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The deubiquitinating enzyme USP19 modulates adipogenesis and potentiates high-fat-diet-induced obesity and glucose intolerance in mice.

Coyne ES, Bédard N, Gong YJ, Faraj M, Tchernof A, Wing SS.

Diabetologia. 2018 Nov 1. doi: 10.1007/s00125-018-4754-4. [Epub ahead of print]


Knockout of USP19 Deubiquitinating Enzyme Prevents Muscle Wasting by Modulating Insulin and Glucocorticoid Signaling.

Coyne ES, Bedard N, Wykes L, Stretch C, Jammoul S, Li S, Zhang K, Sladek RS, Bathe OF, Jagoe RT, Posner BI, Wing SS.

Endocrinology. 2018 Aug 1;159(8):2966-2977. doi: 10.1210/en.2018-00290.


The AMPK agonist 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation-associated cachectic muscle wasting.

Hall DT, Griss T, Ma JF, Sanchez BJ, Sadek J, Tremblay AMK, Mubaid S, Omer A, Ford RJ, Bedard N, Pause A, Wing SS, Di Marco S, Steinberg GR, Jones RG, Gallouzi IE.

EMBO Mol Med. 2018 Jul;10(7). pii: e8307. doi: 10.15252/emmm.201708307.


FAM210A is a novel determinant of bone and muscle structure and strength.

Tanaka KI, Xue Y, Nguyen-Yamamoto L, Morris JA, Kanazawa I, Sugimoto T, Wing SS, Richards JB, Goltzman D.

Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):E3759-E3768. doi: 10.1073/pnas.1719089115. Epub 2018 Apr 4.


Ubiquitin Ligase Huwe1 Modulates Spermatogenesis by Regulating Spermatogonial Differentiation and Entry into Meiosis.

Bose R, Sheng K, Moawad AR, Manku G, O'Flaherty C, Taketo T, Culty M, Fok KL, Wing SS.

Sci Rep. 2017 Dec 19;7(1):17759. doi: 10.1038/s41598-017-17902-0.


Huwe1 Regulates the Establishment and Maintenance of Spermatogonia by Suppressing DNA Damage Response.

Fok KL, Bose R, Sheng K, Chang CW, Katz-Egorov M, Culty M, Su S, Yang M, Ruan YC, Chan HC, Iavarone A, Lasorella A, Cencic R, Pelletier J, Nagano M, Xu W, Wing SS.

Endocrinology. 2017 Nov 1;158(11):4000-4016. doi: 10.1210/en.2017-00396.


Role of the deubiquitinating enzyme ubiquitin-specific protease-14 in proteostasis in renal cells.

Sareen-Khanna K, Papillon J, Wing SS, Cybulsky AV.

Am J Physiol Renal Physiol. 2016 Nov 1;311(5):F1035-F1046. doi: 10.1152/ajprenal.00252.2016. Epub 2016 Sep 14.


Proteolysis - A master regulator in health and disease.

Attaix D, Wing SS.

Int J Biochem Cell Biol. 2016 Oct;79:402. doi: 10.1016/j.biocel.2016.09.001. Epub 2016 Sep 3. No abstract available.


The ubiquitin proteasome system in atrophying skeletal muscle: roles and regulation.

Bilodeau PA, Coyne ES, Wing SS.

Am J Physiol Cell Physiol. 2016 Sep 1;311(3):C392-403. doi: 10.1152/ajpcell.00125.2016. Epub 2016 Aug 10. Review.


Deubiquitinating enzymes in skeletal muscle atrophy-An essential role for USP19.

Wing SS.

Int J Biochem Cell Biol. 2016 Oct;79:462-468. doi: 10.1016/j.biocel.2016.07.028. Epub 2016 Jul 27. Review.


The business of deubiquitination - location, location, location.

Coyne ES, Wing SS.

F1000Res. 2016 Feb 11;5. pii: F1000 Faculty Rev-163. doi: 10.12688/f1000research.7220.1. eCollection 2016. Review.


