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Items: 34

1.

Genomic Status of MET Potentiates Sensitivity to MET and MEK Inhibition in NF1-Related Malignant Peripheral Nerve Sheath Tumors.

Peacock JD, Pridgeon MG, Tovar EA, Essenburg CJ, Bowman M, Madaj Z, Koeman J, Boguslawski EA, Grit J, Dodd RD, Khachaturov V, Cardona DM, Chen M, Kirsch DG, Maina F, Dono R, Winn ME, Graveel CR, Steensma MR.

Cancer Res. 2018 Jul 1;78(13):3672-3687. doi: 10.1158/0008-5472.CAN-17-3167. Epub 2018 May 2.

PMID:
29720369
2.

Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma.

deCarvalho AC, Kim H, Poisson LM, Winn ME, Mueller C, Cherba D, Koeman J, Seth S, Protopopov A, Felicella M, Zheng S, Multani A, Jiang Y, Zhang J, Nam DH, Petricoin EF, Chin L, Mikkelsen T, Verhaak RGW.

Nat Genet. 2018 May;50(5):708-717. doi: 10.1038/s41588-018-0105-0. Epub 2018 Apr 23.

PMID:
29686388
3.

Activation of DAF-16/FOXO by reactive oxygen species contributes to longevity in long-lived mitochondrial mutants in Caenorhabditis elegans.

Senchuk MM, Dues DJ, Schaar CE, Johnson BK, Madaj ZB, Bowman MJ, Winn ME, Van Raamsdonk JM.

PLoS Genet. 2018 Mar 9;14(3):e1007268. doi: 10.1371/journal.pgen.1007268. eCollection 2018 Mar.

4.

Sensitized mutagenesis screen in Factor V Leiden mice identifies thrombosis suppressor loci.

Westrick RJ, Tomberg K, Siebert AE, Zhu G, Winn ME, Dobies SL, Manning SL, Brake MA, Cleuren AC, Hobbs LM, Mishack LM, Johnston AJ, Kotnik E, Siemieniak DR, Xu J, Li JZ, Saunders TL, Ginsburg D.

Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):9659-9664. doi: 10.1073/pnas.1705762114. Epub 2017 Aug 21.

5.

The genomic landscape of tuberous sclerosis complex.

Martin KR, Zhou W, Bowman MJ, Shih J, Au KS, Dittenhafer-Reed KE, Sisson KA, Koeman J, Weisenberger DJ, Cottingham SL, DeRoos ST, Devinsky O, Winn ME, Cherniack AD, Shen H, Northrup H, Krueger DA, MacKeigan JP.

Nat Commun. 2017 Jun 15;8:15816. doi: 10.1038/ncomms15816.

6.

Uncoupling of oxidative stress resistance and lifespan in long-lived isp-1 mitochondrial mutants in Caenorhabditis elegans.

Dues DJ, Schaar CE, Johnson BK, Bowman MJ, Winn ME, Senchuk MM, Van Raamsdonk JM.

Free Radic Biol Med. 2017 Jul;108:362-373. doi: 10.1016/j.freeradbiomed.2017.04.004. Epub 2017 Apr 7.

7.

Evaluation of Club Cell 10-kDa Protein (CC10) Levels in Full-Term Infants.

Gorji N, Pilon AL, Winn ME, Newsome M, Davis JM.

Neonatology. 2017;111(3):247-252. doi: 10.1159/000452267. Epub 2016 Dec 1.

PMID:
27902984
8.

A Developmental and Molecular View of Formation of Auxin-Induced Nodule-Like Structures in Land Plants.

Hiltenbrand R, Thomas J, McCarthy H, Dykema KJ, Spurr A, Newhart H, Winn ME, Mukherjee A.

Front Plant Sci. 2016 Nov 11;7:1692. eCollection 2016.

9.

Lurbinectedin Inactivates the Ewing Sarcoma Oncoprotein EWS-FLI1 by Redistributing It within the Nucleus.

Harlow ML, Maloney N, Roland J, Guillen Navarro MJ, Easton MK, Kitchen-Goosen SM, Boguslawski EA, Madaj ZB, Johnson BK, Bowman MJ, D'Incalci M, Winn ME, Turner L, Hostetter G, Galmarini CM, Aviles PM, Grohar PJ.

Cancer Res. 2016 Nov 15;76(22):6657-6668. doi: 10.1158/0008-5472.CAN-16-0568. Epub 2016 Oct 3.

10.

18F-FLT Positron Emission Tomography (PET) is a Pharmacodynamic Marker for EWS-FLI1 Activity and Ewing Sarcoma.

Osgood CL, Tantawy MN, Maloney N, Madaj ZB, Peck A, Boguslawski E, Jess J, Buck J, Winn ME, Manning HC, Grohar PJ.

Sci Rep. 2016 Sep 27;6:33926. doi: 10.1038/srep33926.

11.

Targeting MET and EGFR crosstalk signaling in triple-negative breast cancers.

