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Items: 1 to 50 of 171


Opioid-galanin receptor heteromers mediate the dopaminergic effects of opioids.

Cai NS, Quiroz C, Bonaventura J, Bonifazi A, Cole TO, Purks J, Billing AS, Massey E, Wagner M, Wish ED, Guitart X, Rea W, Lam S, Moreno E, Casadó-Anguera V, Greenblatt AD, Jacobson AE, Rice KC, Casadó V, Newman AH, Winkelman JW, Michaelides M, Weintraub E, Volkow ND, Belcher AM, Ferré S.

J Clin Invest. 2019 Mar 26;130:2730-2744. doi: 10.1172/JCI126912.


Biological and clinical insights from genetics of insomnia symptoms.

Lane JM, Jones SE, Dashti HS, Wood AR, Aragam KG, van Hees VT, Strand LB, Winsvold BS, Wang H, Bowden J, Song Y, Patel K, Anderson SG, Beaumont RN, Bechtold DA, Cade BE, Haas M, Kathiresan S, Little MA, Luik AI, Loudon AS, Purcell S, Richmond RC, Scheer FAJL, Schormair B, Tyrrell J, Winkelman JW, Winkelmann J; HUNT All In Sleep, Hveem K, Zhao C, Nielsen JB, Willer CJ, Redline S, Spiegelhalder K, Kyle SD, Ray DW, Zwart JA, Brumpton B, Frayling TM, Lawlor DA, Rutter MK, Weedon MN, Saxena R.

Nat Genet. 2019 Mar;51(3):387-393. doi: 10.1038/s41588-019-0361-7. Epub 2019 Feb 25.


Reply to: A note on rotigotine for restless legs syndrome after renal transplantation.

Salminen AV, Allen RP, Högl B, Inoue Y, Oertel W, Winkelman JW, Trenkwalder C, Sampaio C, Winkelmann J.

Mov Disord. 2019 Jan;34(1):152-153. doi: 10.1002/mds.27570. No abstract available.


Reply to: Safety of dopamine agonists for treating restless legs syndrome.

Salminen AV, Allen RP, Högl B, Inoue Y, Oertel W, Winkelman JW, Trenkwalder C, Sampaio C, Winkelmann J.

Mov Disord. 2019 Jan;34(1):150-151. doi: 10.1002/mds.27571. No abstract available.


Short Sleep Duration Is Associated With Increased Serum Homocysteine: Insights From a National Survey.

Chen TY, Winkelman JW, Mao WC, Yeh CB, Huang SY, Kao TW, Yang CCH, Kuo TBJ, Chen WL.

J Clin Sleep Med. 2019 Jan 15;15(1):139-148. doi: 10.5664/jcsm.7588.


Respiratory-Related Leg Movements of Sleep Are Associated With Serotonergic Antidepressants But Not Bupropion.

McCall CA, Winkelman JW.

J Clin Sleep Med. 2018 Sep 15;14(9):1569-1576. doi: 10.5664/jcsm.7338.


In Reply-Additional Safety Considerations Before Prescribing Opioids to Manage Restless Legs Syndrome.

Silber MH, Becker PM, Buchfuhrer MJ, Earley CJ, Ondo WG, Walters AS, Winkelman JW.

Mayo Clin Proc. 2018 Jul;93(7):955-956. doi: 10.1016/j.mayocp.2018.03.021. No abstract available.


Predictors of clinical response in a double-blind placebo controlled crossover trial of gabapentin enacarbil for restless legs syndrome.

Winkelman JW, Jaros MJ.

Sleep Med. 2018 Aug;48:1-7. doi: 10.1016/j.sleep.2018.04.001. Epub 2018 Apr 25.


Treatment of restless legs syndrome: Evidence-based review and implications for clinical practice (Revised 2017)§.

Winkelmann J, Allen RP, Högl B, Inoue Y, Oertel W, Salminen AV, Winkelman JW, Trenkwalder C, Sampaio C.

Mov Disord. 2018 Jul;33(7):1077-1091. doi: 10.1002/mds.27260. Epub 2018 May 14. Review.


Sleep EEG spectral power is correlated with subjective-objective discrepancy of sleep onset latency in major depressive disorder.

Kang SG, Mariani S, Marvin SA, Ko KP, Redline S, Winkelman JW.

Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jul 13;85:122-127. doi: 10.1016/j.pnpbp.2018.04.010. Epub 2018 Apr 19.


Evidence-based and consensus clinical practice guidelines for the iron treatment of restless legs syndrome/Willis-Ekbom disease in adults and children: an IRLSSG task force report.

Allen RP, Picchietti DL, Auerbach M, Cho YW, Connor JR, Earley CJ, Garcia-Borreguero D, Kotagal S, Manconi M, Ondo W, Ulfberg J, Winkelman JW; International Restless Legs Syndrome Study Group (IRLSSG).

