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Items: 1 to 50 of 162

1.

Selective Penicillin-Binding Protein Imaging Probes Reveal Substructure in Bacterial Cell Division.

Kocaoglu O, Calvo RA, Sham LT, Cozy LM, Lanning BR, Francis S, Winkler ME, Kearns DB, Carlson EE.

ACS Chem Biol. 2019 Jul 19;14(7):1672. doi: 10.1021/acschembio.9b00459. Epub 2019 Jul 2. No abstract available.

PMID:
31265231
2.

A Mn-sensing riboswitch activates expression of a Mn2+/Ca2+ ATPase transporter in Streptococcus.

Martin JE, Le MT, Bhattarai N, Capdevila DA, Shen J, Winkler ME, Giedroc DP.

Nucleic Acids Res. 2019 Jul 26;47(13):6885-6899. doi: 10.1093/nar/gkz494.

3.

Competence beyond Genes: Filling in the Details of the Pneumococcal Competence Transcriptome by a Systems Approach.

Winkler ME, Morrison DA.

J Bacteriol. 2019 Jun 10;201(13). pii: e00238-19. doi: 10.1128/JB.00238-19. Print 2019 Jul 1.

PMID:
30988030
4.

Redefining the Small Regulatory RNA Transcriptome in Streptococcus pneumoniae Serotype 2 Strain D39.

Sinha D, Zimmer K, Cameron TA, Rusch DB, Winkler ME, De Lay NR.

J Bacteriol. 2019 Jun 21;201(14). pii: e00764-18. doi: 10.1128/JB.00764-18. Print 2019 Jul 15.

PMID:
30833353
5.

Movement dynamics of divisome proteins and PBP2x:FtsW in cells of Streptococcus pneumoniae.

Perez AJ, Cesbron Y, Shaw SL, Bazan Villicana J, Tsui HT, Boersma MJ, Ye ZA, Tovpeko Y, Dekker C, Holden S, Winkler ME.

Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3211-3220. doi: 10.1073/pnas.1816018116. Epub 2019 Feb 4.

6.

Structure of the Large Extracellular Loop of FtsX and Its Interaction with the Essential Peptidoglycan Hydrolase PcsB in Streptococcus pneumoniae.

Rued BE, Alcorlo M, Edmonds KA, Martínez-Caballero S, Straume D, Fu Y, Bruce KE, Wu H, Håvarstein LS, Hermoso JA, Winkler ME, Giedroc DP.

MBio. 2019 Jan 29;10(1). pii: e02622-18. doi: 10.1128/mBio.02622-18.

7.

The cell cycle regulator GpsB functions as cytosolic adaptor for multiple cell wall enzymes.

Cleverley RM, Rutter ZJ, Rismondo J, Corona F, Tsui HT, Alatawi FA, Daniel RA, Halbedel S, Massidda O, Winkler ME, Lewis RJ.

Nat Commun. 2019 Jan 16;10(1):261. doi: 10.1038/s41467-018-08056-2.

8.

Effect of phase composition on the photocatalytic activity of titanium dioxide obtained from supercritical antisolvent.

Da Silva EP, Winkler MEG, Giufrida WM, Cardozo-Filho L, Alonso CG, Lopes JBO, Rubira AF, Silva R.

J Colloid Interface Sci. 2019 Feb 1;535:245-254. doi: 10.1016/j.jcis.2018.09.098. Epub 2018 Sep 29.

PMID:
30312950
9.

The Opp (AmiACDEF) Oligopeptide Transporter Mediates Resistance of Serotype 2 Streptococcus pneumoniae D39 to Killing by Chemokine CXCL10 and Other Antimicrobial Peptides.

Bruce KE, Rued BE, Tsui HT, Winkler ME.

J Bacteriol. 2018 May 9;200(11). pii: e00745-17. doi: 10.1128/JB.00745-17. Print 2018 Jun 1.

10.

Novel Electrophilic Scaffold for Imaging of Essential Penicillin-Binding Proteins in Streptococcus pneumoniae.

