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Inducible nitric oxide synthase-derived extracellular nitric oxide flux regulates proinflammatory responses at the single cell level.

Somasundaram V, Gilmore AC, Basudhar D, Palmieri EM, Scheiblin DA, Heinz WF, Cheng RYS, Ridnour LA, Altan-Bonnet G, Lockett SJ, McVicar DW, Wink DA.

Redox Biol. 2020 Jan;28:101354. doi: 10.1016/j.redox.2019.101354. Epub 2019 Nov 1.


Nitric Oxide Donor DETA/NO Inhibits the Growth of Endometrial Cancer Cells by Upregulating the Expression of RASSF1 and CDKN1A.

Waheed S, Cheng RY, Casablanca Y, Maxwell GL, Wink DA, Syed V.

Molecules. 2019 Oct 16;24(20). pii: E3722. doi: 10.3390/molecules24203722.


NO and hepatocellular cancer.

Wang R, Geller DA, Wink DA, Cheng B, Billiar TR.

Br J Pharmacol. 2019 Aug 18. doi: 10.1111/bph.14838. [Epub ahead of print] Review.


Role of nitric oxide in pancreatic cancer cells exhibiting the invasive phenotype.

Fujita M, Somasundaram V, Basudhar D, Cheng RYS, Ridnour LA, Higuchi H, Imadome K, No JH, Bharadwaj G, Wink DA.

Redox Biol. 2019 Apr;22:101158. doi: 10.1016/j.redox.2019.101158. Epub 2019 Mar 6.


Understanding the tumour micro-environment communication network from an NOS2/COX2 perspective.

Basudhar D, Bharadwaj G, Somasundaram V, Cheng RYS, Ridnour LA, Fujita M, Lockett SJ, Anderson SK, McVicar DW, Wink DA.

Br J Pharmacol. 2019 Jan;176(2):155-176. doi: 10.1111/bph.14488. Epub 2018 Nov 6. Review.


Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors.

Weiss JM, Davies LC, Karwan M, Ileva L, Ozaki MK, Cheng RY, Ridnour LA, Annunziata CM, Wink DA, McVicar DW.

J Clin Invest. 2018 Aug 31;128(9):3794-3805. doi: 10.1172/JCI99169. Epub 2018 Jul 30.


Biological hydropersulfides and related polysulfides - a new concept and perspective in redox biology.

Fukuto JM, Ignarro LJ, Nagy P, Wink DA, Kevil CG, Feelisch M, Cortese-Krott MM, Bianco CL, Kumagai Y, Hobbs AJ, Lin J, Ida T, Akaike T.

FEBS Lett. 2018 Jun;592(12):2140-2152. doi: 10.1002/1873-3468.13090. Epub 2018 May 24. Review.


Molecular Mechanisms of Nitric Oxide in Cancer Progression, Signal Transduction, and Metabolism.

Somasundaram V, Basudhar D, Bharadwaj G, No JH, Ridnour LA, Cheng RYS, Fujita M, Thomas DD, Anderson SK, McVicar DW, Wink DA.

Antioxid Redox Signal. 2019 Mar 10;30(8):1124-1143. doi: 10.1089/ars.2018.7527. Epub 2018 May 2.


Design, synthesis and biological evaluation of hybrid nitroxide-based non-steroidal anti-inflammatory drugs.

Thomas K, Moody TW, Jensen RT, Tong J, Rayner CL, Barnett NL, Fairfull-Smith KE, Ridnour LA, Wink DA, Bottle SE.

Eur J Med Chem. 2018 Mar 10;147:34-47. doi: 10.1016/j.ejmech.2018.01.077. Epub 2018 Jan 31.


Coexpression of NOS2 and COX2 accelerates tumor growth and reduces survival in estrogen receptor-negative breast cancer.

Basudhar D, Glynn SA, Greer M, Somasundaram V, No JH, Scheiblin DA, Garrido P, Heinz WF, Ryan AE, Weiss JM, Cheng RYS, Ridnour LA, Lockett SJ, McVicar DW, Ambs S, Wink DA.

Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):13030-13035. doi: 10.1073/pnas.1709119114. Epub 2017 Oct 27.


NOS2 as an Emergent Player in Progression of Cancer.

Thomas DD, Wink DA.

Antioxid Redox Signal. 2017 Jun 10;26(17):963-965. doi: 10.1089/ars.2016.6835.


The Reactive Species Interactome: Evolutionary Emergence, Biological Significance, and Opportunities for Redox Metabolomics and Personalized Medicine.

Cortese-Krott MM, Koning A, Kuhnle GGC, Nagy P, Bianco CL, Pasch A, Wink DA, Fukuto JM, Jackson AA, van Goor H, Olson KR, Feelisch M.

Antioxid Redox Signal. 2017 Oct 1;27(10):684-712. doi: 10.1089/ars.2017.7083. Epub 2017 Jun 6. Review.


Regulation and control of nitric oxide (NO) in macrophages: Protecting the "professional killer cell" from its own cytotoxic arsenal via MRP1 and GSTP1.

Kovacevic Z, Sahni S, Lok H, Davies MJ, Wink DA, Richardson DR.

Biochim Biophys Acta Gen Subj. 2017 May;1861(5 Pt A):995-999. doi: 10.1016/j.bbagen.2017.02.021. Epub 2017 Feb 17. Review.


Inducible Nitric Oxide Synthase in the Carcinogenesis of Gastrointestinal Cancers.

de Oliveira GA, Cheng RYS, Ridnour LA, Basudhar D, Somasundaram V, McVicar DW, Monteiro HP, Wink DA.

Antioxid Redox Signal. 2017 Jun 20;26(18):1059-1077. doi: 10.1089/ars.2016.6850. Epub 2016 Oct 31. Review.


Autocrine IL-10 functions as a rheostat for M1 macrophage glycolytic commitment by tuning nitric oxide production.

Baseler WA, Davies LC, Quigley L, Ridnour LA, Weiss JM, Hussain SP, Wink DA, McVicar DW.

Redox Biol. 2016 Dec;10:12-23. doi: 10.1016/j.redox.2016.09.005. Epub 2016 Sep 16.


Nitric Oxide Synthase-2-Derived Nitric Oxide Drives Multiple Pathways of Breast Cancer Progression.

Basudhar D, Somasundaram V, de Oliveira GA, Kesarwala A, Heinecke JL, Cheng RY, Glynn SA, Ambs S, Wink DA, Ridnour LA.

Antioxid Redox Signal. 2017 Jun 20;26(18):1044-1058. doi: 10.1089/ars.2016.6813. Epub 2016 Sep 7. Review.


Thiol-Activated HNO Release from a Ruthenium Antiangiogenesis Complex and HIF-1α Inhibition for Cancer Therapy.

Silva Sousa EH, Ridnour LA, Gouveia FS Jr, Silva da Silva CD, Wink DA, de França Lopes LG, Sadler PJ.

ACS Chem Biol. 2016 Jul 15;11(7):2057-65. doi: 10.1021/acschembio.6b00222. Epub 2016 May 31.


Review of Triple Negative Breast Cancer and the Impact of Inducible Nitric Oxide Synthase on Tumor Biology and Patient Outcomes.

Walsh EM, Keane MM, Wink DA, Callagy G, Glynn SA.

Crit Rev Oncog. 2016;21(5-6):333-351. doi: 10.1615/CritRevOncog.2017021307.


Biological signaling by small inorganic molecules.

Basudhar D, Ridnour LA, Cheng R, Kesarwala AH, Heinecke J, Wink DA.

Coord Chem Rev. 2016 Jan 1;306(Pt 2):708-723.


In vitro Treatment with cis-[Ru(H-dcbpy-)2(Cl)(NO)] Improves the Endothelial Function in Aortic Rings with Endothelial Dysfunction.

Oishi JC, Buzinnari TC, Pestana CR, De Moraes TF, Vatanabe IP, Wink DA Jr, da Silva RS, Bendhack LM, Rodrigues GJ.

J Pharm Pharm Sci. 2015;18(5):696-704.


