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Items: 41

1.

Ceftazidime-Avibactam in Combination With Fosfomycin: A Novel Therapeutic Strategy Against Multidrug-Resistant Pseudomonas aeruginosa.

Papp-Wallace KM, Zeiser ET, Becka SA, Park S, Wilson BM, Winkler ML, D'Souza R, Singh I, Sutton G, Fouts DE, Chen L, Kreiswirth BN, Ellis-Grosse EJ, Drusano GL, Perlin DS, Bonomo RA.

J Infect Dis. 2019 May 17. pii: jiz149. doi: 10.1093/infdis/jiz149. [Epub ahead of print]

PMID:
31099835
2.

Klebsiella pneumoniae Carbapenemase-2 (KPC-2), Substitutions at Ambler Position Asp179, and Resistance to Ceftazidime-Avibactam: Unique Antibiotic-Resistant Phenotypes Emerge from β-Lactamase Protein Engineering.

Barnes MD, Winkler ML, Taracila MA, Page MG, Desarbre E, Kreiswirth BN, Shields RK, Nguyen MH, Clancy C, Spellberg B, Papp-Wallace KM, Bonomo RA.

MBio. 2017 Oct 31;8(5). pii: e00528-17. doi: 10.1128/mBio.00528-17.

3.

Overcoming an Extremely Drug Resistant (XDR) Pathogen: Avibactam Restores Susceptibility to Ceftazidime for Burkholderia cepacia Complex Isolates from Cystic Fibrosis Patients.

Papp-Wallace KM, Becka SA, Zeiser ET, Ohuchi N, Mojica MF, Gatta JA, Falleni M, Tosi D, Borghi E, Winkler ML, Wilson BM, LiPuma JJ, Nukaga M, Bonomo RA.

ACS Infect Dis. 2017 Jul 14;3(7):502-511. doi: 10.1021/acsinfecdis.7b00020. Epub 2017 Mar 30.

4.

Boronic Acid Transition State Inhibitors Active against KPC and Other Class A β-Lactamases: Structure-Activity Relationships as a Guide to Inhibitor Design.

Rojas LJ, Taracila MA, Papp-Wallace KM, Bethel CR, Caselli E, Romagnoli C, Winkler ML, Spellberg B, Prati F, Bonomo RA.

Antimicrob Agents Chemother. 2016 Jan 4;60(3):1751-9. doi: 10.1128/AAC.02641-15.

5.

Exposing a β-Lactamase "Twist": the Mechanistic Basis for the High Level of Ceftazidime Resistance in the C69F Variant of the Burkholderia pseudomallei PenI β-Lactamase.

Papp-Wallace KM, Becka SA, Taracila MA, Winkler ML, Gatta JA, Rholl DA, Schweizer HP, Bonomo RA.

Antimicrob Agents Chemother. 2015 Nov 23;60(2):777-88. doi: 10.1128/AAC.02073-15. Print 2016 Feb.

6.

SHV-129: A Gateway to Global Suppressors in the SHV β-Lactamase Family?

Winkler ML, Bonomo RA.

Mol Biol Evol. 2016 Feb;33(2):429-41. doi: 10.1093/molbev/msv235. Epub 2015 Nov 3.

7.

Activity of ceftazidime/avibactam against isogenic strains of Escherichia coli containing KPC and SHV β-lactamases with single amino acid substitutions in the Ω-loop.

Winkler ML, Papp-Wallace KM, Bonomo RA.

J Antimicrob Chemother. 2015 Aug;70(8):2279-86. doi: 10.1093/jac/dkv094. Epub 2015 May 8.

8.

Activities of ceftazidime, ceftaroline, and aztreonam alone and combined with avibactam against isogenic Escherichia coli strains expressing selected single β-lactamases.

Papp-Wallace KM, Bajaksouzian S, Abdelhamed AM, Foster AN, Winkler ML, Gatta JA, Nichols WW, Testa R, Bonomo RA, Jacobs MR.

Diagn Microbiol Infect Dis. 2015 May;82(1):65-9. doi: 10.1016/j.diagmicrobio.2015.02.003. Epub 2015 Feb 14.

9.

Avibactam and inhibitor-resistant SHV β-lactamases.

Winkler ML, Papp-Wallace KM, Taracila MA, Bonomo RA.

Antimicrob Agents Chemother. 2015 Jul;59(7):3700-9. doi: 10.1128/AAC.04405-14. Epub 2015 Feb 17.

10.

Variants of β-lactamase KPC-2 that are resistant to inhibition by avibactam.

Papp-Wallace KM, Winkler ML, Taracila MA, Bonomo RA.

