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Items: 1 to 50 of 77

1.

IFN-γ drives inflammatory bowel disease pathogenesis through VE-cadherin-directed vascular barrier disruption.

Langer V, Vivi E, Regensburger D, Winkler TH, Waldner MJ, Rath T, Schmid B, Skottke L, Lee S, Jeon NL, Wohlfahrt T, Kramer V, Tripal P, Schumann M, Kersting S, Handtrack C, Geppert CI, Suchowski K, Adams RH, Becker C, Ramming A, Naschberger E, Britzen-Laurent N, Stürzl M.

J Clin Invest. 2019 Sep 30. pii: 124884. doi: 10.1172/JCI124884. [Epub ahead of print]

2.

A viral kinase counteracts in vivo restriction of murine cytomegalovirus by SAMHD1.

Deutschmann J, Schneider A, Gruska I, Vetter B, Thomas D, Kießling M, Wittmann S, Herrmann A, Schindler M, Milbradt J, Ferreirós N, Winkler TH, Wiebusch L, Gramberg T.

Nat Microbiol. 2019 Sep 23. doi: 10.1038/s41564-019-0529-z. [Epub ahead of print]

PMID:
31548683
3.

CD83 orchestrates immunity towards self and non-self in dendritic cells.

Wild AB, Krzyzak L, Peckert K, Stich L, Kuhnt C, Butterhof A, Seitz C, Mattner J, Grüner N, Gänsbauer M, Purtak M, Soulat D, Winkler TH, Nitschke L, Zinser E, Steinkasserer A.

JCI Insight. 2019 Sep 17. pii: 126246. doi: 10.1172/jci.insight.126246. [Epub ahead of print]

4.

Proteomics of diphtheria toxoid vaccines reveals multiple proteins that are immunogenic and may contribute to protection of humans against Corynebacterium diphtheriae.

Möller J, Kraner M, Sonnewald U, Sangal V, Tittlbach H, Winkler J, Winkler TH, Melnikov V, Lang R, Sing A, Mattos-Guaraldi AL, Burkovski A.

Vaccine. 2019 May 21;37(23):3061-3070. doi: 10.1016/j.vaccine.2019.04.059. Epub 2019 Apr 26.

PMID:
31036455
5.

The Role of the Pre-B Cell Receptor in B Cell Development, Repertoire Selection, and Tolerance.

Winkler TH, Mårtensson IL.

Front Immunol. 2018 Nov 15;9:2423. doi: 10.3389/fimmu.2018.02423. eCollection 2018. Review.

6.

Epistatic Interactions Between Mutations of Deoxyribonuclease 1-Like 3 and the Inhibitory Fc Gamma Receptor IIB Result in Very Early and Massive Autoantibodies Against Double-Stranded DNA.

Weisenburger T, von Neubeck B, Schneider A, Ebert N, Schreyer D, Acs A, Winkler TH.

Front Immunol. 2018 Jul 5;9:1551. doi: 10.3389/fimmu.2018.01551. eCollection 2018.

7.

Lupus nephritis progression in FcγRIIB-/-yaa mice is associated with early development of glomerular electron dense deposits and loss of renal DNase I in severe disease.

Horvei KD, Pedersen HL, Fismen S, Thiyagarajan D, Schneider A, Rekvig OP, Winkler TH, Seredkina N.

PLoS One. 2017 Nov 30;12(11):e0188863. doi: 10.1371/journal.pone.0188863. eCollection 2017.

8.

GMP-production of purified human B lymphocytes for the adoptive transfer in patients after allogeneic hematopoietic stem cell transplantation.

Tittlbach H, Schneider A, Strobel J, Zimmermann R, Maas S, Gebhardt B, Rauser G, Mach M, Mackensen A, Winkler TH, Winkler J.

J Transl Med. 2017 Nov 7;15(1):228. doi: 10.1186/s12967-017-1330-5.

9.

Protective capacity of neutralizing and non-neutralizing antibodies against glycoprotein B of cytomegalovirus.

