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Items: 1 to 50 of 53

1.

Characterizing the effects of in utero exposure to valproic acid on murine fetal heart development.

Philbrook NA, Nikolovska A, Maciver RD, Belanger CL, Winn LM.

Birth Defects Res. 2019 Nov 15;111(19):1551-1560. doi: 10.1002/bdr2.1610. Epub 2019 Oct 29.

PMID:
31661193
2.

DNA Damage and Perturbed Topoisomerase IIα as a Target of 1,4-Benzoquinone Toxicity in Murine Fetal Liver Cells.

Holmes TH, Winn LM.

Toxicol Sci. 2019 Jul 24. pii: kfz158. doi: 10.1093/toxsci/kfz158. [Epub ahead of print]

PMID:
31340051
3.

Mouse Whole Embryo Culture.

Tung EWY, Winn LM.

Methods Mol Biol. 2019;1965:187-194. doi: 10.1007/978-1-4939-9182-2_13.

PMID:
31069676
4.

In Vitro Models in Developmental Toxicology.

Winn LM.

Methods Mol Biol. 2019;1965:1-6. doi: 10.1007/978-1-4939-9182-2_1.

PMID:
31069664
5.

Gestational triphenyl phosphate exposure in C57Bl/6 mice perturbs expression of insulin-like growth factor signaling genes in maternal and fetal liver.

Philbrook NA, Restivo VE, Belanger CL, Winn LM.

Birth Defects Res. 2018 Apr 3;110(6):483-494. doi: 10.1002/bdr2.1185. Epub 2018 Jan 8.

PMID:
29316351
6.

Valproic acid increases NF-κB transcriptional activation despite decreasing DNA binding ability in P19 cells, which may play a role in VPA-initiated teratogenesis.

Lamparter CL, Philbrook NA, Winn LM.

Reprod Toxicol. 2017 Dec;74:32-39. doi: 10.1016/j.reprotox.2017.08.019. Epub 2017 Sep 1.

PMID:
28865949
7.

Persistence of risk factors associated with maternal cardiovascular disease following aberrant inflammation in rat pregnancy.

Ushida T, Macdonald-Goodfellow SK, Quadri A, Tse MY, Winn LM, Pang SC, Adams MA, Kotani T, Kikkawa F, Graham CH.

Biol Reprod. 2017 Jul 1;97(1):143-152. doi: 10.1093/biolre/iox072.

PMID:
28859286
8.

Valproic acid exposure decreases Cbp/p300 protein expression and histone acetyltransferase activity in P19 cells.

Lamparter CL, Winn LM.

Toxicol Appl Pharmacol. 2016 Sep 1;306:69-78. doi: 10.1016/j.taap.2016.07.001. Epub 2016 Jul 2.

PMID:
27381264
9.

Benzoquinone toxicity is not prevented by sulforaphane in CD-1 mouse fetal liver cells.

Philbrook NA, Winn LM.

J Appl Toxicol. 2016 Aug;36(8):1015-24. doi: 10.1002/jat.3251. Epub 2015 Oct 12.

PMID:
26456483
10.

Investigating the effects of in utero benzene exposure on epigenetic modifications in maternal and fetal CD-1 mice.

Philbrook NA, Winn LM.

Toxicol Appl Pharmacol. 2015 Nov 15;289(1):12-9. doi: 10.1016/j.taap.2015.08.019. Epub 2015 Sep 1.

PMID:
26341289
11.

Tissue-specific effects of valproic acid on DNA repair genes and apoptosis in postimplantation mouse embryos.

Lamparter C, Winn LM.

Toxicol Sci. 2014 Sep;141(1):59-67. doi: 10.1093/toxsci/kfu105. Epub 2014 Jun 9.

12.

Benzo[a]pyrene increases DNA double strand break repair in vitro and in vivo: a possible mechanism for benzo[a]pyrene-induced toxicity.

Tung EW, Philbrook NA, Belanger CL, Ansari S, Winn LM.

Mutat Res Genet Toxicol Environ Mutagen. 2014 Jan 15;760:64-9. doi: 10.1016/j.mrgentox.2013.12.003. Epub 2014 Jan 8.

PMID:
24412381
13.

NF-κB signaling is increased in HD3 cells following exposure to 1,4-benzoquinone: role of reactive oxygen species and p38-MAPK.

Stokes SE, Winn LM.

