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Items: 33

1.

Regulation of T cell alloimmunity by PI3Kγ and PI3Kδ.

Uehara M, McGrath MM, Ohori S, Solhjou Z, Banouni N, Routray S, Evans C, DiNitto JP, Elkhal A, Turka LA, Strom TB, Tullius SG, Winkler DG, Azzi J, Abdi R.

Nat Commun. 2017 Oct 16;8(1):951. doi: 10.1038/s41467-017-00982-x.

2.

The Selective Phosphoinoside-3-Kinase p110δ Inhibitor IPI-3063 Potently Suppresses B Cell Survival, Proliferation, and Differentiation.

Chiu H, Mallya S, Nguyen P, Mai A, Jackson LV, Winkler DG, DiNitto JP, Brophy EE, McGovern K, Kutok JL, Fruman DA.

Front Immunol. 2017 Jun 30;8:747. doi: 10.3389/fimmu.2017.00747. eCollection 2017.

3.

Corrigendum: PI3Kγ is a molecular switch that controls immune suppression.

Kaneda MM, Messer KS, Ralainirina N, Li H, Leem CJ, Gorjestani S, Woo G, Nguyen AV, Figueiredo CC, Foubert P, Schmid MC, Pink M, Winkler DG, Rausch M, Palombella VJ, Kutok J, McGovern K, Frazer KA, Wu X, Karin M, Sasik R, Cohen EE, Varner JA.

Nature. 2017 Feb 2;542(7639):124. doi: 10.1038/nature21026. Epub 2016 Dec 14. No abstract available.

PMID:
27974794
4.

PI3Kγ is a molecular switch that controls immune suppression.

Kaneda MM, Messer KS, Ralainirina N, Li H, Leem CJ, Gorjestani S, Woo G, Nguyen AV, Figueiredo CC, Foubert P, Schmid MC, Pink M, Winkler DG, Rausch M, Palombella VJ, Kutok J, McGovern K, Frazer KA, Wu X, Karin M, Sasik R, Cohen EE, Varner JA.

Nature. 2016 Nov 17;539(7629):437-442. doi: 10.1038/nature19834. Epub 2016 Sep 19. Erratum in: Nature. 2017 Feb 2;542(7639):124.

5.

Discovery of a Selective Phosphoinositide-3-Kinase (PI3K)-γ Inhibitor (IPI-549) as an Immuno-Oncology Clinical Candidate.

Evans CA, Liu T, Lescarbeau A, Nair SJ, Grenier L, Pradeilles JA, Glenadel Q, Tibbitts T, Rowley AM, DiNitto JP, Brophy EE, O'Hearn EL, Ali JA, Winkler DG, Goldstein SI, O'Hearn P, Martin CM, Hoyt JG, Soglia JR, Cheung C, Pink MM, Proctor JL, Palombella VJ, Tremblay MR, Castro AC.

ACS Med Chem Lett. 2016 Jul 22;7(9):862-7. doi: 10.1021/acsmedchemlett.6b00238. eCollection 2016 Sep 8.

6.

PI3K-δ and PI3K-γ inhibition by IPI-145 abrogates immune responses and suppresses activity in autoimmune and inflammatory disease models.

Winkler DG, Faia KL, DiNitto JP, Ali JA, White KF, Brophy EE, Pink MM, Proctor JL, Lussier J, Martin CM, Hoyt JG, Tillotson B, Murphy EL, Lim AR, Thomas BD, Macdougall JR, Ren P, Liu Y, Li LS, Jessen KA, Fritz CC, Dunbar JL, Porter JR, Rommel C, Palombella VJ, Changelian PS, Kutok JL.

Chem Biol. 2013 Nov 21;20(11):1364-74. doi: 10.1016/j.chembiol.2013.09.017. Epub 2013 Nov 7.

7.

Complement C3a, CpG oligos, and DNA/C3a complex stimulate IFN-α production in a receptor for advanced glycation end product-dependent manner.

