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Microtubule glycylation promotes attachment of basal bodies to the cell cortex.

Junker AD, Soh AWJ, O'Toole ET, Meehl JB, Guha M, Winey M, Honts JE, Gaertig J, Pearson CG.

J Cell Sci. 2019 Aug 7;132(15). pii: jcs233726. doi: 10.1242/jcs.233726.


Tetrahymena RIB72A and RIB72B are microtubule inner proteins in the ciliary doublet microtubules.

Stoddard D, Zhao Y, Bayless BA, Gui L, Louka P, Dave D, Suryawanshi S, Tomasi RF, Dupuis-Williams P, Baroud CN, Gaertig J, Winey M, Nicastro D.

Mol Biol Cell. 2018 Oct 15;29(21):2566-2577. doi: 10.1091/mbc.E18-06-0405. Epub 2018 Aug 22.


Key phosphorylation events in Spc29 and Spc42 guide multiple steps of yeast centrosome duplication.

Jones MH, O'Toole ET, Fabritius AS, Muller EG, Meehl JB, Jaspersen SL, Winey M.

Mol Biol Cell. 2018 Sep 15;29(19):2280-2291. doi: 10.1091/mbc.E18-05-0296. Epub 2018 Jul 25.


The molecular architecture of the yeast spindle pole body core determined by Bayesian integrative modeling.

Viswanath S, Bonomi M, Kim SJ, Klenchin VA, Taylor KC, Yabut KC, Umbreit NT, Van Epps HA, Meehl J, Jones MH, Russel D, Velazquez-Muriel JA, Winey M, Rayment I, Davis TN, Sali A, Muller EG.

Mol Biol Cell. 2017 Nov 7;28(23):3298-3314. doi: 10.1091/mbc.E17-06-0397. Epub 2017 Aug 16.


Building Cell Structures in Three Dimensions: Electron Tomography Methods for Budding Yeast.

O'Toole ET, Giddings TH Jr, Winey M.

Cold Spring Harb Protoc. 2017 Mar 1;2017(3). doi: 10.1101/pdb.top077685.


Cryopreparation and Electron Tomography of Yeast Cells.

O'Toole ET, Giddings TH Jr, Winey M.

Cold Spring Harb Protoc. 2017 Mar 1;2017(3). doi: 10.1101/pdb.prot085589.


Sfr1, a Tetrahymena thermophila Sfi1 Repeat Protein, Modulates the Production of Cortical Row Basal Bodies.

Heydeck W, Stemm-Wolf AJ, Knop J, Poh CC, Winey M.

mSphere. 2016 Nov 16;1(6). pii: e00257-16. eCollection 2016 Nov-Dec.


Tetrahymena Poc1 ensures proper intertriplet microtubule linkages to maintain basal body integrity.

Meehl JB, Bayless BA, Giddings TH Jr, Pearson CG, Winey M.

Mol Biol Cell. 2016 Aug 1;27(15):2394-403. doi: 10.1091/mbc.E16-03-0165. Epub 2016 Jun 1.


Identifying domains of EFHC1 involved in ciliary localization, ciliogenesis, and the regulation of Wnt signaling.

Zhao Y, Shi J, Winey M, Klymkowsky MW.

Dev Biol. 2016 Mar 15;411(2):257-265. doi: 10.1016/j.ydbio.2016.01.004. Epub 2016 Jan 16.


Structured illumination with particle averaging reveals novel roles for yeast centrosome components during duplication.

Burns S, Avena JS, Unruh JR, Yu Z, Smith SE, Slaughter BD, Winey M, Jaspersen SL.

Elife. 2015 Sep 15;4. doi: 10.7554/eLife.08586.


Centrin-2 (Cetn2) mediated regulation of FGF/FGFR gene expression in Xenopus.

Shi J, Zhao Y, Vonderfecht T, Winey M, Klymkowsky MW.

Sci Rep. 2015 May 27;5:10283. doi: 10.1038/srep10283.


Metallothionein as a clonable tag for protein localization by electron microscopy of cells.

Morphew MK, O'Toole ET, Page CL, Pagratis M, Meehl J, Giddings T, Gardner JM, Ackerson C, Jaspersen SL, Winey M, Hoenger A, McIntosh JR.

J Microsc. 2015 Oct;260(1):20-9. doi: 10.1111/jmi.12262. Epub 2015 May 13.


Interaction of CK1δ with γTuSC ensures proper microtubule assembly and spindle positioning.