Bootz A, Karbach A, Spindler J, Kropff B, Reuter N, Sticht H, Winkler TH, Britt WJ, Mach M.

PLoS Pathog. 2017 Aug 30;13(8):e1006601. doi: 10.1371/journal.ppat.1006601. eCollection 2017 Aug.

10.

Synergistic Strategy for Multicolor Two-photon Microscopy: Application to the Analysis of Germinal Center Reactions In Vivo.

Rakhymzhan A, Leben R, Zimmermann H, Günther R, Mex P, Reismann D, Ulbricht C, Acs A, Brandt AU, Lindquist RL, Winkler TH, Hauser AE, Niesner RA.

Sci Rep. 2017 Aug 2;7(1):7101. doi: 10.1038/s41598-017-07165-0.

11.

A defined metabolic state in pre B cells governs B-cell development and is counterbalanced by Swiprosin-2/EFhd1.

Stein M, Dütting S, Mougiakakos D, Bösl M, Fritsch K, Reimer D, Urbanczyk S, Steinmetz T, Schuh W, Bozec A, Winkler TH, Jäck HM, Mielenz D.

Cell Death Differ. 2017 Jul;24(7):1239-1252. doi: 10.1038/cdd.2017.52. Epub 2017 May 19.

12.

Systems Analysis Reveals High Genetic and Antigen-Driven Predetermination of Antibody Repertoires throughout B Cell Development.

Greiff V, Menzel U, Miho E, Weber C, Riedel R, Cook S, Valai A, Lopes T, Radbruch A, Winkler TH, Reddy ST.

Cell Rep. 2017 May 16;19(7):1467-1478. doi: 10.1016/j.celrep.2017.04.054.

13.

The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer.

Krebs AM, Mitschke J, Lasierra Losada M, Schmalhofer O, Boerries M, Busch H, Boettcher M, Mougiakakos D, Reichardt W, Bronsert P, Brunton VG, Pilarsky C, Winkler TH, Brabletz S, Stemmler MP, Brabletz T.

Nat Cell Biol. 2017 May;19(5):518-529. doi: 10.1038/ncb3513. Epub 2017 Apr 17.

PMID:
28414315
14.

Regulation of autoantibody activity by the IL-23-TH17 axis determines the onset of autoimmune disease.

Pfeifle R, Rothe T, Ipseiz N, Scherer HU, Culemann S, Harre U, Ackermann JA, Seefried M, Kleyer A, Uderhardt S, Haugg B, Hueber AJ, Daum P, Heidkamp GF, Ge C, Böhm S, Lux A, Schuh W, Magorivska I, Nandakumar KS, Lönnblom E, Becker C, Dudziak D, Wuhrer M, Rombouts Y, Koeleman CA, Toes R, Winkler TH, Holmdahl R, Herrmann M, Blüml S, Nimmerjahn F, Schett G, Krönke G.

Nat Immunol. 2017 Jan;18(1):104-113. doi: 10.1038/ni.3579. Epub 2016 Nov 7.

15.

Siglec-H protects from virus-triggered severe systemic autoimmunity.

Schmitt H, Sell S, Koch J, Seefried M, Sonnewald S, Daniel C, Winkler TH, Nitschke L.

J Exp Med. 2016 Jul 25;213(8):1627-44. doi: 10.1084/jem.20160189. Epub 2016 Jul 4.

16.

CD83 Modulates B Cell Activation and Germinal Center Responses.

Krzyzak L, Seitz C, Urbat A, Hutzler S, Ostalecki C, Gläsner J, Hiergeist A, Gessner A, Winkler TH, Steinkasserer A, Nitschke L.

J Immunol. 2016 May 1;196(9):3581-94. doi: 10.4049/jimmunol.1502163. Epub 2016 Mar 16.

17.

Reactivation of IgG-switched memory B cells by BCR-intrinsic signal amplification promotes IgG antibody production.

Lutz J, Dittmann K, Bösl MR, Winkler TH, Wienands J, Engels N.