Toxicol Sci. 2014 Feb;137(2):303-10. doi: 10.1093/toxsci/kft256. Epub 2013 Nov 9.

PMID:
24213144
15.

Assessment of xenobiotic biotransformation including reactive oxygen species generation in the embryo using benzene as an example.

Renaud HJ, Rutter A, Winn LM.

Methods Mol Biol. 2012;889:253-63. doi: 10.1007/978-1-61779-867-2_15.

PMID:
22669669
16.

DNA double-strand breaks and DNA recombination in benzene metabolite-induced genotoxicity.

Tung EW, Philbrook NA, Macdonald KD, Winn LM.

Toxicol Sci. 2012 Apr;126(2):569-77. doi: 10.1093/toxsci/kfs001. Epub 2012 Jan 12.

PMID:
22247006
17.

The effect of TiO(2) and Ag nanoparticles on reproduction and development of Drosophila melanogaster and CD-1 mice.

Philbrook NA, Winn LM, Afrooz AR, Saleh NB, Walker VK.

Toxicol Appl Pharmacol. 2011 Dec 15;257(3):429-36. doi: 10.1016/j.taap.2011.09.027. Epub 2011 Oct 8.

PMID:
22005274
18.

Investigating the effects of functionalized carbon nanotubes on reproduction and development in Drosophila melanogaster and CD-1 mice.

Philbrook NA, Walker VK, Afrooz AR, Saleh NB, Winn LM.

Reprod Toxicol. 2011 Dec;32(4):442-8. doi: 10.1016/j.reprotox.2011.09.002. Epub 2011 Sep 24.

PMID:
21963887
19.
20.

Valproic acid-induced DNA damage increases embryonic p27(KIP1) and caspase-3 expression: a mechanism for valproic-acid induced neural tube defects.

Tung EW, Winn LM.

Reprod Toxicol. 2011 Nov;32(3):255-60. doi: 10.1016/j.reprotox.2011.05.020. Epub 2011 Jun 17.

PMID:
21708246
21.

Epigenetic modifications in valproic acid-induced teratogenesis.

Tung EW, Winn LM.

Toxicol Appl Pharmacol. 2010 Nov 1;248(3):201-9. doi: 10.1016/j.taap.2010.08.001. Epub 2010 Aug 10.

PMID:
20705080
22.

Characterization of valproic acid-initiated homologous recombination.

Sha K, Winn LM.

Birth Defects Res B Dev Reprod Toxicol. 2010 Apr;89(2):124-32. doi: 10.1002/bdrb.20236.

PMID:
20437471
23.

Transplacental benzene exposure increases tumor incidence in mouse offspring: possible role of fetal benzene metabolism.

Badham HJ, LeBrun DP, Rutter A, Winn LM.

Carcinogenesis. 2010 Jun;31(6):1142-8. doi: 10.1093/carcin/bgq074. Epub 2010 Apr 16.

PMID:
20400480
24.

In utero and in vitro effects of benzene and its metabolites on erythroid differentiation and the role of reactive oxygen species.

Badham HJ, Winn LM.

Toxicol Appl Pharmacol. 2010 May 1;244(3):273-9. doi: 10.1016/j.taap.2010.01.002. Epub 2010 Jan 18.

PMID:
20083130
25.

Benzene-initiated oxidative stress: Effects on embryonic signaling pathways.

Badham HJ, Renaud SJ, Wan J, Winn LM.

Chem Biol Interact. 2010 Mar 19;184(1-2):218-21. doi: 10.1016/j.cbi.2009.11.005. Epub 2009 Nov 12.

PMID:
19913523
26.

In utero exposure to benzene disrupts fetal hematopoietic progenitor cell growth via reactive oxygen species.

Badham HJ, Winn LM.

Toxicol Sci. 2010 Jan;113(1):207-15. doi: 10.1093/toxsci/kfp242. Epub 2009 Oct 7.

PMID:
19812361
27.

Assessment of embryotoxicity using mouse embryo culture.

Winn LM, Tung EW.

Methods Mol Biol. 2009;550:241-9. doi: 10.1007/978-1-60327-009-0_15.

PMID:
19495708
28.

In utero and acute exposure to benzene: investigation of DNA double-strand breaks and DNA recombination in mice.

Lau A, Belanger CL, Winn LM.