CD47 Receptor Globally Regulates Metabolic Pathways That Control Resistance to Ionizing Radiation.

Miller TW, Soto-Pantoja DR, Schwartz AL, Sipes JM, DeGraff WG, Ridnour LA, Wink DA, Roberts DD.

J Biol Chem. 2015 Oct 9;290(41):24858-74. doi: 10.1074/jbc.M115.665752. Epub 2015 Aug 26.


The Oncogenic Properties Of The Redox Inflammatory Protein Inducible Nitric Oxide Synthase In ER(-) Breast Cancer.

Wink DA, Ridnour LA, Cheng R, Switzer CW, Glynn S, Ambs S.

Redox Biol. 2015 Aug;5:413. doi: 10.1016/j.redox.2015.09.012. Epub 2015 Dec 30.


Signaling and stress: The redox landscape in NOS2 biology.

Thomas DD, Heinecke JL, Ridnour LA, Cheng RY, Kesarwala AH, Switzer CH, McVicar DW, Roberts DD, Glynn S, Fukuto JM, Wink DA, Miranda KM.

Free Radic Biol Med. 2015 Oct;87:204-25. doi: 10.1016/j.freeradbiomed.2015.06.002. Epub 2015 Jun 24. Review.


NOS Inhibition Modulates Immune Polarization and Improves Radiation-Induced Tumor Growth Delay.

Ridnour LA, Cheng RY, Weiss JM, Kaur S, Soto-Pantoja DR, Basudhar D, Heinecke JL, Stewart CA, DeGraff W, Sowers AL, Thetford A, Kesarwala AH, Roberts DD, Young HA, Mitchell JB, Trinchieri G, Wiltrout RH, Wink DA.

Cancer Res. 2015 Jul 15;75(14):2788-99. doi: 10.1158/0008-5472.CAN-14-3011. Epub 2015 May 19.


Chemotherapeutic potential of diazeniumdiolate-based aspirin prodrugs in breast cancer.

Basudhar D, Cheng RC, Bharadwaj G, Ridnour LA, Wink DA, Miranda KM.

Free Radic Biol Med. 2015 Jun;83:101-14. doi: 10.1016/j.freeradbiomed.2015.01.029. Epub 2015 Feb 4.


The impact of human and mouse differences in NOS2 gene expression on the brain's redox and immune environment.

Hoos MD, Vitek MP, Ridnour LA, Wilson J, Jansen M, Everhart A, Wink DA, Colton CA.

Mol Neurodegener. 2014 Nov 17;9:50. doi: 10.1186/1750-1326-9-50.


CD47 in the tumor microenvironment limits cooperation between antitumor T-cell immunity and radiotherapy.

Soto-Pantoja DR, Terabe M, Ghosh A, Ridnour LA, DeGraff WG, Wink DA, Berzofsky JA, Roberts DD.

Cancer Res. 2014 Dec 1;74(23):6771-83. doi: 10.1158/0008-5472.CAN-14-0037-T. Epub 2014 Oct 8.


Redox chemistry and chemical biology of H2S, hydropersulfides, and derived species: implications of their possible biological activity and utility.

Ono K, Akaike T, Sawa T, Kumagai Y, Wink DA, Tantillo DJ, Hobbs AJ, Nagy P, Xian M, Lin J, Fukuto JM.

Free Radic Biol Med. 2014 Dec;77:82-94. doi: 10.1016/j.freeradbiomed.2014.09.007. Epub 2014 Sep 16. Review.


Gene expression profiles of NO- and HNO-donor treated breast cancer cells: insights into tumor response and resistance pathways.

Cheng RY, Basudhar D, Ridnour LA, Heinecke JL, Kesarwala AH, Glynn S, Switzer CH, Ambs S, Miranda KM, Wink DA.

Nitric Oxide. 2014 Dec 1;43:17-28. doi: 10.1016/j.niox.2014.08.003. Epub 2014 Aug 19. Review.


Suberoylanilide hydroxamic acid radiosensitizes tumor hypoxic cells in vitro through the oxidation of nitroxyl to nitric oxide.

