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Items: 26

1.

Mice Carrying a Dominant-Negative Human PI3K Mutation Are Protected From Obesity and Hepatic Steatosis but Not Diabetes.

Solheim MH, Winnay JN, Batista TM, Molven A, Njølstad PR, Kahn CR.

Diabetes. 2018 Jul;67(7):1297-1309. doi: 10.2337/db17-1509. Epub 2018 May 3.

2.

Iris Malformation and Anterior Segment Dysgenesis in Mice and Humans With a Mutation in PI 3-Kinase.

Solheim MH, Clermont AC, Winnay JN, Hallstensen E, Molven A, Njølstad PR, Rødahl E, Kahn CR.

Invest Ophthalmol Vis Sci. 2017 Jun 1;58(7):3100-3106. doi: 10.1167/iovs.16-21347.

3.

Corrigendum: Adipose-derived circulating miRNAs regulate gene expression in other tissues.

Thomou T, Mori MA, Dreyfuss JM, Konishi M, Sakaguchi M, Wolfrum C, Rao TN, Winnay JN, Garcia-Martin R, Grinspoon SK, Gorden P, Kahn CR.

Nature. 2017 May 10;545(7653):252. doi: 10.1038/nature22319. No abstract available.

PMID:
28492253
4.

Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression.

Cai W, Sakaguchi M, Kleinridders A, Gonzalez-Del Pino G, Dreyfuss JM, O'Neill BT, Ramirez AK, Pan H, Winnay JN, Boucher J, Eck MJ, Kahn CR.

Nat Commun. 2017 Mar 27;8:14892. doi: 10.1038/ncomms14892.

5.

Adipose-derived circulating miRNAs regulate gene expression in other tissues.

Thomou T, Mori MA, Dreyfuss JM, Konishi M, Sakaguchi M, Wolfrum C, Rao TN, Winnay JN, Garcia-Martin R, Grinspoon SK, Gorden P, Kahn CR.

Nature. 2017 Feb 23;542(7642):450-455. doi: 10.1038/nature21365. Epub 2017 Feb 15. Erratum in: Nature. 2017 May 10;545(7653):252.

6.

Adipocyte Dynamics and Reversible Metabolic Syndrome in Mice with an Inducible Adipocyte-Specific Deletion of the Insulin Receptor.

Sakaguchi M, Fujisaka S, Cai W, Winnay JN, Konishi M, O'Neill BT, Li M, García-Martín R, Takahashi H, Hu J, Kulkarni RN, Kahn CR.

Cell Metab. 2017 Feb 7;25(2):448-462. doi: 10.1016/j.cmet.2016.12.008. Epub 2017 Jan 5.

7.

Cross-talk between insulin and Wnt signaling in preadipocytes. ROLE OF Wnt CO-RECEPTOR LDL RECEPTOR-RELATED PROTEIN-5 (LRP5).

Palsgaard J, Emanuelli B, Winnay JN, Sumara G, Karsenty G, Kahn CR.

J Biol Chem. 2016 Aug 5;291(32):16878. doi: 10.1074/jbc.A111.337048. No abstract available.

8.

PI3-kinase mutation linked to insulin and growth factor resistance in vivo.

Winnay JN, Solheim MH, Dirice E, Sakaguchi M, Noh HL, Kang HJ, Takahashi H, Chudasama KK, Kim JK, Molven A, Kahn CR, Njølstad PR.

J Clin Invest. 2016 Apr 1;126(4):1401-12. doi: 10.1172/JCI84005. Epub 2016 Mar 14.

9.

p85α deficiency protects β-cells from endoplasmic reticulum stress-induced apoptosis.

Winnay JN, Dirice E, Liew CW, Kulkarni RN, Kahn CR.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1192-7. doi: 10.1073/pnas.1322564111. Epub 2014 Jan 6.

10.

Shox2 is a molecular determinant of depot-specific adipocyte function.