Sleep Med. 2018 Jan;41:27-44. doi: 10.1016/j.sleep.2017.11.1126. Epub 2017 Nov 24.


The Appropriate Use of Opioids in the Treatment of Refractory Restless Legs Syndrome.

Silber MH, Becker PM, Buchfuhrer MJ, Earley CJ, Ondo WG, Walters AS, Winkelman JW; Scientific and Medical Advisory Board, Restless Legs Syndrome Foundation.

Mayo Clin Proc. 2018 Jan;93(1):59-67. doi: 10.1016/j.mayocp.2017.11.007.


Prospective study of restless legs syndrome and total and cardiovascular mortality among women.

Li Y, Li Y, Winkelman JW, Walters AS, Han J, Hu FB, Gao X.

Neurology. 2018 Jan 9;90(2):e135-e141. doi: 10.1212/WNL.0000000000004814. Epub 2017 Dec 15.


Obstructive Sleep Apnea as a Complication of Bipolar Disorder and Its Treatment: A Review and Approach to Management.

Moonga SS, Mischoulon D, Winkelman JW, Stern TA.

Prim Care Companion CNS Disord. 2017 Nov 30;19(6). pii: 17f02194. doi: 10.4088/PCC.17f02194. Review. No abstract available.


Lack of change in glucose metabolism in eszopiclone-treated primary insomnia patients.

Buxton OM, Pavlova MK, O'Connor SP, Wang W, Winkelman JW.

Nat Sci Sleep. 2017 Jul 18;9:187-198. doi: 10.2147/NSS.S130505. eCollection 2017.


The Use of Benzodiazepine Receptor Agonists and the Risk of Hospitalization for Pneumonia: A Nationwide Population-Based Nested Case-Control Study.

Chen TY, Winkelman JW, Mao WC, Liu CL, Hsu CY, Wu CS.

Chest. 2018 Jan;153(1):161-171. doi: 10.1016/j.chest.2017.07.030. Epub 2017 Aug 4.


Therapeutic Utility of Opioids for Restless Legs Syndrome.

Mackie SE, Winkelman JW.

Drugs. 2017 Aug;77(12):1337-1344. doi: 10.1007/s40265-017-0773-6. Review.


Author response: Practice guideline summary: Treatment of restless legs syndrome in adults: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology.

Allen RP, Armstrong MJ, Trenkwalder C, Zee PC, Winkelman JW.

Neurology. 2017 Jun 13;88(24):2337-2338. doi: 10.1212/WNL.0000000000004047. No abstract available.


Restless legs syndrome and cardiovascular disease: a research roadmap: A response.

Gottlieb DJ, Somers VK, Punjabi NM, Winkelman JW.

Sleep Med. 2017 Aug;36:181. doi: 10.1016/j.sleep.2017.05.002. Epub 2017 May 17. No abstract available.


Nocturnal leg cramps: Prevalence and associations with demographics, sleep disturbance symptoms, medical conditions, and cardiometabolic risk factors.

Grandner MA, Winkelman JW.

PLoS One. 2017 Jun 6;12(6):e0178465. doi: 10.1371/journal.pone.0178465. eCollection 2017.


A Novel Automated Slide-Based Technology for Visualization, Counting, and Characterization of the Formed Elements of Blood: A Proof of Concept Study.

Winkelman JW, Tanasijevic MJ, Zahniser DJ.

Arch Pathol Lab Med. 2017 Aug;141(8):1107-1112. doi: 10.5858/arpa.2016-0633-OA. Epub 2017 Apr 19.


Cognitive Behavioral Therapy Using a Mobile Application Synchronizable With Wearable Devices for Insomnia Treatment: A Pilot Study.

Kang SG, Kang JM, Cho SJ, Ko KP, Lee YJ, Lee HJ, Kim L, Winkelman JW.

J Clin Sleep Med. 2017 Apr 15;13(4):633-640. doi: 10.5664/jcsm.6564.


Restless legs syndrome and cardiovascular disease: a research roadmap.

Gottlieb DJ, Somers VK, Punjabi NM, Winkelman JW.

Sleep Med. 2017 Mar;31:10-17. doi: 10.1016/j.sleep.2016.08.008. Epub 2016 Oct 27. Review.


Prevalence of restless legs syndrome during detoxification from alcohol and opioids.

Mackie SE, McHugh RK, McDermott K, Griffin ML, Winkelman JW, Weiss RD.

J Subst Abuse Treat. 2017 Feb;73:35-39. doi: 10.1016/j.jsat.2016.10.001. Epub 2016 Oct 6.