Nat Commun. 2015 Oct 13;6:8575. doi: 10.1038/ncomms9575.

18.

Control of murine cytomegalovirus infection by γδ T cells.

Sell S, Dietz M, Schneider A, Holtappels R, Mach M, Winkler TH.

PLoS Pathog. 2015 Feb 6;11(2):e1004481. doi: 10.1371/journal.ppat.1004481. eCollection 2015 Feb.

19.

The immunoglobulin tail tyrosine motif upgrades memory-type BCRs by incorporating a Grb2-Btk signalling module.

Engels N, König LM, Schulze W, Radtke D, Vanshylla K, Lutz J, Winkler TH, Nitschke L, Wienands J.

Nat Commun. 2014 Nov 21;5:5456. doi: 10.1038/ncomms6456.

20.

Identification of a neutralizing epitope within antigenic domain 5 of glycoprotein B of human cytomegalovirus.

Wiegers AK, Sticht H, Winkler TH, Britt WJ, Mach M.

J Virol. 2015 Jan;89(1):361-72. doi: 10.1128/JVI.02393-14. Epub 2014 Oct 15.

21.

Structural basis for the recognition of human cytomegalovirus glycoprotein B by a neutralizing human antibody.

Spindler N, Diestel U, Stump JD, Wiegers AK, Winkler TH, Sticht H, Mach M, Muller YA.

PLoS Pathog. 2014 Oct 9;10(10):e1004377. doi: 10.1371/journal.ppat.1004377. eCollection 2014 Oct.

22.

With a little help from my old T cell: memory follicular T helper cells driving autoimmunity?

Winkler TH, Waisman A.

Eur J Immunol. 2014 Oct;44(10):2869-71. doi: 10.1002/eji.201445101.

23.

SIGLEC-G deficiency increases susceptibility to develop B-cell lymphoproliferative disorders.

Simonetti G, Bertilaccio MT, Rodriguez TV, Apollonio B, Dagklis A, Rocchi M, Innocenzi A, Casola S, Winkler TH, Nitschke L, Ponzoni M, Caligaris-Cappio F, Ghia P.

Haematologica. 2014 Aug;99(8):1356-64. doi: 10.3324/haematol.2013.100230. Epub 2014 May 23.

24.

The ligand-binding domain of Siglec-G is crucial for its selective inhibitory function on B1 cells.

Hutzler S, Özgör L, Naito-Matsui Y, Kläsener K, Winkler TH, Reth M, Nitschke L.

J Immunol. 2014 Jun 1;192(11):5406-14. doi: 10.4049/jimmunol.1302875. Epub 2014 Apr 30.

25.

Introduction: B cell-mediated autoimmune diseases.

Winkler TH, Voll RE.

Semin Immunopathol. 2014 May;36(3):275-6. doi: 10.1007/s00281-014-0432-x. Epub 2014 Apr 29. No abstract available.

PMID:
24777747
26.

[B-lymphocytes as effectors and regulators in systemic lupus erythematosus].

Winkler TH.

Z Rheumatol. 2014 May;73(4):360-2. doi: 10.1007/s00393-013-1295-6. Review. German. No abstract available.

PMID:
24722870
27.

Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival.

Song J, Lokmic Z, Lämmermann T, Rolf J, Wu C, Zhang X, Hallmann R, Hannocks MJ, Horn N, Ruegg MA, Sonnenberg A, Georges-Labouesse E, Winkler TH, Kearney JF, Cardell S, Sorokin L.

Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):E2915-24. doi: 10.1073/pnas.1218131110. Epub 2013 Jul 11.

28.

Characterization of a discontinuous neutralizing epitope on glycoprotein B of human cytomegalovirus.

Spindler N, Rücker P, Pötzsch S, Diestel U, Sticht H, Martin-Parras L, Winkler TH, Mach M.

J Virol. 2013 Aug;87(16):8927-39. doi: 10.1128/JVI.00434-13. Epub 2013 Jun 5.

29.

Multiple interferon regulatory factor and NF-κB sites cooperate in mediating cell-type- and maturation-specific activation of the human CD83 promoter in dendritic cells.