Peng Y, Moritz M, Han X, Giddings TH, Lyon A, Kollman J, Winey M, Yates J 3rd, Agard DA, Drubin DG, Barnes G.

Mol Biol Cell. 2015 Jul 1;26(13):2505-18. doi: 10.1091/mbc.E14-12-1627. Epub 2015 May 13.


The kinetochore protein, CENPF, is mutated in human ciliopathy and microcephaly phenotypes.

Waters AM, Asfahani R, Carroll P, Bicknell L, Lescai F, Bright A, Chanudet E, Brooks A, Christou-Savina S, Osman G, Walsh P, Bacchelli C, Chapgier A, Vernay B, Bader DM, Deshpande C, O' Sullivan M, Ocaka L, Stanescu H, Stewart HS, Hildebrandt F, Otto E, Johnson CA, Szymanska K, Katsanis N, Davis E, Kleta R, Hubank M, Doxsey S, Jackson A, Stupka E, Winey M, Beales PL.

J Med Genet. 2015 Mar;52(3):147-56. doi: 10.1136/jmedgenet-2014-102691. Epub 2015 Jan 6. Erratum in: J Med Genet. 2016 Oct 13;:.


Licensing of yeast centrosome duplication requires phosphoregulation of sfi1.

Avena JS, Burns S, Yu Z, Ebmeier CC, Old WM, Jaspersen SL, Winey M.

PLoS Genet. 2014 Oct 23;10(10):e1004666. doi: 10.1371/journal.pgen.1004666. eCollection 2014 Oct.


Chromosomal attachments set length and microtubule number in the Saccharomyces cerevisiae mitotic spindle.

Nannas NJ, O'Toole ET, Winey M, Murray AW.

Mol Biol Cell. 2014 Dec 15;25(25):4034-48. doi: 10.1091/mbc.E14-01-0016. Epub 2014 Oct 15.


Minus-end-directed Kinesin-14 motors align antiparallel microtubules to control metaphase spindle length.

Hepperla AJ, Willey PT, Coombes CE, Schuster BM, Gerami-Nejad M, McClellan M, Mukherjee S, Fox J, Winey M, Odde DJ, O'Toole E, Gardner MK.

Dev Cell. 2014 Oct 13;31(1):61-72. doi: 10.1016/j.devcel.2014.07.023.


Chibby functions in Xenopus ciliary assembly, embryonic development, and the regulation of gene expression.

Shi J, Zhao Y, Galati D, Winey M, Klymkowsky MW.

Dev Biol. 2014 Nov 15;395(2):287-98. doi: 10.1016/j.ydbio.2014.09.008. Epub 2014 Sep 16.


Function of the male-gamete-specific fusion protein HAP2 in a seven-sexed ciliate.

Cole ES, Cassidy-Hanley D, Fricke Pinello J, Zeng H, Hsueh M, Kolbin D, Ozzello C, Giddings T Jr, Winey M, Clark TG.

Curr Biol. 2014 Sep 22;24(18):2168-2173. doi: 10.1016/j.cub.2014.07.064. Epub 2014 Aug 21.


Membrane dynamics at the nuclear exchange junction during early mating (one to four hours) in the ciliate Tetrahymena thermophila.

Cole ES, Giddings TH Jr, Ozzello C, Winey M, O'Toole E, Orias J, Hamilton E, Guerrier S, Ballard A, Aronstein T.

Eukaryot Cell. 2015 Feb;14(2):116-27. doi: 10.1128/EC.00164-14. Epub 2014 Aug 8.


Centriole structure.

Winey M, O'Toole E.

Philos Trans R Soc Lond B Biol Sci. 2014 Sep 5;369(1650). pii: 20130457. doi: 10.1098/rstb.2013.0457. Review.


Conventional transmission electron microscopy.

Winey M, Meehl JB, O'Toole ET, Giddings TH Jr.

Mol Biol Cell. 2014 Feb;25(3):319-23. doi: 10.1091/mbc.E12-12-0863.


Distinct roles for antiparallel microtubule pairing and overlap during early spindle assembly.

Nazarova E, O'Toole E, Kaitna S, Francois P, Winey M, Vogel J.

Mol Biol Cell. 2013 Oct;24(20):3238-50. doi: 10.1091/mbc.E13-05-0232. Epub 2013 Aug 21.


Genome-wide haploinsufficiency screen reveals a novel role for γ-TuSC in spindle organization and genome stability.

Choy JS, O'Toole E, Schuster BM, Crisp MJ, Karpova TS, McNally JG, Winey M, Gardner MK, Basrai MA.

