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Items: 39


Introduction of a C-terminal hexa-lysine tag increases thermal stability of the LacDiNac binding adhesin (LabA) exodomain from Helicobacter pylori.

Paraskevopoulou V, Artiaga VG, Rowlinson R, Winkler GS, Gellert P, Stolnik S, Overman R, Falcone FH.

Protein Expr Purif. 2019 Nov;163:105446. doi: 10.1016/j.pep.2019.105446. Epub 2019 Jul 1.


1-Hydroxy-xanthine derivatives inhibit the human Caf1 nuclease and Caf1-containing nuclease complexes via Mg2+-dependent binding.

Airhihen B, Pavanello L, Jadhav GP, Fischer PM, Winkler GS.

FEBS Open Bio. 2019 Mar 7;9(4):717-727. doi: 10.1002/2211-5463.12605. eCollection 2019 Apr.


An Integrated Dyspepsia Module for First-year Pharmacy Students.

De Matteis CI, Randall MD, Harvey EJ, Morris A, Winkler GS, Boardman HF.

Am J Pharm Educ. 2019 Feb;83(1):6508. doi: 10.5688/ajpe6508.


The central region of CNOT1 and CNOT9 stimulates deadenylation by the Ccr4-Not nuclease module.

Pavanello L, Hall B, Airhihen B, Winkler GS.

Biochem J. 2018 Nov 9;475(21):3437-3450. doi: 10.1042/BCJ20180456.


Post-transcriptional Control of Tumor Cell Autonomous Metastatic Potential by CCR4-NOT Deadenylase CNOT7.

Faraji F, Hu Y, Yang HH, Lee MP, Winkler GS, Hafner M, Hunter KW.

PLoS Genet. 2016 Jan 25;12(1):e1005820. doi: 10.1371/journal.pgen.1005820. eCollection 2016 Jan.


Structural basis of Lewis(b) antigen binding by the Helicobacter pylori adhesin BabA.

Hage N, Howard T, Phillips C, Brassington C, Overman R, Debreczeni J, Gellert P, Stolnik S, Winkler GS, Falcone FH.

Sci Adv. 2015 Aug 14;1(7):e1500315. doi: 10.1126/sciadv.1500315. eCollection 2015 Aug.


Phosphonium Polymethacrylates for Short Interfering RNA Delivery: Effect of Polymer and RNA Structural Parameters on Polyplex Assembly and Gene Knockdown.

Loczenski Rose V, Shubber S, Sajeesh S, Spain SG, Puri S, Allen S, Lee DK, Winkler GS, Mantovani G.

Biomacromolecules. 2015 Nov 9;16(11):3480-90. doi: 10.1021/acs.biomac.5b00898. Epub 2015 Oct 7.


Discovery, synthesis and biochemical profiling of purine-2,6-dione derivatives as inhibitors of the human poly(A)-selective ribonuclease Caf1.

Jadhav GP, Kaur I, Maryati M, Airhihen B, Fischer PM, Winkler GS.

Bioorg Med Chem Lett. 2015 Oct 1;25(19):4219-24. doi: 10.1016/j.bmcl.2015.07.095. Epub 2015 Aug 6.


The enzyme activities of Caf1 and Ccr4 are both required for deadenylation by the human Ccr4-Not nuclease module.

Maryati M, Airhihen B, Winkler GS.

Biochem J. 2015 Jul 1;469(1):169-76. doi: 10.1042/BJ20150304. Epub 2015 May 6.


Improved expression and purification of the Helicobacter pylori adhesin BabA through the incorporation of a hexa-lysine tag.

Hage N, Renshaw JG, Winkler GS, Gellert P, Stolnik S, Falcone FH.

Protein Expr Purif. 2015 Feb;106:25-30. doi: 10.1016/j.pep.2014.10.009. Epub 2014 Oct 25.


Heterogeneity and complexity within the nuclease module of the Ccr4-Not complex.

Winkler GS, Balacco DL.

Front Genet. 2013 Dec 23;4:296. doi: 10.3389/fgene.2013.00296. Review.