Ruan BH, Li X, Winkler AR, Cunningham KM, Kuai J, Greco RM, Nocka KH, Fitz LJ, Wright JF, Pittman DD, Tan XY, Paulsen JE, Lin LL, Winkler DG.

J Immunol. 2010 Oct 1;185(7):4213-22. doi: 10.4049/jimmunol.1000863. Epub 2010 Sep 3.

8.

TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines.

Kuai J, Gregory B, Hill A, Pittman DD, Feldman JL, Brown T, Carito B, O'Toole M, Ramsey R, Adolfsson O, Shields KM, Dower K, Hall JP, Kurdi Y, Beech JT, Nanchahal J, Feldmann M, Foxwell BM, Brennan FM, Winkler DG, Lin LL.

Rheumatology (Oxford). 2009 Nov;48(11):1352-8. doi: 10.1093/rheumatology/kep235. Epub 2009 Aug 27.

PMID:
19713442
9.

Complex responses to a diverse environment.

Collins M, Winkler DG, Lin LL.

Genome Biol. 2008;9(6):311. doi: 10.1186/gb-2008-9-6-311. Epub 2008 Jun 3.

10.

Sclerostin inhibition of Wnt-3a-induced C3H10T1/2 cell differentiation is indirect and mediated by bone morphogenetic proteins.

Winkler DG, Sutherland MS, Ojala E, Turcott E, Geoghegan JC, Shpektor D, Skonier JE, Yu C, Latham JA.

J Biol Chem. 2005 Jan 28;280(4):2498-502. Epub 2004 Nov 12.

11.

Sclerostin promotes the apoptosis of human osteoblastic cells: a novel regulation of bone formation.

Sutherland MK, Geoghegan JC, Yu C, Turcott E, Skonier JE, Winkler DG, Latham JA.

Bone. 2004 Oct;35(4):828-35.

PMID:
15454089
12.

Unique regulation of SOST, the sclerosteosis gene, by BMPs and steroid hormones in human osteoblasts.

Sutherland MK, Geoghegan JC, Yu C, Winkler DG, Latham JA.

Bone. 2004 Aug;35(2):448-54.

PMID:
15268896
13.

Noggin and sclerostin bone morphogenetic protein antagonists form a mutually inhibitory complex.

Winkler DG, Yu C, Geoghegan JC, Ojala EW, Skonier JE, Shpektor D, Sutherland MK, Latham JA.

J Biol Chem. 2004 Aug 27;279(35):36293-8. Epub 2004 Jun 14.

14.

Osteocyte control of bone formation via sclerostin, a novel BMP antagonist.

Winkler DG, Sutherland MK, Geoghegan JC, Yu C, Hayes T, Skonier JE, Shpektor D, Jonas M, Kovacevich BR, Staehling-Hampton K, Appleby M, Brunkow ME, Latham JA.

EMBO J. 2003 Dec 1;22(23):6267-76.

15.

Identification of residues in the cysteine-rich domain of Raf-1 that control Ras binding and Raf-1 activity.

Winkler DG, Cutler RE Jr, Drugan JK, Campbell S, Morrison DK, Cooper JA.

J Biol Chem. 1998 Aug 21;273(34):21578-84.

16.

Identification and characterization of mutations in Ha-Ras that selectively decrease binding to cRaf-1.

Winkler DG, Johnson JC, Cooper JA, Vojtek AB.

J Biol Chem. 1997 Sep 26;272(39):24402-9.

17.

Modification of Ser59 in the unique N-terminal region of tyrosine kinase p56lck regulates specificity of its Src homology 2 domain.

Joung I, Kim T, Stolz LA, Payne G, Winkler DG, Walsh CT, Strominger JL, Shin J.

Proc Natl Acad Sci U S A. 1995 Jun 20;92(13):5778-82.

18.

Phosphorylation of Ser-42 and Ser-59 in the N-terminal region of the tyrosine kinase p56lck.

Winkler DG, Park I, Kim T, Payne NS, Walsh CT, Strominger JL, Shin J.

Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):5176-80.

19.

Purification and initial characterization of the lymphoid-cell protein-tyrosine kinase p56lck from a baculovirus expression system.

Ramer SE, Winkler DG, Carrera A, Roberts TM, Walsh CT.

Proc Natl Acad Sci U S A. 1991 Jul 15;88(14):6254-8.

20.
21.

Application of cell-image analysis to the diagnosis of cellular atypias in sputum: a review.

Greenberg SD, Hunter NR, Taylor GR, Swank PR, Winkler DG, Spjut HJ, Estrada RG, Grenia C, Clark M, Herson J.

Diagn Cytopathol. 1986 Apr-Jun;2(2):168-74.

PMID:
3522138
22.

Cell atypia profiles for monitoring preneoplastic changes in pulmonary squamous cell carcinogenesis.

Swank PR, Greenberg SD, Winkler DG, Taylor GR, Hunter NR, Montalvo J, Thompson JL, Spjut HJ, Estrada R.

Pathol Immunopathol Res. 1986;5(1):47-53. No abstract available.

PMID:
3774754
23.

The application of visual cell profiles in the study of premalignant atypias in sputum.

Swank PR, Greenberg SD, Montalvo J, Hunter NR, Spjut HJ, Estrada R, Winkler DG, Taylor GR.

Acta Cytol. 1985 May-Jun;29(3):373-8.

PMID:
3859138
24.

Precision cell location and relocation techniques. An application for cell image analysis.

Hunter NR, Taylor GR, Swank PR, Winkler DG, Thompson JL, Montalvo J, Greenberg SD, McFadyen GM, Estrada R.

Anal Quant Cytol. 1984 Jun;6(2):139-43.

PMID:
6380365
25.

A systems approach to cell image analysis.

Winkler DG, Thompson JL, Hunter NR, Taylor GR.

Monogr Clin Cytol. 1984;9:181-96. No abstract available.

PMID:
6387449
26.

Classification of bronchial epithelial atypias by the atypia status index.

Swank PR, Greenberg SD, Montalvo J, Hunter NR, Thompson JL, Winkler DG, Spjut HJ, Estrada R, Taylor GR.

Anal Quant Cytol. 1983 Dec;5(4):255-62.

PMID:
6670793
27.

Nuclear segmentation of bronchial epithelial cells by minimax and thresholding techniques. A comparison.

Swank PR, Greenberg SD, Winkler DG, Hunter NR, Spjut HJ, Estrada R, Taylor GR.

Anal Quant Cytol. 1983 Sep;5(3):153-8.

PMID:
6359993
28.

Visual cell profiles for quantitation of premalignant cells in sputum: a preliminary report.

Greenberg SD, Smith S, Swank PR, Winkler DG, Spjut HJ, Estrada R, Hunter N, Taylor GR.

Acta Cytol. 1982 Nov-Dec;26(6):809-13.

PMID:
6961717
29.

Image analysis of atypical bronchial squamous epithelial cells. A quantitative and qualitative examination of squamous cell carcinogenesis.

Winkler DG, Baky AA, Hunter NR, Greenberg SD, Rogers TD, Spjut HJ, Estrada R.

Anal Quant Cytol. 1981 Dec;3(4):295-98.

PMID:
7332157
30.

Nuclear boundary detection algorithm based on a minimax derivative statistic for atypical bronchial squamous epithelial cells.

Baky AA, Winkler DG, Hunter NR, Greenberg SD, Hodapp CJ, Kimzey SL.

Anal Quant Cytol. 1981 Mar;3(1):33-8.

PMID:
7015942
31.
32.

Aytpia status index of respiratory cells: a measurement for the detection and monitoring of neoplastic changes in squamous cell carcinogenesis.

Baky AA, Winkler DG, Hunter NR, Subach JA, Greenberg SD, Spjut HJ, Estrada R, Kimzey SL.

Anal Quant Cytol. 1980 Sep;2(3):175-85.

PMID:
7425438
33.

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