Inactivation of the ubiquitin-specific protease 19 deubiquitinating enzyme protects against muscle wasting.

Bédard N, Jammoul S, Moore T, Wykes L, Hallauer PL, Hastings KE, Stretch C, Baracos V, Chevalier S, Plourde M, Coyne E, Wing SS.

FASEB J. 2015 Sep;29(9):3889-98. doi: 10.1096/fj.15-270579. Epub 2015 Jun 5.


USP19 deubiquitinating enzyme inhibits muscle cell differentiation by suppressing unfolded-protein response signaling.

Wiles B, Miao M, Coyne E, Larose L, Cybulsky AV, Wing SS.

Mol Biol Cell. 2015 Mar 1;26(5):913-23. doi: 10.1091/mbc.E14-06-1129. Epub 2015 Jan 7.


USP2 regulates the intracellular localization of PER1 and circadian gene expression.

Yang Y, Duguay D, Fahrenkrug J, Cermakian N, Wing SS.

J Biol Rhythms. 2014 Aug;29(4):243-56. doi: 10.1177/0748730414544741.


A central role for ubiquitination within a circadian clock protein modification code.

Stojkovic K, Wing SS, Cermakian N.

Front Mol Neurosci. 2014 Aug 7;7:69. doi: 10.3389/fnmol.2014.00069. eCollection 2014. Review.


Ubiquitin-proteasome system in spermatogenesis.

Bose R, Manku G, Culty M, Wing SS.

Adv Exp Med Biol. 2014;759:181-213. doi: 10.1007/978-1-4939-0817-2_9. Review.


Deubiquitinases in skeletal muscle atrophy.

Wing SS.

Int J Biochem Cell Biol. 2013 Oct;45(10):2130-5. doi: 10.1016/j.biocel.2013.05.002. Epub 2013 May 13. Review.


Regulation of behavioral circadian rhythms and clock protein PER1 by the deubiquitinating enzyme USP2.

Yang Y, Duguay D, Bédard N, Rachalski A, Baquiran G, Na CH, Fahrenkrug J, Storch KF, Peng J, Wing SS, Cermakian N.

Biol Open. 2012 Aug 15;1(8):789-801. doi: 10.1242/bio.20121990. Epub 2012 Jun 28.


Expression of the ubiquitin proteasome system in neonatal rat gonocytes and spermatogonia: role in gonocyte differentiation.

Manku G, Wing SS, Culty M.

Biol Reprod. 2012 Aug 23;87(2):44. doi: 10.1095/biolreprod.112.099143. Print 2012 Aug.


Complement modulates the function of the ubiquitin-proteasome system and endoplasmic reticulum-associated degradation in glomerular epithelial cells.

Kitzler TM, Papillon J, Guillemette J, Wing SS, Cybulsky AV.

Biochim Biophys Acta. 2012 May;1823(5):1007-16. doi: 10.1016/j.bbamcr.2012.03.001. Epub 2012 Mar 8.


Targeting protein synthesis in a Myc/mTOR-driven model of anorexia-cachexia syndrome delays its onset and prolongs survival.

Robert F, Mills JR, Agenor A, Wang D, DiMarco S, Cencic R, Tremblay ML, Gallouzi IE, Hekimi S, Wing SS, Pelletier J.

Cancer Res. 2012 Feb 1;72(3):747-56. doi: 10.1158/0008-5472.CAN-11-2739. Epub 2011 Dec 12.


Ataxin-3 deubiquitination is coupled to Parkin ubiquitination via E2 ubiquitin-conjugating enzyme.

Durcan TM, Kontogiannea M, Bedard N, Wing SS, Fon EA.

J Biol Chem. 2012 Jan 2;287(1):531-41. doi: 10.1074/jbc.M111.288449. Epub 2011 Nov 11.