A fluorescence-based assay suitable for quantitative analysis of deadenylase enzyme activity.

Maryati M, Kaur I, Jadhav GP, Olotu-Umoren L, Oveh B, Hashmi L, Fischer PM, Winkler GS.

Nucleic Acids Res. 2014 Mar;42(5):e30. doi: 10.1093/nar/gkt972. Epub 2013 Oct 28.


Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells.

Collins HM, Abdelghany MK, Messmer M, Yue B, Deeves SE, Kindle KB, Mantelingu K, Aslam A, Winkler GS, Kundu TK, Heery DM.

BMC Cancer. 2013 Jan 29;13:37. doi: 10.1186/1471-2407-13-37.


RNA decay machines: deadenylation by the Ccr4-not and Pan2-Pan3 complexes.

Wahle E, Winkler GS.

Biochim Biophys Acta. 2013 Jun-Jul;1829(6-7):561-70. doi: 10.1016/j.bbagrm.2013.01.003. Epub 2013 Jan 19.


The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex.

Doidge R, Mittal S, Aslam A, Winkler GS.

PLoS One. 2012;7(12):e51331. doi: 10.1371/journal.pone.0051331. Epub 2012 Dec 7.


Deadenylation of cytoplasmic mRNA by the mammalian Ccr4-Not complex.

Doidge R, Mittal S, Aslam A, Winkler GS.

Biochem Soc Trans. 2012 Aug;40(4):896-901. doi: 10.1042/BST20120074. Review.


The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4-Not complex contribute to the prevention of cell death and senescence.

Mittal S, Aslam A, Doidge R, Medica R, Winkler GS.

Mol Biol Cell. 2011 Mar 15;22(6):748-58. doi: 10.1091/mbc.E10-11-0898. Epub 2011 Jan 13.


The mammalian anti-proliferative BTG/Tob protein family.

Winkler GS.

J Cell Physiol. 2010 Jan;222(1):66-72. doi: 10.1002/jcp.21919. Review.


The Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferation.

Aslam A, Mittal S, Koch F, Andrau JC, Winkler GS.

Mol Biol Cell. 2009 Sep;20(17):3840-50. doi: 10.1091/mbc.E09-02-0146. Epub 2009 Jul 15.


E2-c-Cbl recognition is necessary but not sufficient for ubiquitination activity.

Huang A, de Jong RN, Wienk H, Winkler GS, Timmers HT, Boelens R.

J Mol Biol. 2009 Jan 16;385(2):507-19. doi: 10.1016/j.jmb.2008.10.044. Epub 2008 Nov 1.


Modulation of Ubc4p/Ubc5p-mediated stress responses by the RING-finger-dependent ubiquitin-protein ligase Not4p in Saccharomyces cerevisiae.

Mulder KW, Inagaki A, Cameroni E, Mousson F, Winkler GS, De Virgilio C, Collart MA, Timmers HT.

Genetics. 2007 May;176(1):181-92.


Human Ccr4-Not complex is a ligand-dependent repressor of nuclear receptor-mediated transcription.

Winkler GS, Mulder KW, Bardwell VJ, Kalkhoven E, Timmers HT.

EMBO J. 2006 Jul 12;25(13):3089-99. Epub 2006 Jun 15.


Menin links estrogen receptor activation to histone H3K4 trimethylation.

Dreijerink KM, Mulder KW, Winkler GS, Höppener JW, Lips CJ, Timmers HT.

Cancer Res. 2006 May 1;66(9):4929-35.


Structure-based approaches to create new E2-E3 enzyme pairs.

Winkler GS, Timmers HT.

Methods Enzymol. 2005;399:355-66.


DNA damage and replication stress induced transcription of RNR genes is dependent on the Ccr4-Not complex.

Mulder KW, Winkler GS, Timmers HT.

Nucleic Acids Res. 2005 Nov 7;33(19):6384-92. Print 2005.


Elongator interactions with nascent mRNA revealed by RNA immunoprecipitation.

Gilbert C, Kristjuhan A, Winkler GS, Svejstrup JQ.

Mol Cell. 2004 May 21;14(4):457-64.


