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The TYRP1-mediated protection of human tyrosinase activity does not involve stable interactions of tyrosinase domains.

Dolinska MB, Wingfield PT, Young KL 2nd, Sergeev YV.

Pigment Cell Melanoma Res. 2019 May 11. doi: 10.1111/pcmr.12791. [Epub ahead of print]


Structures of Hepatitis B Virus Core- and e-Antigen Immune Complexes Suggest Multi-point Inhibition.

Eren E, Watts NR, Dearborn AD, Palmer IW, Kaufman JD, Steven AC, Wingfield PT.

Structure. 2018 Oct 2;26(10):1314-1326.e4. doi: 10.1016/j.str.2018.06.012. Epub 2018 Aug 9.


Structure of an RNA Aptamer that Can Inhibit HIV-1 by Blocking Rev-Cognate RNA (RRE) Binding and Rev-Rev Association.

Dearborn AD, Eren E, Watts NR, Palmer IW, Kaufman JD, Steven AC, Wingfield PT.

Structure. 2018 Sep 4;26(9):1187-1195.e4. doi: 10.1016/j.str.2018.06.001. Epub 2018 Jul 12.


Membrane-associated human tyrosinase is an enzymatically active monomeric glycoprotein.

Kus NJ, Dolinska MB, Young KL 2nd, Dimitriadis EK, Wingfield PT, Sergeev YV.

PLoS One. 2018 Jun 5;13(6):e0198247. doi: 10.1371/journal.pone.0198247. eCollection 2018.


A new HIV-1 Rev structure optimizes interaction with target RNA (RRE) for nuclear export.

Watts NR, Eren E, Zhuang X, Wang YX, Steven AC, Wingfield PT.

J Struct Biol. 2018 Aug;203(2):102-108. doi: 10.1016/j.jsb.2018.03.011. Epub 2018 Mar 29.


HIV-1 gp41 transmembrane oligomerization monitored by FRET and FCS.

Schroeder S, Kaufman JD, Grunwald M, Walla PJ, Lakomek NA, Wingfield PT.

FEBS Lett. 2018 Mar;592(6):939-948. doi: 10.1002/1873-3468.13010. Epub 2018 Mar 5.


IL-12p35 induces expansion of IL-10 and IL-35-expressing regulatory B cells and ameliorates autoimmune disease.

Dambuza IM, He C, Choi JK, Yu CR, Wang R, Mattapallil MJ, Wingfield PT, Caspi RR, Egwuagu CE.

Nat Commun. 2017 Sep 28;8(1):719. doi: 10.1038/s41467-017-00838-4.


Chimeric rabbit/human Fab antibodies against the hepatitis Be-antigen and their potential applications in assays, characterization, and therapy.

Zhuang X, Watts NR, Palmer IW, Kaufman JD, Dearborn AD, Trenbeath JL, Eren E, Steven AC, Rader C, Wingfield PT.

J Biol Chem. 2017 Oct 6;292(40):16760-16772. doi: 10.1074/jbc.M117.802272. Epub 2017 Aug 23.


Purification of Recombinant Human Tyrosinase from Insect Larvae Infected with the Baculovirus Vector.

Dolinska MB, Wingfield PT, Sergeev YV.

Curr Protoc Protein Sci. 2017 Aug 1;89:6.15.1-6.15.12. doi: 10.1002/cpps.37.


BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency.

Afzali B, Grönholm J, Vandrovcova J, O'Brien C, Sun HW, Vanderleyden I, Davis FP, Khoder A, Zhang Y, Hegazy AN, Villarino AV, Palmer IW, Kaufman J, Watts NR, Kazemian M, Kamenyeva O, Keith J, Sayed A, Kasperaviciute D, Mueller M, Hughes JD, Fuss IJ, Sadiyah MF, Montgomery-Recht K, McElwee J, Restifo NP, Strober W, Linterman MA, Wingfield PT, Uhlig HH, Roychoudhuri R, Aitman TJ, Kelleher P, Lenardo MJ, O'Shea JJ, Cooper N, Laurence ADJ.

