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Items: 38


TSPO-PET and diffusion-weighted MRI for imaging a mouse model of infiltrative human glioma.

Pigeon H, Pérès EA, Truillet C, Jego B, Boumezbeur F, Caillé F, Zinnhardt B, Jacobs AH, Le Bihan D, Winkeler A.

Neuro Oncol. 2019 Jun 10;21(6):755-764. doi: 10.1093/neuonc/noz029.


Identification of new molecular targets for PET imaging of the microglial anti-inflammatory activation state.

Villa A, Klein B, Janssen B, Pedragosa J, Pepe G, Zinnhardt B, Vugts DJ, Gelosa P, Sironi L, Beaino W, Damont A, Dollé F, Jego B, Winkeler A, Ory D, Solin O, Vercouillie J, Funke U, Laner-Plamberger S, Blomster LV, Christophersen P, Vegeto E, Aigner L, Jacobs A, Planas AM, Maggi A, Windhorst AD.

Theranostics. 2018 Oct 27;8(19):5400-5418. doi: 10.7150/thno.25572. eCollection 2018.


From Structure-Activity Relationships on Thiazole Derivatives to the In Vivo Evaluation of a New Radiotracer for Cannabinoid Subtype 2 PET Imaging.

Caillé F, Cacheux F, Peyronneau MA, Jego B, Jaumain E, Pottier G, Ullmer C, Grether U, Winkeler A, Dollé F, Damont A, Kuhnast B.

Mol Pharm. 2017 Nov 6;14(11):4064-4078. doi: 10.1021/acs.molpharmaceut.7b00746. Epub 2017 Oct 18.


Combined PET Imaging of the Inflammatory Tumor Microenvironment Identifies Margins of Unique Radiotracer Uptake.

Zinnhardt B, Pigeon H, Thézé B, Viel T, Wachsmuth L, Fricke IB, Schelhaas S, Honold L, Schwegmann K, Wagner S, Faust A, Faber C, Kuhlmann MT, Hermann S, Schäfers M, Winkeler A, Jacobs AH.

Cancer Res. 2017 Apr 15;77(8):1831-1841. doi: 10.1158/0008-5472.CAN-16-2628. Epub 2017 Jan 30.


PET imaging of cannabinoid type 2 receptors with [11C]A-836339 did not evidence changes following neuroinflammation in rats.

Pottier G, Gómez-Vallejo V, Padro D, Boisgard R, Dollé F, Llop J, Winkeler A, Martín A.

J Cereb Blood Flow Metab. 2017 Mar;37(3):1163-1178. doi: 10.1177/0271678X16685105. Epub 2017 Jan 12.


Evaluation of PET Imaging Performance of the TSPO Radioligand [18F]DPA-714 in Mouse and Rat Models of Cancer and Inflammation.

Zheng J, Winkeler A, Peyronneau MA, Dollé F, Boisgard R.

Mol Imaging Biol. 2016 Feb;18(1):127-34. doi: 10.1007/s11307-015-0877-x.


The translocator protein radioligand 18F-DPA-714 monitors antitumor effect of erufosine in a rat 9L intracranial glioma model.

Awde AR, Boisgard R, Thézé B, Dubois A, Zheng J, Dollé F, Jacobs AH, Tavitian B, Winkeler A.

J Nucl Med. 2013 Dec;54(12):2125-31. doi: 10.2967/jnumed.112.118794. Epub 2013 Nov 8.


Analysis of the growth dynamics of angiogenesis-dependent and -independent experimental glioblastomas by multimodal small-animal PET and MRI.

Viel T, Talasila KM, Monfared P, Wang J, Jikeli JF, Waerzeggers Y, Neumaier B, Backes H, Brekka N, Thorsen F, Stieber D, Niclou SP, Winkeler A, Tavitian B, Hoehn M, Bjerkvig R, Miletic H, Jacobs AH.

J Nucl Med. 2012 Jul;53(7):1135-45. doi: 10.2967/jnumed.111.101659. Epub 2012 Jun 11.


Specific biomarkers of receptors, pathways of inhibition and targeted therapies: clinical applications.

Waerzeggers Y, Ullrich RT, Monfared P, Viel T, Weckesser M, Stummer W, Schober O, Winkeler A, Jacobs AH.

Br J Radiol. 2011 Dec;84 Spec No 2:S179-95. doi: 10.1259/bjr/76389842. Review.


Specific biomarkers of receptors, pathways of inhibition and targeted therapies: pre-clinical developments.

Waerzeggers Y, Monfared P, Viel T, Faust A, Kopka K, Schäfers M, Tavitian B, Winkeler A, Jacobs A.

Br J Radiol. 2011 Dec;84 Spec No 2:S168-78. doi: 10.1259/bjr/66405626. Review.


The translocator protein ligand [¹⁸F]DPA-714 images glioma and activated microglia in vivo.

Winkeler A, Boisgard R, Awde AR, Dubois A, Thézé B, Zheng J, Ciobanu L, Dollé F, Viel T, Jacobs AH, Tavitian B.