Sharifzadeh S, Boersma MJ, Kocaoglu O, Shokri A, Brown CL, Shirley JD, Winkler ME, Carlson EE.

ACS Chem Biol. 2017 Nov 17;12(11):2849-2857. doi: 10.1021/acschembio.7b00614. Epub 2017 Oct 18.

11.

Absence of the KhpA and KhpB (JAG/EloR) RNA-binding proteins suppresses the requirement for PBP2b by overproduction of FtsA in Streptococcus pneumoniae D39.

Zheng JJ, Perez AJ, Tsui HT, Massidda O, Winkler ME.

Mol Microbiol. 2017 Dec;106(5):793-814. doi: 10.1111/mmi.13847. Epub 2017 Nov 2.

12.

The zinc efflux activator SczA protects Streptococcus pneumoniae serotype 2 D39 from intracellular zinc toxicity.

Martin JE, Edmonds KA, Bruce KE, Campanello GC, Eijkelkamp BA, Brazel EB, McDevitt CA, Winkler ME, Giedroc DP.

Mol Microbiol. 2017 May;104(4):636-651. doi: 10.1111/mmi.13654. Epub 2017 Mar 21.

13.

Perturbation of manganese metabolism disrupts cell division in Streptococcus pneumoniae.

Martin JE, Lisher JP, Winkler ME, Giedroc DP.

Mol Microbiol. 2017 Apr;104(2):334-348. doi: 10.1111/mmi.13630. Epub 2017 Feb 21.

14.

Biological and Chemical Adaptation to Endogenous Hydrogen Peroxide Production in Streptococcus pneumoniae D39.

Lisher JP, Tsui HT, Ramos-Montañez S, Hentchel KL, Martin JE, Trinidad JC, Winkler ME, Giedroc DP.

mSphere. 2017 Jan 4;2(1). pii: e00291-16. doi: 10.1128/mSphere.00291-16. eCollection 2017 Jan-Feb.

15.

Suppression and synthetic-lethal genetic relationships of ΔgpsB mutations indicate that GpsB mediates protein phosphorylation and penicillin-binding protein interactions in Streptococcus pneumoniae D39.

Rued BE, Zheng JJ, Mura A, Tsui HT, Boersma MJ, Mazny JL, Corona F, Perez AJ, Fadda D, Doubravová L, Buriánková K, Branny P, Massidda O, Winkler ME.

Mol Microbiol. 2017 Mar;103(6):931-957. doi: 10.1111/mmi.13613. Epub 2017 Feb 7.

16.

Roles of the Essential Protein FtsA in Cell Growth and Division in Streptococcus pneumoniae.

Mura A, Fadda D, Perez AJ, Danforth ML, Musu D, Rico AI, Krupka M, Denapaite D, Tsui HT, Winkler ME, Branny P, Vicente M, Margolin W, Massidda O.

J Bacteriol. 2017 Jan 12;199(3). pii: e00608-16. doi: 10.1128/JB.00608-16. Print 2017 Feb 1.

17.

Physiological Roles of the Dual Phosphate Transporter Systems in Low and High Phosphate Conditions and in Capsule Maintenance of Streptococcus pneumoniae D39.

Zheng JJ, Sinha D, Wayne KJ, Winkler ME.

Front Cell Infect Microbiol. 2016 Jun 20;6:63. doi: 10.3389/fcimb.2016.00063. eCollection 2016.

18.

Biochemical characterization of essential cell division proteins FtsX and FtsE that mediate peptidoglycan hydrolysis by PcsB in Streptococcus pneumoniae.

Bajaj R, Bruce KE, Davidson AL, Rued BE, Stauffacher CV, Winkler ME.

Microbiologyopen. 2016 Oct;5(5):738-752. doi: 10.1002/mbo3.366. Epub 2016 May 10.

19.

Suppression of a deletion mutation in the gene encoding essential PBP2b reveals a new lytic transglycosylase involved in peripheral peptidoglycan synthesis in Streptococcus pneumoniae D39.