Nat Immunol. 2017 Jul;18(7):813-823. doi: 10.1038/ni.3753. Epub 2017 May 22.


N-Terminal Methionine Processing.

Wingfield PT.

Curr Protoc Protein Sci. 2017 Apr 3;88:6.14.1-6.14.3. doi: 10.1002/cpps.29.


Expression and Purification of ZASP Subdomains and Clinically Important Isoforms: High-Affinity Binding to G-Actin.

Watts NR, Zhuang X, Kaufman JD, Palmer IW, Dearborn AD, Coscia S, Blech-Hermoni Y, Alfano C, Pastore A, Mankodi A, Wingfield PT.

Biochemistry. 2017 Apr 11;56(14):2061-2070. doi: 10.1021/acs.biochem.7b00067. Epub 2017 Apr 3.


Oculocutaneous albinism type 1: link between mutations, tyrosinase conformational stability, and enzymatic activity.

Dolinska MB, Kus NJ, Farney SK, Wingfield PT, Brooks BP, Sergeev YV.

Pigment Cell Melanoma Res. 2017 Jan;30(1):41-52. doi: 10.1111/pcmr.12546.


The Structure of HIV-1 Rev Filaments Suggests a Bilateral Model for Rev-RRE Assembly.

DiMattia MA, Watts NR, Cheng N, Huang R, Heymann JB, Grimes JM, Wingfield PT, Stuart DI, Steven AC.

Structure. 2016 Jul 6;24(7):1068-80. doi: 10.1016/j.str.2016.04.015. Epub 2016 Jun 2.


An Investigation of Patient Preferences for Music Played Before Electroconvulsive Therapy.

Graff V, Wingfield P, Adams D, Rabinowitz T.

J ECT. 2016 Sep;32(3):192-6. doi: 10.1097/YCT.0000000000000315.


Overview of the purification of recombinant proteins.

Wingfield PT.

Curr Protoc Protein Sci. 2015 Apr 1;80:6.1.1-35. doi: 10.1002/0471140864.ps0601s80. Review.


Folding and Purification of Insoluble (Inclusion Body) Proteins from Escherichia coli.

Wingfield PT, Palmer I, Liang SM.

Curr Protoc Protein Sci. 2014 Nov 3;78:6.5.1-30. doi: 10.1002/0471140864.ps0605s78. Review.


Preparation of Soluble Proteins from Escherichia coli.

Wingfield PT.

Curr Protoc Protein Sci. 2014 Nov 3;78:6.2.1-22. doi: 10.1002/0471140864.ps0602s78. Review.


HIV-1 envelope protein gp41: an NMR study of dodecyl phosphocholine embedded gp41 reveals a dynamic prefusion intermediate conformation.

Lakomek NA, Kaufman JD, Stahl SJ, Wingfield PT.

Structure. 2014 Sep 2;22(9):1311-1321. doi: 10.1016/j.str.2014.06.016. Epub 2014 Aug 14.


Thermodynamic analysis of weak protein interactions using sedimentation equilibrium.

Sergeev YV, Dolinska MB, Wingfield PT.

Curr Protoc Protein Sci. 2014 Aug 1;77:20.13.1-15. doi: 10.1002/0471140864.ps2013s77. Review.


Activated STING in a vascular and pulmonary syndrome.

Liu Y, Jesus AA, Marrero B, Yang D, Ramsey SE, Sanchez GAM, Tenbrock K, Wittkowski H, Jones OY, Kuehn HS, Lee CR, DiMattia MA, Cowen EW, Gonzalez B, Palmer I, DiGiovanna JJ, Biancotto A, Kim H, Tsai WL, Trier AM, Huang Y, Stone DL, Hill S, Kim HJ, St Hilaire C, Gurprasad S, Plass N, Chapelle D, Horkayne-Szakaly I, Foell D, Barysenka A, Candotti F, Holland SM, Hughes JD, Mehmet H, Issekutz AC, Raffeld M, McElwee J, Fontana JR, Minniti CP, Moir S, Kastner DL, Gadina M, Steven AC, Wingfield PT, Brooks SR, Rosenzweig SD, Fleisher TA, Deng Z, Boehm M, Paller AS, Goldbach-Mansky R.