Mutat Res. 2009 May 31;676(1-2):74-82. doi: 10.1016/j.mrgentox.2009.04.001. Epub 2009 Apr 10.

PMID:
19486867
29.

The effects of 1,4-benzoquinone on c-Myb and topoisomerase II in K-562 cells.

Singh R, Winn LM.

Mutat Res. 2008 Oct 14;645(1-2):33-8. doi: 10.1016/j.mrfmmm.2008.08.007. Epub 2008 Aug 20.

PMID:
18778717
30.

Reactive oxygen species, diabetes and toxicity in the placenta - a workshop report.

Foster W, Myllynen P, Winn LM, Ornoy A, Miller RK.

Placenta. 2008 Mar;29 Suppl A:S105-7. doi: 10.1016/j.placenta.2007.10.014. Epub 2008 Feb 20.

PMID:
18281091
31.

In utero exposure to benzene increases embryonic c-Myb and Pim-1 protein levels in CD-1 mice.

Wan J, Winn LM.

Toxicol Appl Pharmacol. 2008 May 1;228(3):326-33. doi: 10.1016/j.taap.2007.12.014. Epub 2007 Dec 23.

PMID:
18281070
32.

Benzene's metabolites alter c-MYB activity via reactive oxygen species in HD3 cells.

Wan J, Winn LM.

Toxicol Appl Pharmacol. 2007 Jul 15;222(2):180-9. Epub 2007 May 21.

PMID:
17614109
33.

In utero-initiated cancer: the role of reactive oxygen species.

Wan J, Winn LM.

Birth Defects Res C Embryo Today. 2006 Dec;78(4):326-32. Review.

PMID:
17315246
34.

Investigating the role of the aryl hydrocarbon receptor in benzene-initiated toxicity in vitro.

Badham HJ, Winn LM.

Toxicology. 2007 Jan 18;229(3):177-85. Epub 2006 Nov 7.

PMID:
17161514
35.

Thalidomide alters c-MYB and PIM-1 signaling in K-562 cells.

Thadani NA, McNamee JP, Winn LM.

Pharmacol Res. 2006 Aug;54(2):91-6. Epub 2006 Mar 8.

PMID:
16616857
37.

Folic acid and pantothenic acid protection against valproic acid-induced neural tube defects in CD-1 mice.

Dawson JE, Raymond AM, Winn LM.

Toxicol Appl Pharmacol. 2006 Mar 1;211(2):124-32. Epub 2005 Aug 22.

PMID:
16112698
38.

The effects of benzene and the metabolites phenol and catechol on c-Myb and Pim-1 signaling in HD3 cells.

Wan J, Winn LM.

Toxicol Appl Pharmacol. 2004 Dec 1;201(2):194-201.

PMID:
15541759
39.

TCDD-induced homologous recombination: the role of the Ah receptor versus oxidative DNA damage.

Chan CY, Kim PM, Winn LM.

Mutat Res. 2004 Sep 12;563(1):71-9.

PMID:
15324750
40.

TCDD affects DNA double strand-break repair.

Chan CY, Kim PM, Winn LM.

Toxicol Sci. 2004 Sep;81(1):133-8. Epub 2004 Jun 16.

PMID:
15201442
41.

Pim-1 phosphorylates the DNA binding domain of c-Myb.

Winn LM, Lei W, Ness SA.

Cell Cycle. 2003 May-Jun;2(3):258-62.

PMID:
12734436
42.

Oxidative stress-induced homologous recombination as a novel mechanism for phenytoin-initiated toxicity.

Winn LM, Kim PM, Nickoloff JA.

J Pharmacol Exp Ther. 2003 Aug;306(2):523-7. Epub 2003 May 2.

PMID:
12730361
43.
44.

Evidence for Ras-dependent signal transduction in phenytoin teratogenicity.

Winn LM, Wells PG.

Toxicol Appl Pharmacol. 2002 Nov 1;184(3):144-52.

PMID:
12460742
45.

Maternal administration of superoxide dismutase and catalase in phenytoin teratogenicity.

Winn LM, Wells PG.

Free Radic Biol Med. 1999 Feb;26(3-4):266-74.

PMID:
9895216
47.

Oxidative damage in chemical teratogenesis.

Wells PG, Kim PM, Laposa RR, Nicol CJ, Parman T, Winn LM.

Mutat Res. 1997 Dec 12;396(1-2):65-78. Review.

PMID:
9434860
48.

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