Stein MF, Lang S, Winkler TH, Deinzer A, Erber S, Nettelbeck DM, Naschberger E, Jochmann R, Stürzl M, Slany RK, Werner T, Steinkasserer A, Knippertz I.

Mol Cell Biol. 2013 Apr;33(7):1331-44. doi: 10.1128/MCB.01051-12. Epub 2013 Jan 22.

30.

The role of somatic hypermutation in the generation of pathogenic antibodies in SLE.

Schroeder K, Herrmann M, Winkler TH.

Autoimmunity. 2013 Mar;46(2):121-7. doi: 10.3109/08916934.2012.748751. Epub 2013 Jan 9. Review.

PMID:
23181829
31.

B cell repertoire analysis identifies new antigenic domains on glycoprotein B of human cytomegalovirus which are target of neutralizing antibodies.

Pötzsch S, Spindler N, Wiegers AK, Fisch T, Rücker P, Sticht H, Grieb N, Baroti T, Weisel F, Stamminger T, Martin-Parras L, Mach M, Winkler TH.

PLoS Pathog. 2011 Aug;7(8):e1002172. doi: 10.1371/journal.ppat.1002172. Epub 2011 Aug 11.

32.

Autoantibodies: Focus on anti-DNA antibodies.

Almqvist N, Winkler TH, Mårtensson IL.

Self Nonself. 2011 Jan;2(1):11-18. Epub 2011 Jan 1.

33.

A hypomorphic IgH-chain allele affects development of B-cell subsets and favours receptor editing.

Brenner S, Drewel D, Steinbart T, Weisel F, Härtel E, Pötzsch S, Welzel H, Brandl A, Yu P, Mudde GC, Schweizer A, Nitschke L, Winkler TH.

EMBO J. 2011 May 27;30(13):2705-18. doi: 10.1038/emboj.2011.168.

34.

Grb2 regulates B-cell maturation, B-cell memory responses and inhibits B-cell Ca2+ signalling.

Ackermann JA, Radtke D, Maurberger A, Winkler TH, Nitschke L.

EMBO J. 2011 Apr 20;30(8):1621-33. doi: 10.1038/emboj.2011.74. Epub 2011 Mar 22.

35.

Unique requirements for reactivation of virus-specific memory B lymphocytes.

Weisel FJ, Appelt UK, Schneider AM, Horlitz JU, van Rooijen N, Korner H, Mach M, Winkler TH.

J Immunol. 2010 Oct 1;185(7):4011-21. doi: 10.4049/jimmunol.1001540. Epub 2010 Aug 25.

36.

Polymorphisms in the Hsp70 gene locus are genetically associated with systemic lupus erythematosus.

Fürnrohr BG, Wach S, Kelly JA, Haslbeck M, Weber CK, Stach CM, Hueber AJ, Graef D, Spriewald BM, Manger K, Herrmann M, Kaufman KM, Frank SG, Goodmon E, James JA, Schett G, Winkler TH, Harley JB, Voll RE.

Ann Rheum Dis. 2010 Nov;69(11):1983-9. doi: 10.1136/ard.2009.122630. Epub 2010 May 24.

37.

CD22 x Siglec-G double-deficient mice have massively increased B1 cell numbers and develop systemic autoimmunity.

Jellusova J, Wellmann U, Amann K, Winkler TH, Nitschke L.

J Immunol. 2010 Apr 1;184(7):3618-27. doi: 10.4049/jimmunol.0902711. Epub 2010 Mar 3.

38.

Inefficient clearance of dying cells in patients with SLE: anti-dsDNA autoantibodies, MFG-E8, HMGB-1 and other players.

Kruse K, Janko C, Urbonaviciute V, Mierke CT, Winkler TH, Voll RE, Schett G, Muñoz LE, Herrmann M.

Apoptosis. 2010 Sep;15(9):1098-113. doi: 10.1007/s10495-010-0478-8. Review.

PMID:
20198437
39.