Mol Biol Cell. 2013 Sep;24(17):2753-63. doi: 10.1091/mbc.E12-12-0902. Epub 2013 Jul 3.


ε-tubulin is essential in Tetrahymena thermophila for the assembly and stability of basal bodies.

Ross I, Clarissa C, Giddings TH Jr, Winey M.

J Cell Sci. 2013 Aug 1;126(Pt 15):3441-51. doi: 10.1242/jcs.128694. Epub 2013 May 23.


Activation of the yeast Hippo pathway by phosphorylation-dependent assembly of signaling complexes.

Rock JM, Lim D, Stach L, Ogrodowicz RW, Keck JM, Jones MH, Wong CC, Yates JR 3rd, Winey M, Smerdon SJ, Yaffe MB, Amon A.

Science. 2013 May 17;340(6134):871-5. doi: 10.1126/science.1235822. Epub 2013 Apr 11.


Sfr13, a member of a large family of asymmetrically localized Sfi1-repeat proteins, is important for basal body separation and stability in Tetrahymena thermophila.

Stemm-Wolf AJ, Meehl JB, Winey M.

J Cell Sci. 2013 Apr 1;126(Pt 7):1659-71. doi: 10.1242/jcs.120238. Epub 2013 Feb 20.


Mps1 and Ipl1/Aurora B act sequentially to correctly orient chromosomes on the meiotic spindle of budding yeast.

Meyer RE, Kim S, Obeso D, Straight PD, Winey M, Dawson DS.

Science. 2013 Mar 1;339(6123):1071-4. doi: 10.1126/science.1232518. Epub 2013 Jan 31.


Bld10/Cep135 stabilizes basal bodies to resist cilia-generated forces.

Bayless BA, Giddings TH Jr, Winey M, Pearson CG.

Mol Biol Cell. 2012 Dec;23(24):4820-32. doi: 10.1091/mbc.E12-08-0577. Epub 2012 Oct 31.


The two human centrin homologues have similar but distinct functions at Tetrahymena basal bodies.

Vonderfecht T, Cookson MW, Giddings TH Jr, Clarissa C, Winey M.

Mol Biol Cell. 2012 Dec;23(24):4766-77. doi: 10.1091/mbc.E12-06-0454. Epub 2012 Oct 19.


Bioleaching of fly ash by the tropical marine yeast, Yarrowia lipolytica NCIM 3589.

Bankar A, Winey M, Prakash D, Kumar AR, Gosavi S, Kapadnis B, Zinjarde S.

Appl Biochem Biotechnol. 2012 Dec;168(8):2205-17. doi: 10.1007/s12010-012-9930-2. Epub 2012 Oct 18.


Mitotic spindle form and function.

Winey M, Bloom K.

Genetics. 2012 Apr;190(4):1197-224. doi: 10.1534/genetics.111.128710.


The MPS1 family of protein kinases.

Liu X, Winey M.

Annu Rev Biochem. 2012;81:561-85. doi: 10.1146/annurev-biochem-061611-090435. Epub 2012 Apr 5. Review.


Cytological analysis of Tetrahymena thermophila.

Winey M, Stemm-Wolf AJ, Giddings TH Jr, Pearson CG.

Methods Cell Biol. 2012;109:357-78. doi: 10.1016/B978-0-12-385967-9.00013-X. Review.


Ubiquitin ligase Ufd2 is required for efficient degradation of Mps1 kinase.

Liu C, van Dyk D, Choe V, Yan J, Majumder S, Costanzo M, Bao X, Boone C, Huo K, Winey M, Fisk H, Andrews B, Rao H.

J Biol Chem. 2011 Dec 23;286(51):43660-7. doi: 10.1074/jbc.M111.286229. Epub 2011 Nov 1.


Cell cycle phosphorylation of mitotic exit network (MEN) proteins.

Jones MH, Keck JM, Wong CC, Xu T, Yates JR 3rd, Winey M.

Cell Cycle. 2011 Oct 15;10(20):3435-40. doi: 10.4161/cc.10.20.17790. Epub 2011 Oct 15.


The Aurora kinase Ipl1 is necessary for spindle pole body cohesion during budding yeast meiosis.

Shirk K, Jin H, Giddings TH Jr, Winey M, Yu HG.

J Cell Sci. 2011 Sep 1;124(Pt 17):2891-6. doi: 10.1242/jcs.086652.


A cell cycle phosphoproteome of the yeast centrosome.