Tsui HC, Zheng JJ, Magallon AN, Ryan JD, Yunck R, Rued BE, Bernhardt TG, Winkler ME.

Mol Microbiol. 2016 Jun;100(6):1039-65. doi: 10.1111/mmi.13366. Epub 2016 Apr 15.

20.

1H, 13C, 15N resonance assignments of the extracellular loop 1 domain (ECL1) of Streptococcus pneumoniae D39 FtsX, an essential cell division protein.

Fu Y, Bruce KE, Rued B, Winkler ME, Giedroc DP.

Biomol NMR Assign. 2016 Apr;10(1):89-92. doi: 10.1007/s12104-015-9644-9. Epub 2015 Sep 14.

21.

Minimal Peptidoglycan (PG) Turnover in Wild-Type and PG Hydrolase and Cell Division Mutants of Streptococcus pneumoniae D39 Growing Planktonically and in Host-Relevant Biofilms.

Boersma MJ, Kuru E, Rittichier JT, VanNieuwenhze MS, Brun YV, Winkler ME.

J Bacteriol. 2015 Nov;197(21):3472-85. doi: 10.1128/JB.00541-15. Epub 2015 Aug 24.

22.

A new quorum-sensing system (TprA/PhrA) for Streptococcus pneumoniae D39 that regulates a lantibiotic biosynthesis gene cluster.

Hoover SE, Perez AJ, Tsui HC, Sinha D, Smiley DL, DiMarchi RD, Winkler ME, Lazazzera BA.

Mol Microbiol. 2015 Jul;97(2):229-43. doi: 10.1111/mmi.13029. Epub 2015 May 26.

23.

Profiling of β-lactam selectivity for penicillin-binding proteins in Streptococcus pneumoniae D39.

Kocaoglu O, Tsui HC, Winkler ME, Carlson EE.

Antimicrob Agents Chemother. 2015;59(6):3548-55. doi: 10.1128/AAC.05142-14. Epub 2015 Apr 6.

24.

Pbp2x localizes separately from Pbp2b and other peptidoglycan synthesis proteins during later stages of cell division of Streptococcus pneumoniae D39.

Tsui HT, Boersma MJ, Vella SA, Kocaoglu O, Kuru E, Peceny JK, Carlson EE, VanNieuwenhze MS, Brun YV, Shaw SL, Winkler ME.

Mol Microbiol. 2014 Oct;94(1):21-40. doi: 10.1111/mmi.12745. Epub 2014 Aug 21.

25.

Requirement of essential Pbp2x and GpsB for septal ring closure in Streptococcus pneumoniae D39.

Land AD, Tsui HC, Kocaoglu O, Vella SA, Shaw SL, Keen SK, Sham LT, Carlson EE, Winkler ME.

Mol Microbiol. 2013 Dec;90(5):939-55. doi: 10.1111/mmi.12408. Epub 2013 Oct 17.

26.

Involvement of FtsE ATPase and FtsX extracellular loops 1 and 2 in FtsEX-PcsB complex function in cell division of Streptococcus pneumoniae D39.

Sham LT, Jensen KR, Bruce KE, Winkler ME.

MBio. 2013 Jul 16;4(4). pii: e00431-13. doi: 10.1128/mBio.00431-13.

27.

A new structural paradigm in copper resistance in Streptococcus pneumoniae.

Fu Y, Tsui HC, Bruce KE, Sham LT, Higgins KA, Lisher JP, Kazmierczak KM, Maroney MJ, Dann CE 3rd, Winkler ME, Giedroc DP.

Nat Chem Biol. 2013 Mar;9(3):177-83. doi: 10.1038/nchembio.1168. Epub 2013 Jan 27.

28.

Involvement of WalK (VicK) phosphatase activity in setting WalR (VicR) response regulator phosphorylation level and limiting cross-talk in Streptococcus pneumoniae D39 cells.

Wayne KJ, Li S, Kazmierczak KM, Tsui HC, Winkler ME.