Passive immunization reduces murine cytomegalovirus-induced brain pathology in newborn mice.

Cekinović D, Golemac M, Pugel EP, Tomac J, Cicin-Sain L, Slavuljica I, Bradford R, Misch S, Winkler TH, Mach M, Britt WJ, Jonjić S.

J Virol. 2008 Dec;82(24):12172-80. doi: 10.1128/JVI.01214-08. Epub 2008 Oct 8.

40.

Censoring of autoreactive B cell development by the pre-B cell receptor.

Keenan RA, De Riva A, Corleis B, Hepburn L, Licence S, Winkler TH, Mårtensson IL.

Science. 2008 Aug 1;321(5889):696-9. doi: 10.1126/science.1157533. Epub 2008 Jun 19.

41.

The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis.

Neubert K, Meister S, Moser K, Weisel F, Maseda D, Amann K, Wiethe C, Winkler TH, Kalden JR, Manz RA, Voll RE.

Nat Med. 2008 Jul;14(7):748-55. doi: 10.1038/nm1763. Epub 2008 Jun 8.

PMID:
18542049
42.

Autoreactive B cells get activated in extrafollicular sites.

Weisel F, Wellmann U, Winkler TH.

Eur J Immunol. 2007 Dec;37(12):3330-3.

43.

Protection from CMV infection in immunodeficient hosts by adoptive transfer of memory B cells.

Klenovsek K, Weisel F, Schneider A, Appelt U, Jonjic S, Messerle M, Bradel-Tretheway B, Winkler TH, Mach M.

Blood. 2007 Nov 1;110(9):3472-9. Epub 2007 Jul 26.

PMID:
17656648
44.

Siglec-G is a B1 cell-inhibitory receptor that controls expansion and calcium signaling of the B1 cell population.

Hoffmann A, Kerr S, Jellusova J, Zhang J, Weisel F, Wellmann U, Winkler TH, Kneitz B, Crocker PR, Nitschke L.

Nat Immunol. 2007 Jul;8(7):695-704. Epub 2007 Jun 17.

PMID:
17572677
45.

Toll-like receptor 9-independent aggravation of glomerulonephritis in a novel model of SLE.

Yu P, Wellmann U, Kunder S, Quintanilla-Martinez L, Jennen L, Dear N, Amann K, Bauer S, Winkler TH, Wagner H.

Int Immunol. 2006 Aug;18(8):1211-9. Epub 2006 Jun 23.

PMID:
16798839
46.

The pre-B-cell receptor induces silencing of VpreB and lambda5 transcription.

Parker MJ, Licence S, Erlandsson L, Galler GR, Chakalova L, Osborne CS, Morgan G, Fraser P, Jumaa H, Winkler TH, Skok J, Mårtensson IL.

EMBO J. 2005 Nov 16;24(22):3895-905. Epub 2005 Nov 10.

47.

The evolution of human anti-double-stranded DNA autoantibodies.

Wellmann U, Letz M, Herrmann M, Angermüller S, Kalden JR, Winkler TH.

Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9258-63. Epub 2005 Jun 20.

48.

Surface mu heavy chain signals down-regulation of the V(D)J-recombinase machinery in the absence of surrogate light chain components.

Galler GR, Mundt C, Parker M, Pelanda R, Mårtensson IL, Winkler TH.

J Exp Med. 2004 Jun 7;199(11):1523-32. Epub 2004 Jun 1.

49.

Activation of virus-specific memory B cells in the absence of T cell help.

Hebeis BJ, Klenovsek K, Rohwer P, Ritter U, Schneider A, Mach M, Winkler TH.

J Exp Med. 2004 Feb 16;199(4):593-602. Epub 2004 Feb 9.

50.

The oncoprotein MLL-ENL disturbs hematopoietic lineage determination and transforms a biphenotypic lymphoid/myeloid cell.

Zeisig BB, García-Cuéllar MP, Winkler TH, Slany RK.

Oncogene. 2003 Mar 20;22(11):1629-37.

PMID:
12642866

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