World Association of Sleep Medicine (WASM) 2016 standards for recording and scoring leg movements in polysomnograms developed by a joint task force from the International and the European Restless Legs Syndrome Study Groups (IRLSSG and EURLSSG).

Ferri R, Fulda S, Allen RP, Zucconi M, Bruni O, Chokroverty S, Ferini-Strambi L, Frauscher B, Garcia-Borreguero D, Hirshkowitz M, Högl B, Inoue Y, Jahangir A, Manconi M, Marcus CL, Picchietti DL, Plazzi G, Winkelman JW, Zak RS; International and European Restless Legs Syndrome Study Groups (IRLSSG and EURLSSG).

Sleep Med. 2016 Oct;26:86-95. doi: 10.1016/j.sleep.2016.10.010. Epub 2016 Nov 7.


Practice guideline summary: Treatment of restless legs syndrome in adults: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology.

Winkelman JW, Armstrong MJ, Allen RP, Chaudhuri KR, Ondo W, Trenkwalder C, Zee PC, Gronseth GS, Gloss D, Zesiewicz T.

Neurology. 2016 Dec 13;87(24):2585-2593. Epub 2016 Nov 16.


A method to switch from oral dopamine agonists to rotigotine in patients with restless legs syndrome and mild augmentation.

Winkelman JW, Mackie SE, Mei LA, Platt S, Schoerning L.

Sleep Med. 2016 Aug;24:18-23. doi: 10.1016/j.sleep.2016.05.004. Epub 2016 Jun 23.


Guidelines for the first-line treatment of restless legs syndrome/Willis-Ekbom disease, prevention and treatment of dopaminergic augmentation: a combined task force of the IRLSSG, EURLSSG, and the RLS-foundation.

Garcia-Borreguero D, Silber MH, Winkelman JW, Högl B, Bainbridge J, Buchfuhrer M, Hadjigeorgiou G, Inoue Y, Manconi M, Oertel W, Ondo W, Winkelmann J, Allen RP.

Sleep Med. 2016 May;21:1-11. doi: 10.1016/j.sleep.2016.01.017. Epub 2016 Feb 23.


Probable insomnia is associated with future total energy intake and diet quality in men.

Cheng FW, Li Y, Winkelman JW, Hu FB, Rimm EB, Gao X.

Am J Clin Nutr. 2016 Aug;104(2):462-9. doi: 10.3945/ajcn.116.131060. Epub 2016 Jul 13.


Rotigotine's effect on PLM-associated blood pressure elevations in restless legs syndrome: An RCT.

Bauer A, Cassel W, Benes H, Kesper K, Rye D, Sica D, Winkelman JW, Bauer L, Grieger F, Joeres L, Moran K, Schollmayer E, Whitesides J, Carney HC, Walters AS, Oertel W, Trenkwalder C; SP0977 study investigators.

Neurology. 2016 May 10;86(19):1785-93. doi: 10.1212/WNL.0000000000002649. Epub 2016 Apr 13.


Sleep disordered breathing and cardiovascular risk in older patients initiating dialysis in the United States: a retrospective observational study using medicare data.

Tuohy CV, Montez-Rath ME, Turakhia M, Chang TI, Winkelman JW, Winkelmayer WC.

BMC Nephrol. 2016 Feb 9;17:16. doi: 10.1186/s12882-016-0229-3.


Rotigotine in Hemodialysis-Associated Restless Legs Syndrome: A Randomized Controlled Trial.

Dauvilliers Y, Benes H, Partinen M, Rauta V, Rifkin D, Dohin E, Goldammer N, Schollmayer E, Schröder H, Winkelman JW.

Am J Kidney Dis. 2016 Sep;68(3):434-43. doi: 10.1053/j.ajkd.2015.12.027. Epub 2016 Feb 3.


Association between sleeping difficulty and type 2 diabetes in women.

Li Y, Gao X, Winkelman JW, Cespedes EM, Jackson CL, Walters AS, Schernhammer E, Redline S, Hu FB.

Diabetologia. 2016 Apr;59(4):719-27. doi: 10.1007/s00125-015-3860-9. Epub 2016 Jan 28.


Response to Letter to the Editor: "Ferritin deficiency may deteriorate the symptoms of Restless Legs Syndrome".

Winkelman JW.

Sleep Med. 2016 Jun;22:105. doi: 10.1016/j.sleep.2015.09.012. Epub 2015 Oct 22. No abstract available.


Impact of Restless Legs Syndrome on Cardiovascular Autonomic Control.

Bertisch SM, Muresan C, Schoerning L, Winkelman JW, Taylor JA.

Sleep. 2016 Mar 1;39(3):565-71. doi: 10.5665/sleep.5528.


Genetic associations of periodic limb movements of sleep in the elderly for the MrOS sleep study.