Mol Microbiol. 2012 Nov;86(3):645-60. doi: 10.1111/mmi.12006. Epub 2012 Sep 27.

29.

Selective penicillin-binding protein imaging probes reveal substructure in bacterial cell division.

Kocaoglu O, Calvo RA, Sham LT, Cozy LM, Lanning BR, Francis S, Winkler ME, Kearns DB, Carlson EE.

ACS Chem Biol. 2012 Oct 19;7(10):1746-53. doi: 10.1021/cb300329r. Epub 2012 Aug 21. Erratum in: ACS Chem Biol. 2019 Jul 19;14(7):1672.

30.

Recent advances in pneumococcal peptidoglycan biosynthesis suggest new vaccine and antimicrobial targets.

Sham LT, Tsui HC, Land AD, Barendt SM, Winkler ME.

Curr Opin Microbiol. 2012 Apr;15(2):194-203. doi: 10.1016/j.mib.2011.12.013. Epub 2012 Jan 24. Review.

31.

Essential PcsB putative peptidoglycan hydrolase interacts with the essential FtsXSpn cell division protein in Streptococcus pneumoniae D39.

Sham LT, Barendt SM, Kopecky KE, Winkler ME.

Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):E1061-9. doi: 10.1073/pnas.1108323108. Epub 2011 Oct 17.

32.

Dynamic distribution of the SecA and SecY translocase subunits and septal localization of the HtrA surface chaperone/protease during Streptococcus pneumoniae D39 cell division.

Tsui HC, Keen SK, Sham LT, Wayne KJ, Winkler ME.

MBio. 2011 Oct 11;2(5). pii: e00202-11. doi: 10.1128/mBio.00202-11. Print 2011.

33.

DegU-phosphate activates expression of the anti-sigma factor FlgM in Bacillus subtilis.

Hsueh YH, Cozy LM, Sham LT, Calvo RA, Gutu AD, Winkler ME, Kearns DB.

Mol Microbiol. 2011 Aug;81(4):1092-108. doi: 10.1111/j.1365-2958.2011.07755.x. Epub 2011 Jul 18.

34.

The requirement for pneumococcal MreC and MreD is relieved by inactivation of the gene encoding PBP1a.

Land AD, Winkler ME.

J Bacteriol. 2011 Aug;193(16):4166-79. doi: 10.1128/JB.05245-11. Epub 2011 Jun 17.

35.
36.

Interplay between manganese and zinc homeostasis in the human pathogen Streptococcus pneumoniae.

Jacobsen FE, Kazmierczak KM, Lisher JP, Winkler ME, Giedroc DP.

Metallomics. 2011 Jan;3(1):38-41.

37.

Phenotypic landscape of a bacterial cell.

Nichols RJ, Sen S, Choo YJ, Beltrao P, Zietek M, Chaba R, Lee S, Kazmierczak KM, Lee KJ, Wong A, Shales M, Lovett S, Winkler ME, Krogan NJ, Typas A, Gross CA.

Cell. 2011 Jan 7;144(1):143-56. doi: 10.1016/j.cell.2010.11.052. Epub 2010 Dec 23.

38.

The putative hydrolase YycJ (WalJ) affects the coordination of cell division with DNA replication in Bacillus subtilis and may play a conserved role in cell wall metabolism.

Biller SJ, Wayne KJ, Winkler ME, Burkholder WF.

J Bacteriol. 2011 Feb;193(4):896-908. doi: 10.1128/JB.00594-10. Epub 2010 Dec 17.

39.

Instability of ackA (acetate kinase) mutations and their effects on acetyl phosphate and ATP amounts in Streptococcus pneumoniae D39.

Ramos-Montañez S, Kazmierczak KM, Hentchel KL, Winkler ME.

J Bacteriol. 2010 Dec;192(24):6390-400. doi: 10.1128/JB.00995-10. Epub 2010 Oct 15.

40.

The metalloregulatory zinc site in Streptococcus pneumoniae AdcR, a zinc-activated MarR family repressor.