Keck JM, Jones MH, Wong CC, Binkley J, Chen D, Jaspersen SL, Holinger EP, Xu T, Niepel M, Rout MP, Vogel J, Sidow A, Yates JR 3rd, Winey M.

Science. 2011 Jun 24;332(6037):1557-61. doi: 10.1126/science.1205193.


The two domains of centrin have distinct basal body functions in Tetrahymena.

Vonderfecht T, Stemm-Wolf AJ, Hendershott M, Giddings TH Jr, Meehl JB, Winey M.

Mol Biol Cell. 2011 Jul 1;22(13):2221-34. doi: 10.1091/mbc.E11-02-0151. Epub 2011 May 11.


KIF7 mutations cause fetal hydrolethalus and acrocallosal syndromes.

Putoux A, Thomas S, Coene KL, Davis EE, Alanay Y, Ogur G, Uz E, Buzas D, Gomes C, Patrier S, Bennett CL, Elkhartoufi N, Frison MH, Rigonnot L, Joyé N, Pruvost S, Utine GE, Boduroglu K, Nitschke P, Fertitta L, Thauvin-Robinet C, Munnich A, Cormier-Daire V, Hennekam R, Colin E, Akarsu NA, Bole-Feysot C, Cagnard N, Schmitt A, Goudin N, Lyonnet S, Encha-Razavi F, Siffroi JP, Winey M, Katsanis N, Gonzales M, Vekemans M, Beales PL, Attié-Bitach T.

Nat Genet. 2011 Jun;43(6):601-6. doi: 10.1038/ng.826. Epub 2011 May 8.


Structure-function analysis of the C-terminal domain of CNM67, a core component of the Saccharomyces cerevisiae spindle pole body.

Klenchin VA, Frye JJ, Jones MH, Winey M, Rayment I.

J Biol Chem. 2011 May 20;286(20):18240-50. doi: 10.1074/jbc.M111.227371. Epub 2011 Mar 24.


Mip1 associates with both the Mps1 kinase and actin, and is required for cell cortex stability and anaphase spindle positioning.

Mattison CP, Stumpff J, Wordeman L, Winey M.

Cell Cycle. 2011 Mar 1;10(5):783-93. Epub 2011 Mar 1.


Plk4/SAK/ZYG-1 in the regulation of centriole duplication.

Pearson CG, Winey M.

F1000 Biol Rep. 2010 Aug 9;2:58. doi: 10.3410/B2-58.


Electron tomography and immuno-labeling of Tetrahymena thermophila basal bodies.

Giddings TH Jr, Meehl JB, Pearson CG, Winey M.

Methods Cell Biol. 2010;96:117-41. doi: 10.1016/S0091-679X(10)96006-8.


Basal body stability and ciliogenesis requires the conserved component Poc1.

Pearson CG, Osborn DP, Giddings TH Jr, Beales PL, Winey M.

J Cell Biol. 2009 Dec 14;187(6):905-20. doi: 10.1083/jcb.200908019.


High pressure freezing, electron microscopy, and immuno-electron microscopy of Tetrahymena thermophila basal bodies.

Meehl JB, Giddings TH Jr, Winey M.

Methods Mol Biol. 2009;586:227-41. doi: 10.1007/978-1-60761-376-3_12.


Nested genes CDA12 and CDA13 encode proteins associated with membrane trafficking in the ciliate Tetrahymena thermophila.

Zweifel E, Smith J, Romero D, Giddings TH Jr, Winey M, Honts J, Dahlseid J, Schneider B, Cole ES.

Eukaryot Cell. 2009 Jun;8(6):899-912. doi: 10.1128/EC.00342-08. Epub 2009 Mar 13.


Budding yeast centrosome duplication requires stabilization of Spc29 via Mps1-mediated phosphorylation.

Holinger EP, Old WM, Giddings TH Jr, Wong C, Yates JR 3rd, Winey M.

J Biol Chem. 2009 May 8;284(19):12949-55. doi: 10.1074/jbc.M900088200. Epub 2009 Mar 5.


Basal body assembly in ciliates: the power of numbers.

Pearson CG, Winey M.

Traffic. 2009 May;10(5):461-71. doi: 10.1111/j.1600-0854.2009.00885.x. Epub 2009 Jan 24. Review.


The two SAS-6 homologs in Tetrahymena thermophila have distinct functions in basal body assembly.

Culver BP, Meehl JB, Giddings TH Jr, Winey M.

Mol Biol Cell. 2009 Mar;20(6):1865-77. doi: 10.1091/mbc.E08-08-0838. Epub 2009 Jan 21.

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