Eur J Nucl Med Mol Imaging. 2012 May;39(5):811-23. doi: 10.1007/s00259-011-2041-4. Epub 2012 Jan 21.


Imaging herpes simplex virus type 1 amplicon vector-mediated gene expression in human glioma spheroids.

Kaestle C, Winkeler A, Richter R, Sauer H, Hescheler J, Fraefel C, Wartenberg M, Jacobs AH.

Mol Imaging. 2011 Jun;10(3):197-205. doi: 10.2310/7290.2010.00036. Epub 2011 Mar 1.


Imaging bone morphogenetic protein 7 induced cell cycle arrest in experimental gliomas.

Klose A, Waerzeggers Y, Monfared P, Vukicevic S, Kaijzel EL, Winkeler A, Wickenhauser C, Löwik CW, Jacobs AH.

Neoplasia. 2011 Mar;13(3):276-85.


[18F]FLT PET for non-invasive monitoring of early response to gene therapy in experimental gliomas.

Rueger MA, Ameli M, Li H, Winkeler A, Rueckriem B, Vollmar S, Galldiks N, Hesselmann V, Fraefel C, Wienhard K, Heiss WD, Jacobs AH.

Mol Imaging Biol. 2011 Jun;13(3):547-557. doi: 10.1007/s11307-010-0361-6.


Mouse models in neurological disorders: applications of non-invasive imaging.

Waerzeggers Y, Monfared P, Viel T, Winkeler A, Jacobs AH.

Biochim Biophys Acta. 2010 Oct;1802(10):819-39. doi: 10.1016/j.bbadis.2010.04.009. Epub 2010 May 13. Review.


Radioisotopic imaging of neuroinflammation.

Winkeler A, Boisgard R, Martin A, Tavitian B.

J Nucl Med. 2010 Jan;51(1):1-4. doi: 10.2967/jnumed.109.065680. Epub 2009 Dec 15. Review.


Methods to monitor gene therapy with molecular imaging.

Waerzeggers Y, Monfared P, Viel T, Winkeler A, Voges J, Jacobs AH.

Methods. 2009 Jun;48(2):146-60. doi: 10.1016/j.ymeth.2009.03.007. Epub 2009 Mar 24. Review.


Early detection of erlotinib treatment response in NSCLC by 3'-deoxy-3'-[F]-fluoro-L-thymidine ([F]FLT) positron emission tomography (PET).

Ullrich RT, Zander T, Neumaier B, Koker M, Shimamura T, Waerzeggers Y, Borgman CL, Tawadros S, Li H, Sos ML, Backes H, Shapiro GI, Wolf J, Jacobs AH, Thomas RK, Winkeler A.

PLoS One. 2008;3(12):e3908. doi: 10.1371/journal.pone.0003908. Epub 2008 Dec 12.


Multimodal imaging of neural progenitor cell fate in rodents.

Waerzeggers Y, Klein M, Miletic H, Himmelreich U, Li H, Monfared P, Herrlinger U, Hoehn M, Coenen HH, Weller M, Winkeler A, Jacobs AH.

Mol Imaging. 2008 Mar-Apr;7(2):77-91.


Noninvasive assessment of E2F-1-mediated transcriptional regulation in vivo.

Monfared P, Winkeler A, Klein M, Li H, Klose A, Hoesel M, Waerzeggers Y, Korsching S, Jacobs AH.

Cancer Res. 2008 Jul 15;68(14):5932-40. doi: 10.1158/0008-5472.CAN-07-6373.


Molecular imaging-guided gene therapy of gliomas.

Rueger MA, Winkeler A, Thomas AV, Kracht LW, Jacobs AH.

Handb Exp Pharmacol. 2008;(185 Pt 2):341-59. doi: 10.1007/978-3-540-77496-9_15. Review.


Imaging noradrenergic influence on amyloid pathology in mouse models of Alzheimer's disease.

Winkeler A, Waerzeggers Y, Klose A, Monfared P, Thomas AV, Schubert M, Heneka MT, Jacobs AH.

Eur J Nucl Med Mol Imaging. 2008 Mar;35 Suppl 1:S107-13. doi: 10.1007/s00259-007-0710-0. Review.


In vivo evaluation of the uptake of [(123)I]FIAU, [(123)I]IVFRU and [(123)I]IVFAU by normal mouse brain: potential for noninvasive assessment of HSV-1 thymidine kinase gene expression in gliomas.

Li HF, Winkeler A, Moharram S, Knaus EE, Dittmar K, Stöckle M, Heiss WD, Wiebe LI, Jacobs AH.

Nucleosides Nucleotides Nucleic Acids. 2008 Jan;27(1):57-66. doi: 10.1080/15257770701571933. Erratum in: Nucleosides Nucleotides Nucleic Acids. 2008 Aug;27(8):1009.. Jacob, A J [corrected to Jacobs A H].


Normal brain cells contribute to the bystander effect in suicide gene therapy of malignant glioma.