Protein from red cabbage (Brassica oleracea) seeds with antifungal, antibacterial, and anticancer activities.

Ye XJ, Ng TB, Wu ZJ, Xie LH, Fang EF, Wong JH, Pan WL, Wing SS, Zhang YB.

J Agric Food Chem. 2011 Sep 28;59(18):10232-8. doi: 10.1021/jf201874j. Epub 2011 Aug 24.


Proteolysis in illness-associated skeletal muscle atrophy: from pathways to networks.

Wing SS, Lecker SH, Jagoe RT.

Crit Rev Clin Lab Sci. 2011 Mar-Apr;48(2):49-70. doi: 10.3109/10408363.2011.586171. Epub 2011 Jun 24. Review.


Mice lacking the USP2 deubiquitinating enzyme have severe male subfertility associated with defects in fertilization and sperm motility.

Bedard N, Yang Y, Gregory M, Cyr DG, Suzuki J, Yu X, Chian RC, Hermo L, O'Flaherty C, Smith CE, Clarke HJ, Wing SS.

Biol Reprod. 2011 Sep;85(3):594-604. doi: 10.1095/biolreprod.110.088542. Epub 2011 May 4.


Identification of distinctive patterns of USP19-mediated growth regulation in normal and malignant cells.

Lu Y, Bedard N, Chevalier S, Wing SS.

PLoS One. 2011 Jan 17;6(1):e15936. doi: 10.1371/journal.pone.0015936.


Mechanisms involved in 3',5'-cyclic adenosine monophosphate-mediated inhibition of the ubiquitin-proteasome system in skeletal muscle.

Gonçalves DA, Lira EC, Baviera AM, Cao P, Zanon NM, Arany Z, Bedard N, Tanksale P, Wing SS, Lecker SH, Kettelhut IC, Navegantes LC.

Endocrinology. 2009 Dec;150(12):5395-404. doi: 10.1210/en.2009-0428. Epub 2009 Oct 16.


USP19-deubiquitinating enzyme regulates levels of major myofibrillar proteins in L6 muscle cells.

Sundaram P, Pang Z, Miao M, Yu L, Wing SS.

Am J Physiol Endocrinol Metab. 2009 Dec;297(6):E1283-90. doi: 10.1152/ajpendo.00409.2009. Epub 2009 Sep 22.


The UPS in diabetes and obesity.

Wing SS.

BMC Biochem. 2008 Oct 21;9 Suppl 1:S6. doi: 10.1186/1471-2091-9-S1-S6. Review.


USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1.

Lu Y, Adegoke OA, Nepveu A, Nakayama KI, Bedard N, Cheng D, Peng J, Wing SS.

Mol Cell Biol. 2009 Jan;29(2):547-58. doi: 10.1128/MCB.00329-08. Epub 2008 Nov 17. Erratum in: Mol Cell Biol. 2009 Jun;29(11):3241.


Fed-state clamp stimulates cellular mechanisms of muscle protein anabolism and modulates glucose disposal in normal men.

Adegoke OA, Chevalier S, Morais JA, Gougeon R, Kimball SR, Jefferson LS, Wing SS, Marliss EB.

Am J Physiol Endocrinol Metab. 2009 Jan;296(1):E105-13. doi: 10.1152/ajpendo.90752.2008. Epub 2008 Oct 28.


A new method of purification of proteasome substrates reveals polyubiquitination of 20 S proteasome subunits.

Ventadour S, Jarzaguet M, Wing SS, Chambon C, Combaret L, Béchet D, Attaix D, Taillandier D.

J Biol Chem. 2007 Feb 23;282(8):5302-9. Epub 2006 Dec 21.


Poly(A) binding protein (PABP) homeostasis is mediated by the stability of its inhibitor, Paip2.

Yoshida M, Yoshida K, Kozlov G, Lim NS, De Crescenzo G, Pang Z, Berlanga JJ, Kahvejian A, Gehring K, Wing SS, Sonenberg N.