N Engl J Med. 2014 Aug 7;371(6):507-518. doi: 10.1056/NEJMoa1312625. Epub 2014 Jul 16.


A cell-penetrating antibody fragment against HIV-1 Rev has high antiviral activity: characterization of the paratope.

Zhuang X, Stahl SJ, Watts NR, DiMattia MA, Steven AC, Wingfield PT.

J Biol Chem. 2014 Jul 18;289(29):20222-33. doi: 10.1074/jbc.M114.581090. Epub 2014 May 30.


A conserved hydrogen-bonding network of P2 bis-tetrahydrofuran-containing HIV-1 protease inhibitors (PIs) with a protease active-site amino acid backbone aids in their activity against PI-resistant HIV.

Yedidi RS, Garimella H, Aoki M, Aoki-Ogata H, Desai DV, Chang SB, Davis DA, Fyvie WS, Kaufman JD, Smith DW, Das D, Wingfield PT, Maeda K, Ghosh AK, Mitsuya H.

Antimicrob Agents Chemother. 2014 Jul;58(7):3679-88. doi: 10.1128/AAC.00107-14. Epub 2014 Apr 21.


Interleukin-35 induces regulatory B cells that suppress autoimmune disease.

Wang RX, Yu CR, Dambuza IM, Mahdi RM, Dolinska MB, Sergeev YV, Wingfield PT, Kim SH, Egwuagu CE.

Nat Med. 2014 Jun;20(6):633-41. doi: 10.1038/nm.3554. Epub 2014 Apr 17. Erratum in: Nat Med. 2014 Jun;20(6). doi: 10.1038/nm.3554.


Assessment of differences in the conformational flexibility of hepatitis B virus core-antigen and e-antigen by hydrogen deuterium exchange-mass spectrometry.

Bereszczak JZ, Watts NR, Wingfield PT, Steven AC, Heck AJ.

Protein Sci. 2014 Jul;23(7):884-96. doi: 10.1002/pro.2470. Epub 2014 Apr 17.


Z-disc-associated, alternatively spliced, PDZ motif-containing protein (ZASP) mutations in the actin-binding domain cause disruption of skeletal muscle actin filaments in myofibrillar myopathy.

Lin X, Ruiz J, Bajraktari I, Ohman R, Banerjee S, Gribble K, Kaufman JD, Wingfield PT, Griggs RC, Fischbeck KH, Mankodi A.

J Biol Chem. 2014 May 9;289(19):13615-26. doi: 10.1074/jbc.M114.550418. Epub 2014 Mar 25.


Generation and use of antibody fragments for structural studies of proteins refractory to crystallization.

Stahl SJ, Watts NR, Wingfield PT.

Methods Mol Biol. 2014;1131:549-61. doi: 10.1007/978-1-62703-992-5_35.


Albinism-causing mutations in recombinant human tyrosinase alter intrinsic enzymatic activity.

Dolinska MB, Kovaleva E, Backlund P, Wingfield PT, Brooks BP, Sergeev YV.

PLoS One. 2014 Jan 2;9(1):e84494. doi: 10.1371/journal.pone.0084494. eCollection 2014.


Sizing up large protein complexes by electrospray ionisation-based electrophoretic mobility and native mass spectrometry: morphology selective binding of Fabs to hepatitis B virus capsids.

Bereszczak JZ, Havlik M, Weiss VU, Marchetti-Deschmann M, van Duijn E, Watts NR, Wingfield PT, Allmaier G, Steven AC, Heck AJ.

Anal Bioanal Chem. 2014 Feb;406(5):1437-46. doi: 10.1007/s00216-013-7548-z. Epub 2013 Dec 20.


An unusual topological structure of the HIV-1 Rev response element.

Fang X, Wang J, O'Carroll IP, Mitchell M, Zuo X, Wang Y, Yu P, Liu Y, Rausch JW, Dyba MA, Kjems J, Schwieters CD, Seifert S, Winans RE, Watts NR, Stahl SJ, Wingfield PT, Byrd RA, Le Grice SF, Rein A, Wang YX.