Winkelman JW, Blackwell T, Stone K, Ancoli-Israel S, Tranah GJ, Redline S; Osteoporotic Fractures in Men (MrOS) Study Research Group.

Sleep Med. 2015 Nov;16(11):1360-1365. doi: 10.1016/j.sleep.2015.07.017. Epub 2015 Aug 11.


CLINICAL PRACTICE. Insomnia Disorder.

Winkelman JW.

N Engl J Med. 2015 Oct 8;373(15):1437-44. doi: 10.1056/NEJMcp1412740. Review. No abstract available.


Prevalence and associations of respiratory-related leg movements: the MrOS sleep study.

Aritake S, Blackwell T, Peters KW, Rueschman M, Mobley D, Morrical MG, Platt SF, Dam TT, Redline S, Winkelman JW; Osteoporotic Fractures in Men (MrOS) Study Research Group.

Sleep Med. 2015 Oct;16(10):1236-44. doi: 10.1016/j.sleep.2015.06.012. Epub 2015 Jun 30.


Restless Legs Syndrome in Patients With Chronic Kidney Disease.

Novak M, Winkelman JW, Unruh M.

Semin Nephrol. 2015 Jul;35(4):347-58. doi: 10.1016/j.semnephrol.2015.06.006. Review.


Restless Legs Syndrome and Psychiatric Disorders.

Mackie S, Winkelman JW.

Sleep Med Clin. 2015 Sep;10(3):351-7, xv. doi: 10.1016/j.jsmc.2015.05.009. Epub 2015 Jun 27. Review.


Long-Term Treatment of Restless Legs Syndrome (RLS): An Approach to Management of Worsening Symptoms, Loss of Efficacy, and Augmentation.

Mackie S, Winkelman JW.

CNS Drugs. 2015 May;29(5):351-7. doi: 10.1007/s40263-015-0250-2. Review.


An evidence-based recommendation for a new definition of respiratory-related leg movements.

Manconi M, Zavalko I, Fanfulla F, Winkelman JW, Fulda S.

Sleep. 2015 Feb 1;38(2):295-304. doi: 10.5665/sleep.4418.


Restless legs syndrome and central nervous system gamma-aminobutyric acid: preliminary associations with periodic limb movements in sleep and restless leg syndrome symptom severity.

Winkelman JW, Schoerning L, Platt S, Jensen JE.

Sleep Med. 2014 Oct;15(10):1225-30. doi: 10.1016/j.sleep.2014.05.019. Epub 2014 Jun 12.


Restless legs syndrome/Willis-Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria--history, rationale, description, and significance.

Allen RP, Picchietti DL, Garcia-Borreguero D, Ondo WG, Walters AS, Winkelman JW, Zucconi M, Ferri R, Trenkwalder C, Lee HB; International Restless Legs Syndrome Study Group.

Sleep Med. 2014 Aug;15(8):860-73. doi: 10.1016/j.sleep.2014.03.025. Epub 2014 May 17.


Comparison of pregabalin with pramipexole for restless legs syndrome.

Allen RP, Chen C, Garcia-Borreguero D, Polo O, DuBrava S, Miceli J, Knapp L, Winkelman JW.

N Engl J Med. 2014 Feb 13;370(7):621-31. doi: 10.1056/NEJMoa1303646.


National use of prescription medications for insomnia: NHANES 1999-2010.

Bertisch SM, Herzig SJ, Winkelman JW, Buettner C.

Sleep. 2014 Feb 1;37(2):343-9. doi: 10.5665/sleep.3410.


Valid measures of periodic leg movements (PLMs) during a suggested immobilization test using the PAM-RL leg activity monitors require adjusting detection parameters for noise and signal in each recording.

Yang MS, Montplaisir J, Desautels A, Winkelman JW, Cramer Bornemann MA, Earley CJ, Allen RP.

Sleep Med. 2014 Jan;15(1):132-7. doi: 10.1016/j.sleep.2013.08.788. Epub 2013 Oct 16.


Association between insomnia symptoms and mortality: a prospective study of U.S. men.

Li Y, Zhang X, Winkelman JW, Redline S, Hu FB, Stampfer M, Ma J, Gao X.

Circulation. 2014 Feb 18;129(7):737-46. doi: 10.1161/CIRCULATIONAHA.113.004500. Epub 2013 Nov 13.


Measuring sleep: accuracy, sensitivity, and specificity of wrist actigraphy compared to polysomnography.

Marino M, Li Y, Rueschman MN, Winkelman JW, Ellenbogen JM, Solet JM, Dulin H, Berkman LF, Buxton OM.

Sleep. 2013 Nov 1;36(11):1747-55. doi: 10.5665/sleep.3142.

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