EMBO J. 2006 May 3;25(9):1934-44. Epub 2006 Apr 6.


BH3-ligand regulates access of MCL-1 to its E3 ligase.

Warr MR, Acoca S, Liu Z, Germain M, Watson M, Blanchette M, Wing SS, Shore GC.

FEBS Lett. 2005 Oct 24;579(25):5603-8. Epub 2005 Sep 28.


Control of ubiquitination in skeletal muscle wasting.

Wing SS.

Int J Biochem Cell Biol. 2005 Oct;37(10):2075-87. Epub 2004 Dec 15. Review.


Mice lacking the UBC4-testis gene have a delay in postnatal testis development but normal spermatogenesis and fertility.

Bedard N, Hingamp P, Pang Z, Karaplis A, Morales C, Trasler J, Cyr D, Gagnon C, Wing SS.

Mol Cell Biol. 2005 Aug;25(15):6346-54.


A proinflammatory tumor that activates protein degradation sensitizes rats to catabolic effects of endotoxin.

Mackenzie ML, Bedard N, Wing SS, Baracos VE.

Am J Physiol Endocrinol Metab. 2005 Oct;289(4):E527-33. Epub 2005 Jun 7.


USP19 is a ubiquitin-specific protease regulated in rat skeletal muscle during catabolic states.

Combaret L, Adegoke OA, Bedard N, Baracos V, Attaix D, Wing SS.

Am J Physiol Endocrinol Metab. 2005 Apr;288(4):E693-700. Epub 2004 Nov 23.


Deubiquitinating enzymes--the importance of driving in reverse along the ubiquitin-proteasome pathway.

Wing SS.

Int J Biochem Cell Biol. 2003 May;35(5):590-605. Review.


Effect of heart failure on the regulation of skeletal muscle protein synthesis, breakdown, and apoptosis.

Persinger R, Janssen-Heininger Y, Wing SS, Matthews DE, LeWinter MM, Toth MJ.

Am J Physiol Endocrinol Metab. 2003 May;284(5):E1001-8. Epub 2003 Feb 11.


Characterization of rat100, a 300-kilodalton ubiquitin-protein ligase induced in germ cells of the rat testis and similar to the Drosophila hyperplastic discs gene.

Oughtred R, Bedard N, Adegoke OA, Morales CR, Trasler J, Rajapurohitam V, Wing SS.

Endocrinology. 2002 Oct;143(10):3740-7.


Cloning and characterization of an androgen receptor N-terminal-interacting protein with ubiquitin-protein ligase activity.

Beitel LK, Elhaji YA, Lumbroso R, Wing SS, Panet-Raymond V, Gottlieb B, Pinsky L, Trifiro MA.

J Mol Endocrinol. 2002 Aug;29(1):41-60.


Ubiquitin-conjugating enzyme E214k/HR6B is dispensable for increased protein catabolism in muscle of fasted mice.

Adegoke OA, Bédard N, Roest HP, Wing SS.

Am J Physiol Endocrinol Metab. 2002 Sep;283(3):E482-9.


Control of ubiquitination of proteins in rat tissues by ubiquitin conjugating enzymes and isopeptidases.

Rajapurohitam V, Bedard N, Wing SS.

Am J Physiol Endocrinol Metab. 2002 Apr;282(4):E739-45.


Divergent N-terminal sequences of a deubiquitinating enzyme modulate substrate specificity.

Lin H, Yin L, Reid J, Wilkinson KD, Wing SS.

J Biol Chem. 2001 Jun 8;276(23):20357-63. Epub 2001 Mar 13.


Divergent N-terminal sequences target an inducible testis deubiquitinating enzyme to distinct subcellular structures.

Lin H, Keriel A, Morales CR, Bedard N, Zhao Q, Hingamp P, Lefrançois S, Combaret L, Wing SS.

Mol Cell Biol. 2000 Sep;20(17):6568-78.

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