Antimicrob Agents Chemother. 2015 Jul;59(7):3710-7. doi: 10.1128/AAC.04406-14. Epub 2015 Feb 9.

11.

Unexpected challenges in treating multidrug-resistant Gram-negative bacteria: resistance to ceftazidime-avibactam in archived isolates of Pseudomonas aeruginosa.

Winkler ML, Papp-Wallace KM, Hujer AM, Domitrovic TN, Hujer KM, Hurless KN, Tuohy M, Hall G, Bonomo RA.

Antimicrob Agents Chemother. 2015 Feb;59(2):1020-9. doi: 10.1128/AAC.04238-14. Epub 2014 Dec 1.

12.

Current and emerging MR imaging techniques for the diagnosis and management of CSF flow disorders: a review of phase-contrast and time-spatial labeling inversion pulse.

Yamada S, Tsuchiya K, Bradley WG, Law M, Winkler ML, Borzage MT, Miyazaki M, Kelly EJ, McComb JG.

AJNR Am J Neuroradiol. 2015 Apr;36(4):623-30. doi: 10.3174/ajnr.A4030. Epub 2014 Jul 10. Review.

13.

Reclaiming the efficacy of β-lactam-β-lactamase inhibitor combinations: avibactam restores the susceptibility of CMY-2-producing Escherichia coli to ceftazidime.

Papp-Wallace KM, Winkler ML, Gatta JA, Taracila MA, Chilakala S, Xu Y, Johnson JK, Bonomo RA.

Antimicrob Agents Chemother. 2014 Aug;58(8):4290-7. doi: 10.1128/AAC.02625-14. Epub 2014 May 12.

14.

Penam sulfones and β-lactamase inhibition: SA2-13 and the importance of the C2 side chain length and composition.

Rodkey EA, Winkler ML, Bethel CR, Pagadala SR, Buynak JD, Bonomo RA, van den Akker F.

PLoS One. 2014 Jan 16;9(1):e85892. doi: 10.1371/journal.pone.0085892. eCollection 2014.

15.

Design and exploration of novel boronic acid inhibitors reveals important interactions with a clavulanic acid-resistant sulfhydryl-variable (SHV) β-lactamase.

Winkler ML, Rodkey EA, Taracila MA, Drawz SM, Bethel CR, Papp-Wallace KM, Smith KM, Xu Y, Dwulit-Smith JR, Romagnoli C, Caselli E, Prati F, van den Akker F, Bonomo RA.

J Med Chem. 2013 Feb 14;56(3):1084-97. doi: 10.1021/jm301490d. Epub 2013 Feb 4.

16.

Exploring the role of a conserved class A residue in the Ω-Loop of KPC-2 β-lactamase: a mechanism for ceftazidime hydrolysis.

Levitt PS, Papp-Wallace KM, Taracila MA, Hujer AM, Winkler ML, Smith KM, Xu Y, Harris ME, Bonomo RA.

J Biol Chem. 2012 Sep 14;287(38):31783-93. doi: 10.1074/jbc.M112.348540. Epub 2012 Jul 26.

17.

Traversing K space with fast MR scans.

Winkler ML, Schwartz GM.

Diagn Imaging (San Franc). 1994 May;16(5):83, 87-96, 102. No abstract available.

PMID:
10147090
18.

Induction of three histochemically distinct populations of hepatic foci in C57BL/6J mice.

Hanigan MH, Winkler ML, Drinkwater NR.

Carcinogenesis. 1993 May;14(5):1035-40.

PMID:
8099313
19.

Partial hepatectomy is a promoter of hepatocarcinogenesis in C57BL/6J male mice but not in C3H/HeJ male mice.

Hanigan MH, Winkler ML, Drinkwater NR.

Carcinogenesis. 1990 Apr;11(4):589-94.

PMID:
2323000
20.

Hepatic neoplasia: breath-hold MR imaging.

Winkler ML, Thoeni RF, Luh N, Kaufman L, Margulis AR.

Radiology. 1989 Mar;170(3 Pt 1):801-6.

PMID:
2916032
21.

Midfield and low-field magnetic resonance imaging of the spine.

Rothschild PA, Winkler ML, Grönemeyer DH, Kaufman L, D'Amour P.

Top Magn Reson Imaging. 1988 Dec;1(1):11-23. Review. No abstract available.

PMID:
3078534
22.

Preservation of sickle cell blood-flow patterns during MR imaging: an in vivo study.

Brody AS, Embury SH, Mentzer WC, Winkler ML, Gooding CA.

AJR Am J Roentgenol. 1988 Jul;151(1):139-41.

PMID:
3259797
23.

Invasive cervical carcinoma: comparison of MR imaging and surgical findings.