Structural model of the UbcH5B/CNOT4 complex revealed by combining NMR, mutagenesis, and docking approaches.

Dominguez C, Bonvin AM, Winkler GS, van Schaik FM, Timmers HT, Boelens R.

Structure. 2004 Apr;12(4):633-44.


An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair.

Winkler GS, Albert TK, Dominguez C, Legtenberg YI, Boelens R, Timmers HT.

J Mol Biol. 2004 Mar 12;337(1):157-65.


Elongator is a histone H3 and H4 acetyltransferase important for normal histone acetylation levels in vivo.

Winkler GS, Kristjuhan A, Erdjument-Bromage H, Tempst P, Svejstrup JQ.

Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3517-22.


Purification and characterization of the human elongator complex.

Hawkes NA, Otero G, Winkler GS, Marshall N, Dahmus ME, Krappmann D, Scheidereit C, Thomas CL, Schiavo G, Erdjument-Bromage H, Tempst P, Svejstrup JQ.

J Biol Chem. 2002 Jan 25;277(4):3047-52. Epub 2001 Nov 19.


RNA polymerase II elongator holoenzyme is composed of two discrete subcomplexes.

Winkler GS, Petrakis TG, Ethelberg S, Tokunaga M, Erdjument-Bromage H, Tempst P, Svejstrup JQ.

J Biol Chem. 2001 Aug 31;276(35):32743-9. Epub 2001 Jul 2.


Novel functional interactions between nucleotide excision DNA repair proteins influencing the enzymatic activities of TFIIH, XPG, and ERCC1-XPF.

Winkler GS, Sugasawa K, Eker AP, de Laat WL, Hoeijmakers JH.

Biochemistry. 2001 Jan 9;40(1):160-5.


Cloning of a human homolog of the yeast nucleotide excision repair gene MMS19 and interaction with transcription repair factor TFIIH via the XPB and XPD helicases.

Seroz T, Winkler GS, Auriol J, Verhage RA, Vermeulen W, Smit B, Brouwer J, Eker AP, Weeda G, Egly JM, Hoeijmakers JH.

Nucleic Acids Res. 2000 Nov 15;28(22):4506-13.


TFIIH with inactive XPD helicase functions in transcription initiation but is defective in DNA repair.

Winkler GS, Araújo SJ, Fiedler U, Vermeulen W, Coin F, Egly JM, Hoeijmakers JH, Wood RD, Timmers HT, Weeda G.

J Biol Chem. 2000 Feb 11;275(6):4258-66.


Involvement of a nuclear matrix association region in the regulation of the SPRR2A keratinocyte terminal differentiation marker.

Fischer DF, van Drunen CM, Winkler GS, van de Putte P, Backendorf C.

Nucleic Acids Res. 1998 Dec 1;26(23):5288-94.


From a DNA helicase to brittle hair.

Winkler GS, Hoeijmakers JH.

Nat Genet. 1998 Oct;20(2):106-7. No abstract available.


Affinity purification of human DNA repair/transcription factor TFIIH using epitope-tagged xeroderma pigmentosum B protein.

Winkler GS, Vermeulen W, Coin F, Egly JM, Hoeijmakers JH, Weeda G.

J Biol Chem. 1998 Jan 9;273(2):1092-8.


The XPB subunit of repair/transcription factor TFIIH directly interacts with SUG1, a subunit of the 26S proteasome and putative transcription factor.

Weeda G, Rossignol M, Fraser RA, Winkler GS, Vermeulen W, van 't Veer LJ, Ma L, Hoeijmakers JH, Egly JM.

Nucleic Acids Res. 1997 Jun 15;25(12):2274-83.


Mammalian nucleotide excision repair and syndromes.

Vermeulen W, de Boer J, Citterio E, van Gool AJ, van der Horst GT, Jaspers NG, de Laat WL, Sijbers AM, van der Spek PJ, Sugasawa K, Weeda G, Winkler GS, Bootsma D, Egly JM, Hoeijmakers JH.

Biochem Soc Trans. 1997 Feb;25(1):309-15. Review. No abstract available.


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