Samuni Y, Wink DA, Krishna MC, Mitchell JB, Goldstein S.

Free Radic Biol Med. 2014 Aug;73:291-8. doi: 10.1016/j.freeradbiomed.2014.05.019. Epub 2014 May 28.


Persulfides and the cellular thiol landscape.

Miranda KM, Wink DA.

Proc Natl Acad Sci U S A. 2014 May 27;111(21):7505-6. doi: 10.1073/pnas.1405665111. Epub 2014 May 14. No abstract available.


Tumor microenvironment-based feed-forward regulation of NOS2 in breast cancer progression.

Heinecke JL, Ridnour LA, Cheng RY, Switzer CH, Lizardo MM, Khanna C, Glynn SA, Hussain SP, Young HA, Ambs S, Wink DA.

Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):6323-8. doi: 10.1073/pnas.1401799111. Epub 2014 Apr 14.


Synthesis and chemical and biological comparison of nitroxyl- and nitric oxide-releasing diazeniumdiolate-based aspirin derivatives.

Basudhar D, Bharadwaj G, Cheng RY, Jain S, Shi S, Heinecke JL, Holland RJ, Ridnour LA, Caceres VM, Spadari-Bratfisch RC, Paolocci N, Velázquez-Martínez CA, Wink DA, Miranda KM.

J Med Chem. 2013 Oct 24;56(20):7804-20. doi: 10.1021/jm400196q. Epub 2013 Oct 8.


Biological nitric oxide signalling: chemistry and terminology.

Heinrich TA, da Silva RS, Miranda KM, Switzer CH, Wink DA, Fukuto JM.

Br J Pharmacol. 2013 Aug;169(7):1417-29. doi: 10.1111/bph.12217. Review.


Blockade of CD47 increases survival of mice exposed to lethal total body irradiation.

Soto-Pantoja DR, Ridnour LA, Wink DA, Roberts DD.

Sci Rep. 2013;3:1038. doi: 10.1038/srep01038. Epub 2013 Jan 8.


Molecular pathways: toll-like receptors in the tumor microenvironment--poor prognosis or new therapeutic opportunity.

Ridnour LA, Cheng RY, Switzer CH, Heinecke JL, Ambs S, Glynn S, Young HA, Trinchieri G, Wink DA.

Clin Cancer Res. 2013 Mar 15;19(6):1340-6. doi: 10.1158/1078-0432.CCR-12-0408. Epub 2012 Dec 27. Review.


Preparation and rearrangement of N-vinyl nitrones: synthesis of spiroisoxazolines and fluorene-tethered isoxazoles.

Mo DL, Wink DA, Anderson LL.

Org Lett. 2012 Oct 19;14(20):5180-3. doi: 10.1021/ol3022885. Epub 2012 Oct 9.


Nitric oxide-mediated regulation of β-amyloid clearance via alterations of MMP-9/TIMP-1.

Ridnour LA, Dhanapal S, Hoos M, Wilson J, Lee J, Cheng RY, Brueggemann EE, Hines HB, Wilcock DM, Vitek MP, Wink DA, Colton CA.

J Neurochem. 2012 Dec;123(5):736-49. doi: 10.1111/jnc.12028. Epub 2012 Oct 25.


Ets-1 is a transcriptional mediator of oncogenic nitric oxide signaling in estrogen receptor-negative breast cancer.

Switzer CH, Cheng RY, Ridnour LA, Glynn SA, Ambs S, Wink DA.

Breast Cancer Res. 2012 Sep 12;14(5):R125. doi: 10.1186/bcr3319.


Macrophages, nitric oxide and microRNAs are associated with DNA damage response pathway and senescence in inflammatory bowel disease.

Sohn JJ, Schetter AJ, Yfantis HG, Ridnour LA, Horikawa I, Khan MA, Robles AI, Hussain SP, Goto A, Bowman ED, Hofseth LJ, Bartkova J, Bartek J, Wogan GN, Wink DA, Harris CC.

PLoS One. 2012;7(9):e44156. doi: 10.1371/journal.pone.0044156. Epub 2012 Sep 6.