Cell. 2013 Oct 24;155(3):594-605. doi: 10.1016/j.cell.2013.10.008. Epub 2013 Oct 24.


Activation of virus uptake through induction of macropinocytosis with a novel polymerizing peptide.

Daniels SI, Soule EE, Davidoff KS, Bernbaum JG, Hu D, Maeda K, Stahl SJ, Naiman NE, Waheed AA, Freed EO, Wingfield P, Yarchoan R, Davis DA.

FASEB J. 2014 Jan;28(1):106-16. doi: 10.1096/fj.13-238113. Epub 2013 Oct 4.


P2' benzene carboxylic acid moiety is associated with decrease in cellular uptake: evaluation of novel nonpeptidic HIV-1 protease inhibitors containing P2 bis-tetrahydrofuran moiety.

Yedidi RS, Maeda K, Fyvie WS, Steffey M, Davis DA, Palmer I, Aoki M, Kaufman JD, Stahl SJ, Garimella H, Das D, Wingfield PT, Ghosh AK, Mitsuya H.

Antimicrob Agents Chemother. 2013 Oct;57(10):4920-7. doi: 10.1128/AAC.00868-13. Epub 2013 Jul 22.


Epitope-distal effects accompany the binding of two distinct antibodies to hepatitis B virus capsids.

Bereszczak JZ, Rose RJ, van Duijn E, Watts NR, Wingfield PT, Steven AC, Heck AJ.

J Am Chem Soc. 2013 May 1;135(17):6504-12. doi: 10.1021/ja402023x. Epub 2013 Apr 18.


IL-1 enhances expansion, effector function, tissue localization, and memory response of antigen-specific CD8 T cells.

Ben-Sasson SZ, Hogg A, Hu-Li J, Wingfield P, Chen X, Crank M, Caucheteux S, Ratner-Hurevich M, Berzofsky JA, Nir-Paz R, Paul WE.

J Exp Med. 2013 Mar 11;210(3):491-502. doi: 10.1084/jem.20122006. Epub 2013 Mar 4.


Internal dynamics of the homotrimeric HIV-1 viral coat protein gp41 on multiple time scales.

Lakomek NA, Kaufman JD, Stahl SJ, Louis JM, Grishaev A, Wingfield PT, Bax A.

Angew Chem Int Ed Engl. 2013 Apr 2;52(14):3911-5. doi: 10.1002/anie.201207266. Epub 2013 Feb 28. No abstract available.


Antigenic switching of hepatitis B virus by alternative dimerization of the capsid protein.

DiMattia MA, Watts NR, Stahl SJ, Grimes JM, Steven AC, Stuart DI, Wingfield PT.

Structure. 2013 Jan 8;21(1):133-142. doi: 10.1016/j.str.2012.10.017. Epub 2012 Dec 6.


Preparation and extraction of insoluble (inclusion-body) proteins from Escherichia coli.

Palmer I, Wingfield PT.

Curr Protoc Protein Sci. 2012 Nov;Chapter 6:Unit6.3. doi: 10.1002/0471140864.ps0603s70.


Specificity of an anti-capsid antibody associated with Hepatitis B Virus-related acute liver failure.

Wu W, Chen Z, Cheng N, Watts NR, Stahl SJ, Farci P, Purcell RH, Wingfield PT, Steven AC.

J Struct Biol. 2013 Jan;181(1):53-60. doi: 10.1016/j.jsb.2012.10.004. Epub 2012 Oct 16.


The UL36 tegument protein of herpes simplex virus 1 has a composite binding site at the capsid vertices.

Cardone G, Newcomb WW, Cheng N, Wingfield PT, Trus BL, Brown JC, Steven AC.

J Virol. 2012 Apr;86(8):4058-64. doi: 10.1128/JVI.00012-12. Epub 2012 Feb 15.


βB1-crystallin: thermodynamic profiles of molecular interactions.

Dolinska MB, Wingfield PT, Sergeev YV.