Hricak H, Lacey CG, Sandles LG, Chang YC, Winkler ML, Stern JL.

Radiology. 1988 Mar;166(3):623-31.

PMID:
3340756
24.

Body MRI: the state of use.

Winkler ML.

Adm Radiol. 1988 Feb;7(2):71. No abstract available.

PMID:
10286335
25.

Characteristics of partial flip angle and gradient reversal MR imaging.

Winkler ML, Ortendahl DA, Mills TC, Crooks LE, Sheldon PE, Kaufman L, Kramer DM.

Radiology. 1988 Jan;166(1 Pt 1):17-26. Review. No abstract available.

PMID:
3275967
26.

Hemorrhagic and nonhemorrhagic brain lesions: evaluation with 0.35-T fast MR imaging.

Winkler ML, Olsen WL, Mills TC, Kaufman L.

Radiology. 1987 Oct;165(1):203-7.

PMID:
3628772
27.

MR imaging of pulmonary arterial hypertension and pulmonary emboli.

White RD, Winkler ML, Higgins CB.

AJR Am J Roentgenol. 1987 Jul;149(1):15-21.

PMID:
3495975
28.

Undescended testis: value of MR imaging.

Fritzsche PJ, Hricak H, Kogan BA, Winkler ML, Tanagho EA.

Radiology. 1987 Jul;164(1):169-73.

PMID:
2884693
29.

Adenomyosis and leiomyoma: differential diagnosis with MR imaging.

Mark AS, Hricak H, Heinrichs LW, Hendrickson MR, Winkler ML, Bachica JA, Stickler JE.

Radiology. 1987 May;163(2):527-9.

PMID:
3562836
30.

Carcinomatous encephalitis: CT and MR findings.

Olsen WL, Winkler ML, Ross DA.

AJNR Am J Neuroradiol. 1987 May-Jun;8(3):553-4. No abstract available.

PMID:
3111217
31.

MR imaging in the diagnosis of pancreatic disease.

Tscholakoff D, Hricak H, Thoeni R, Winkler ML, Margulis AR.

AJR Am J Roentgenol. 1987 Apr;148(4):703-9.

PMID:
3493653
32.

MR imaging of diffusely infiltrating gastric carcinoma.

Winkler ML, Hricak H, Higgins CB.

J Comput Assist Tomogr. 1987 Mar-Apr;11(2):337-9.

PMID:
3819137
33.

Endometrial carcinoma staging by MR imaging.

Hricak H, Stern JL, Fisher MR, Shapeero LG, Winkler ML, Lacey CG.

Radiology. 1987 Feb;162(2):297-305.

PMID:
3797641
34.

Gated acquisition of MR images of the thorax: advantages for the study of the hila and mediastinum.

Mark AS, Winkler ML, Peltzer M, Kaufmann L, Higgins CB.

Magn Reson Imaging. 1987;5(1):57-63.

PMID:
3586873
35.

Gestational trophoblastic neoplasm of the uterus: MR assessment.

Hricak H, Demas BE, Braga CA, Fisher MR, Winkler ML.

Radiology. 1986 Oct;161(1):11-6.

PMID:
3020607
36.

MRI of perivalvular infectious pseudoaneurysms.

Winkler ML, Higgins CB.

AJR Am J Roentgenol. 1986 Aug;147(2):253-6.

PMID:
3487937
37.

Pelvis imaging with MR: technique for improvement.

Winkler ML, Hricak H.

Radiology. 1986 Mar;158(3):848-9.

PMID:
3945763
38.

Cholecystitis: detection with MR imaging.

McCarthy S, Hricak H, Cohen M, Fisher MR, Winkler ML, Filly RA, Margulis AR.

Radiology. 1986 Feb;158(2):333-6.

PMID:
3510441
39.

Increased hepatic density and phospholipidosis due to amiodarone.

Goldman IS, Winkler ML, Raper SE, Barker ME, Keung E, Goldberg HI, Boyer TD.

AJR Am J Roentgenol. 1985 Mar;144(3):541-6.

PMID:
3871563
40.

Electron microscopic demonstration of lysosomal inclusion bodies in lung, liver, lymph nodes, and blood leukocytes of patients with amiodarone pulmonary toxicity.

Dake MD, Madison JM, Montgomery CK, Shellito JE, Hinchcliffe WA, Winkler ML, Bainton DF.

Am J Med. 1985 Mar;78(3):506-12.

PMID:
2983550
41.

Hemodynamic correlates of right ventricular ejection fraction measured with gated radionuclide angiography.

Korr KS, Gandsman EJ, Winkler ML, Shulman RS, Bough EW.

Am J Cardiol. 1982 Jan;49(1):71-7.

PMID:
6274183

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