Lee KY, Yamamoto Y, Boucher J, Winnay JN, Gesta S, Cobb J, Blüher M, Kahn CR.

Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11409-14. doi: 10.1073/pnas.1310331110. Epub 2013 Jun 24. Erratum in: Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):E2347.

11.

Cross-talk between insulin and Wnt signaling in preadipocytes: role of Wnt co-receptor low density lipoprotein receptor-related protein-5 (LRP5).

Palsgaard J, Emanuelli B, Winnay JN, Sumara G, Karsenty G, Kahn CR.

J Biol Chem. 2012 Apr 6;287(15):12016-26. doi: 10.1074/jbc.M111.337048. Epub 2012 Feb 15. Erratum in: J Biol Chem. 2016 Aug 5;291(32):16878.

12.

PI 3-kinase regulatory subunits as regulators of the unfolded protein response.

Winnay JN, Kahn CR.

Methods Enzymol. 2011;490:147-58. doi: 10.1016/B978-0-12-385114-7.00009-X.

13.

A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response.

Winnay JN, Boucher J, Mori MA, Ueki K, Kahn CR.

Nat Med. 2010 Apr;16(4):438-45. doi: 10.1038/nm.2121. Epub 2010 Mar 28.

14.

Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 2.

Assmann A, Ueki K, Winnay JN, Kadowaki T, Kulkarni RN.

Mol Cell Biol. 2009 Jun;29(11):3219-28. doi: 10.1128/MCB.01489-08. Epub 2009 Mar 9.

15.

New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure.

Tseng YH, Kokkotou E, Schulz TJ, Huang TL, Winnay JN, Taniguchi CM, Tran TT, Suzuki R, Espinoza DO, Yamamoto Y, Ahrens MJ, Dudley AT, Norris AW, Kulkarni RN, Kahn CR.

Nature. 2008 Aug 21;454(7207):1000-4. doi: 10.1038/nature07221.

16.

Steroid receptor coactivator-1-deficient mice exhibit altered hypothalamic-pituitary-adrenal axis function.

Winnay JN, Xu J, O'Malley BW, Hammer GD.

Endocrinology. 2006 Mar;147(3):1322-32. Epub 2005 Dec 8.

PMID:
16339206
17.
18.

PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance.

Kulkarni RN, Jhala US, Winnay JN, Krajewski S, Montminy M, Kahn CR.

J Clin Invest. 2004 Sep;114(6):828-36.

19.

Phosphorylation of C/EBPalpha inhibits granulopoiesis.

Ross SE, Radomska HS, Wu B, Zhang P, Winnay JN, Bajnok L, Wright WS, Schaufele F, Tenen DG, MacDougald OA.

Mol Cell Biol. 2004 Jan;24(2):675-86.

20.
21.

Convergence of Wnt signaling and steroidogenic factor-1 (SF-1) on transcription of the rat inhibin alpha gene.

Gummow BM, Winnay JN, Hammer GD.

J Biol Chem. 2003 Jul 18;278(29):26572-9. Epub 2003 May 5.

22.

A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes.

Mauvais-Jarvis F, Virkamaki A, Michael MD, Winnay JN, Zisman A, Kulkarni RN, Kahn CR.

Diabetes. 2000 Dec;49(12):2126-34.

PMID:
11118016
23.

Gab-1-mediated IGF-1 signaling in IRS-1-deficient 3T3 fibroblasts.

Winnay JN, Brüning JC, Burks DJ, Kahn CR.

J Biol Chem. 2000 Apr 7;275(14):10545-50.

24.

Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines.

Kulkarni RN, Winnay JN, Daniels M, Brüning JC, Flier SN, Hanahan D, Kahn CR.

J Clin Invest. 1999 Dec;104(12):R69-75.

25.
26.

A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance.

Brüning JC, Michael MD, Winnay JN, Hayashi T, Hörsch D, Accili D, Goodyear LJ, Kahn CR.

Mol Cell. 1998 Nov;2(5):559-69.

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