Miletic H, Fischer YH, Giroglou T, Rueger MA, Winkeler A, Li H, Himmelreich U, Stenzel W, Jacobs AH, von Laer D.

Clin Cancer Res. 2007 Nov 15;13(22 Pt 1):6761-8.


Switching on the lights for gene therapy.

Winkeler A, Sena-Esteves M, Paulis LE, Li H, Waerzeggers Y, Rückriem B, Himmelreich U, Klein M, Monfared P, Rueger MA, Heneka M, Vollmar S, Hoehn M, Fraefel C, Graf R, Wienhard K, Heiss WD, Jacobs AH.

PLoS One. 2007 Jun 13;2(6):e528.


Multitracer positron emission tomographic imaging of exogenous gene expression mediated by a universal herpes simplex virus 1 amplicon vector.

Kummer C, Winkeler A, Dittmar C, Bauer B, Rueger MA, Rueckriem B, Heneka MT, Vollmar S, Wienhard K, Fraefel C, Heiss WD, Jacobs AH.

Mol Imaging. 2007 May-Jun;6(3):181-92.


Bystander killing of malignant glioma by bone marrow-derived tumor-infiltrating progenitor cells expressing a suicide gene.

Miletic H, Fischer Y, Litwak S, Giroglou T, Waerzeggers Y, Winkeler A, Li H, Himmelreich U, Lange C, Stenzel W, Deckert M, Neumann H, Jacobs AH, von Laer D.

Mol Ther. 2007 Jul;15(7):1373-81. Epub 2007 Apr 24.


Role of in vivo imaging of the central nervous system for developing novel drugs.

Rueger MA, Kracht LW, Hilker R, Thiel A, Sobesky J, Winkeler A, Thomas AV, Heneka MT, Graf R, Herholz K, Heiss WD, Jacobs AH.

Q J Nucl Med Mol Imaging. 2007 Jun;51(2):164-81. Review.


Imaging-guided gene therapy of experimental gliomas.

Jacobs AH, Rueger MA, Winkeler A, Li H, Vollmar S, Waerzeggers Y, Rueckriem B, Kummer C, Dittmar C, Klein M, Heneka MT, Herrlinger U, Fraefel C, Graf R, Wienhard K, Heiss WD.

Cancer Res. 2007 Feb 15;67(4):1706-15.


Variability in infectivity of primary cell cultures of human brain tumors with HSV-1 amplicon vectors.

Rueger MA, Winkeler A, Miletic H, Kaestle C, Richter R, Schneider G, Hilker R, Heneka MT, Ernestus RI, Hampl JA, Fraefel C, Jacobs AH.

Gene Ther. 2005 Apr;12(7):588-96.


Imaging in gene therapy of patients with glioma.

Jacobs AH, Voges J, Kracht LW, Dittmar C, Winkeler A, Thomas A, Wienhard K, Herholz K, Heiss WD.

J Neurooncol. 2003 Dec;65(3):291-305. Review.


BiP-dependent export of cholera toxin from endoplasmic reticulum-derived microsomes.

Winkeler A, Gödderz D, Herzog V, Schmitz A.

FEBS Lett. 2003 Nov 20;554(3):439-42.


Molecular imaging of gliomas.

Jacobs AH, Dittmar C, Winkeler A, Garlip G, Heiss WD.

Mol Imaging. 2002 Oct;1(4):309-35. Review.


PET-based molecular imaging in neuroscience.

Jacobs AH, Li H, Winkeler A, Hilker R, Knoess C, Rüger A, Galldiks N, Schaller B, Sobesky J, Kracht L, Monfared P, Klein M, Vollmar S, Bauer B, Wagner R, Graf R, Wienhard K, Herholz K, Heiss WD.

Eur J Nucl Med Mol Imaging. 2003 Jul;30(7):1051-65. Epub 2003 May 23. Review.


Improved herpes simplex virus type 1 amplicon vectors for proportional coexpression of positron emission tomography marker and therapeutic genes.

Jacobs AH, Winkeler A, Hartung M, Slack M, Dittmar C, Kummer C, Knoess C, Galldiks N, Vollmar S, Wienhard K, Heiss WD.

Hum Gene Ther. 2003 Feb 10;14(3):277-97.


Prospects of molecular imaging in neurology.

Jacobs AH, Winkeler A, Dittmar C, Hilker R, Heiss WD.

J Cell Biochem Suppl. 2002;39:98-109. Review.


Performance evaluation of the microPET R4 PET scanner for rodents.

Knoess C, Siegel S, Smith A, Newport D, Richerzhagen N, Winkeler A, Jacobs A, Goble RN, Graf R, Wienhard K, Heiss WD.

Eur J Nucl Med Mol Imaging. 2003 May;30(5):737-47. Epub 2003 Jan 21.


Cholera toxin is exported from microsomes by the Sec61p complex.

Schmitz A, Herrgen H, Winkeler A, Herzog V.

J Cell Biol. 2000 Mar 20;148(6):1203-12.

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