Linklater ES, Tovar EA, Essenburg CJ, Turner L, Madaj Z, Winn ME, Melnik MK, Korkaya H, Maroun CR, Christensen JG, Steensma MR, Boerner JL, Graveel CR.

Oncotarget. 2016 Oct 25;7(43):69903-69915. doi: 10.18632/oncotarget.12065.

12.

Miz1, a Novel Target of ING4, Can Drive Prostate Luminal Epithelial Cell Differentiation.

Berger PL, Winn ME, Miranti CK.

Prostate. 2017 Jan;77(1):49-59. doi: 10.1002/pros.23249. Epub 2016 Aug 16.

PMID:
27527891
13.

High type I error and misrepresentations in search for transgenerational epigenetic inheritance: response to Guerrero-Bosagna.

Iqbal K, Tran DA, Li AX, Warden C, Bai AY, Singh P, Madaj ZB, Winn ME, Wu X, Pfeifer GP, Szabó PE.

Genome Biol. 2016 Jul 12;17(1):154. doi: 10.1186/s13059-016-0981-5.

14.

Identification of Mithramycin Analogues with Improved Targeting of the EWS-FLI1 Transcription Factor.

Osgood CL, Maloney N, Kidd CG, Kitchen-Goosen S, Segars L, Gebregiorgis M, Woldemichael GM, He M, Sankar S, Lessnick SL, Kang M, Smith M, Turner L, Madaj ZB, Winn ME, Núñez LE, González-Sabín J, Helman LJ, Morís F, Grohar PJ.

Clin Cancer Res. 2016 Aug 15;22(16):4105-18. doi: 10.1158/1078-0432.CCR-15-2624. Epub 2016 Mar 15.

15.

Cabozantinib (XL184) Inhibits Growth and Invasion of Preclinical TNBC Models.

Sameni M, Tovar EA, Essenburg CJ, Chalasani A, Linklater ES, Borgman A, Cherba DM, Anbalagan A, Winn ME, Graveel CR, Sloane BF.

Clin Cancer Res. 2016 Feb 15;22(4):923-34. doi: 10.1158/1078-0432.CCR-15-0187. Epub 2015 Oct 2.

16.

Melanoma patient derived xenografts acquire distinct Vemurafenib resistance mechanisms.

Monsma DJ, Cherba DM, Eugster EE, Dylewski DL, Davidson PT, Peterson CA, Borgman AS, Winn ME, Dykema KJ, Webb CP, MacKeigan JP, Duesbery NS, Nickoloff BJ, Monks NR.

Am J Cancer Res. 2015 Mar 15;5(4):1507-18. eCollection 2015.

17.

The longitudinal transcriptomic response of the substantia nigra to intrastriatal 6-hydroxydopamine reveals significant upregulation of regeneration-associated genes.

Kanaan NM, Collier TJ, Cole-Strauss A, Grabinski T, Mattingly ZR, Winn ME, Steece-Collier K, Sortwell CE, Manfredsson FP, Lipton JW.

PLoS One. 2015 May 20;10(5):e0127768. doi: 10.1371/journal.pone.0127768. eCollection 2015.

18.

Anoikis-resistant subpopulations of human osteosarcoma display significant chemoresistance and are sensitive to targeted epigenetic therapies predicted by expression profiling.

Foley JM, Scholten DJ 2nd, Monks NR, Cherba D, Monsma DJ, Davidson P, Dylewski D, Dykema K, Winn ME, Steensma MR.

J Transl Med. 2015 Apr 2;13:110. doi: 10.1186/s12967-015-0466-4.

19.

Oculoectodermal syndrome is a mosaic RASopathy associated with KRAS alterations.

Peacock JD, Dykema KJ, Toriello HV, Mooney MR, Scholten DJ 2nd, Winn ME, Borgman A, Duesbery NS, Hiemenga JA, Liu C, Campbell S, Nickoloff BP, Williams BO, Steensma M.

Am J Med Genet A. 2015 Jul;167(7):1429-35. doi: 10.1002/ajmg.a.37048. Epub 2015 Mar 21.

PMID:
25808193
20.

Critical analysis of the potential for microRNA biomarkers in breast cancer management.

Graveel CR, Calderone HM, Westerhuis JJ, Winn ME, Sempere LF.

Breast Cancer (Dove Med Press). 2015 Feb 23;7:59-79. doi: 10.2147/BCTT.S43799. eCollection 2015. Review.

21.

Stromal expression of miR-21 identifies high-risk group in triple-negative breast cancer.

MacKenzie TA, Schwartz GN, Calderone HM, Graveel CR, Winn ME, Hostetter G, Wells WA, Sempere LF.

Am J Pathol. 2014 Dec;184(12):3217-25. doi: 10.1016/j.ajpath.2014.08.020. Epub 2014 Nov 6.

22.

Preclinical evaluation of human secretoglobin 3A2 in mouse models of lung development and fibrosis.

Cai Y, Winn ME, Zehmer JK, Gillette WK, Lubkowski JT, Pilon AL, Kimura S.