PLoS One. 2012;7(1):e29227. doi: 10.1371/journal.pone.0029227. Epub 2012 Jan 6.


Cryo-EM study of Hepatitis B virus core antigen capsids decorated with antibodies from a human patient.

Kandiah E, Watts NR, Cheng N, Cardone G, Stahl SJ, Heller T, Liang TJ, Wingfield PT, Steven AC.

J Struct Biol. 2012 Jan;177(1):145-51. doi: 10.1016/j.jsb.2011.10.003. Epub 2011 Oct 25.


Role of the propeptide in controlling conformation and assembly state of hepatitis B virus e-antigen.

Watts NR, Conway JF, Cheng N, Stahl SJ, Steven AC, Wingfield PT.

J Mol Biol. 2011 Jun 3;409(2):202-13. doi: 10.1016/j.jmb.2011.03.049. Epub 2011 Apr 2.


The initial step in human immunodeficiency virus type 1 GagProPol processing can be regulated by reversible oxidation.

Daniels SI, Davis DA, Soule EE, Stahl SJ, Tebbs IR, Wingfield P, Yarchoan R.

PLoS One. 2010 Oct 22;5(10):e13595. doi: 10.1371/journal.pone.0013595.


Squeezing protein shells: how continuum elastic models, molecular dynamics simulations, and experiments coalesce at the nanoscale.

Roos WH, Gibbons MM, Arkhipov A, Uetrecht C, Watts NR, Wingfield PT, Steven AC, Heck AJ, Schulten K, Klug WS, Wuite GJ.

Biophys J. 2010 Aug 9;99(4):1175-81. doi: 10.1016/j.bpj.2010.05.033.


Subunit exchange rates in Hepatitis B virus capsids are geometry- and temperature-dependent.

Uetrecht C, Watts NR, Stahl SJ, Wingfield PT, Steven AC, Heck AJ.

Phys Chem Chem Phys. 2010 Nov 7;12(41):13368-71. doi: 10.1039/c0cp00692k. Epub 2010 Jul 30.


Molecular basis for the high degree of antigenic cross-reactivity between hepatitis B virus capsids (HBcAg) and dimeric capsid-related protein (HBeAg): insights into the enigmatic nature of the e-antigen.

Watts NR, Vethanayagam JG, Ferns RB, Tedder RS, Harris A, Stahl SJ, Steven AC, Wingfield PT.

J Mol Biol. 2010 May 14;398(4):530-41. doi: 10.1016/j.jmb.2010.03.026. Epub 2010 Mar 20.


Implications of the HIV-1 Rev dimer structure at 3.2 A resolution for multimeric binding to the Rev response element.

DiMattia MA, Watts NR, Stahl SJ, Rader C, Wingfield PT, Stuart DI, Steven AC, Grimes JM.

Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5810-4. doi: 10.1073/pnas.0914946107. Epub 2010 Mar 15.


Generation and characterization of a chimeric rabbit/human Fab for co-crystallization of HIV-1 Rev.

Stahl SJ, Watts NR, Rader C, DiMattia MA, Mage RG, Palmer I, Kaufman JD, Grimes JM, Stuart DI, Steven AC, Wingfield PT.

J Mol Biol. 2010 Apr 2;397(3):697-708. doi: 10.1016/j.jmb.2010.01.061. Epub 2010 Feb 4.


Activator Gcn4 employs multiple segments of Med15/Gal11, including the KIX domain, to recruit mediator to target genes in vivo.

Jedidi I, Zhang F, Qiu H, Stahl SJ, Palmer I, Kaufman JD, Nadaud PS, Mukherjee S, Wingfield PT, Jaroniec CP, Hinnebusch AG.

J Biol Chem. 2010 Jan 22;285(4):2438-55. doi: 10.1074/jbc.M109.071589. Epub 2009 Nov 23.


N-terminal extension of beta B1-crystallin: identification of a critical region that modulates protein interaction with beta A3-crystallin.

Dolinska MB, Sergeev YV, Chan MP, Palmer I, Wingfield PT.

Biochemistry. 2009 Oct 13;48(40):9684-95. doi: 10.1021/bi9013984.

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