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Items: 16

1.

Structure of the M2 muscarinic receptor-β-arrestin complex in a lipid nanodisc.

Staus DP, Hu H, Robertson MJ, Kleinhenz ALW, Wingler LM, Capel WD, Latorraca NR, Lefkowitz RJ, Skiniotis G.

Nature. 2020 Jan 16. doi: 10.1038/s41586-020-1954-0. [Epub ahead of print]

PMID:
31945772
2.

Detergent- and phospholipid-based reconstitution systems have differential effects on constitutive activity of G-protein-coupled receptors.

Staus DP, Wingler LM, Pichugin D, Prosser RS, Lefkowitz RJ.

J Biol Chem. 2019 Sep 6;294(36):13218-13223. doi: 10.1074/jbc.AC119.009848. Epub 2019 Jul 30.

PMID:
31362983
3.

Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody.

Wingler LM, McMahon C, Staus DP, Lefkowitz RJ, Kruse AC.

Cell. 2019 Jan 24;176(3):479-490.e12. doi: 10.1016/j.cell.2018.12.006. Epub 2019 Jan 10.

4.

Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations.

Wingler LM, Elgeti M, Hilger D, Latorraca NR, Lerch MT, Staus DP, Dror RO, Kobilka BK, Hubbell WL, Lefkowitz RJ.

Cell. 2019 Jan 24;176(3):468-478.e11. doi: 10.1016/j.cell.2018.12.005. Epub 2019 Jan 10.

5.

G protein-coupled receptor kinases (GRKs) orchestrate biased agonism at the β2-adrenergic receptor.

Choi M, Staus DP, Wingler LM, Ahn S, Pani B, Capel WD, Lefkowitz RJ.

Sci Signal. 2018 Aug 21;11(544). pii: eaar7084. doi: 10.1126/scisignal.aar7084.

PMID:
30131371
6.

Small-Molecule Positive Allosteric Modulators of the β2-Adrenoceptor Isolated from DNA-Encoded Libraries.

Ahn S, Pani B, Kahsai AW, Olsen EK, Husemoen G, Vestergaard M, Jin L, Zhao S, Wingler LM, Rambarat PK, Simhal RK, Xu TT, Sun LD, Shim PJ, Staus DP, Huang LY, Franch T, Chen X, Lefkowitz RJ.

Mol Pharmacol. 2018 Aug;94(2):850-861. doi: 10.1124/mol.118.111948. Epub 2018 May 16.

7.

Sortase ligation enables homogeneous GPCR phosphorylation to reveal diversity in β-arrestin coupling.

Staus DP, Wingler LM, Choi M, Pani B, Manglik A, Kruse AC, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3834-3839. doi: 10.1073/pnas.1722336115. Epub 2018 Mar 26.

8.

Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library.

Ahn S, Kahsai AW, Pani B, Wang QT, Zhao S, Wall AL, Strachan RT, Staus DP, Wingler LM, Sun LD, Sinnaeve J, Choi M, Cho T, Xu TT, Hansen GM, Burnett MB, Lamerdin JE, Bassoni DL, Gavino BJ, Husemoen G, Olsen EK, Franch T, Costanzi S, Chen X, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1708-1713. doi: 10.1073/pnas.1620645114. Epub 2017 Jan 27.

9.

Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation.

Staus DP, Strachan RT, Manglik A, Pani B, Kahsai AW, Kim TH, Wingler LM, Ahn S, Chatterjee A, Masoudi A, Kruse AC, Pardon E, Steyaert J, Weis WI, Prosser RS, Kobilka BK, Costa T, Lefkowitz RJ.

Nature. 2016 Jul 21;535(7612):448-52. Epub 2016 Jul 13.

10.

Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor.

Kahsai AW, Wisler JW, Lee J, Ahn S, Cahill Iii TJ, Dennison SM, Staus DP, Thomsen AR, Anasti KM, Pani B, Wingler LM, Desai H, Bompiani KM, Strachan RT, Qin X, Alam SM, Sullenger BA, Lefkowitz RJ.

Nat Chem Biol. 2016 Sep;12(9):709-16. doi: 10.1038/nchembio.2126. Epub 2016 Jul 11.

11.

Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor.

Aristotelous T, Ahn S, Shukla AK, Gawron S, Sassano MF, Kahsai AW, Wingler LM, Zhu X, Tripathi-Shukla P, Huang XP, Riley J, Besnard J, Read KD, Roth BL, Gilbert IH, Hopkins AL, Lefkowitz RJ, Navratilova I.

ACS Med Chem Lett. 2013 Oct 10;4(10):1005-1010. Epub 2013 Sep 3.

12.

Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies.

Staus DP, Wingler LM, Strachan RT, Rasmussen SG, Pardon E, Ahn S, Steyaert J, Kobilka BK, Lefkowitz RJ.

Mol Pharmacol. 2014 Mar;85(3):472-81. doi: 10.1124/mol.113.089516. Epub 2013 Dec 6.

13.

Transcriptional regulation improves the throughput of three-hybrid counter selections in Saccharomyces cerevisiae.

Harton MD, Wingler LM, Cornish VW.

Biotechnol J. 2013 Dec;8(12):1485-91. doi: 10.1002/biot.201300186. Epub 2013 Dec 4.

PMID:
24318638
14.

Gene assembly and combinatorial libraries in S. cerevisiae via reiterative recombination.

Ostrov N, Wingler LM, Cornish VW.

Methods Mol Biol. 2013;978:187-203. doi: 10.1007/978-1-62703-293-3_14.

PMID:
23423898
15.

Reiterative Recombination for the in vivo assembly of libraries of multigene pathways.

Wingler LM, Cornish VW.

Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15135-40. doi: 10.1073/pnas.1100507108. Epub 2011 Aug 26.

16.

A library approach for the discovery of customized yeast three-hybrid counter selections.

Wingler LM, Cornish VW.

Chembiochem. 2011 Mar 21;12(5):715-7. doi: 10.1002/cbic.201000543. Epub 2011 Feb 25. No abstract available.

PMID:
21404416

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