Am J Physiol Lung Cell Mol Physiol. 2014 Jan 1;306(1):L10-22. doi: 10.1152/ajplung.00037.2013. Epub 2013 Nov 8.

23.

A blood-based gene expression test for obstructive coronary artery disease tested in symptomatic nondiabetic patients referred for myocardial perfusion imaging the COMPASS study.

Thomas GS, Voros S, McPherson JA, Lansky AJ, Winn ME, Bateman TM, Elashoff MR, Lieu HD, Johnson AM, Daniels SE, Ladapo JA, Phelps CE, Douglas PS, Rosenberg S.

Circ Cardiovasc Genet. 2013 Apr;6(2):154-62. doi: 10.1161/CIRCGENETICS.112.964015. Epub 2013 Feb 15.

PMID:
23418288
24.

Age-dependent brain gene expression and copy number anomalies in autism suggest distinct pathological processes at young versus mature ages.

Chow ML, Pramparo T, Winn ME, Barnes CC, Li HR, Weiss L, Fan JB, Murray S, April C, Belinson H, Fu XD, Wynshaw-Boris A, Schork NJ, Courchesne E.

PLoS Genet. 2012;8(3):e1002592. doi: 10.1371/journal.pgen.1002592. Epub 2012 Mar 22.

25.

Preprocessing and Quality Control Strategies for Illumina DASL Assay-Based Brain Gene Expression Studies with Semi-Degraded Samples.

Chow ML, Winn ME, Li HR, April C, Wynshaw-Boris A, Fan JB, Fu XD, Courchesne E, Schork NJ.

Front Genet. 2012 Feb 24;3:11. doi: 10.3389/fgene.2012.00011. eCollection 2012.

26.

Genome-wide expression assay comparison across frozen and fixed postmortem brain tissue samples.

Chow ML, Li HR, Winn ME, April C, Barnes CC, Wynshaw-Boris A, Fan JB, Fu XD, Courchesne E, Schork NJ.

BMC Genomics. 2011 Sep 10;12:449. doi: 10.1186/1471-2164-12-449.

27.

Gene expression profiling of human whole blood samples with the Illumina WG-DASL assay.

Winn ME, Shaw M, April C, Klotzle B, Fan JB, Murray SS, Schork NJ.

BMC Genomics. 2011 Aug 15;12:412. doi: 10.1186/1471-2164-12-412.

28.

Multicenter validation of the diagnostic accuracy of a blood-based gene expression test for assessing obstructive coronary artery disease in nondiabetic patients.

Rosenberg S, Elashoff MR, Beineke P, Daniels SE, Wingrove JA, Tingley WG, Sager PT, Sehnert AJ, Yau M, Kraus WE, Newby LK, Schwartz RS, Voros S, Ellis SG, Tahirkheli N, Waksman R, McPherson J, Lansky A, Winn ME, Schork NJ, Topol EJ; PREDICT (Personalized Risk Evaluation and Diagnosis in the Coronary Tree) Investigators.

Ann Intern Med. 2010 Oct 5;153(7):425-34. doi: 10.7326/0003-4819-153-7-201010050-00005.

29.

Spontaneous Irs1 passenger mutation linked to a gene-targeted SerpinB2 allele.

Westrick RJ, Mohlke KL, Korepta LM, Yang AY, Zhu G, Manning SL, Winn ME, Dougherty KM, Ginsburg D.

Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16904-9. doi: 10.1073/pnas.1012050107. Epub 2010 Sep 13.

30.

The effects of globin on microarray-based gene expression analysis of mouse blood.

Winn ME, Zapala MA, Hovatta I, Risbrough VB, Lillie E, Schork NJ.

Mamm Genome. 2010 Jun;21(5-6):268-75. doi: 10.1007/s00335-010-9261-y. Epub 2010 May 16.

31.

Murine models of vascular thrombosis (Eitzman series).

Westrick RJ, Winn ME, Eitzman DT.

Arterioscler Thromb Vasc Biol. 2007 Oct;27(10):2079-93. Epub 2007 Jun 28. Review.

PMID:
17600224
32.

Evidence for autocrine or paracrine roles of alpha2-macroglobulin in regulation of estradiol production by granulosa cells and development of dominant follicles.

Ireland JL, Jimenez-Krassel F, Winn ME, Burns DS, Ireland JJ.

Endocrinology. 2004 Jun;145(6):2784-94. Epub 2004 Mar 4.

PMID:
15001551
33.

Identification of genes involved in apoptosis and dominant follicle development during follicular waves in cattle.

Evans AC, Ireland JL, Winn ME, Lonergan P, Smith GW, Coussens PM, Ireland JJ.

Biol Reprod. 2004 May;70(5):1475-84. Epub 2004 Jan 21.

PMID:
14736815
34.

Evidence for a negative intrafollicular role for inhibin in regulation of estradiol production by granulosa cells.

Jimenez-Krassel F, Winn ME, Burns D, Ireland JL, Ireland JJ.

Endocrinology. 2003 May;144(5):1876-86.

PMID:
12697695

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