Nitric oxide synthase and breast cancer: role of TIMP-1 in NO-mediated Akt activation.

Ridnour LA, Barasch KM, Windhausen AN, Dorsey TH, Lizardo MM, Yfantis HG, Lee DH, Switzer CH, Cheng RY, Heinecke JL, Brueggemann E, Hines HB, Khanna C, Glynn SA, Ambs S, Wink DA.

PLoS One. 2012;7(9):e44081. doi: 10.1371/journal.pone.0044081. Epub 2012 Sep 5.


S-nitrosylation of EGFR and Src activates an oncogenic signaling network in human basal-like breast cancer.

Switzer CH, Glynn SA, Cheng RY, Ridnour LA, Green JE, Ambs S, Wink DA.

Mol Cancer Res. 2012 Sep;10(9):1203-15. Epub 2012 Aug 9.


CD47 deficiency confers cell and tissue radioprotection by activation of autophagy.

Soto-Pantoja DR, Miller TW, Pendrak ML, DeGraff WG, Sullivan C, Ridnour LA, Abu-Asab M, Wink DA, Tsokos M, Roberts DD.

Autophagy. 2012 Nov;8(11):1628-42. doi: 10.4161/auto.21562. Epub 2012 Aug 9.


Nitroxyl-mediated disulfide bond formation between cardiac myofilament cysteines enhances contractile function.

Gao WD, Murray CI, Tian Y, Zhong X, DuMond JF, Shen X, Stanley BA, Foster DB, Wink DA, King SB, Van Eyk JE, Paolocci N.

Circ Res. 2012 Sep 28;111(8):1002-11. Epub 2012 Jul 31.


Dithiolethiones inhibit NF-κB activity via covalent modification in human estrogen receptor-negative breast cancer.

Switzer CH, Cheng RY, Ridnour LA, Murray MC, Tazzari V, Sparatore A, Del Soldato P, Hines HB, Glynn SA, Ambs S, Wink DA.

Cancer Res. 2012 May 1;72(9):2394-404. doi: 10.1158/0008-5472.CAN-11-3115. Epub 2012 Mar 21.


β-Caryophyllene ameliorates cisplatin-induced nephrotoxicity in a cannabinoid 2 receptor-dependent manner.

Horváth B, Mukhopadhyay P, Kechrid M, Patel V, Tanchian G, Wink DA, Gertsch J, Pacher P.

Free Radic Biol Med. 2012 Apr 15;52(8):1325-33. doi: 10.1016/j.freeradbiomed.2012.01.014. Epub 2012 Jan 31.


Small molecule signaling agents: the integrated chemistry and biochemistry of nitrogen oxides, oxides of carbon, dioxygen, hydrogen sulfide, and their derived species.

Fukuto JM, Carrington SJ, Tantillo DJ, Harrison JG, Ignarro LJ, Freeman BA, Chen A, Wink DA.

Chem Res Toxicol. 2012 Apr 16;25(4):769-93. doi: 10.1021/tx2005234. Epub 2012 Feb 9. Review.


S-Nitrosation Mediates Multiple Pathways That Lead to Tumor Progression in Estrogen Receptor-Negative Breast Cancer.

Switzer CH, Ridnour LA, Cheng R, Heinecke J, Burke A, Glynn S, Ambs S, Wink DA.

For Immunopathol Dis Therap. 2012;3(2):117-124.


Activation of matrix metalloproteinases following anti-Aβ immunotherapy; implications for microhemorrhage occurrence.

Wilcock DM, Morgan D, Gordon MN, Taylor TL, Ridnour LA, Wink DA, Colton CA.

J Neuroinflammation. 2011 Sep 9;8:115. doi: 10.1186/1742-2094-8-115.


Nitric oxide and protein phosphatase 2A provide novel therapeutic opportunities in ER-negative breast cancer.

Switzer CH, Glynn SA, Ridnour LA, Cheng RY, Vitek MP, Ambs S, Wink DA.

Trends Pharmacol Sci. 2011 Nov;32(11):644-51. doi: 10.1016/ Epub 2011 Sep 4. Review.

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