fink M, Fischmeister R, Franz MR, Garny A, Giles WR, Hannes T, Harding SE, Hunter PJ, Iribe G, Jalife J, Johnson CR, Kass RS, Kodama I, Koren G, Lord P, Markhasin VS, Matsuoka S, McCulloch AD, Mirams GR, Morley GE, Nattel S, Noble D, Olesen SP, Panfilov AV, Trayanova NA, Ravens U, Richard S, Rosenbaum DS, Rudy Y, Sachs F, Sachse FB, Saint DA, Schotten U, Solovyova O, Taggart P, Tung L, Varr├│ A, Volders PG, Wang K, Weiss JN, Wettwer E, White E, Wilders R, Winslow RL, Kohl P.

Prog Biophys Mol Biol. 2011 Oct;107(1):4-10. doi: 10.1016/j.pbiomolbio.2011.07.001. Epub 2011 Jul 6.


Cardiac myocytes and local signaling in nano-domains.

Winslow RL, Greenstein JL.

Prog Biophys Mol Biol. 2011 Oct;107(1):48-59. doi: 10.1016/j.pbiomolbio.2011.06.005. Epub 2011 Jun 21. Review.


Mitochondrial energetics, pH regulation, and ion dynamics: a computational-experimental approach.

Wei AC, Aon MA, O'Rourke B, Winslow RL, Cortassa S.

Biophys J. 2011 Jun 22;100(12):2894-903. doi: 10.1016/j.bpj.2011.05.027.


High resolution mapping of the cardiac transmural proteome using reverse phase protein microarrays.

Anderson T, Wulfkuhle J, Petricoin E 3rd, Winslow RL.

Mol Cell Proteomics. 2011 Jul;10(7):M111.008037. doi: 10.1074/mcp.M111.008037. Epub 2011 Apr 13.


Mitochondrial Ca2+ influx and efflux rates in guinea pig cardiac mitochondria: low and high affinity effects of cyclosporine A.

Wei AC, Liu T, Cortassa S, Winslow RL, O'Rourke B.

Biochim Biophys Acta. 2011 Jul;1813(7):1373-81. doi: 10.1016/j.bbamcr.2011.02.012. Epub 2011 Feb 26.


Integrative systems models of cardiac excitation-contraction coupling.

Greenstein JL, Winslow RL.

Circ Res. 2011 Jan 7;108(1):70-84. doi: 10.1161/CIRCRESAHA.110.223578. Review.


Integrative modeling of the cardiac ventricular myocyte.

Winslow RL, Cortassa S, O'Rourke B, Hashambhoy YL, Rice JJ, Greenstein JL.

Wiley Interdiscip Rev Syst Biol Med. 2011 Jul-Aug;3(4):392-413. doi: 10.1002/wsbm.122. Epub 2010 Sep 23. Review.


Role of CaMKII in RyR leak, EC coupling and action potential duration: a computational model.

Hashambhoy YL, Greenstein JL, Winslow RL.

J Mol Cell Cardiol. 2010 Oct;49(4):617-24. doi: 10.1016/j.yjmcc.2010.07.011. Epub 2010 Jul 23.


A reaction-diffusion model of ROS-induced ROS release in a mitochondrial network.

Zhou L, Aon MA, Almas T, Cortassa S, Winslow RL, O'Rourke B.

PLoS Comput Biol. 2010 Jan 29;6(1):e1000657. doi: 10.1371/journal.pcbi.1000657.


Cardiac Motion Analysis in Ischemic and Non-Ischemic Cardiomyopathy Using Parallel Transport.

Ardekani S, Weiss RG, Lardo AC, Miller MI, Winslow RL, Younes L.

Proc IEEE Int Symp Biomed Imaging. 2009 Jun:899.


Improved reproducibility of reverse-phase protein microarrays using array microenvironment normalization.

Anderson T, Wulfkuhle J, Liotta L, Winslow RL, Petricoin E 3rd.

Proteomics. 2009 Dec;9(24):5562-6. doi: 10.1002/pmic.200900505.


Transport of Relational Structures in Groups of Diffeomorphisms.

Younes L, Qiu A, Winslow RL, Miller MI.

J Math Imaging Vis. 2008 Sep 1;32(1):41-56.


Modeling cardiac action potential shortening driven by oxidative stress-induced mitochondrial oscillations in guinea pig cardiomyocytes.

Zhou L, Cortassa S, Wei AC, Aon MA, Winslow RL, O'Rourke B.

Biophys J. 2009 Oct 7;97(7):1843-52. doi: 10.1016/j.bpj.2009.07.029.


Control and regulation of integrated mitochondrial function in metabolic and transport networks.

Cortassa S, O'Rourke B, Winslow RL, Aon MA.

Int J Mol Sci. 2009 Apr 1;10(4):1500-13. Review.


Identification of novel serological biomarkers for inflammatory bowel disease using Escherichia coli proteome chip.

Chen CS, Sullivan S, Anderson T, Tan AC, Alex PJ, Brant SR, Cuffari C, Bayless TM, Talor MV, Burek CL, Wang H, Li R, Datta LW, Wu Y, Winslow RL, Zhu H, Li X.

Mol Cell Proteomics. 2009 Aug;8(8):1765-76. doi: 10.1074/mcp.M800593-MCP200. Epub 2009 Apr 7.


Computational method for identifying and quantifying shape features of human left ventricular remodeling.

Ardekani S, Weiss RG, Lardo AC, George RT, Lima JA, Wu KC, Miller MI, Winslow RL, Younes L.

Ann Biomed Eng. 2009 Jun;37(6):1043-54. doi: 10.1007/s10439-009-9677-2. Epub 2009 Mar 26.

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