Reyes-Caballero H, Guerra AJ, Jacobsen FE, Kazmierczak KM, Cowart D, Koppolu UM, Scott RA, Winkler ME, Giedroc DP.

J Mol Biol. 2010 Oct 22;403(2):197-216. doi: 10.1016/j.jmb.2010.08.030. Epub 2010 Sep 8.

41.

Localization and cellular amounts of the WalRKJ (VicRKX) two-component regulatory system proteins in serotype 2 Streptococcus pneumoniae.

Wayne KJ, Sham LT, Tsui HC, Gutu AD, Barendt SM, Keen SK, Winkler ME.

J Bacteriol. 2010 Sep;192(17):4388-94. doi: 10.1128/JB.00578-10. Epub 2010 Jul 9.

42.

Kinetic characterization of the WalRKSpn (VicRK) two-component system of Streptococcus pneumoniae: dependence of WalKSpn (VicK) phosphatase activity on its PAS domain.

Gutu AD, Wayne KJ, Sham LT, Winkler ME.

J Bacteriol. 2010 May;192(9):2346-58. doi: 10.1128/JB.01690-09. Epub 2010 Feb 26.

43.

Identification and characterization of noncoding small RNAs in Streptococcus pneumoniae serotype 2 strain D39.

Tsui HC, Mukherjee D, Ray VA, Sham LT, Feig AL, Winkler ME.

J Bacteriol. 2010 Jan;192(1):264-79. doi: 10.1128/JB.01204-09.

44.

Biosynthesis of Histidine.

Winkler ME, Ramos-Montañez S.

EcoSal Plus. 2009 Aug;3(2). doi: 10.1128/ecosalplus.3.6.1.9.

45.

Roles of rel(Spn) in stringent response, global regulation and virulence of serotype 2 Streptococcus pneumoniae D39.

Kazmierczak KM, Wayne KJ, Rechtsteiner A, Winkler ME.

Mol Microbiol. 2009 May;72(3):590-611. doi: 10.1111/j.1365-2958.2009.06669.x.

46.

Influences of capsule on cell shape and chain formation of wild-type and pcsB mutants of serotype 2 Streptococcus pneumoniae.

Barendt SM, Land AD, Sham LT, Ng WL, Tsui HC, Arnold RJ, Winkler ME.

J Bacteriol. 2009 May;191(9):3024-40. doi: 10.1128/JB.01505-08. Epub 2009 Mar 6.

47.

Essentiality, bypass, and targeting of the YycFG (VicRK) two-component regulatory system in gram-positive bacteria.

Winkler ME, Hoch JA.

J Bacteriol. 2008 Apr;190(8):2645-8. doi: 10.1128/JB.01682-07. Epub 2008 Feb 1. No abstract available.

48.

Serum-free differentiation of murine embryonic stem cells into alveolar type II epithelial cells.

Winkler ME, Mauritz C, Groos S, Kispert A, Menke S, Hoffmann A, Gruh I, Schwanke K, Haverich A, Martin U.

Cloning Stem Cells. 2008 Mar;10(1):49-64. doi: 10.1089/clo.2007.0075.

PMID:
18241124
49.

Polymorphism and regulation of the spxB (pyruvate oxidase) virulence factor gene by a CBS-HotDog domain protein (SpxR) in serotype 2 Streptococcus pneumoniae.

Ramos-Montañez S, Tsui HC, Wayne KJ, Morris JL, Peters LE, Zhang F, Kazmierczak KM, Sham LT, Winkler ME.

Mol Microbiol. 2008 Feb;67(4):729-46. doi: 10.1111/j.1365-2958.2007.06082.x. Epub 2007 Dec 19.

50.

Type II pneumocyte-restricted green fluorescent protein expression after lentiviral transduction of lung epithelial cells.

Wunderlich S, Gruh I, Winkler ME, Beier J, Radtke K, Schmiedl A, Groos S, Haverich A, Martin U.

Hum Gene Ther. 2008 Jan;19(1):39-52.

PMID:
18052721

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